Cited by 238Sex and Gender in HealthcareDiversity and Career in MedicineCareer Development and Diversity

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Sex inclusion in basic research drives discovery

Open access

Klein, Sabra L., Schiebinger, Londa, Stefanick, Marcia L., Cahill, Larry, Danska, Jayne, de Vries, Geert J., Kibbe, Melina R., McCarthy, Margaret M., Mogil, Jeffrey S., Woodruff, Teresa K., Zucker, Irving·2015·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1502843112PMC PMC4418862

Open this paper in CoChat — free account

Abstract

Much of our understanding of disease processes and treatments begins with preclinical studies that use nonhuman animals and cell cultures. Such studies are integral to biomedical research and the development pipeline for drugs, devices, and biologics. Most preclinical biomedical research, however, has been conducted with inadequate consideration of sex (1⇓–3).

Integrity signals

Registry

Crossref · 10.1073/pnas.1502843112

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Policy: NIH to balance sex in cell and animal studies
Clayton, J. A., & Collins, F. S. (2014) · Nature · doi:10.1038/509282a · Cited by 1,816
Sex bias in neuroscience and biomedical research
Beery, A. K., & Zucker, I. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.002 · Cited by 1,763
Self-citation
Olfactory exposure to males, including men, causes stress and related analgesia in rodents
Sorge, R. E., Martin, L. J., Isbester, K. A., Sotocinal, S. G., Rosen, S., Tuttle, A. H., Wieskopf, J. S., Acland, E. L., Dokova, A., Kadoura, B., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2935 · Cited by 905
Self-citation
Strategies and Methods for Research on Sex Differences in Brain and Behavior
Becker, J. B., Arnold, A. P., Berkley, K. J., Blaustein, J. D., Eckel, L. A., Hampson, E., Herman, J. P., Marts, S. A., Sadée, W., Steiner, M. S., et al. (2004) · Endocrinology · doi:10.1210/en.2004-1142 · Cited by 833
Female mice liberated for inclusion in neuroscience and biomedical research
Prendergast, B. J., Onishi, K. G., & Zucker, I. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.001 · Cited by 788
Self-citation
Sex and gender differences in health: Science & Society Series on Sex and Science
Regitz‐Zagrosek, V. (2012) · The EMBO Reports · doi:10.1038/embor.2012.87 · Cited by 572
Minireview: sex differences in adult and developing brains: compensation, compensation, compensation
De Vries, G. J. (2004) · Endocrinology · doi:10.1210/en.2003-1504 · Cited by 486
Sex bias exists in basic science and translational surgical research
Yoon, D. Y., Mansukhani, N. A., Stubbs, V. C., Helenowski, I. B., Woodruff, T. K., & Kibbe, M. R. (2014) · Surgery · doi:10.1016/j.surg.2014.07.001 · Cited by 270
Self-citation
A role for cell sex in stem cell–mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency
Deasy, B. M., Lu, A., Tebbets, J. C., Feduska, J. M., Schugar, R. C., Pollett, J. B., Sun, B., Urish, K. L., Gharaibeh, B. M., Cao, B., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612094 · Cited by 251
Do you know the sex of your cells?
Shah, K., McCormack, C. E., & Bradbury, N. A. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00281.2013 · Cited by 219

Show all 18 references

Research works printed but not linked: 2

; US General Accounting Office Drug Safety: Most Drugs Withdrawn in Recent Years Had Greater Health Risks for Women (Government Publishing Office, Washington, DC, 2001).
V Regitz-Zagrosek, Sex and gender differences in health. European Molecular Biology Organization Reports 13, 596–603 (2012).

