The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Exceedingly small iron oxide nanoparticles as positive MRI contrast agents
Open accessAbstract
Significance: Gadolinium (Gd)-based contrast agents (GBCAs) are currently the mainstream clinical MRI contrast agents. Some GBCAs have shown a long-term toxicity—nephrogenic systemic fibrosis (NSF)—and Gd depositions in the brain. The NSF has triggered a Food and Drug Administration (FDA) black-box warning and a contraindication of some GBCAs. The finding of Gd depositions led to an ongoing FDA investigation to monitor their possible long-term adverse effects. Here, we present T 1 -weighted contrast-enhanced MR imaging and angiography using zwitterion-coated exceedingly small superparamagnetic iron oxide nanoparticles (ZES-SPIONs) in mice and rats. Renal clearance and biodistribution results further demonstrate that ZES-SPIONs are qualitatively different from previously reported SPIONs. This work may open up opportunities to develop exceedingly small SPIONs that show effective T 1 contrast as Gd-free alternatives to GBCAs.
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Cites
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Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery
Guo, Y., Sun, Q., Wu, F., Dai, Y., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202007356 · Cited by 650
Jeon, M., Halbert, M. V., Stephen, Z. R., & Zhang, M. (2021) · Advanced Materials · doi:10.1002/adma.201906539 · Cited by 477
Xie, W., Guo, Z., Gao, F., Gao, Q., Wang, D., Liaw, B.-S., Cai, Q., Sun, X., Wang, X., & Zhao, L. (2018) · Theranostics · doi:10.7150/thno.25220 · Cited by 391
Recent applications of immunomodulatory biomaterials for disease immunotherapy
Dai, H., Fan, Q., & Wang, C. (2022) · Exploration · doi:10.1002/exp.20210157 · Cited by 268
Nowak-Jary, J., & Machnicka, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212013 · Cited by 74
Metadata
- Authors
- Wei, H., Bruns, O. T., Kaul, M. G., Hansen, E. C., Barch, M., Wiśniowska, A., Chen, O., Chen, Y., Li, N., Okada, S., Cordero, J. M., Heine, M., Farrar, C. T., Montana, D. M., Adam, G., Ittrich, H., Jasanoff, A., Nielsen, P., & Bawendi, M. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-02-13
- Volume
- 114
- Issue
- 9
- Pages
- 2325-2330
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2588704542
- Cited by
- 489
- References
- 45
- FWCI
- 23.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wei, H., Bruns, O. T., Kaul, M. G., Hansen, E. C., Barch, M., Wiśniowska, A., Chen, O., Chen, Y., Li, N., Okada, S., Cordero, J. M., Heine, M., Farrar, C. T., Montana, D. M., Adam, G., Ittrich, H., Jasanoff, A., Nielsen, P., & Bawendi, M. G. (2017). Exceedingly small iron oxide nanoparticles as positive MRI contrast agents. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1620145114
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