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Cited by 261Neurotransmitter Receptor Influence on BehaviorSleep and Wakefulness ResearchNeural dynamics and brain function

Behavioral correlates of dopaminergic unit activity in freely moving cats

Steinfels, George F., Heym, James, Strecker, Robert E., Jacobs, Barry L.·1983·Brain Research
DOI 10.1016/0006-8993(83)91145-9
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Abstract

Single unit activity of dopaminergic neurons in the substantia nigra was recorded in freely moving cats under a variety of conditions. These neurons displayed their highest discharge rate during active waking (3.68 +/- 0.30 spikes/s), which was 20% greater than their discharge rate during quiet waking (3.07 +/- 0.20). Although these cells fired somewhat faster during active waking, their activity displayed no correlation with phasic EMG changes, and, in general, their activity showed little relationship to overt behavioral changes. As the cat progressed from quiet waking through slow-wave sleep and REM sleep there was no significant change in either the rate or pattern of firing of dopaminergic neurons. In addition, no correlation was observed between the activity of these neurons and either sleep spindles or PGO waves. These neurons did respond, however, to the repeated presentation of a click or light flash with excitation followed by inhibition, with no evidence of habituation. One of the most impressive changes in dopaminergic unit activity was a large decrease in association with orienting responses. This was seen in over 50% of the cells in which this relationship was examined. As the behavioral orientation habituated with repeated stimulus presentation, so did the associated dopaminergic unit suppression. In conclusion, dopaminergic neurons maintain a remarkably constant rate and pattern of firing across a variety of behaviors and states. However, this stability can be dramatically altered under special circumstances, such as during and following orienting responses.

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Crossref · 10.1016/0006-8993(83)91145-9

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27 of 27 references verified0 citation errors · 0 not checkable

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  • Stimuli of all sensory modalities are effective in eliciting the initial response component.

    “Stimuli of all sensory modalities are effective in eliciting this initial response component; those tested include loud sounds, intense light flashes, rapidly moving visual objects and liquids touching the mouth2,9,16,19,20,35.”

    From Dopamine reward prediction-error signalling: A two-component response (2016) · cites this paper as [16]

  • Recognition of the two-component structure of phasic dopamine responses may resolve earlier controversies that suggested an attentional rather than rewarding role of the dopamine prediction-error signal.

    “Recognition of the two-component structure of phasic dopamine responses may also resolve earlier controversies, which suggested an attentional rather than rewarding role of the dopamine prediction-error signal64,65 on the basis of activations following exposure to physically salient stimuli16,20 and punishers24.”

    From Dopamine reward prediction-error signalling: A two-component response (2016) · cites this paper as [16]

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Related

Authors
Steinfels, G. F., Heym, J., Strecker, R. E., & Jacobs, B. L.
Affiliations
Princeton University (US)
ORCID
Strecker, Robert E.
Venue
Brain Research
Publisher
Elsevier BV
Published
1983-01
Volume
258
Issue
2
Pages
217-228
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(83)91145-9
OpenAlex
W1963772961
Cited by
261
References
28
Citations by year
2026: 2 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 11 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 6
FWCI
2.72
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • U.S. Public Health Service
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
dopaminergic neurons, substantia nigra, single-unit activity, wakefulness, sleep spindles, PGO waves, orienting response, habituation, REM sleep, slow-wave sleep
MeSH terms
Animals, Apomorphine, Behavior, Animal, Cats, Dopamine, Female, Motor Activity, Neurons, Sleep, Sleep, REM, Substantia Nigra, Wakefulness

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