The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Imaging robust microglial activation after lipopolysaccharide administration in humans with PET
Open accessAbstract
Significance: Neuroinflammation is a brain immune response that is associated with neurodegenerative diseases and is primarily driven by activation of microglia, the brain’s resident macrophages. Dysfunctional microglial activation may contribute to the behavioral changes observed in neurodegenerative diseases. Upon activation, microglia express translocator protein, which can be imaged with the radiotracer [ 11 C]PBR28 and positron emission tomography (PET) in the living human brain. We imaged healthy human subjects with [ 11 C]PBR28 and PET before and after i.v. administration of lipopolysaccharide (LPS), a potent immune activator. LPS produced a marked increase in brain microglial activation, peripheral inflammatory cytokine levels, and self-reported sickness symptoms. This imaging paradigm can provide a direct approach to test new medications for their potential to reduce acute neuroinflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Adding endotoxin at such levels to blood of healthy humans induces systemic inflammation and brain microglial activation.”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [15]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“data from endotoxin administration to healthy volunteers indicates that radiolabelled TSPO ligands can readily identify cellular activation in several regions of the brain following a potent peripheral immune stimulus63.”
From The role of inflammation in depression: from evolutionary imperative to modern treatment target (2016) · cites this paper as [63]
In the citing paper
“Thus, a relatively mild dose of blood endotoxin (e.g. less than that found in Alzheimer’s patients) can cause acute microglial activation within the brain.”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [15]
In the citing paper
“Human neuroimaging findings show heightened microglia activation after LPS administration that produces depressive-like sickness symptoms [79].”
From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [79]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,188
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Microglial M1/M2 polarization and metabolic states
Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070
Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands
Innis, R. B., Cunningham, V. J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R. N., Holden, J., Houle, S., Huang, S.-C., Ichise, M., et al. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600493 · Cited by 1,955
Self-citationImmune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483
Papadopoulos, V., Baraldi, M., Guilarte, T. R., Knudsen, T. B., Lacapère, J.-J., Lindemann, P., Norenberg, M. D., Nutt, D., Weizman, A., Zhang, M.-R., et al. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.06.005 · Cited by 1,389
Cited by
Sorted by citations
Items 101–200 of 356
Neuroinflammatory and Immunological Aspects of Fibromyalgia
Findeisen, K. E., Guymer, E. K., & Littlejohn, G. O. (2025) · Brain Sciences · doi:10.3390/brainsci15020206 · Cited by 63
Byrne, M. L., Whittle, S., & Allen, N. B. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000311 · Cited by 55
Mizobuchi, H., & Soma, G. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.308067 · Cited by 55
Canale, M. P., Noce, A., Lauro, M. D., Marrone, G., Cantelmo, M., Cardillo, C., Federici, M., Daniele, N. D., & Tesauro, M. (2021) · Nutrients · doi:10.3390/nu13041162 · Cited by 51
Neuro-Inflammation Modulation and Post-Traumatic Brain Injury Lesions: From Bench to Bed-Side
Jacquens, A., Needham, E., Zanier, E. R., Degos, V., Gressèns, P., & Menon, D. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911193 · Cited by 53
Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates
Hillmer, A. T., Holden, D., Fowles, K., Nabulsi, N., West, B. L., Carson, R. E., & Cosgrove, K. (2017) · EJNMMI Research · doi:10.1186/s13550-017-0305-0 · Cited by 51