Sorted by citations

Sex and gender: modifiers of health, disease, and medicine
Mauvais-Jarvis, F., Bairey Merz, N., Barnes, P. J., Brinton, R. D., Carrero, J.-J., DeMeo, D. L., De Vries, G. J., Epperson, C. N., Govindan, R., Klein, S. L., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31561-0 · Cited by 2,001
Self-citation
Considering how biological sex impacts immune responses and COVID-19 outcomes
Scully, E. P., Haverfield, J., Ursin, R. L., Tannenbaum, C., & Klein, S. L. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0348-8 · Cited by 954
Self-citation
Animal models of obesity and diabetes mellitus
Kleinert, M., Clemmensen, C., Hofmann, S. M., Moore, M. C., Renner, S., Woods, S. C., Huypens, P., Beckers, J., de Angelis, M. H., Schürmann, A., et al. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.161 · Cited by 893
Sex differences in metabolic homeostasis, diabetes, and obesity
Mauvais-Jarvis, F. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0033-y · Cited by 626
“studying female rodents due to the added complexity of research plans [1], without regard for the consequences of generating data that is mostly relevant to only half of the population.”
Background
An energetic view of stress: Focus on mitochondria
Picard, M. A., McEwen, B. S., Epel, E. S., & Sandi, C. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.01.001 · Cited by 584
Reproducibility of animal research in light of biological variation
Voelkl, B., Altman, N., Forsman, A., Forstmeier, W., Gurevitch, J., Jarić, I., Karp, N. A., Kas, M. J., Schielzeth, H., de Casteele, T. V., et al. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0313-3 · Cited by 415
Why sex and gender matter in implementation research
Tannenbaum, C., Greaves, L., & Graham, I. D. (2016) · BMC Medical Research Methodology · doi:10.1186/s12874-016-0247-7 · Cited by 386
Inclusion of females does not increase variability in rodent research studies
Beery, A. K. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.06.016 · Cited by 386
Psychological Stress and Mitochondria: A Systematic Review
Picard, M. A., & McEwen, B. S. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000545 · Cited by 360
A 10-year follow-up study of sex inclusion in the biological sciences
Woitowich, N. C., Beery, A. K., & Woodruff, T. K. (2020) · eLife · doi:10.7554/elife.56344 · Cited by 344
Self-citation
Intersectional inequalities in science
Kozlowski, D., Larivière, V., Sugimoto, C. R., & Monroe‐White, T. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113067119 · Cited by 374
Sex differences in neuroimmunity and pain
Rosen, S., Ham, B., & Mogil, J. S. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23831 · Cited by 318
Self-citation
Factors affecting sex-related reporting in medical research: a cross-disciplinary bibliometric analysis
Sugimoto, C. R., Ahn, Y., Smith, E. M. R., Macaluso, B., & Larivière, V. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32995-7 · Cited by 323
A Guide for the Design of Pre-clinical Studies on Sex Differences in Metabolism
Mauvais‐Jarvis, F., Arnold, A. P., & Reue, K. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.033 · Cited by 284
Prevalence of sexual dimorphism in mammalian phenotypic traits
Karp, N. A., Mason, J., Beaudet, A. L., Benjamini, Y., Bower, L., Braun, R. E., Brown, S. D. M., Chesler, E. J., Dickinson, M. E., Flenniken, A. M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15475 · Cited by 257
Sex, Gender, and Pain
Fillingim, R. B. (2017) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-803506-1.00038-3 · Cited by 256
Gender-related variables for health research
Nielsen, M. W., Stefanick, M. L., Peragine, D., Neilands, T. B., Ioannidis, J. P. A., Pilote, L., Prochaska, J. J., Cullen, M. R., Einstein, G., Klinge, I., et al. (2021) · Biology of Sex Differences · doi:10.1186/s13293-021-00366-3 · Cited by 238
Self-citation
Sex hormones and adult hippocampal neurogenesis: Regulation, implications, and potential mechanisms
Mahmoud, R., Wainwright, S. R., & Galea, L. A. M. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.002 · Cited by 208
Sex- and Gender-Based Pharmacological Response to Drugs
Mauvais‐Jarvis, F., Berthold, H. K., Campesi, I., Carrero, J. J., Dhakal, S., Franconi, F., Gouni‐Berthold, I., Heiman, M. L., Kautzky‐Willer, A., Klein, S. L., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000206 · Cited by 203
Self-citation
Considering Sex as a Biological Variable Will Be Valuable for Neuroscience Research
Shansky, R. M., & Woolley, C. S. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1390-16.2016 · Cited by 191
