Evidence for a novel functional role of cannabinoid CB2 receptors in the thalamus of neuropathic rats
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Cannabinoid CB(1) receptors have analgesic effects in models of neuropathic pain, but can also produce psychoactive side-effects. A supraspinal location of CB(2) receptors has recently been described. CB(2) agonists are also antinociceptive, although the functional role of supraspinal CB(2) receptors in the control of nociception is unknown. Herein, we provide evidence that CB(2) receptors in the thalamus play a functional role in the modulation of responses of neurons in the ventral posterior nucleus (VPL) of the thalamus in neuropathic, but not sham-operated, rats. Spontaneous and mechanically evoked activity of VPL neurons was recorded with a multichannel electrode array in anaesthetized spinal nerve-ligated (SNL) rats and compared to sham-operated rats. Intra-VPL administration of the CB(2) agonist JWH-133 (30 ng in 500 nL) significantly reduced spontaneous (P < 0.05), non-noxious (P < 0.001) and noxious (P < 0.01) mechanically evoked responses of VPL neurons in SNL rats, but not in sham-operated rats. Inhibitory effects of JWH-133 on spontaneous (P < 0.01) and noxious-evoked (P < 0.001) responses of neurons were blocked by the CB(2) antagonist SR144528. Local administration of SR144528 alone did not alter spontaneous or evoked responses of VPL neurons, but increased burst activity of VPL neurons in SNL rats. There were, however, no differences in levels of the endocannabinoids anandamide and 2AG in the thalamus of SNL and sham-operated rats. These data suggest that supraspinal CB(2) receptors in the thalamus may contribute to the modulation of neuropathic pain responses.
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Local injection of JWH133 into the ventroposterolateral nucleus of the thalamus attenuated spontaneous and mechanically-evoked neuronal activity in SNL, but not sham rats, in a CB2-dependent manner.
“Local injection of JWH133 into the ventroposterolateral nucleus of the thalamus attenuated spontaneous and mechanically-evoked neuronal activity in SNL, but not sham rats, in a CB2-dependent manner.87”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [87]
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The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Quantitative assessment of tactile allodynia in the rat paw
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740 · see citing works
Ho Kim, S., & Mo Chung, J. (1992) · Pain · doi:10.1016/0304-3959(92)90041-9 · Cited by 3,069 · see citing works
Pharmacology of cannabinoid CB1 and CB2 receptors
Pertwee, R. G. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)82001-3 · Cited by 1,489 · see citing works
Identification and Functional Characterization of Brainstem Cannabinoid CB<sub>2</sub>Receptors
Van Sickle, M. D., Duncan, M., Kingsley, P. J., Mouihate, A., Urbani, P., Mackie, K., Stella, N., Makriyannis, A., Piomelli, D., Davison, J. S., et al. (2005) · Science · doi:10.1126/science.1115740 · Cited by 1,470 · see citing works
Bisogno, T., Hanuš, L., PETROCELLIS, L. D., Tchilibon, S., Ponde, D. E., Brandi, I., Moriello, A. S., Davis, J. B., Mechoulam, R., & Marzo, V. D. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704327 · Cited by 1,315 · see citing works
Cannabinoid CB2 receptors: immunohistochemical localization in rat brain
Gong, J.-P., Onaivi, E. S., Ishiguro, H., Liu, Q.-R., Tagliaferro, P. A., Brusco, A., & Uhl, G. R. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.035 · Cited by 820 · see citing works
Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration
Walter, L. M., Franklin, A. A., Witting, A., Wade, C. B., Xie, Y., Kunos, G., Mackie, K., & Stella, N. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01398.2003 · Cited by 666 · see citing works
Benito, C., Núñez, E., Tolón, R. M., Carrier, E. J., Rábano, A., Hillard, C. J., & Romero, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11136.2003 · Cited by 624 · see citing works
Reliability and State Dependence of Pyramidal Cell–Interneuron Synapses in the Hippocampus
