The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Sex inclusion in basic research drives discovery
Open accessAbstract
Much of our understanding of disease processes and treatments begins with preclinical studies that use nonhuman animals and cell cultures. Such studies are integral to biomedical research and the development pipeline for drugs, devices, and biologics. Most preclinical biomedical research, however, has been conducted with inadequate consideration of sex (1⇓–3).
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“Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans [1]”
From Sex differences in metabolic homeostasis, diabetes, and obesity (2015) · cites this paper as [1]
Citations
Cites
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Self-citationStrategies and Methods for Research on Sex Differences in Brain and Behavior
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Female mice liberated for inclusion in neuroscience and biomedical research
Prendergast, B. J., Onishi, K. G., & Zucker, I. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.001 · Cited by 788
Self-citationSex and gender differences in health: Science & Society Series on Sex and Science
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Sex bias exists in basic science and translational surgical research
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Do you know the sex of your cells?
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Of Mice and Women: The Bias in Animal Models
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Self-citationMapping ecologically relevant social behaviours by gene knockout in wild mice
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Sex-Dependent Attenuation of Plaque Growth After Treatment With Bone Marrow Mononuclear Cells
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Sex and basic science. A Title IX position
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Research works printed but not linked: 2
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Cited by
Sorted by citations
Sex and gender: modifiers of health, disease, and medicine
Mauvais-Jarvis, F., Bairey Merz, N., Barnes, P. J., Brinton, R. D., Carrero, J.-J., DeMeo, D. L., De Vries, G. J., Epperson, C. N., Govindan, R., Klein, S. L., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31561-0 · Cited by 2,001
Self-citationConsidering how biological sex impacts immune responses and COVID-19 outcomes
Scully, E. P., Haverfield, J., Ursin, R. L., Tannenbaum, C., & Klein, S. L. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0348-8 · Cited by 954
Self-citationAnimal models of obesity and diabetes mellitus
Kleinert, M., Clemmensen, C., Hofmann, S. M., Moore, M. C., Renner, S., Woods, S. C., Huypens, P., Beckers, J., de Angelis, M. H., Schürmann, A., et al. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.161 · Cited by 893
Sex differences in metabolic homeostasis, diabetes, and obesity
Mauvais-Jarvis, F. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0033-y · Cited by 626
“studying female rodents due to the added complexity of research plans [1], without regard for the consequences of generating data that is mostly relevant to only half of the population.”
BackgroundAn energetic view of stress: Focus on mitochondria
Picard, M. A., McEwen, B. S., Epel, E. S., & Sandi, C. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.01.001 · Cited by 584
Metadata
- Authors
- Klein, S. L., Schiebinger, L., Stefanick, M. L., Cahill, L., Danska, J., de Vries, G. J., Kibbe, M. R., McCarthy, M. M., Mogil, J. S., Woodruff, T. K., & Zucker, I.
- Affiliations
- Johns Hopkins University (US)
- History of Science, and
- Stanford Medicine (US)
- University of California, Irvine (US)
- University of Toronto (CA)
- Neuroscience Institute, Georgia State University, Atlanta, GA 30302;
- Northwestern University (US)
- University of Maryland, Baltimore (US)
- McGill University (CA)
- University of California, Berkeley (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-04-20
- Volume
- 112
- Issue
- 17
- Pages
- 5257-5258
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4418862
- OpenAlex
- W2095228051
- Cited by
- 238
- References
- 18
- Citations by year
- 2026: 10 · 2025: 23 · 2024: 15 · 2023: 19 · 2022: 24 · 2021: 23 · 2020: 20 · 2019: 15 · 2018: 19 · 2017: 32 · 2016: 31 · 2015: 7
- FWCI
- 31.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P30CA060553)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Social Sciences › Gender Studies › Diversity and Career in Medicine
- Social Sciences › Psychology › Applied Psychology › Career Development and Diversity
- Keywords
- sex differences, basic research, scientific discovery, gender diversity in research
- MeSH terms
- Animals, Female, Humans, Male, Reproduction, Biomedical Research
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