Perils and pitfalls of reporting sex differences
Maney, D. L. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0119 · Cited by 201
Multifaceted origins of sex differences in the brain
McCarthy, M. M. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0106 · Cited by 176
Self-citation
Sex in basic research: concepts in the cardiovascular field
Ventura‐Clapier, R., Dworatzek, E., Seeland, U., Kararigas, G., Arnal, J., Brunelleschi, S., Carpenter, T., Erdmann, J., Franconi, F., Giannetta, E., et al. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx066 · Cited by 169
Problems and Progress regarding Sex Bias and Omission in Neuroscience Research
Will, T., Proaño, S. B., Thomas, A. M., Kunz, L. M., Thompson, K. C., Ginnari, L. A., Jones, C. H., Lucas, S.-C., Reavis, E. M., Dorris, D. M., et al. (2017) · eNeuro · doi:10.1523/eneuro.0278-17.2017 · Cited by 163
Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research
Provencher, S., Archer, S. L., Ramirez, F. D., Hibbert, B. M., Paulin, R., Boucherat, O., Lacasse, Y., & Bonnet, S. (2018) · Circulation Research · doi:10.1161/circresaha.117.312579 · Cited by 139
Sex differences in the brain: a whole body perspective
Vries, G. J. D., & Forger, N. G. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0032-z · Cited by 149
Sex bias and omission in neuroscience research is influenced by research model and journal, but not reported NIH funding
Mamlouk, G. M., Dorris, D. M., Barrett, L. R., & Meitzen, J. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100835 · Cited by 142
Neuroinflammatory priming to stress is differentially regulated in male and female rats
Fonken, L. K., Frank, M. G., Gaudet, A. D., D’Angelo, H. M., Daut, R. A., Hampson, E. C., Ayala, M. T., Watkins, L. R., & Maier, S. F. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.03.005 · Cited by 119
Editorial policies for sex and gender analysis
Schiebinger, L. L., Leopold, S. S., & Miller, V. M. (2016) · The Lancet · doi:10.1016/s0140-6736(16)32392-3 · Cited by 118
Self-citation
Determining If Sex Bias Exists in Human Surgical Clinical Research
Mansukhani, N. A., Yoon, D. Y., Teter, K., Stubbs, V. C., Helenowski, I., Woodruff, T. K., & Kibbe, M. R. (2016) · JAMA Surgery · doi:10.1001/jamasurg.2016.2032 · Cited by 116
Self-citation
Sex differences shape the response to infectious diseases
Ingersoll, M. A. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006688 · Cited by 115
Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications
Zajitschek, S. R. K., Zajitschek, F., Bonduriansky, R., Brooks, R. C., Cornwell, W. K., Falster, D. S., Lagisz, M., Mason, J., Senior, A. M., Noble, D. W. A., et al. (2020) · eLife · doi:10.7554/elife.63170 · Cited by 107
Focus on preclinical sex differences will not address women’s and men’s health disparities
Richardson, S. S., Reiches, M. W., Shattuck‐Heidorn, H., LaBonte, M. L., & Consoli, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516958112 · Cited by 114
Optimized solubilization of TRIzol-precipitated protein permits Western blotting analysis to maximize data available from brain tissue
Kopec, A. M., Rivera, P. D., Lacagnina, M. J., Hanamsagar, R., & Bilbo, S. D. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.02.002 · Cited by 100
How does sex matter? Behavior, stress and animal models of neurobehavioral disorders
Palanza, P., & Parmigiani, S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.037 · Cited by 107
Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors
Peretz, J., Pekosz, A. S., Lane, A. P., & Klein, S. L. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00398.2015 · Cited by 104
Self-citation
Sex Differences and Gender Diversity in Stress Responses and Allostatic Load Among Workers and LGBT People
Juster, R., Torre, M. B. D., Kerr, P., Kheloui, S., Rossi, M., & Bourdon, O. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1104-2 · Cited by 107
Genes that escape X chromosome inactivation modulate sex differences in valve myofibroblasts
Aguado, B. A., Walker, C. J., Grim, J. C., Schroeder, M. E., Batan, D., Vogt, B. J., Rodriguez, A. G., Schwisow, J. A., Moulton, K. S., Weiss, R. M., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.054108 · Cited by 87
Sex and gender differences in HIV-1 infection
Griesbeck, M., Scully, E. P., & Altfeld, M. A. (2016) · Clinical Science · doi:10.1042/cs20160112 · Cited by 95
Are females more variable than males in gene expression? Meta-analysis of microarray datasets
