Variability in the Munc13-1 content of excitatory release sites.
Open accessAbstract
The molecular mechanisms underlying the diversity of cortical glutamatergic synapses are still incompletely understood. Here, we tested the hypothesis that presynaptic active zones (AZs) are constructed from molecularly uniform, independent release sites (RSs), the number of which scales linearly with the AZ size. Paired recordings between hippocampal CA1 pyramidal cells and fast-spiking interneurons in acute slices from adult mice followed by quantal analysis demonstrate large variability in the number of RSs ( N ) at these connections. High-resolution molecular analysis of functionally characterized synapses reveals variability in the content of one of the key vesicle priming factors – Munc13-1 – in AZs that possess the same N . Replica immunolabeling also shows a threefold variability in the total Munc13-1 content of AZs of identical size and a fourfold variability in the size and density of Munc13-1 clusters within the AZs. Our results provide evidence for quantitative molecular heterogeneity of RSs and support a model in which the AZ is built up from variable numbers of molecularly heterogeneous, but independent RSs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The corresponding active zone membrane association can be detected by freeze-fracture replica labeling.
“The corresponding AZ membrane association can be detected by FRL [23,61,66,67].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [67]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1996) · Cited by 20,179 · see citing works
Südhof, T. C. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.012 · Cited by 1,062 · cited 1× · see citing works
“…climbing fiber etc. synapses), most studies converged to the conclusion that different pre- (e.g. different types of Ca channels, Ca sensors) and postsynaptic (e.g. different types of AMPA receptor subunits) molecule isoforms underlie the functional variability (reviewed by Südhof, 2012).”
BackgroundMolecular machines governing exocytosis of synaptic vesicles
Jahn, R., & Fasshauer, D. (2012) · Nature · doi:10.1038/nature11320 · Cited by 973 · see citing works
Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles
Augustin, I., Rosenmund, C., Südhof, T. C., & Brose, N. (1999) · Nature · doi:10.1038/22768 · Cited by 787 · see citing works
Target-cell-specific facilitation and depression in neocortical circuits
Reyes, A., Lujan, R., Rozov, A., Burnashev, N., Somogyi, P., & Sakmann, B. (1998) · Nature Neuroscience · doi:10.1038/1092 · Cited by 716 · see citing works
A trans-synaptic nanocolumn aligns neurotransmitter release to receptors
Tang, A.-H., Chen, H., Li, T. P., Metzbower, S. R., MacGillavry, H. D., & Blanpied, T. A. (2016) · Nature · doi:10.1038/nature19058 · Cited by 677 · see citing works
Varoqueaux, F., Sigler, A., Rhee, J.-S., Brose, N., Enk, C., Reim, K., & Rosenmund, C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122623799 · Cited by 619 · see citing works
Interplay between Facilitation, Depression, and Residual Calcium at Three Presynaptic Terminals
Dittman, J. S., Kreitzer, A. C., & Regehr, W. G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01374.2000 · Cited by 526 · see citing works
Tests of 'Randomness' for Spatial Point Patterns
Ripley, B. D. (1979) · Journal of the Royal Statistical Society Series B (Statistical Methodology) · doi:10.1111/j.2517-6161.1979.tb01091.x · Cited by 484 · see citing works
Differences in Synaptic GABAA Receptor Number Underlie Variation in GABA Mini Amplitude
Nusser, Z., Cull-Candy, S., & Farrant, M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80382-7 · Cited by 449 · see citing works
Self-citationRouting of spike series by dynamic circuits in the hippocampus
Pouille, F., & Scanziani, M. (2004) · Nature · doi:10.1038/nature02615 · Cited by 434 · see citing works
Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming
Betz, A., Thakur, P., Junge, H. J., Ashery, U., Rhee, J.-S., Scheuss, V., Rosenmund, C., Rettig, J., & Brose, N. (2001) · Neuron · doi:10.1016/s0896-6273(01)00272-0 · Cited by 425 · see citing works
Release probability of hippocampal glutamatergic terminals scales with the size of the active zone
Holderith, N., Lorincz, A., Katona, G., Rózsa, B., Kulik, A., Watanabe, M., & Nusser, Z. (2012) · Nature Neuroscience · doi:10.1038/nn.3137 · Cited by 405 · see citing works
