Cannabinoid CB 2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice

Zhang, Hai-Ying; Gao, Ming; Liu, Qing-Rong; Bi, Guo-Hua; Li, Xia; Yang, Hong-Ju; Gardner, Eliot L.; Wu, Jie; Xi, Zheng-Xiong

doi:10.1073/pnas.1413210111

Cited by 334Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cannabinoid CB 2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice

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Zhang, Hai-Ying, Gao, Ming, Liu, Qing-Rong, Bi, Guo-Hua, Li, Xia, Yang, Hong-Ju, Gardner, Eliot L., Wu, Jie +1 more·2014·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1413210111PMC PMC4246322

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Abstract

Significance: Although early studies suggested that cannabinoid CB 2 receptors (CB 2 Rs) are absent in the brain, this view has been challenged by recent findings of significant brain CB 2 R involvement in several dopamine (DA)-related CNS disorders. The cellular mechanisms underlying these actions are unclear, however. Using multiple approaches, we found that CB 2 R genes and receptors are expressed in midbrain DA neurons, and that activation of CB 2 Rs inhibits DA neuronal firing and i.v. cocaine self-administration. These findings not only challenge the long-held view that brain CB 2 Rs are not expressed in neurons, but also suggest that neuronal CB 2 Rs modulate DA neuronal activity and DA-regulated behavior. Thus, brain CB 2 Rs may constitute a new therapeutic target in medication development for treatment of a number of CNS disorders.

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CB2 activation reduces ventral tegmental area dopamine neuron firing and immobility in forced-swim and tail-suspension tests.
“CB2 activation reduces VTA dopamine neuron firing [39] and immobility in forced-swim and tail-suspension tests [40].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [39]

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Authors: Zhang, H.-Y., Gao, M., Liu, Q.-R., Bi, G.-H., Li, X., Yang, H.-J., Gardner, E. L., Wu, J., & Xi, Z.-X.
Affiliations: National Institute on Drug Abuse (US)
Barrow Neurological Institute (US)
University of California San Diego (US)
ORCID: Zhang, Hai-Ying
Gao, Ming
Liu, Qing-Rong
Bi, Guo-Hua
Gardner, Eliot L.
Wu, Jie
Xi, Zheng-Xiong
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2014-11-03
Volume: 111
Issue: 46
Pages: E5007-15
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1413210111
PMC: PMC4246322
OpenAlex: W2135184362
Cited by: 334
References: 57
Citations by year: 2026: 14 · 2025: 15 · 2024: 18 · 2023: 20 · 2022: 40 · 2021: 44 · 2020: 31 · 2019: 28 · 2018: 38 · 2017: 37 · 2016: 24 · 2015: 25
FWCI: 20.90
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Bristol-Myers Squibb
Brigham Young University
National Institutes of Health (GAD67)
Indiana University Bloomington
National Institute on Drug Abuse
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: CB2 receptor, ventral tegmental area, dopaminergic neurons, neuronal excitability, JWH-133, cocaine self-administration, CB2 knockout mice, CB1 receptor, midbrain dopamine
MeSH terms: Action Potentials, Animals, Appetitive Behavior, Cannabinoids, Cocaine, Dopamine, Feeding Behavior, Indoles, Male, Mice, Inbred C57BL, Microinjections, Nerve Tissue Proteins, Neuroglia, Reward, RNA, Messenger, Self Administration, Spleen, Ventral Tegmental Area, Mice, Knockout, Cocaine-Related Disorders, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2, Mice, Dopaminergic Neurons

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Cannabinoid CB 2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice

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