Csicsvari, J., Hirase, H., Czurko, A., & Buzsáki, G. (1998) · Neuron · doi:10.1016/s0896-6273(00)80525-5 · Cited by 606 · see citing works
HU-308: A specific agonist for CB 2 , a peripheral cannabinoid receptor
Hanus, L. O., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R. G., Ross, R. A., Mechoulam, R., & Fride, E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14228 · Cited by 574 · see citing works
Pharmacology of Cannabinoid Receptors
Howlett, A. C. (1995) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.003135 · Cited by 493 · see citing works
Ibrahim, M. M., Deng, H., Zvonok, A., Cockayne, D. A., Kwan, J., Mata, H. P., Vanderah, T. W., Lai, J., Porreca, F., Makriyannis, A., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834309100 · Cited by 491 · see citing works
Burst firing in sensory systems
Krahe, R., & Gabbiani, F. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1296 · Cited by 465 · see citing works
Zhang, J., Hoffert, C., Vu, H. K., Groblewski, T., Ahmad, S., & O'Donnell, D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02704.x · Cited by 419 · see citing works
Abeles, M., & Goldstein, M. H. (1977) · Proceedings of the IEEE · doi:10.1109/proc.1977.10559 · Cited by 391 · see citing works
Fox, A., Kesingland, A., Gentry, C., McNair, K., Patel, S., Urban, L., & James, I. (2001) · Pain · doi:10.1016/s0304-3959(00)00474-7 · Cited by 379 · see citing works
Carlisle, S. J., Marciano‐Cabral, F., Staab, A., LUDWICK, C., & Cabral, G. A. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00147-3 · Cited by 344 · see citing works
Carrier, E. J., Kearn, C. S., Barkmeier, A. J., Breese, N. M., Yang, W., Nithipatikom, K., Pfister, S. L., Campbell, W. B., & Hillard, C. J. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.4.999 · Cited by 336 · see citing works
Núñez, E., Benito, C., Pazos, M. R., Barbáchano, A., Fajardo, O., González, S. R., Tolón, R. M., & Romero, J. (2004) · Synapse · doi:10.1002/syn.20050 · Cited by 334 · see citing works
CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms
Beltramo, M., Bernardini, N., Bertorelli, R., Campanella, M., Nicolussi, E., Fredduzzi, S., & Reggiani, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04684.x · Cited by 290 · see citing works
Valenzano, K. J., Tafesse, L., Lee, G., Harrison, J. E., Boulet, J. M., Gottshall, S. L., Mark, L., Pearson, M. S., Miller, W., Shan, S., et al. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.12.008 · Cited by 288 · see citing works
Cannabinoids ablate release of TNFα in rat microglial cells stimulated with lypopolysaccharide
Facchinetti, F., Giudice, E. D., Furegato, S., Passarotto, M., & Leon, A. (2002) · Glia · doi:10.1002/glia.10177 · Cited by 275 · see citing works
Lichtman, A. H., Cook, S. A., & Martin, B. R. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12310-0 · Cited by 261 · see citing works
Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons
Wotherspoon, G., Fox, A., McIntyre, P., Colley, S., Bevan, S., & Winter, J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.009 · Cited by 251 · see citing works
CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain
Clayton, N., Marshall, F. H., Bountra, C., & O'Shaughnessy, C. T. (2002) · Pain · doi:10.1016/s0304-3959(01)00454-7 · Cited by 247 · see citing works
Klegeris, A., Bissonnette, C. J., & McGeer, P. L. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705304 · Cited by 244 · see citing works
Cannabinoid receptors in microglia of the central nervous system: immune functional relevance
Cabral, G. A., & Marciano‐Cabral, F. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0405216 · Cited by 240 · see citing works
Thalamic bursting in rats during different awake behavioral states
Fanselow, E. E., Sameshima, K., Baccalá, L. A., & Nicolelis, M. A. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261273898 · Cited by 236 · see citing works
Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats
Petrosino, S., Palazzo, E., de Novellis, V., Bisogno, T., Rossi, F., Maione, S., & Di Marzo, V. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.08.011 · Cited by 227 · see citing works
CB cannabinoid receptor agonists: pain relief without psychoactive effects?