Self-citationShigemoto, R., Kulik, A., Roberts, J. D. B., Ohishi, H., Nusser, Z., Kaneko, T., & Somogyi, P. (1996) · Nature · doi:10.1038/381523a0 · Cited by 400 · see citing works
Self-citationBalance and Stability of Synaptic Structures during Synaptic Plasticity
Meyer, D., Bonhoeffer, T., & Scheuss, V. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.031 · Cited by 395 · see citing works
Rozov, A., Burnashev, N., Sakmann, B., & Neher, E. (2001) · Journal of Physiology · doi:10.1111/j.1469-7793.2001.0807h.x · Cited by 392 · see citing works
The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones
Imig, C., Min, S.-W., Krinner, S., Arancillo, M., Rosenmund, C., Südhof, T. C., Rhee, J., Brose, N., & Cooper, B. H. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.009 · Cited by 389 · see citing works
Multivesicular Release at Climbing Fiber-Purkinje Cell Synapses
Wadiche, J. I., & Jahr, C. E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00488-3 · Cited by 373 · see citing works
Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex
Ma, C., Li, W., Xu, Y., & Rizo, J. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2047 · Cited by 363 · see citing works
Molecular Identity of Dendritic Voltage-Gated Sodium Channels
Lőrincz, A., & Nusser, Z. (2010) · Science · doi:10.1126/science.1187958 · Cited by 297 · see citing works
Self-citationThomson, A. M. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.131bl.x · Cited by 270 · see citing works
Weiser, M., Bueno, E., Sekirnjak, C., Martone, M. E., Baker, H., Hillman, D. E., Chen, S., Thornhill, W. B., Ellisman, M. H., & Rudy, B. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04298.1995 · Cited by 241 · see citing works
Synaptic weight set by Munc13-1 supramolecular assemblies
Sakamoto, H., Ariyoshi, T., Kimpara, N., Sugao, K., Taiko, I., Takikawa, K., Asanuma, D., Namiki, S., & Hirose, K. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0041-9 · Cited by 235 · see citing works
Target Cell-Dependent Normalization of Transmitter Release at Neocortical Synapses
Koester, H. J., & Johnston, D. (2005) · Science · doi:10.1126/science.1100815 · Cited by 222 · see citing works
The Relationship between PSD-95 Clustering and Spine Stability <i>In Vivo</i>
Cane, M., Maco, B., Knott, G., & Holtmaat, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3353-13.2014 · Cited by 216 · see citing works
Deep molecular diversity of mammalian synapses: why it matters and how to measure it
O'Rourke, N. A., Weiler, N. C., Micheva, K. D., & Smith, S. J. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3170 · Cited by 210 · see citing works
Quantitative fine-structural analysis of olfactory cortical synapses
Schikorski, T., & Stevens, C. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4107 · Cited by 204 · see citing works
Neher, E. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00144 · Cited by 203 · see citing works
Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity
Schlüter, O. M., Basu, J., Südhof, T. C., & Rosenmund, C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3553-05.2006 · Cited by 199 · see citing works
UNC-13 and UNC-10/Rim Localize Synaptic Vesicles to Specific Membrane Domains
Weimer, R., Gracheva, E. O., Meyrignac, O., Miller, K. G., Richmond, J., & Bessereau, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2350-06.2006 · Cited by 169 · see citing works
Buhl, E., Tamás, G., Szilágyi, T., Stricker, C., Paulsen, O., & Somogyi, P. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp022053 · Cited by 169 · see citing works
Silver, R. A. (2003) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2003.09.030 · Cited by 168 · see citing works
Target cell-specific modulation of transmitter release at terminals from a single axon
Scanziani, M., Gähwiler, B. H., & Charpak, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.12004 · Cited by 167 · see citing works
Multivesicular Release at Single Functional Synaptic Sites in Cerebellar Stellate and Basket Cells
Auger, C., Kondo, S., & Marty, A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04532.1998 · Cited by 158 · see citing works
Elfn1 Regulates Target-Specific Release Probability at CA1-Interneuron Synapses
