CoChat
Sign Up
Cited by 282Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Place-Selective Firing of CA1 Pyramidal Cells during Sharp Wave/Ripple Network Patterns in Exploratory Behavior

Open access
O'Neill, Joseph, Senior, Timothy, Csicsvari, Jozsef·2006·Neuron
DOI 10.1016/j.neuron.2005.10.037
Open this paper in CoChat — free accountOpen PDF

Abstract

We observed sharp wave/ripples (SWR) during exploration within brief (<2.4 s) interruptions of or during theta oscillations. CA1 network responses of SWRs occurring during exploration (eSWR) and SWRs detected in waking immobility or sleep were similar. However, neuronal activity during eSWR was location dependent, and eSWR-related firing was stronger inside the place field than outside. The eSPW-related firing increase was stronger than the baseline increase inside compared to outside, suggesting a "supralinear" summation of eSWR and place-selective inputs. Pairs of cells with similar place fields and/or correlated firing during exploration showed stronger coactivation during eSWRs and subsequent sleep-SWRs. Sequential activation of place cells was not required for the reactivation of waking co-firing patterns; cell pairs with symmetrical cross-correlations still showed reactivated waking co-firing patterns during sleep-SWRs. We suggest that place-selective firing during eSWRs facilitates initial associations between cells with similar place fields that enable place-related ensemble patterns to recur during subsequent sleep-SWRs.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2005.10.037

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Signs of assembly reactivation occur in the hippocampus and several other regions of the brain during sleep after exploration.

    “These studies uniformly confirmed that signs of assembly reactivation occur in the hippocampus and several other regions of the brain also during sleep after exploration (870, 871, 985).”

    From About Sleep's Role in Memory (2013) · cites this paper as [870]

    The Discussion (page unavailable) reports reactivation of waking co-firing patterns during sleep, supporting the hippocampal part of the claim. The paper’s account concerns CA1 activity; the passages do not establish assembly reactivation in several other brain regions. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Neuron assemblies linked to place fields that were longer or more frequently explored during waking showed stronger reactivation during succeeding sleep.

    “Neuron assemblies linked to place fields that were longer or more frequently explored during waking showed stronger reactivation during succeeding sleep (870, 871).”

    From About Sleep's Role in Memory (2013) · cites this paper as [870]

    The Results section reports stronger co-firing during sleep after exploration for cells with overlapping place fields, supporting place-related reactivation. It does not link stronger reactivation to place fields being explored for longer or more frequently during waking; the comparison is between overlapping and nonoverlapping fields. Page numbers are not available in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Wake reactivations occur conjointly with SW-Rs that are observed at somewhat lower rates during wakefulness than during SWS.

    “They also occur conjointly with SW-Rs that are observed at somewhat lower rates during wakefulness than during SWS (159,191,870).”

    From About Sleep's Role in Memory (2013) · cites this paper as [870]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

2 of the 67 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [47]47. Nimmrich, V. ∙ Maier, N. ∙ Schmitz, D. ... Induced sharp wave-ripple complexes in the absence of synaptic inhibition J. Physiol. 2005; 563:663-670 Crossref Scopus (78) PubMed Google Scholar

Cited by

Sorted by citations

Related

Authors
O'Neill, J., Senior, T., & Csicsvari, J.
Affiliations
University of Oxford (GB)
Corresponding author
Csicsvari, Jozsef
ORCID
Csicsvari, Jozsef
Venue
Neuron
Publisher
Elsevier BV
Published
2006-01
Volume
49
Issue
1
Pages
143-155
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2005.10.037
OpenAlex
W2129356785
Cited by
281
References
67
Citations by year
2026: 6 · 2025: 16 · 2024: 11 · 2023: 5 · 2022: 11 · 2021: 13 · 2020: 6 · 2019: 28 · 2018: 22 · 2017: 16 · 2016: 10 · 2015: 14 · 2014: 19 · 2013: 17 · 2012: 10
FWCI
8.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders
  • Wellcome Trust
  • Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
place cells, CA1 pyramidal neurons, place fields, exploratory behavior, theta oscillations, sleep, memory reactivation, ensemble coding, correlated firing, hippocampus
MeSH terms
Action Potentials, Animals, Electrophysiology, Exploratory Behavior, Male, Rats, Inbred Strains, Sleep Stages, Space Perception, Theta Rhythm, Wakefulness, Pyramidal Cells, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review