MALANJR, T., IBRAHIM, M., LAI, J., Vanderah, T. W., Makriyannis, A., & Porreca, F. (2003) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00004-8 · Cited by 223 · see citing works
Immediate thalamic sensory plasticity depends on corticothalamic feedback
Krupa, D. J., Ghazanfar, A. A., & Nicolelis, M. A. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8200 · Cited by 212 · see citing works
Expression of the cannabinoid CB2 receptor in the rat cerebellum: An immunohistochemical study
Ashton, J. C., Friberg, D., Darlington, C. L., & Smith, P. F. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.038 · Cited by 208 · see citing works
The significance of action potential bursting in the brain reward circuit
Cooper, D. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(02)00068-2 · Cited by 178 · see citing works
Nackley, A. G., Makriyannis, A., & Hohmann, A. G. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00126-x · Cited by 176 · see citing works
Chapman, V., Suzuki, R., & Dickenson, A. H. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.881bs.x · Cited by 173 · see citing works
Richardson, D. S., Ortori, C. A., Chapman, V., Kendall, D. A., & Barrett, D. A. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.10.039 · Cited by 168 · see citing works
Martin, W. J., Coffin, P. O., Attias, E., Balinsky, M., Tsou, K., & Walker, J. M. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01368-7 · Cited by 164 · see citing works
Elmes, S. J. R., Jhaveri, M. D., Smart, D., Kendall, D. A., & Chapman, V. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03690.x · Cited by 160 · see citing works
Guilbaud, G., Benoist, J. M., Jazat, F., & Gautron, M. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.64.5.1537 · Cited by 160 · see citing works
Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain
Jhaveri, M. D., Richardson, D., Kendall, D. A., Barrett, D. A., & Chapman, V. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3326-06.2006 · Cited by 159 · see citing works
Sagar, D. R., Kelly, S., Millns, P. J., O'Shaughnessey, C. T., Kendall, D. A., & Chapman, V. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04206.x · Cited by 154 · see citing works
Walczak, J.-S., Pichette, V., Leblond, F., Desbiens, K., & Beaulieu, P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.010 · Cited by 133 · see citing works
Ashton, J. C., Rahman, R. M. A., Nair, S. M., Sutherland, B. A., Glass, M., & Appleton, I. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.10.053 · Cited by 131 · see citing works
Scott, D. A., Wright, C. E., & Angus, J. A. (2004) · Pain · doi:10.1016/j.pain.2004.01.020 · Cited by 128 · see citing works
Involvement of cannabinoid receptors in inflammatory hypersensitivity to colonic distension in rats
Sanson, M., Bueno, L. P., & Fioramonti, J. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00819.x · Cited by 111 · see citing works
Cannabinoid CB1 receptor upregulation in a rat model of chronic neuropathic pain
Siegling, A., Hofmann, H. A., Denzer, D., Mauler, F., & De Vry, J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00798-1 · Cited by 108 · see citing works
Hains, B. C., Saab, C. Y., & Waxman, S. G. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01009.2005 · Cited by 106 · see citing works
Chin, C.-L., Tovcimak, A. E., Hradil, V. P., Seifert, T. R., Hollingsworth, P. R., Chandran, P., Zhu, C. Z., Gauvin, D. M., Pai, M., Wetter, J. B., et al. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707506 · Cited by 96 · see citing works
Whiteside, G. T., Gottshall, S. L., Boulet, J. M., Chaffer, S. M., Harrison, J., Pearson, M. S., Turchin, P. I., Mark, L., Garrison, A. E., & Valenzano, K. J. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.10.043 · Cited by 94 · see citing works
Costa, B., Colleoni, M., Conti, S., Trovato, A. E., Bianchi, M., Sotgiu, M. L., & Giagnoni, G. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705587 · Cited by 89 · cited 2× · see citing works
“(CB1) agonists attenuate pain behaviour and evoked neuronal responses in neuropathic rats (Fox et al., 2001; Costa et al., 2004; Scott et al., 2004; Sagar et al., 2005; Liu & Walker, 2006).”