Self-citationMicroglial activation and responses to vasculature that result from an acute LPS exposure
Bowyer, J. F., Sarkar, S., Burks, S. M., Hess, J. N., Tolani, S., O'Callaghan, J. P., & Hanig, J. P. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.01.014 · Cited by 56
Plavén‐Sigray, P., Matheson, G. J., Coughlin, J. M., Hafizi, S., Laurikainen, H., Ottoy, J., Picker, L. D., Rusjan, P., Hietala, J. A., Howes, O. D., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.05.028 · Cited by 53
Nettis, M. A., Veronese, M., Nikkheslat, N., Mariani, N., Lombardo, G., Sforzini, L., Enache, D., Harrison, N. A., Turkheimer, F., Mondelli, V., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0768-z · Cited by 51
Mechanisms of long-term cognitive dysfunction of sepsis: from blood-borne leukocytes to glial cells
Michels, M., Steckert, A. V., Quevedo, J., Barichello, T., & Dal‐Pizzol, F. (2015) · Intensive Care Medicine Experimental · doi:10.1186/s40635-015-0066-x · Cited by 48
Influenza infection triggers disease in a genetic model of experimental autoimmune encephalomyelitis
Blackmore, S., Hernandez, J., Juda, M. B., Ryder, E., Freund, G. G., Johnson, R. W., & Steelman, A. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620415114 · Cited by 48
Chaves-Filho, A. J. M., Macêdo, D. S., de Lucena, D. F., & Maes, M. H. J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111975 · Cited by 47
Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain
Wimberley, C., Lavisse, S., Hillmer, A. T., Hinz, R., Turkheimer, F., & Zanotti‐Fregonara, P. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05248-9 · Cited by 52
Milde, S., van Tartwijk, F. W., Vilalta, A., Hornik, T. C., Dundee, J. M., Puigdellívol, M., & Brown, G. C. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02280-2 · Cited by 50
Systemic inflammation induced the delayed reduction of excitatory synapses in the CA3 during ageing
Manabe, T., Rácz, I., Schwartz, S., Oberle, L., Santarelli, F., Emmrich, J. V., Neher, J. J., & Heneka, M. T. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15491 · Cited by 44
Liu, F., Duan, M., Fu, H., Zhao, G., Han, Y., Lan, F., Ahmed, Z., Cao, G., Li, Z., Ma, D., et al. (2022) · Annals of Surgery · doi:10.1097/sla.0000000000005489 · Cited by 47
Characterization and modulation of microglial phenotypes in an animal model of severe sepsis
Michels, M., Abatti, M. R., Ávila, P. R. M., Vieira, A. A. D. S., Borges, H. D. M., Carvalho, C. C., Wendhausen, D. L., Gasparotto, J., Ribeiro, C. T., Moreira, J. C. F., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14606 · Cited by 47
Lifetime modulation of the pain system via neuroimmune and neuroendocrine interactions
Zouikr, I., & Karshikoff, B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00276 · Cited by 45
van Ton, A. M. P., Verbeek, M. M., Alkema, W. B. L., Pickkers, P., & Abdo, W. F. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.06.027 · Cited by 48
Wasiak, J., & Gawlik-Kotelnicka, O. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114459 · Cited by 47
Patkar, O. L., Mohamed, A. Z., Narayanan, A., Mardon, K., Cowin, G., Bhalla, R., Stimson, D. H. R., Kassiou, M., Beecher, K., Belmer, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-90817-z · Cited by 45
Fattori, V., Zaninelli, T. H., Ferraz, C. R., Brasil-Silva, L., Borghi, S. M., da Cunha, J. M., Chichorro, J. G., Casagrande, R., & Verri, W. A., Jr. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109189 · Cited by 44
Młynarska, E., Wasiak, J., Gajewska, A., Steć, G., Jasińska, J., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16121938 · Cited by 46
Recent Developments in Diagnosis of Epilepsy: Scope of MicroRNA and Technological Advancements
Bandopadhyay, R., Singh, T., Ghoneim, M. M., Alshehri, S., Angelopoulou, E., Paudel, Y. N., Piperi, C., Ahmad, J., Alhakamy, N. A., Alfaleh, M. A., et al. (2021) · Biology · doi:10.3390/biology10111097 · Cited by 44
De Marco, R., Ronen, I., Branzoli, F., Amato, M. L., Asllani, I., Colasanti, A., Harrison, N. A., & Cercignani, M. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.10.005 · Cited by 40
