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Cited by 971

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA

Open access
Zhang, Chuanzhao, Samanta, Debangshu, Lu, Haiquan, Bullen, John W., Zhang, Huimin, Chen, Ivan, He, Xiaoshun, Semenza, Gregg L.·2016·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1602883113
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Abstract

Significance: Pluripotency factors, such as NANOG, play a critical role in the maintenance and specification of cancer stem cells, which are required for primary tumor formation and metastasis. In this study, we report that exposure of breast cancer cells to hypoxia (i.e., reduced O 2 availability), which is a critical feature of the tumor microenvironment, induces N 6 -methyladenosine (m 6 A) demethylation and stabilization of NANOG mRNA, thereby promoting the breast cancer stem cell (BCSC) phenotype. We show that inhibiting the expression of AlkB homolog 5 (ALKBH5), which demethylates m 6 A, or the hypoxia-inducible factors (HIFs) HIF-1α and HIF-2α, which activate ALKBH5 gene transcription in hypoxic breast cancer cells, is an effective strategy to decrease NANOG expression and target BCSCs in vivo.

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Metadata

Authors
Zhang, C., Samanta, D., Lu, H., Bullen, J. W., Zhang, H., Chen, I., He, X., & Semenza, G. L.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2016-03-21
Volume
113
Issue
14
Pages
E2047-56
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1602883113
OpenAlex
W2306179365
Cited by
971
References
8
FWCI
34.91
Type
journal article
Language
en
Open access
bronze
Licence
www.pnas.org/preview_site/misc/userlicense.xhtml (vor, 184 d)
Funders
  • American Cancer Society (122437-RP-12-090-01-COUN)
  • China Scholarship Council (201406380067)

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CoChat. (2026). Citation check: Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA. https://app.cochat.ai/papers/10.1073/pnas.1602883113
The paper
Zhang, C., Samanta, D., Lu, H., Bullen, J. W., Zhang, H., Chen, I., He, X., & Semenza, G. L. (2016). Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1602883113

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.