BackgroundPalazzo, E., De Novellis, V., Petrosino, S., Marabese, I., Vita, D., Giordano, C., Di Marzo, V., Mangoni, G. S., Rossi, F., & Maione, S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05086.x · Cited by 86 · see citing works
Penile Erection Evoked From Forebrain Structures in Macaca mulatta
Robinson, B. W., & Mishkin, M. (1968) · Archives of Neurology · doi:10.1001/archneur.1968.00480020070007 · Cited by 77 · see citing works
Walczak, J., Pichette, V., Leblond, F., Desbiens, K., & Beaulieu, P. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20821 · Cited by 62 · see citing works
Bordi, F., & Quartaroli, M. (2000) · Pain · doi:10.1016/s0304-3959(99)00205-5 · Cited by 46 · see citing works
Hasanein, P., Parviz, M., Keshavarz, M., & Javanmardi, K. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04592.x · Cited by 43 · see citing works
Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain
Liu, C., & Walker, J. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00498.2006 · Cited by 37 · see citing works
Jafari, M. R., Golmohammadi, S., Ghiasvand, F., Zarrindast, M., & DJAHANGUIRI, B. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282f00c10 · Cited by 22 · see citing works
Aziz, A. A. A., Finn, D. P., Mason, R., & Chapman, V. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.11.002 · Cited by 21 · see citing works
Luo Jia, H. O. N. G., MUBARAK, W. A. E.-D., SUNAMI, Y., Murakami, S., FUYAMA, Y., Ohtsuka, A., & MURAKAMI, T. (2000) · Archivum histologicum japonicum · doi:10.1679/aohc.63.459 · Cited by 7 · see citing works
洪, 珞. (2001) · Institutional Repositories DataBase (IRDB) · doi:10.11501/3182360 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Abeles M Goldstein MHJ Mutlispike train analysis IEEE Trans. Biomed. Eng. 1977 65 762 773
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CB2: a cannabinoid receptor with an identity crisis
Atwood, B. K., & Mackie, K. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00729.x · Cited by 633 · see citing works
Emerging strategies for exploiting cannabinoid receptor agonists as medicines
Pertwee, R. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00048.x · Cited by 436 · see citing works
Brain cannabinoid CB2 receptors modulate cocaine's actions in mice
Xi, Z.-X., Peng, X.-Q., Li, X., Song, R., Zhang, H.-Y., Liu, Q.-R., Yang, H.-J., Bi, G.-H., Li, J., & Gardner, E. L. (2011) · Nature Neuroscience · doi:10.1038/nn.2874 · Cited by 397 · see citing works
Zhang, H.-Y., Gao, M., Liu, Q.-R., Bi, G.-H., Li, X., Yang, H.-J., Gardner, E. L., Wu, J., & Xi, Z.-X. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413210111 · Cited by 334 · see citing works
Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain
Kinsey, S. G., Long, J. Z., O’Neal, S. T., Abdullah, R. A., Poklis, J. L., Boger, D. L., Cravatt, B. F., & Lichtman, A. H. (2009) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.155465 · Cited by 330 · see citing works
Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside
Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works
Progress in brain cannabinoid CB2 receptor research: From genes to behavior
Jordan, C. J., & Xi, Z. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.12.026 · Cited by 197 · see citing works
Cannabinoids and Pain: Sites and Mechanisms of Action
Starowicz, K., & Finn, D. P. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.05.003 · Cited by 192 · see citing works
den Boon, F. S., Chameau, P. J. P., Schaafsma-Zhao, Q., van Aken, W., Bari, M., Oddi, S., Kruse, C. G., Maccarrone, M., Wadman, W. J., & Werkman, T. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118167109 · Cited by 185 · see citing works
CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity
Onaivi, E. S., Ishiguro, H., Gu, S., & Liu, Q. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111400652 · Cited by 184 · see citing works
The Endocannabinoid System, Cannabinoids, and Pain
Fine, P. G., & Rosenfeld, M. J. (2013) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10129 · Cited by 203 · see citing works
Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors
Serrano, A., & Parsons, L. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.06.005 · Cited by 180 · see citing works
Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus
Brusco, A., Tagliaferro, P. A., Saez, T. M. M., & Onaivi, E. S. (2008) · Synapse · doi:10.1002/syn.20569 · Cited by 166 · see citing works
Role of different brain areas in peripheral nerve injury-induced neuropathic pain
Jaggi, A. S., & Singh, N. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.002 · Cited by 147 · see citing works
Suárez, J., Llorente, R., Romero‐Zerbo, S., Mateos, B., Bermúdez‐Silva, F. J., de Fonseca, F. R., & Viveros, M. (2008) · Hippocampus · doi:10.1002/hipo.20537 · Cited by 142 · see citing works
Haspula, D., & Clark, M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207693 · Cited by 137 · see citing works
Rahn, E. J., Zvonok, A. M., Thakur, G. A., Khanolkar, A. D., Makriyannis, A., & Hohmann, A. G. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.141994 · Cited by 116 · see citing works
The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice
de Paula-Freire, L. I. G., Andersen, M. L., Gama, V. S., Molska, G. R., & Carlini, E. A. (2013) · Phytomedicine · doi:10.1016/j.phymed.2013.08.006 · Cited by 110 · see citing works
Pain-related changes in the brain: diagnostic and therapeutic potentials
Saab, C. Y. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.06.002 · Cited by 98 · see citing works
Dynamic Regulation of the Endocannabinoid System: Implications for Analgesia
Sagar, D. R., Gaw, A. G., Okine, B. N., Woodhams, S. G., Wong, A., Kendall, D. A., & Chapman, V. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-59 · Cited by 96 · see citing works
The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress
Corcoran, L., Roche, M., & Finn, D. P. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.10.003 · Cited by 86 · see citing works
Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
Roche, M., & Finn, D. P. (2010) · Pharmaceuticals · doi:10.3390/ph3082517 · Cited by 87 · see citing works
Hashiesh, H. M., Sharma, C., Goyal, S. N., Sadek, B. S., Jha, N. K., Kaabi, J. A., & Ojha, S. K. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111639 · Cited by 90 · see citing works
Curto-Reyes, V., Llames, S. G., Hidalgo, A., Menéndez, L., & Baamonde, A. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00629.x · Cited by 84 · see citing works
Schuelert, N., Zhang, C., Mogg, A. J., Broad, L. M., Hepburn, D. L., Nisenbaum, E. S., Johnson, M. P., & McDougall, J. J. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.09.005 · Cited by 77 · see citing works
Galdino, G., Romero, T., Pinho da Silva, J. F., Aguiar, D., de Paula, A. M., Cruz, J., Parrella, C., Piscitelli, F., Duarte, I., Di Marzo, V., et al. (2014) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000000340 · Cited by 72 · see citing works
Self-medication of a cannabinoid CB2 agonist in an animal model of neuropathic pain
Gutierrez, T., Crystal, J. D., Zvonok, A. M., Makriyannis, A., & Hohmann, A. G. (2011) · Pain · doi:10.1016/j.pain.2011.03.038 · Cited by 71 · see citing works
Cannabinoid Receptors in Brain
Onaivi, E. S. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)88012-4 · Cited by 71 · see citing works
CB2 receptor in the CNS: From immune and neuronal modulation to behavior
Grabon, W., Rheims, S., Smith, J., Bodennec, J., Belmeguenaï, A., & Bezin, L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105226 · Cited by 67 · see citing works