Effects of Antipsychotic Drugs: Cross Talk Between the Nervous and Innate Immune System
Dinesh, A. A., Islam, J., Khan, J., Turkheimer, F., & Vernon, A. C. (2020) · CNS Drugs · doi:10.1007/s40263-020-00765-x · Cited by 40
Systemic inflammation as a central player in the initiation and development of Alzheimer’s disease
Bayraktaroğlu, I., Ortí-Casañ, N., Dam, D. V., Deyn, P. P. D., & Eisel, U. L. M. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00529-5 · Cited by 49
Benson, S., Engler, H., Wegner, A., Rebernik, L., Spreitzer, I., Schedlowski, M., & Elsenbruch, S. (2017) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.618 · Cited by 39
Pittenger, C. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2016_127 · Cited by 39
Chu, M., Wen, L., Jiang, D., Liu, L., Nan, H., Yue, A., Wang, Y., Wang, Y., Qu, M., Wang, N., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02746-5 · Cited by 33
Biomarker Predictors of Delirium in Acutely Ill Patients: A Systematic Review
Michels, M., Michelon, C. M., Damasio, D. D. C., Vitali, Â. M., Ritter, C., & Dal‐Pizzol, F. (2019) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988719834346 · Cited by 36
Młynarska, E., Wasiak, J., Gajewska, A., Bilińska, A., Steć, G., Jasińska, J., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16234079 · Cited by 39
LPS and palmitic acid Co-upregulate microglia activation and neuroinflammatory response
Lu, Z., Liu, S., Lopes-Virella, M. F., & Wang, Z. (2021) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100048 · Cited by 38
Savitz, J. B., Figueroa‐Hall, L. K., Teague, T. K., Yeh, H., Zheng, H., Kuplicki, R., Burrows, K., El-Sabbagh, N. S., Thomas, M., Ewers, I., et al. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20240142 · Cited by 34
Tremoleda, J. L., Thau‐Zuchman, O., Davies, M., Foster, J., Khan, I., Vadivelu, K. C., Yip, P. K., Sosabowski, J. K., Trigg, W., & Michael-Titus, A. T. (2016) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-016-3391-8 · Cited by 34
Hughes, F. M., Odom, M. R., Cervantes, A., Livingston, A. J., & Purves, J. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032821 · Cited by 33
In VivoMRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation
Tang, T., Valenzuela, A. E., Petit, F., Chow, S. S. L., Leung, K. H., Gorin, F. A., Louie, A. Y., & Dhénain, M. (2018) · Contrast Media & Molecular Imaging · doi:10.1155/2018/3476476 · Cited by 35
Soares, G. B., Mahmoud, O., Yosipovitch, G., & Mochizuki, H. (2024) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.19813 · Cited by 36
Metabolic Endotoxemia: From the Gut to Neurodegeneration
Chmielarz, M., Sobieszczańska, B., & Środa-Pomianek, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137006 · Cited by 37
Giridharan, V. V., Collodel, A., Generoso, J. S., Scaini, G., Wassather, R., Selvaraj, S., Hasbun, R., Dal‐Pizzol, F., Petronilho, F. C., & Barichello, T. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1692-0 · Cited by 32
What can neuroimmunology teach us about the symptoms of long-COVID?
Mondelli, V., & Pariante, C. M. (2021) · Oxford Open Immunology · doi:10.1093/oxfimm/iqab004 · Cited by 32
Schubert, J. J., Veronese, M., Fryer, T. D., Manavaki, R., Kitzbichler, M. G., Nettis, M. A., Mondelli, V., Pariante, C. M., Bullmore, E. T., Wlazly, D., et al. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.12.017 · Cited by 33
Tamm, S., Červenka, S., Forsberg, A., Estelius, J., Grünewald, J., Gyllfors, P., Karshikoff, B., Kosek, E., Lampa, J., Lensmar, C., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.013 · Cited by 32
Su, W., Yang, Y., Zhao, X., Cheng, J., Li, Y., Wu, S., & Wu, C. (2023) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2023.08.001 · Cited by 32
Szöllősi, D., Hegedűs, N., Veres, D. S., Futó, I., Horváth, I., Kovács, N., Martinecz, B., Dénes, Á., Seifert, D., Bergmann, R., et al. (2018) · Molecular Imaging and Biology · doi:10.1007/s11307-018-1201-3 · Cited by 31
Correlation between interleukin-6 levels and methadone maintenance therapy outcomes