Sylwestrak, E. L., & Ghosh, A. (2012) · Science · doi:10.1126/science.1222482 · Cited by 151 · see citing works
Multivesicular Release at Schaffer Collateral–CA1 Hippocampal Synapses
Christie, J. M., & Jahr, C. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4307-05.2006 · Cited by 144 · see citing works
Reddy‐Alla, S., Böhme, M. A., Reynolds, E., Beis, C., Grasskamp, A. T., Mampell, M. M., Maglione, M., Jusyte, M., Rey, U., Babikir, H. A., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.016 · Cited by 141 · see citing works
Rebola, N., Reva, M., Kirizs, T., Szoboszlay, M., Lőrincz, A., Moneron, G., Nusser, Z., & DiGregorio, D. A. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.014 · Cited by 136 · see citing works
Self-citationLosonczy, A., Zhang, L., Shigemoto, R., Somogyi, P., & Nusser, Z. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.020024 · Cited by 129 · see citing works
Self-citationTaschenberger, H., Woehler, A., & Neher, E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606383113 · Cited by 128 · see citing works
Molnár, G., Rózsa, M., Baka, J., Holderith, N., Barzó, P., Nusser, Z., & Tamás, G. (2016) · eLife · doi:10.7554/elife.18167 · Cited by 111 · see citing works
Self-citationHanse, E., & Gustafsson, B. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0481i.x · Cited by 96 · see citing works
Quantal Size Is Independent of the Release Probability at Hippocampal Excitatory Synapses
Biró, Á. A., Holderith, N. B., & Nusser, Z. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3688-04.2005 · Cited by 96 · see citing works
Self-citationThe ubiquitous nature of multivesicular release
Rudolph, S., Tsai, M., von Gersdorff, H., & Wadiche, J. I. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.05.008 · Cited by 95 · see citing works
Hagiwara, A., Fukazawa, Y., Deguchi‐Tawarada, M., Ohtsuka, T., & Shigemoto, R. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20633 · Cited by 90 · see citing works
Spatiotemporal Regulation of Synaptic Vesicle Fusion Sites in Central Synapses
Maschi, D., & Klyachko, V. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.006 · Cited by 86 · see citing works
Miki, T., Kaufmann, W. A., Malagón, G., Gomez, L. C., Tabuchi, K., Watanabe, M., Shigemoto, R., & Marty, A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704470114 · Cited by 84 · see citing works
Biró, Á. A., Holderith, N. B., & Nusser, Z. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3106-06.2006 · Cited by 80 · see citing works
Self-citationReceptor Occupancy Limits Synaptic Depression at Climbing Fiber Synapses
Harrison, J., & Jahr, C. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00377.2003 · Cited by 71 · see citing works
Ariel, P., Hoppa, M. B., & Ryan, T. A. (2013) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2012.00009 · Cited by 67 · see citing works
Quantal Fluctuations in Central Mammalian Synapses: Functional Role of Vesicular Docking Sites
Pulido, C., & Marty, A. (2017) · Physiological Reviews · doi:10.1152/physrev.00032.2016 · Cited by 60 · see citing works
Vesicular Release Statistics and Unitary Postsynaptic Current at Single GABAergic Synapses
Pulido, C., Trigo, F. F., Llano, I., & Marty, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.12.006 · Cited by 58 · see citing works
Brockmann, M. M., Zarebidaki, F., Camacho, M., Grauel, M. K., Trimbuch, T., Südhof, T. C., & Rosenmund, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107960 · Cited by 53 · see citing works
Éltes, T., Kirizs, T., Nusser, Z., & Holderith, N. B. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2024-16.2017 · Cited by 52 · see citing works
Self-citationSome Subtle Lessons from the Calyx of Held Synapse
Neher, E. (2017) · Biophysical Journal · doi:10.1016/j.bpj.2016.12.017 · Cited by 46 · see citing works
Desynchronization of Multivesicular Release Enhances Purkinje Cell Output
Rudolph, S., Overstreet‐Wadiche, L., & Wadiche, J. I. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.029 · Cited by 44 · see citing works
Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression
Fukazawa, Y., & Shigemoto, R. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.01.006 · Cited by 38 · see citing works
Maschi, D., & Klyachko, V. A. (2020) · eLife · doi:10.7554/elife.55210 · Cited by 32 · see citing works