Basic neuroanatomy and neuropharmacology of cannabinoids
Breivogel, C. S., & Sim‐Selley, L. J. (2009) · International Review of Psychiatry · doi:10.1080/09540260902782760 · Cited by 66 · see citing works
CB 1receptor antagonists: new discoveries leading to new perspectives
Kirilly, E., Gonda, X., & Bagdy, G. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02402.x · Cited by 78 · see citing works
Brownjohn, P. W., & Ashton, J. C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.028 · Cited by 57 · see citing works
Escobar, W., Ramirez, K., Avila, C., Limongi, R., Vanegas, H., & Vázquez, E. (2011) · European Journal of Pain · doi:10.1002/j.1532-2149.2011.00057.x · Cited by 59 · see citing works
Zhang, H., Shen, H., Jordan, C. J., Liu, Q., Gardner, E. L., Bonci, A., & Xi, Z. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0037-3 · Cited by 57 · see citing works
The Milk Thistle Seed Cakes and Hempseed Cakes are Potential Feed for Poultry
Šťastník, O., Pavlata, L., & Mrkvicová, E. (2020) · Animals · doi:10.3390/ani10081384 · Cited by 50 · see citing works
Blaszczyk, L., Maître, M., Lesté-Lasserre, T., Clark, S., Cota, D., Oliet, S. H. R., & Fénelon, V. S. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1378-z · Cited by 49 · see citing works
Koch, M., Kreutz, S., Böttger, C., Benz, A., Maronde, E., Ghadban, C., Korf, H., & Dehghani, F. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9166-2 · Cited by 46 · see citing works
Is There Any Clinically Relevant Cannabinoid-Induced Analgesia?
Kraft, B. (2012) · Pharmacology · doi:10.1159/000337376 · Cited by 44 · see citing works
Endocannabinoid Receptor Pharmacology
Yao, B. B., & Mackie, K. (2009) · Current topics in behavioral neurosciences · doi:10.1007/978-3-540-88955-7_2 · Cited by 43 · see citing works
Presynaptic and extrasynaptic regulation of posterior nucleus of thalamus
Park, A., Li, Y., Masri, R. M., & Keller, A. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00862.2016 · Cited by 37 · see citing works
Hoot, M. R., Sim‐Selley, L. J., Poklis, J. L., Abdullah, R. A., Scoggins, K. L., Selley, D. E., & Dewey, W. L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.105 · Cited by 32 · see citing works
A Treatment Algorithm for Neuropathic Pain: An Update
Namaka, M., Leong, C., Grossberndt, A., Klowak, M., Turcotte, D., Esfahani, F., Gomori, A. J., & Intrater, H. M. (2009) · The Consultant Pharmacist · doi:10.4140/tcp.n.2009.885 · Cited by 32 · see citing works
Cannabinoids for Neuropathic Pain
Fine, P. G., & Rosenfeld, M. J. (2014) · Current Pain and Headache Reports · doi:10.1007/s11916-014-0451-2 · Cited by 32 · see citing works
Rahn, E. J., Zvonok, A. M., Makriyannis, A., & Hohmann, A. G. (2010) · The AAPS Journal · doi:10.1208/s12248-009-9170-8 · Cited by 24 · see citing works
Curto-Reyes, V., Boto, T., Hidalgo, A., Menéndez, L., & Baamonde, A. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.06.057 · Cited by 24 · see citing works
Basolateral amygdala activity during the retrieval of associative learning under anesthesia
Fenton, G. E., Spicer, C. H., Halliday, D. M., Mason, R., & Stevenson, C. W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.039 · Cited by 23 · see citing works
Characteristics of local field potentials correlate with pain relief by deep brain stimulation
Huang, Y., Luo, H., Green, A. L., Aziz, T. Z., & Wang, S. (2016) · Clinical Neurophysiology · doi:10.1016/j.clinph.2016.04.011 · Cited by 23 · see citing works
Pacheco, D. D. F., Romero, T. R. L., & Duarte, I. D. G. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.01.059 · Cited by 23 · see citing works
Tseng, W.-T., Tsai, M., Iwata, K., & Yen, C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1828-12.2012 · Cited by 22 · see citing works