Itoh, Y., & Arnold, A. P. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0036-8 · Cited by 92
Sex contextualism in laboratory research: Enhancing rigor and precision in the study of sex-related variables
Pape, M., Miyagi, M., Ritz, S. A., Boulicault, M., Richardson, S. S., & Maney, D. L. (2024) · Cell · doi:10.1016/j.cell.2024.02.008 · Cited by 111
Molecules in pain and sex: a developing story
Mapplebeck, J. C. S., Beggs, S., & Salter, M. W. (2017) · Molecular Brain · doi:10.1186/s13041-017-0289-8 · Cited by 91
Sex Differences: A Resultant of an Evolutionary Pressure?
Torre, S. D., & Maggi, A. C. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.01.006 · Cited by 88
Diversity and representation: Key issues for psychophysiological science
Gatzke‐Kopp, L. M. (2015) · Psychophysiology · doi:10.1111/psyp.12566 · Cited by 86
Sex differences in gene regulation in the dorsal root ganglion after nerve injury
Stephens, K., Zhou, W., Ji, Z., Chen, Z., He, S., Ji, H., Guan, Y., & Taverna, S. D. (2019) · BMC Genomics · doi:10.1186/s12864-019-5512-9 · Cited by 83
Sex differences in Drosophila behavior: qualitative and quantitative dimorphism
Asahina, K. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.04.004 · Cited by 86
Gendered knowledge in fields and academic careers
Kim, L., Smith, D. S., Hofstra, B., & McFarland, D. A. (2021) · Research Policy · doi:10.1016/j.respol.2021.104411 · Cited by 76
Evaluating sex as a biological variable in preclinical research: the devil in the details
Tannenbaum, C., Schwarz, J. M., Clayton, J. A., Vries, G. J. D., & Sullivan, C. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0066-x · Cited by 76
Balance of the Sexes: Addressing Sex Differences in Preclinical Research.
Zakiniaeiz, Y., Cosgrove, K., Potenza, M. N., & Mazure, C. M. (2016) · PubMed Central · Cited by 72
Sex chromosomes drive gene expression and regulatory dimorphisms in mouse embryonic stem cells
Werner, R. J., Schultz, B. M., Huhn, J. M., Jelı́nek, J., Madžo, J., & Engel, N. (2017) · Biology of Sex Differences · doi:10.1186/s13293-017-0150-x · Cited by 73
Emerging awareness on the importance of skeletal muscle in liver diseases: time to dig deeper into mechanisms!
Nachit, M., & Leclercq, I. A. (2019) · Clinical Science · doi:10.1042/cs20180421 · Cited by 75
Sex and gender affect the social brain: Beyond simplicity
Pavlova, M. A. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23871 · Cited by 70
Implementation of the NIH Sex-Inclusion Policy: Attitudes and Opinions of Study Section Members
Woitowich, N. C., & Woodruff, T. K. (2018) · Journal of Women s Health · doi:10.1089/jwh.2018.7396 · Cited by 68
Self-citation
Pervasive Neglect of Sex Differences in Biomedical ResearchPreprint
Zucker, I., Prendergast, B. J., & Beery, A. K. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a039156 · Cited by 67
Self-citation
Sex-biased impact of endocrine disrupting chemicals on behavioral development and vulnerability to disease: Of mice and children
Palanza, P., Paterlini, S., Brambilla, M., Ramundo, G., Caviola, G., Gioiosa, L., Parmigiani, S., Saal, F. S. V., & Ponzi, D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.015 · Cited by 61
Sex differences in the renin-angiotensin-aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases
Nwia, S. M., Leite, A. P. D. O., Li, X. C., & Zhuo, J. L. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1198090 · Cited by 65
Why and How to Account for Sex and Gender in Brain and Behavioral Research
Eliot, L., Beery, A. K., Jacobs, E. G., LeBlanc, H. F., Maney, D. L., & McCarthy, M. M. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0020-23.2023 · Cited by 68
Self-citation
Association Between Obesity and Migraine in Women
Pavlovic, J. M., Vieira, J. R., Lipton, R. B., & Bond, D. S. (2017) · Current Pain and Headache Reports · doi:10.1007/s11916-017-0634-8 · Cited by 59
Sex-Related Differences in Drugs with Anti-Inflammatory Properties
Farkouh, A., Baumgärtel, C., Gottardi, R., Hemetsberger, M., Czejka, M. J., & Kautzky‐Willer, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10071441 · Cited by 65
A Neuroscientist’s Guide to the Vole
Kenkel, W. M., Gustison, M. L., & Beery, A. K. (2021) · Current Protocols · doi:10.1002/cpz1.175 · Cited by 52
From classic ethology to modern neuroethology: overcoming the three biases in social behavior research
Zilkha, N., Sofer, Y., Beny, Y., & Kimchi, T. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.04.014 · Cited by 52
Recent advances toward understanding the mysteries of the acute to chronic pain transition