Lu, R., Wang, T., Lee, S.-Y., Chen, S., Chang, Y.-H., Chen, P. S., Lin, S., Chu, C., Huang, S., Tzeng, N., et al. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.06.018 · Cited by 29
Self-citationHeterogeneity of Microglia Phenotypes: Developmental, Functional and Some Therapeutic Considerations
Yuan, Y., Wu, C., & Ling, E. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190722114248 · Cited by 31
Tanimoto, Y., Yamasaki, T., Nagoshi, N., Nishiyama, Y., Nori, S., Nishimura, S., Iida, T., Ozaki, M., Tsuji, O., Ji, B., et al. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0150 · Cited by 31
Advances of Molecular Imaging in Epilepsy
Galovic, M., & Koepp, M. J. (2016) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-016-0660-7 · Cited by 30
Translocator protein in late stage Alzheimer’s disease and Dementia with Lewy bodies brains
Xu, J., Sun, J., Perrin, R. J., Mach, R. H., Bales, K. R., Morris, J. C., Benzinger, T. L. S., & Holtzman, D. M. (2019) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.50837 · Cited by 31
Fujinaga, M., Luo, R., Kumata, K., Zhang, Y., Hatori, A., Yamasaki, T., Xie, L., Mori, W., Kurihara, Y., Ogawa, M., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00374 · Cited by 30
Neuroimmune Mechanisms and Sex/Gender-Dependent Effects in the Pathophysiology of Mental Disorders
Kokkosis, A. G., & Tsirka, S. E. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.266163 · Cited by 29
From “Leaky Gut” to Impaired Glia-Neuron Communication in Depression
Rudzki, L., & Maes, M. H. J. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6044-0_9 · Cited by 31
Takata, K., Kimura, H., Yanagisawa, D., Harada, K., Nishimura, K., Kitamura, Y., Shimohama, S., & Tooyama, I. (2022) · Molecules · doi:10.3390/molecules27092780 · Cited by 29
Imaging the inflammatory phenotype in migraine
Christensen, R. H., Gollion, C., Amin, F. M., Moskowitz, M. A., Hadjikhani, N. K., & Ashina, M. (2022) · The Journal of Headache and Pain · doi:10.1186/s10194-022-01430-y · Cited by 29
The translocator protein (18 kDa) and its role in neuropsychiatric disorders
Barichello, T., Simões, L. R., Collodel, A., Giridharan, V. V., Dal‐Pizzol, F., Macêdo, D. S., & Quevedo, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.010 · Cited by 30
Vicente-Rodríguez, M., Singh, N., Turkheimer, F., Peris-Yague, A., Randall, K., Veronese, M., Simmons, C., Karim Haji-Dheere, A., Bordoloi, J., Sander, K., et al. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.05.025 · Cited by 28
Postmortem Evidence of Brain Inflammatory Markers and Injury in Septic Patients: A Systematic Review
Barichello, T., Generoso, J. S., Dominguini, D., Córneo, E. D. S., Giridharan, V. V., Sahrapour, T. A., Simões, L. R., da Rosa, M. I., Petronilho, F. C., Ritter, C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005307 · Cited by 30
The Effects of Peripheral Inflammation on the Brain—A Neuroimaging Perspective
Millett, C. E., Burdick, K. E., & Kubicki, M. R. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000323 · Cited by 27
Microglial activation and neuroinflammation in acute and chronic cognitive deficits in sepsis
Denver, P., & Cunningham, C. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110285 · Cited by 33
Replicating predictive serum correlates of greater translocator protein distribution volume in brain
Attwells, S., Setiawan, E., Wilson, A. A., Rusjan, P., Miler, L., Xu, C., Hutton, C., Husain, M. I., Kish, S. J., Vasdev, N., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0561-y · Cited by 27
Imaging the Neuroimmune Dynamics Across Space and Time
Carrier, M., Robert, M.-È., Ibáñez, F. G., Desjardins, M., & Tremblay, M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00903 · Cited by 28
Greene, R. K., Walsh, E. C., Mosner, M. G., & Dichter, G. S. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.12.008 · Cited by 29
Eiff, B., Bullmore, E. T., Clatworthy, M. R., Fryer, T. D., Pariante, C. M., Mondelli, V., Maccioni, L., Hadjikhani, N. K., Loggia, M. L., Moskowitz, M. A., et al. (2024) · Brain · doi:10.1093/brain/awae343 · Cited by 27