Holderith, N. B., Herédi, J., Kis, V., & Nusser, Z. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107968 · Cited by 30 · see citing works
Self-citationObjective quantification of nanoscale protein distributions
Szoboszlay, M., Kirizs, T., & Nusser, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-15695-w · Cited by 17 · see citing works
Self-citationKleindienst, D., Montanaro, J., Bhandari, P., Case, M. J., Fukazawa, Y., & Shigemoto, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186737 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lin, K., Taschenberger, H., & Neher, E. (2022) · bioRxiv · doi:10.1073/pnas.2207987119 · Cited by 57 · see citing works
SNARE Regulatory Proteins in Synaptic Vesicle Fusion and Recycling
Sauvola, C. W., & Littleton, J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.733138 · Cited by 53 · see citing works
Aldahabi, M., Balint, F., Holderith, N., Lorincz, A., Reva, M., & Nusser, Z. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.035 · Cited by 50 · see citing works
Self-citationFukaya, R., Hirai, H., Sakamoto, H., Hashimotodani, Y., Hirose, K., & Sakaba, T. (2023) · Science Advances · doi:10.1126/sciadv.add3616 · Cited by 34 · see citing works
Gou, X., Ramsey, A. M., & Tang, A. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102540 · Cited by 29 · see citing works
Differential nanoscale organization of excitatory synapses onto excitatory vs. inhibitory neurons
Dharmasri, P. A., Levy, A. D., & Blanpied, T. A. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315379121 · Cited by 23 · see citing works
Dannhäuser, S., Mrestani, A., Gundelach, F., Pauli, M., Komma, F., Kollmannsberger, P., Sauer, M., Heckmann, M., & Paul, M. M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1074304 · Cited by 24 · see citing works
Aldahabi, M., Neher, E., & Nusser, Z. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322550121 · Cited by 15 · see citing works
Self-citationTrans-synaptic molecular context of NMDA receptor nanodomains
Anderson, M. C., Dharmasri, P. A., Damenti, M., Metzbower, S. R., Laghaei, R., Blanpied, T. A., & Levy, A. D. (2025) · Nature Communications · doi:10.1038/s41467-025-62766-y · Cited by 16 · see citing works
Activity-Driven Synaptic Translocation of LGI1 Controls Excitatory Neurotransmission
Cuhadar, U., Calzado-Reyes, L., Pascual-Caro, C., Aberra, A. S., Ritzau‐Jost, A., Aggarwal, A., Ibata, K., Podgorski, K., Yuzaki, M., Geis, C., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2024.114186 · Cited by 16 · see citing works
Bhaskar, B. R., Yadav, L., Sriram, M., Sanghrajka, K., Gupta, M., Boby, K., V, Nellikka, R. K., & Das, D. (2024) · Nature Communications · doi:10.1038/s41467-024-46965-7 · Cited by 16 · see citing works
Kim, O., Okamoto, Y., Kaufmann, W. A., Brose, N., Shigemoto, R., & Jonas, P. (2024) · PLOS Biology · doi:10.1371/journal.pbio.3002879 · Cited by 15 · see citing works
Bera, M., Grushin, K. S., Sundaram, R. V. K., Hinzen, J. S., Chen, J., Chatterjee, A., Radhakrishnan, A., Lee, S., Padmanarayana, M., Coleman, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62420-7 · Cited by 15 · see citing works
Diverse organization of voltage-gated calcium channels at presynaptic active zones
Zhang, W., Jiang, H.-H., & Luo, F. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.1023256 · Cited by 12 · see citing works
Laser microscopy acquisition and analysis of premotor synapses in the murine spinal cord
Buettner, J. M., Kirmann, T., Mentis, G. Z., Hallermann, S., & Simon, C. M. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101236 · Cited by 10 · see citing works
(M)Unc13s in Active Zone Diversity: A Drosophila Perspective
Piao, C., & Sigrist, S. J. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.798204 · Cited by 8 · see citing works
Sakamoto, H., Kimpara, N., Namiki, S., Hamada, S., Ohtsuka, T., & Hirose, K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.11.483942 · Cited by 15 · see citing works
Tuning synapse strength by nanocolumn plasticity
Xu, N., Chen, S.-Y., & Tang, A. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2024.12.009 · Cited by 10 · see citing works
Blaum, N., Ghelani, T., Götz, T., Chronister, K. S., Bengochea, M., Ceresnova, L., Christensen, C., Moulin, T. C., Kern, H. B., Thomas, U., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2514151122 · Cited by 9 · see citing works
