Cited by 88Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsPain Management and Treatment

Evidence for a novel functional role of cannabinoid CB2 receptors in the thalamus of neuropathic rats

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Jhaveri, M. D., Elmes, S. J. R., Richardson, D., Barrett, D. A., Kendall, D. A., Mason, R., Chapman, V.·2008·European Journal of Neuroscience

Abstract

Cannabinoid CB(1) receptors have analgesic effects in models of neuropathic pain, but can also produce psychoactive side-effects. A supraspinal location of CB(2) receptors has recently been described. CB(2) agonists are also antinociceptive, although the functional role of supraspinal CB(2) receptors in the control of nociception is unknown. Herein, we provide evidence that CB(2) receptors in the thalamus play a functional role in the modulation of responses of neurons in the ventral posterior nucleus (VPL) of the thalamus in neuropathic, but not sham-operated, rats. Spontaneous and mechanically evoked activity of VPL neurons was recorded with a multichannel electrode array in anaesthetized spinal nerve-ligated (SNL) rats and compared to sham-operated rats. Intra-VPL administration of the CB(2) agonist JWH-133 (30 ng in 500 nL) significantly reduced spontaneous (P < 0.05), non-noxious (P < 0.001) and noxious (P < 0.01) mechanically evoked responses of VPL neurons in SNL rats, but not in sham-operated rats. Inhibitory effects of JWH-133 on spontaneous (P < 0.01) and noxious-evoked (P < 0.001) responses of neurons were blocked by the CB(2) antagonist SR144528. Local administration of SR144528 alone did not alter spontaneous or evoked responses of VPL neurons, but increased burst activity of VPL neurons in SNL rats. There were, however, no differences in levels of the endocannabinoids anandamide and 2AG in the thalamus of SNL and sham-operated rats. These data suggest that supraspinal CB(2) receptors in the thalamus may contribute to the modulation of neuropathic pain responses.

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Crossref · 10.1111/j.1460-9568.2008.06162.x

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  • Local injection of JWH133 into the ventroposterolateral nucleus of the thalamus attenuated spontaneous and mechanically-evoked neuronal activity in SNL, but not sham rats, in a CB2-dependent manner.

    “Local injection of JWH133 into the ventroposterolateral nucleus of the thalamus attenuated spontaneous and mechanically-evoked neuronal activity in SNL, but not sham rats, in a CB2-dependent manner.87”

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  1. Abeles M Goldstein MHJ Mutlispike train analysis IEEE Trans. Biomed. Eng. 1977 65 762 773

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Authors
Jhaveri, M. D., Elmes, S. J. R., Richardson, D., Barrett, D. A., Kendall, D. A., Mason, R., & Chapman, V.
Affiliations
  • University of Nottingham (GB)
  • AstraZeneca (Canada) (CA)
  • Pfizer (United Kingdom) (GB)
Corresponding author
Jhaveri, M. D.
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2008-03-31
Volume
27
Issue
7
Pages
1722-1730
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2025055783
Cited by
88
References
62
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 7
FWCI
8.65
Type
journal article
Language
en
Update notices
erratum (2008-04-25)
Open access
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Medical Research Council
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
CB2 receptor, thalamus, ventral posterior nucleus, neuropathic pain, spinal nerve ligation, JWH-133, SR144528, nociception, spontaneous neuronal activity, endocannabinoids, anandamide, 2-arachidonoylglycerol
MeSH terms
Action Potentials, Animals, Cannabinoids, Male, Pain, Peripheral Nervous System Diseases, Thalamus, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB2, Rats

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