Price, T. J., & Ray, P. R. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.05.015 · Cited by 54
A New Autosomal Myh11-CreER T2 Smooth Muscle Cell Lineage Tracing and Gene Knockout Mouse Model—Brief Report
Deaton, R. A., Bulut, G. B., Serbulea, V., Salamon, A., Shankman, L. S., Nguyen, A. T., & Owens, G. K. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318160 · Cited by 51
Best practices to promote rigor and reproducibility in the era of sex-inclusive research
Rich-Edwards, J. W., & Maney, D. L. (2023) · eLife · doi:10.7554/elife.90623 · Cited by 50
Comparative Analysis of Pain Behaviours in Humanized Mouse Models of Sickle Cell Anemia
Lei, J., Benson, B. A., Tran, H., Ofori-Acquah, S. F., & Gupta, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160608 · Cited by 52
Evaluating the National Institutes of Health's Sex as a Biological Variable Policy: Conflicting Accounts from the Front Lines of Animal Research
Waltz, M., Fisher, J. A., Lyerly, A. D., & Walker, R. L. (2020) · Journal of Women s Health · doi:10.1089/jwh.2020.8674 · Cited by 47
Let's Talk About Sex—Biological Sex Is Underreported in Biomaterial Studies
James, B. D., Guerin, P., & Allen, J. B. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001034 · Cited by 50
Sex differences in cognition and aging and the influence of sex hormones
Gurvich, C., Thomas, N., & Kulkarni, J. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64123-6.00008-4 · Cited by 47
Organ‐on‐a‐Chip Systems for Women's Health Applications
Nawroth, J. C., Rogal, J., Weiß, M., Brucker, S. Y., & Loskill, P. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700550 · Cited by 44
Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental Health
Wierenga, L. M., Ruigrok, A. N. V., Aksnes, E. R., Barth, C., Beck, D., Burke, S., Crestol, A., van Drunen, L., Ferrara, M., Galea, L. A. M., et al. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2023.100283 · Cited by 49
The importance of breast cancer resistance protein to the kidneys excretory function and chemotherapeutic resistance
Caetano-Pinto, P., Jansen, J., Assaraf, Y. G., & Masereeuw, R. (2017) · Drug Resistance Updates · doi:10.1016/j.drup.2017.01.002 · Cited by 40
Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons
Ishii, K., Wohl, M. P., DeSouza, A., & Asahina, K. (2020) · eLife · doi:10.7554/elife.52701 · Cited by 36
Sex bias in basic and preclinical noise-induced hearing loss research
Lauer, A. M., & Schrode, K. (2017) · Noise and Health · doi:10.4103/nah.nah_12_17 · Cited by 39
Mapping the past, present and future research landscape of paternal effects
Rutkowska, J., Lagisz, M., Bonduriansky, R., & Nakagawa, S. (2020) · BMC Biology · doi:10.1186/s12915-020-00892-3 · Cited by 39
Early life social stress and resting state functional connectivity in postpartum rat anterior cingulate circuits
Nephew, B. C., Febo, M., Huang, W., Colón-Pérez, L. M., Payne, L., Poirier, G. L., Greene, O., & King, J. A. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.12.089 · Cited by 38
Sex still matters: has the prevalence of male-only studies of drug effects on rodent behaviour changed during the past decade?
Hughes, R. N. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000410 · Cited by 40
Factors Influencing Individual Variation in Farm Animal Cognition and How to Account for These Statistically
Bushby, E. V., Friel, M., Goold, C. M., Gray, H. E., Smith, L., & Collins, L. (2018) · Frontiers in Veterinary Science · doi:10.3389/fvets.2018.00193 · Cited by 42
Research community needs to better appreciate the value of sex-based research
Woitowich, N. C., & Woodruff, T. K. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903586116 · Cited by 35
Self-citation
Sex differences in allometry for phenotypic traits in mice indicate that females are not scaled males
Wilson, L. A. B., Zajitschek, S. R. K., Lagisz, M., Mason, J., Haselimashhadi, H., & Nakagawa, S. (2022) · Nature Communications · doi:10.1038/s41467-022-35266-6 · Cited by 31
Resistance exercise decreases heroin self-administration and alters gene expression in the nucleus accumbens of heroin-exposed rats
Smith, M. A., Fronk, G. E., Abel, J. M., Lacy, R. T., Bills, S. E., & Lynch, W. J. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4840-9 · Cited by 34
A Call to Action: A Systematic Review Examining the Failure to Include Females and Members of Minoritized Racial/Ethnic Groups in Clinical Trials of Pharmacological Treatments for Alcohol Use Disorder
Schick, M. R., Spillane, N. S., & Hostetler, K. L. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14440 · Cited by 33
