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Cited by 173Memory and Neural MechanismsSleep and Wakefulness ResearchNeural dynamics and brain function

Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience

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Hirase, Hajime, Leinekugel, Xavier, Czurkó, András, Csicsvari, Jozsef, Buzsáki, György·2001·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.161274398PMC PMC55430
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Abstract

What determines the firing rate of cortical neurons in the absence of external sensory input or motor behavior, such as during sleep? Here we report that, in a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated across sleep–wake–sleep sequences. However, both measures were affected when new sets of neurons were activated in a novel environment. Nevertheless, the grand mean firing rate of the whole pyramidal cell population remained constant across behavioral states and testing conditions. The findings suggest that long-term firing patterns of single cells can be modified by experience. We hypothesize that increased firing rates of recently used neurons are associated with a concomitant decrease in the discharge activity of the remaining population, leaving the mean excitability of the hippocampal network unaltered.

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Crossref · 10.1073/pnas.161274398

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  • When rats repeatedly perform stereotypical behaviors in a familiar environment, firing patterns during pretraining sleep periods become more similar to postsleep periods, and this similarity is reduced when the rat learns a new behavior.

    “Thus, when rats repeatedly perform stereotypical behaviors in a familiar environment, also the firing patterns during pretraining sleep periods become more similar to postsleep periods, and this similarity is reduced when the rat learns a new behavior (551).”

    From About Sleep's Role in Memory (2013) · cites this paper as [551]

    The Results (page not provided) report strong correlations between firing rates in sleep sessions before and after familiar behavior, but a much weaker, nonsignificant correlation before and after exploration of a novel environment. The paper does not show that similarity progressively increases with repeated performance, and it tests novel-environment exploration rather than learning a new behavior. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • During SWS, firing patterns observed during waking are replayed at a much faster (10-20 times) rate.

    “1) during SWS, firing patterns observed during waking are replayed at a much faster (10 -20 times) rate, suggesting a time-compressed form of memory reactivation (160, 551, 606, 715, 843, 1090);”

    From About Sleep's Role in Memory (2013) · cites this paper as [551]

    The Results report that cell pairs coactivated during waking also showed high correlations during sleep, supporting a connection between waking and sleep activity patterns. Neither the Results nor the Discussion reports replay at 10–20 times the waking speed or measures time compression; that specific part of the claim is unsupported. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Cites

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Research works printed but not linked: 1

  1. [15]Moore G P, Rosenberg J R, Hary D, Breeze P. Science. 1966;274:1216–1217. [PubMed] [Google Scholar]

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Authors
Hirase, H., Leinekugel, X., Czurkó, A., Csicsvari, J., & Buzsáki, G.
Affiliations
Rutgers, The State University of New Jersey (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2001-07-24
Volume
98
Issue
16
Pages
9386-9390
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.161274398
PMC
PMC55430
OpenAlex
W2093513928
Cited by
173
References
32
Citations by year
2025: 3 · 2024: 7 · 2023: 9 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 20 · 2018: 4 · 2017: 10 · 2016: 7 · 2015: 3 · 2014: 6 · 2013: 8 · 2012: 5
FWCI
4.72
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (R01MH054671, MH54671)
  • National Institute of Neurological Disorders and Stroke (R01NS034994, NS-34994)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
hippocampal neurons, firing rate, CA1 pyramidal neurons, sleep-wake cycle, novel environment, single-unit recording, memory consolidation, neuroplasticity
MeSH terms
Animals, Hippocampus, Male, Neurons, Sleep, Wakefulness, Rats, Long-Evans, Rats

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