Amalraj, A., Jacob, J., C., K. V. A., & Gopi, S. (2020) · ACS Omega · doi:10.1021/acsomega.0c03456 · Cited by 20 · see citing works
The endocannabinoid system as a therapeutic target in neuropathic pain: a review
Quintero, J.-M., Díaz, L. E., Galve‐Roperh, I., Bustos, R., Leon, M.-X., Beltran, S., & Dodd, S. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2407824 · Cited by 18 · see citing works
Corcoran, L., Mattimoe, D., Roche, M., & Finn, D. P. (2020) · British Journal of Pharmacology · doi:10.1111/bph.14976 · Cited by 16 · see citing works
Narouze, S. (2020) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2020-102114 · Cited by 18 · see citing works
The endocannabinoid system in the brain undergoes long-lasting changes following neuropathic pain
Zhang, M., Wang, T., Meng, F., Jiang, M., Wu, S., & Xu, H. (2024) · iScience · doi:10.1016/j.isci.2024.111409 · Cited by 16 · see citing works
Visualizing the Complex Brain Dynamics of Chronic Pain
Saab, C. Y. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9378-8 · Cited by 15 · see citing works
Zhang, L., Kolaj, M., & Renaud, L. P. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.10.015 · Cited by 14 · see citing works
Kim, H. Y., Wang, J., & Gwak, Y. S. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2012.2396 · Cited by 14 · see citing works
Cannabinoids: Role in Neurological Diseases and Psychiatric Disorders
Kumar, U. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010152 · Cited by 14 · see citing works
New Insights Into Peptide Cannabinoids: Structure, Biosynthesis and Signaling
Riquelme-Sandoval, A., de Sá-Ferreira, C. O., Miyakoshi, L. M., & Hedin‐Pereira, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.596572 · Cited by 13 · see citing works
Hashiesh, H. M., Jha, N. K., Sharma, C., Gupta, P. K., Jha, S. K., Patil, C. R., Goyal, S. N., & Ojha, S. K. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174398 · Cited by 13 · see citing works
Zhang, L., Kolaj, M., & Renaud, L. P. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.047 · Cited by 12 · see citing works
Targeting the Cannabinoid System to Produce Analgesia
Sagar, D. R., Jhaveri, M. D., & Chapman, V. (2009) · Current topics in behavioral neurosciences · doi:10.1007/978-3-540-88955-7_11 · Cited by 10 · see citing works
Industrial hemp in animal feed applications
Šťastník, O., Mrkvicová, E., & Pavlata, L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90910-5.00012-9 · Cited by 8 · see citing works
Cannabinoids For the Treatment of Neuropathic Pain: Are They Safe and Effective?
Gutierrez, T., & Hohmann, A. G. (2011) · Future Neurology · doi:10.2217/fnl.11.6 · Cited by 8 · see citing works
Chou, C.-W., Wong, G. T. C., Lim, G., Wang, S., Irwin, M. G., & Mao, J. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.03.018 · Cited by 8 · see citing works
Antiallodynic effect of PhAR‐DBH‐Me involves cannabinoid and TRPV1 receptors
Quiñonez‐Bastidas, G. N., Palomino‐Hernández, O., López‐Ortíz, M., Rocha-González, H. I., González‐Anduaga, G. M., Regla, I., & Navarrete, A. (2020) · Pharmacology Research & Perspectives · doi:10.1002/prp2.663 · Cited by 7 · see citing works
Overlapping pathways of migraine and the endocannabinoid system: Potential therapeutic targets
Pietra, A. D., & Russo, A. F. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e00833 · Cited by 6 · see citing works
Therapeutic properties of cannabinoid drugs and marijuana in several disorders: A narrative review
Alvarado, R. N., Dirección General Adjunta de Políticas y Programas contra las Adicciones, C. N. C. L. A., Sánchez, R. M. D. C., Salcedo, V. V., Dirección General de Políticas y Programas contra las Adicciones, C. N. C. L. A., & Departamento de Investigación Clínica, I. N. D. P. R. D. L. F. M. (2017) · Salud Mental · doi:10.17711/sm.0185-3325.2017.014 · Cited by 6 · see citing works
