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Dopamine transporters govern diurnal variation in extracellular dopamine tone
Open accessAbstract
Significance: The mechanism for diurnal (i.e., light/dark) oscillations in extracellular dopamine tone in mesolimbic and nigrostriatal systems is unknown. This is because, unlike other neurotransmitter systems, variation in dopamine tone does not correlate with variation in dopamine cell firing. The current research pinpoints the dopamine transporter as a critical governor of diurnal variation in both extracellular dopamine tone and the intracellular availability of releasable dopamine. These data describe shifts in the function of the dopamine system over time, which may have implications for diurnal effects on dopamine-dependent learning, sleep/wake behavior, locomotor activity, reward, and drug addiction.
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“Diurnal variation in dopamine neurotransmission is well known35 with evidence for functional consequences.”
From Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank (2023) · cites this paper as [35]
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Metadata
- Authors
- Ferris, M. J., España, R. A., Locke, J. L., Konstantopoulos, J. K., Rose, J. H., Chen, R., & Jones, S. R.
- Affiliations
- Wake Forest University Health Sciences (US)
- Drexel University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-06-16
- Volume
- 111
- Issue
- 26
- Pages
- E2751-9
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4084435
- OpenAlex
- W2013743740
- Cited by
- 192
- References
- 63
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 13 · 2023: 15 · 2022: 15 · 2021: 22 · 2020: 19 · 2019: 17 · 2018: 16 · 2017: 17 · 2016: 13 · 2015: 10 · 2014: 4
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DA031791, DA-006634)
- National Institute on Alcohol Abuse and Alcoholism (P01AA021099, U01AA014091)
- National Institute on Drug Abuse (F31DA035558, R01DA021325, T32DA007246, P50DA006634, R01DA030161, K01DA025279, R01DA014030, K99DA031791)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- dopamine transporter, diurnal variation, dopamine uptake, dopamine release, striatum, dopamine autoreceptors, dopamine D2 receptor, tyrosine hydroxylase, dopamine metabolism, dopaminergic neurons, circadian rhythm
- MeSH terms
- Animals, Chromatography, High Pressure Liquid, Circadian Rhythm, Dopamine, Extracellular Space, Male, Tyrosine 3-Monooxygenase, Blotting, Western, Rats, Sprague-Dawley, Microdialysis, Mice, Knockout, Dopamine Plasma Membrane Transport Proteins, Mice, Rats
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