Examination of Sex-Specific Participant Inclusion in Exercise Physiology Endothelial Function Research: A Systematic Review
Lew, L. A., Williams, J. S., Stone, J. C., Au, A. K. W., Pyke, K. E., & MacDonald, M. J. (2022) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2022.860356 · Cited by 34
Regulation of Sexually Dimorphic Expression of Major Urinary Proteins
Penn, D. J., Zala, S. M., & Luzynski, K. C. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.822073 · Cited by 36
Tactics for preclinical validation of receptor-binding radiotracers
Lever, S. Z., Fan, K.-H., & Lever, J. R. (2016) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2016.08.015 · Cited by 33
Acute exposure to progesterone attenuates cardiac contraction by modifying myofilament calcium sensitivity in the female mouse heart
Feridooni, H. A., MacDonald, J. K., Ghimire, A., Pyle, W. G., & Howlett, S. E. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00073.2016 · Cited by 35
Sex Differences in Pharmacokinetics
Zucker, I., & Prendergast, B. J. (2023) · Handbook of experimental pharmacology · doi:10.1007/164_2023_669 · Cited by 30
Self-citation
Intranasal oxytocin reduces reactive aggression in men but not in women: A computational approach
Zhu, R., Liu, C., Li, T., Xu, Z., Fung, B. J., Feng, C., Wu, H., Luo, Y., & Wang, L. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.06.016 · Cited by 30
Gendered Innovations: integrating sex, gender, and intersectional analysis into science, health & medicine, engineering, and environment
Schiebinger, L. L. (2021) · Tapuya Latin American Science Technology and Society · doi:10.1080/25729861.2020.1867420 · Cited by 42
Self-citation
Female sex-specific considerations to improve rigor and reproducibility in cardiovascular research
Chang, D. H., Dumanski, S. M., & Ahmed, S. B. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00462.2022 · Cited by 34
Sex—the most underappreciated variable in research: insights from helminth-infected hosts
Wesołowska, A. (2022) · Veterinary Research · doi:10.1186/s13567-022-01103-3 · Cited by 33
Considering hormones as sex- and gender-related factors in biomedical research: Challenging false dichotomies and embracing complexity
Williams, J. S., Fattori, M. R., Honeyborne, I. R., & Ritz, S. A. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105442 · Cited by 34
Biomedical Researchers' Perceptions of the NIH's Sex as a Biological Variable Policy for Animal Research: Results from a U.S. National Survey
Waltz, M., Saylor, K. W., Fisher, J. A., & Walker, R. L. (2021) · Journal of Women s Health · doi:10.1089/jwh.2020.8997 · Cited by 29
The effects of resistance exercise on cocaine self-administration, muscle hypertrophy, and BDNF expression in the nucleus accumbens
Strickland, J. C., Abel, J. M., Lacy, R. T., Beckmann, J. S., Witte, M. A., Lynch, W. J., & Smith, M. A. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.04.019 · Cited by 32
Sex Reporting in Preclinical Microbiological and Immunological Research
Potluri, T., Engle, K., Fink, A. L., Steeg, L. G. V., & Klein, S. L. (2017) · mBio · doi:10.1128/mbio.01868-17 · Cited by 29
Self-citation
Quantification of pain in sickle mice using facial expressions and body measurements
Mittal, A. M., Gupta, M., Lamarre, Y., Jahagirdar, B., & Gupta, K. (2015) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2015.12.006 · Cited by 28
The Duration of Stress Determines Sex Specificities in the Vulnerability to Depression and in the Morphologic Remodeling of Neurons and Microglia
Gaspar, R., Soares‐Cunha, C., Domingues, A. V., Coimbra, B., Baptista, F. I., Pinto, L., Ambrósio, A. F., Rodrigues, A. J., & Gomes, C. A. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.834821 · Cited by 31
Using a memory systems lens to view the effects of estrogens on cognition: Implications for human health
Korol, D. L., & Wang, W. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.11.022 · Cited by 28
Sex effects in pyelonephritis
Albracht, C. D., Hreha, T. N., & Hunstad, D. A. (2020) · Pediatric Nephrology · doi:10.1007/s00467-020-04492-9 · Cited by 27
Biological sex, not reproductive cycle, influences peripheral blood immune cell prevalence in mice
Breznik, J. A., Schulz, C., Ma, J., Sloboda, D. M., & Bowdish, D. M. E. (2021) · The Journal of Physiology · doi:10.1113/jp280637 · Cited by 25
Genetics of Anxiety Disorders
Otowa, T., Roberson‐Nay, R., Bekhbat, M., Neigh, G. N., & Hettema, J. M. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190681425.003.0033 · Cited by 27