Cannabinoids and Pain: Mechanisms of Action
Narouze, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-69186-8_24 · Cited by 5 · see citing works
Glial Modulation in Pain States: Translation into Humans
Horvath, R. J., Romero-Sandoval, E. A., & Leo, J. A. D. (2010) · Europe PMC (PubMed Central) · Cited by 3 · see citing works
Zhang, H., & Xi, Z. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803750-8.00070-1 · Cited by 2 · see citing works
Jhaveri, M. D., Elmes, S. J. R., Richardson, D. S., Barrett, D. A., Kendall, D. A., Mason, R., & Chapman, V. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06274.x · Cited by 2 · see citing works
Jin, S., & Cho, H. (2024) · Pain · doi:10.1097/j.pain.0000000000003332 · Cited by 1 · see citing works
The Management of Neuropathic Pain
Toth, C., & Moulin, D. E. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139152211.019 · Cited by 1 · see citing works
Cannabinoid Receptor Mediated Analgesia: Novel Targets for Chronic Pain States
Chapman, V., Kendall, D. A., & Sagar, D. R. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0226-9_15 · Cited by 1 · see citing works
Shatalina, E., Ertl, N., Petrilli, K., Ofori, S., Borissova, A., Mokrysz, C., Curran, H. V., Lawn, W., Freeman, T. P., Howes, O. D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.02.657387 · Cited by 1 · see citing works
Fu, Z., Hutchison, K. E., Iraji, A., Jing Sui (Beijing Normal University), my correct affiliation is beijing normal university, N. Q. U. O. S. A. T., & Calhoun, V. D. (2025) · Research Square · doi:10.21203/rs.3.rs-6977015/v1 · Cited by 1 · see citing works
Llames, S. G., Hidalgo, A., Menéndez, L., & Baamonde, A. (2010)
CB1 Receptor Antagonist AM-251: Effect on Spatial Memory in Male Mice
Green, B. M. (2009) · California State University ScholarWorks (system-wide DSpace)
Ware, M. A. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139152211.022
The cannabinoid system and its role in nociception
Beltramo, M. (2016) · Wiley eBooks · doi:10.1002/9781118455968.ch6
Gamaleddin, I. (2013) · TSpace (University of Toronto)
Cannabinoid CB2 Receptor: A New Target for Treatment of Cocaine Addiction
Zhang, H., & Xi, Z. (2017) · Academic Press eBooks
Changes in the Endocannabinoid system in the Brain Following Bilateral Vestibular Damage
Baek, J. (2011) · Otago University Research Archive (University of Otago)
Alyu, F., Petrella, M., Masi, A., Borruto, A. M., Ciccocioppo, R., & Öztürk, Y. (2025) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2024-0302
Lindborg, K. A. (2010) · UA Campus Repository (The University of Arizona)
Bagher, A. M. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179130
- Authors
- Jhaveri, M. D., Elmes, S. J. R., Richardson, D., Barrett, D. A., Kendall, D. A., Mason, R., & Chapman, V.
- Affiliations
- University of Nottingham (GB)
- AstraZeneca (Canada) (CA)
- Pfizer (United Kingdom) (GB)
- Corresponding author
- Jhaveri, M. D.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2008-03-31
- Volume
- 27
- Issue
- 7
- Pages
- 1722-1730
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC2327204
- OpenAlex
- W2025055783
- Cited by
- 88
- References
- 62
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 7
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Update notices
- erratum (2008-04-25)
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- CB2 receptor, thalamus, ventral posterior nucleus, neuropathic pain, spinal nerve ligation, JWH-133, SR144528, nociception, spontaneous neuronal activity, endocannabinoids, anandamide, 2-arachidonoylglycerol
- MeSH terms
- Action Potentials, Animals, Cannabinoids, Male, Pain, Peripheral Nervous System Diseases, Thalamus, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB2, Rats
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