Han, Y., Sun, C.-Y., Meng, S., Tabarak, S., Yuan, K., Cao, L., Yan, W., Xu, L., Deng, J., Zhu, W., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0470-9 · Cited by 25
Husain, M. I., Cullen, C., Umer, M., Carvalho, A. F., Kloiber, S. M., Meyer, J. H., Ortiz, A., Knyahnytska, Y., Husain, M. O., Giddens, J. L., et al. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02553-9 · Cited by 26
The Bidirectional Signal Communication of Microbiota‐Gut‐Brain Axis in Hypertension
Wang, X., Chen, Z., Geng, B., & Cai, J. (2021) · International Journal of Hypertension · doi:10.1155/2021/8174789 · Cited by 29
Neuroinflammation in the Brain and Role of Intestinal Microbiota: An Overview of the Players
Cavaliere, G., & Traina, G. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2206148 · Cited by 29
Neuroinflammatory mechanisms of hypertension
Winklewski, P. J., Radkowski, M., & Demkow, U. A. (2016) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000250 · Cited by 26
Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review
Woodcock, E. A., Hillmer, A. T., Mason, G. F., & Cosgrove, K. (2019) · Complex Psychiatry · doi:10.1159/000499621 · Cited by 27
Self-citationHanger, B., Couch, A. C. M., Rajendran, L., Srivastava, D. P., & Vernon, A. C. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00789 · Cited by 23
Giollabhui, N. M., Alloy, L. B., & Hartman, C. A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.08.030 · Cited by 24
Fisher, A. S., Lanigan, M. T., Upton, N., & Lione, L. A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.614990 · Cited by 28
Inflammation, Obsessive-Compulsive Disorder, and Related Disorders
Meyer, J. H. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_210 · Cited by 26
van Ton, A. M. P., Leijsen, E. M. C. M.-V., Bergkamp, M. I., Bronkhorst, E. M., Pickkers, P., de Leeuw, F., Tuladhar, A. M., & Abdo, W. F. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005313 · Cited by 26
Hedde, J. R., Hanks, A. N., Schmidt, C. J., & Hughes, Z. A. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.04.015 · Cited by 24
Molina‐Martínez, P., Corpas, R., García-Lara, E., Cosín‐Tomás, M., Cristòfol, R. M., Kaliman, P., Solà, C., Molinuevo, J. L., Sánchez‐Valle, R., Antonell, A., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.622360 · Cited by 24
Traumatic Brain Injury and Gut Brain Axis: The Disruption of an Alliance
Ferrara, M., Bertozzi, G., Zanza, C., Longhitano, Y., Piccolella, F., Lauritano, E. C., Volonnino, G., Manetti, A. C., Maiese, A., & Russa, R. L. (2022) · Reviews on Recent Clinical Trials · doi:10.2174/1574887117666220622143423 · Cited by 23
HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation
Radford‐Smith, D. E., Yates, A. G., Rizvi, L., Anthony, D. C., & Probert, F. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01817-z · Cited by 24
Schildt, A., Walker, M. D., Dinelle, K., Miao, Q., Schulzer, M., OʼKusky, J. R., Farrer, M. J., Doudet, D. J., & Sossi, V. (2018) · Journal of Parkinson s Disease · doi:10.3233/jpd-181446 · Cited by 25
Forsberg, A., Lampa, J., Estelius, J., Červenka, S., Farde, L., Halldin, C., Lekander, M., Höglund, C. O., & Kosek, E. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.577000 · Cited by 25
Auvity, S., Saba, W., Goutal, S., Leroy, C., Buvat, I., Cayla, J., Caillé, F., Bottlaender, M., Cisternino, S., & Tournier, N. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw077 · Cited by 22
Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi, R. E., Hillmer, A. T., Woodcock, E. A., Bhatt, S., Rusowicz, A., Angarita, G. A., Carson, R. E., Davis, M. T., Esterlis, I., Nabulsi, N., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2406005121 · Cited by 22
Self-citationWang, K., Li, Y., Huang, J., Xu, L., Yin, L., Ji, Y., Wang, C., Xu, Z., & Niu, J. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122259 · Cited by 21
Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis
Picker, L. D., & Morrens, M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00362 · Cited by 21
Depression Phenotype, Inflammation, and the Brain
Krishnadas, R., & Harrison, N. A. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000339 · Cited by 21
Kumata, K., Zhang, Y., Fujinaga, M., Ohkubo, T., Mori, W., Yamasaki, T., Hanyu, M., Xie, L., Hatori, A., & Zhang, M. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.08.017 · Cited by 21
van Rees, G. F., Lago, S. G., Cox, D., Tomasik, J., Rustogi, N., Weigelt, K., Özcan, S., Cooper, J. D., Drexhage, H. A., Leweke, F. M., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.003 · Cited by 22
Suhara, T., Chaki, S., Kimura, H., Furusawa, M., Matsumoto, M., Ogura, H., Negishi, T., Saijo, T., Higuchi, M., Omura, T., et al. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw111 · Cited by 19
Perioperative neurocognitive disorders: Advances in molecular mechanisms and bioactive molecules
Mao, L., Wang, L., Huang, Z., Switzer, J. A., Hess, D. C., & Zhang, Q. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102885 · Cited by 24
André, P., de Barros, J.-P. P., Merle, B. M. J., Samieri, C., Helmer, C., Delcourt, C., & Féart, C. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab126 · Cited by 20
Dietary fiber ameliorates lead‐induced gut microbiota disturbance and alleviates neuroinflammation
Yao, M., Shao, X., Wei, Y., Zhang, X., Wang, H., & Xu, F. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12074 · Cited by 20
Current status of PET tracers for the early diagnosis of Alzheimer's disease
Li, Y., Liu, T., Zeng, Q., & Cui, M. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.117546 · Cited by 20
Park, Y., Paing, Y. M. M., Cho, N., Kim, C., Yoo, J., Choi, J. W., & Lee, S. H. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2023.184 · Cited by 19
Associations of Microbiota and Nutrition with Cognitive Impairment in Diseases
Młynarska, E., Jakubowska, P., Frąk, W., Gajewska, A., Sornowska, J., Skwira, S., Wasiak, J., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16203570 · Cited by 19
Shishkina, G. T., Bannova, A. V., Komysheva, N. P., & Дыгало, Н. Н. (2020) · Stress · doi:10.1080/10253890.2020.1793943 · Cited by 19
The brain-gut axis: A prime therapeutic target in traumatic brain injury
Weaver, J. L. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147225 · Cited by 18
Giga, H., Ji, B., Kikutani, K., Fukuda, S., Kitajima, T., Katsumata, S., Matsumata, M., Suhara, T., Yamawaki, S., Shime, N., et al. (2020) · Shock · doi:10.1097/shk.0000000000001703 · Cited by 18
Morena, D., Lippi, M., Scopetti, M., Turillazzi, E., & Fineschi, V. (2025) · Diagnostics · doi:10.3390/diagnostics15131683 · Cited by 24
Hodges, S. L., Nolan, S. O., Tomac, L. A., Muhammad, I. D. A., Binder, M. S., Taube, J. H., & Lugo, J. N. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112776 · Cited by 20
Metadata
- Authors
- Sandiego, C. M., Gallezot, J.-D., Pittman, B., Nabulsi, N., Lim, K., Lin, S.-F., Matuskey, D., Lee, J.-Y., O’Connor, K. C., Huang, Y., Carson, R. E., Hannestad, J., & Cosgrove, K. P.
- Affiliations
- Yale University (US)
- UCB Pharma (Belgium) (BE)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-09-18
- Volume
- 112
- Issue
- 40
- Pages
- 12468-12473
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4603509
- OpenAlex
- W2145625835
- Cited by
- 356
- References
- 66
- Citations by year
- 2026: 19 · 2025: 30 · 2024: 29 · 2023: 21 · 2022: 30 · 2021: 42 · 2020: 49 · 2019: 38 · 2018: 32 · 2017: 40 · 2016: 23 · 2015: 3
- FWCI
- 17.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yale University
- National Institute on Aging (P50AG047270)
- UCB Pharma
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- microglial activation, neuroinflammation, lipopolysaccharide challenge, [11C]PBR28, translocator protein (TSPO), inflammatory cytokines, sickness behavior, systemic inflammation, anti-inflammatory drug testing
- MeSH terms
- Acetamides, Adult, Brain, Carbon Radioisotopes, Humans, Lipopolysaccharides, Male, Protein Binding, Pyridines, Reproducibility of Results, Biomarkers, Cytokines, Microglia, Receptors, GABA, Inflammation Mediators, Radiopharmaceuticals, Positron-Emission Tomography, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review