The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells
Open accessAbstract
Significance: Methylation of cytosine bases in DNA is an epigenetic modification that influences gene expression. TET (Ten-Eleven Translocation) enzymes regulate DNA methylation status and facilitate DNA demethylation by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further oxidation products in mammalian genomes. Of the three mammalian TET proteins, Tet1 and Tet2 are the major regulators of 5hmC levels in mouse embryonic stem (ES) cells. We show that Tet1 and Tet2 have distinct roles in mouse ES cells: Tet1 primarily regulates 5hmC levels at gene promoters and transcription start sites, whereas Tet2 mainly regulates 5hmC levels in gene bodies and exon boundaries of highly-expressed genes and exons respectively. Our results suggest a complex interplay between the functions of Tet1 and Tet2 proteins in mESC.
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Citations
Cites
Human DNA methylomes at base resolution show widespread epigenomic differences
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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451
Global epigenomic reconfiguration during mammalian brain development
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Self-citationMutation in TET2 in Myeloid Cancers
Delhommeau, F., Dupont, S., Valle, V. D., James, C., Trannoy, S., Massé, A., Kosmider, O., Le Couedic, J.-P., Robert, F., Alberdi, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810069 · Cited by 1,776
DNA-binding factors shape the mouse methylome at distal regulatory regions
Stadler, M. B., Murr, R., Burger, L., Ivanek, R., Lienert, F., Schöler, A., Nimwegen, E. V., Wirbelauer, C., Oakeley, E. J., Gaidatzis, D., et al. (2011) · Nature · doi:10.1038/nature10716 · Cited by 1,383
A map of the cis-regulatory sequences in the mouse genome
Shen, Y., Yue, F., McCleary, D. F., Ye, Z., Edsall, L., Kuan, S., Wagner, U., Dixon, J., Lee, L., Lobanenkov, V. V., et al. (2012) · Nature · doi:10.1038/nature11243 · Cited by 1,361 · cited 2×
“Indeed, DHMRs that showed gain of 5hmC in Tet2 kd mESC were enriched for Tet1 binding sites (21), which tend to be present at regions of DNase I hypersensitivity that bear histone marks associated with promoters and active enhancers (H3K4me2, H3K4me3 and H3K27Ac) (22) (Fig.”
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TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
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MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
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TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
Pastor, W. A., Aravind, L., & Rao, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3589 · Cited by 897 · cited 3×
“The oxidized methylcytosines produced by TET proteins are likely to be players in several pathways of DNA demethylation (1, 4, 5), thus loss of TET proteins is generally expected to result in increased DNA methylation.”
BackgroundSelf-citationGenome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
Pastor, W. A., Pape, U. J., Huang, Y., Henderson, H. R., Lister, R., Ko, M., McLoughlin, E. M., Brudno, Y., Mahapatra, S., Kapranov, P., et al. (2011) · Nature · doi:10.1038/nature10102 · Cited by 804
Self-citationLoss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
Lian, C. G., Xu, Y., Ceol, C., Wu, F., Larson, A., Dresser, K., Xu, W., Tan, L., Hu, Y., Zhan, Q., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.033 · Cited by 789
Dawlaty, M. M., Ganz, K., Powell, B. E., Hu, Y.-C., Markoulaki, S., Cheng, A. W., Gao, Q., Kim, J., Choi, S.-W., Page, D. C., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.07.010 · Cited by 508
Mutation in TET2 in Myeloid Cancers
(2009) · New England Journal of Medicine · doi:10.1056/nejmc091348 · Cited by 66
Cited by
TET-mediated active DNA demethylation: mechanism, function and beyond
Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661
Hon, G. C., Song, C.-X., Du, T., Jin, F., Selvaraj, S., Lee, A. Y., Yen, C.-A., Ye, Z., Mao, S.-Q., Wang, B.-A., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.026 · Cited by 344
Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells
Dawlaty, M. M., Breiling, A., Le, T., Barrasa, M. I., Raddatz, G., Gao, Q., Powell, B. E., Cheng, A. W., Faull, K. F., Lyko, F., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.03.003 · Cited by 338
Phthalate exposure and long-term epigenomic consequences: a review
Dutta, S., Haggerty, D. K., Rappolee, D. A., & Ruden, D. M. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00405 · Cited by 212
Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208
Metadata
- Authors
- Huang, Y., Chavez, L., Chang, X., Wang, X., Pastor, W. A., Kang, J., Zepeda-Martínez, J. A., Pape, U. J., Jacobsen, S. E., Peters, B., & Rao, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-01-13
- Volume
- 111
- Issue
- 4
- Pages
- 1361-1366
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978805574
- Cited by
- 259
- References
- 15
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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