Holderith, N. B., Aldahabi, M., & Nusser, Z. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.773209 · Cited by 9 · see citing works
Self-citationLin, K., Taschenberger, H., & Neher, E. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4075232 · Cited by 8 · see citing works
Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95Preprint
Dharmasri, P. A., DeMarco, E. M., Anderson, M. C., Levy, A. D., & Blanpied, T. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.12.574705 · Cited by 8 · see citing works
Guerrero‐Given, D., Goldin, S. L., Thomas, C. I., Anthony, S. A., Jerez, D., & Kamasawa, N. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.855218 · Cited by 7 · see citing works
Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapses
Gotor, J. J. R., Mahfooz, K., Pérez‐Otaño, I., & Wesseling, J. F. (2023) · eLife · doi:10.7554/elife.88212 · Cited by 8 · see citing works
Glavač, D., Mladinić, M., Ban, J., Mazzone, G. L., Sámano, C., Tomljanović, I., Jezernik, G., & Ravnik‐Glavač, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911360 · Cited by 5 · see citing works
Lőrincz, A., Ashaber, M., & Nusser, Z. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0645-25.2025 · Cited by 4 · see citing works
Self-citationParallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapses
Gotor, J. J. R., Mahfooz, K., Pérez‐Otaño, I., & Wesseling, J. F. (2024) · eLife · doi:10.7554/elife.88212.3 · Cited by 4 · see citing works
Ranjan, M., Lin, K., Mueller, B. D., Wojcik, S. M., Lohse, M., Südhof, T. C., Jørgensen, E. M., Neher, E., Lipstein, N., Brose, N., et al. (2026) · Science Advances · doi:10.1126/sciadv.aea0449 · Cited by 3 · see citing works
Multivesicular release favors short term synaptic depression in hippocampal autapses
Segundo, P. M. S., Terni, B., & Llobet, A. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1057242 · Cited by 3 · see citing works
Fekete, Z., Weisz, F., Karlócai, M. R., Veres, J. M., Andrási, T., & Hájos, N. (2024) · The Journal of Physiology · doi:10.1113/jp286284 · Cited by 2 · see citing works
Kim, O., Okamoto, Y., Brose, N., Shigemoto, R., & Jónás, P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.04.569907 · Cited by 2 · see citing works
Taking a closer look at the synapse
Dittman, J. S. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2412457121 · Cited by 1 · see citing works
Active Zone: Linking Resolution Levels of Microscopic Modalities
Galkov, M., Nemcova, P., Dietrich, D., & Schoch, S. (2026) · Advances in neurobiology · doi:10.1007/978-3-032-12594-1_4 · Cited by 1 · see citing works
Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapsesPreprint
Mahfooz, K., Gotor, J. J. R., Pérez‐Otaño, I., & Wesseling, J. F. (2023) · eLife · doi:10.7554/elife.88212.1
Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapsesPreprint
Gotor, J. J. R., Mahfooz, K., Pérez‐Otaño, I., & Wesseling, J. F. (2024) · eLife · doi:10.7554/elife.88212.2
Selective, genetically induced increase in synaptic vesicle priming
Aldahabi, M., Bálint, F., Lőrincz, A., Lipstein, N., Brose, N., & Nusser, Z. (2026) · Science Advances · doi:10.1126/sciadv.aee6848
Self-citation
- Authors
- Karlocai, M. R., Heredi, J., Benedek, T., Holderith, N., Lorincz, A., & Nusser, Z.
- Affiliations
- Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Budapest, Hungary
- University of Alabama at Birmingham (US)
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2021-04-27
- Volume
- 10
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC8116053
- OpenAlex
- W3157632604
- Cited by
- 37
- References
- 61
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 5 · 2022: 13 · 2021: 1
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Research Council (ERC-AG 787157)
- National Research Development and Innovation Office (NAP2.0)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- Munc13-1, release sites, active zone, synaptic vesicle priming, glutamatergic synapses, synaptic heterogeneity, CA1 pyramidal neurons, fast-spiking interneurons, quantal analysis, paired recordings, synaptic vesicle release
- MeSH terms
- Animals, Electrophysiology, Female, Fluorescent Antibody Technique, Freeze Fracturing, Male, Mice, Inbred C57BL, Nerve Tissue Proteins, Synapses, Presynaptic Terminals, Mice, CA1 Region, Hippocampal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review