Authors: Klein, S. L., Schiebinger, L., Stefanick, M. L., Cahill, L., Danska, J., de Vries, G. J., Kibbe, M. R., McCarthy, M. M., Mogil, J. S., Woodruff, T. K., & Zucker, I.
Affiliations: Johns Hopkins University (US)
History of Science, and
Stanford Medicine (US)
University of California, Irvine (US)
University of Toronto (CA)
Neuroscience Institute, Georgia State University, Atlanta, GA 30302;
Northwestern University (US)
University of Maryland, Baltimore (US)
McGill University (CA)
University of California, Berkeley (US)
ORCID: Klein, Sabra L.
Schiebinger, Londa
Stefanick, Marcia L.
Danska, Jayne
Kibbe, Melina R.
McCarthy, Margaret M.
Mogil, Jeffrey S.
Woodruff, Teresa K.
Zucker, Irving
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2015-04-20
Volume: 112
Issue: 17
Pages: 5257-5258
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1502843112
PMC: PMC4418862
OpenAlex: W2095228051
Cited by: 238
References: 18
Citations by year: 2026: 10 · 2025: 23 · 2024: 15 · 2023: 19 · 2022: 24 · 2021: 23 · 2020: 20 · 2019: 15 · 2018: 19 · 2017: 32 · 2016: 31 · 2015: 7
FWCI: 31.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P30CA060553)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Social Sciences › Gender Studies › Diversity and Career in Medicine
Social Sciences › Psychology › Applied Psychology › Career Development and Diversity
Keywords: sex differences, basic research, scientific discovery, gender diversity in research
MeSH terms: Animals, Female, Humans, Male, Reproduction, Biomedical Research

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sex inclusion in basic research drives discovery

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks