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The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors

Buckley, Catherine M., Gopaldass, Navin, Bosmani, Cristina, Johnston, Simon A., Soldati, Thierry, Insall, Robert H., King, Jason S.·2016·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1524532113
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Abstract

Significance: Macropinocytosis is a way for cells to engulf large volumes of their extracellular fluid. This process allows immune cells to sense their environment and detect antigens, but can also supply nutrients to both cancer cells and some unicellular organisms. However, little is known about the fate of the membrane components internalized via macropinosomes. This study explains how cells avoid the bulk digestion of their surface proteins. We identify several core components of this pathway and show that they are required for early recycling from macropinosomes. We demonstrate that this pathway is crucial for cells undergoing continuous macropinocytosis to maintain surface protein levels and is therefore physiologically important for such cells to sustain normal functions.

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Crossref · 10.1073/pnas.1524532113

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  • Among proteins decreased from surface were established SNX17 cargoes β1-integrin, LRP1, APP, JAG1 and VLDLR.

    “Among proteins decreased from the surface were established SNX17 cargoes β1-integrin, LRP1, APP, JAG1 and VLDLR, which validated our experimental approach26, 32, 33, 51, 52.”

    From Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling (2017) · cites this paper as [52]

    The Discussion (page unavailable) discusses integrin recycling, and the References list a study reporting that SNX17 protects integrins from degradation. The paper does not identify LRP1, APP, JAG1 or VLDLR as SNX17 cargoes, so it supports only the integrin-related part of the attributed claim. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 72

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Metadata

Authors
Buckley, C. M., Gopaldass, N., Bosmani, C., Johnston, S. A., Soldati, T., Insall, R. H., & King, J. S.
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2016-09-19
Volume
113
Issue
40
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1524532113
Cited by
96
References
4
Language
en
Licence
www.pnas.org/site/misc/userlicense.xhtml (vor)
Funders
  • Royal Society (UF140624)
  • Cancer Research UK (Core)
  • Swiss National Science Foundation (310030_149390)
  • Medical Research Council (MR/J009156/1and R/140419)
  • Wellcome Trust (097377/Z/11/Z)

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