Genome-wide gene expression profiles of the developing mouse hippocampus
Open accessAbstract
We have analyzed the developmental molecular programs of the mouse hippocampus, a cortical structure critical for learning and memory, by means of large-scale DNA microarray techniques. Of 11,000 genes and expressed sequence tags examined, 1,926 showed dynamic changes during hippocampal development from embryonic day 16 to postnatal day 30. Gene-cluster analysis was used to group these genes into 16 distinct clusters with striking patterns that appear to correlate with major developmental hallmarks and cellular events. These include genes involved in neuronal proliferation, differentiation, and synapse formation. A complete list of the transcriptional changes has been compiled into a comprehensive gene profile database ( http://BrainGenomics.Princeton.edu ), which should prove valuable in advancing our understanding of the molecular and genetic programs underlying both the development and the functions of the mammalian brain.
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During early postnatal development, microglia undergo morphological maturation that matches synaptic maturation and express receptors for neuronal signaling factors upregulated during this period.
“Clues to this activity come from observations that during early postnatal development microglia undergo morphological maturation that matches synaptic maturation4, and that they express receptors for neuronal signaling factors that are upregulated during this period5.”
From Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction (2018) · cites this paper as [5]
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- Authors
- Mody, M., Cao, Y., Cui, Z., Tay, K.-Y., Shyong, A., Shimizu, E., Pham, K., Schultz, P., Welsh, D., & Tsien, J. Z.
- Affiliations
- Genomics Institute of the Novartis Research Foundation (US)
- Corresponding author
- Mody, Monica
- Cao, Yanxiang
- Tsien, Joe Z.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-07-03
- Volume
- 98
- Issue
- 15
- Pages
- 8862-8867
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC37526
- OpenAlex
- W2052536256
- Cited by
- 205
- References
- 54
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 12 · 2016: 6 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 5
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- hippocampus development, gene expression profiling, mice, embryonic development, postnatal development, neuronal proliferation, neuronal differentiation, synaptogenesis, gene clusters, gene expression changes, gene expression database, brain development
- MeSH terms
- Animals, Animals, Newborn, Female, Hippocampus, Male, Mice, Inbred C57BL, Transcription, Genetic, Up-Regulation, Gene Expression Regulation, Developmental, Gene Expression Profiling, Mice
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