Multimodal mapping of the brain's functional connectivity and the adult outcome of attention deficit hyperactivity disorder
Open accessAbstract
Significance: Many children do not simply “outgrow” attention deficit hyperactivity disorder (ADHD). The disorder often persists and affects around one in 40 adults, presenting a major public health challenge. Defining the mechanisms that underpin this variable clinical outcome could stimulate novel approaches to boost recovery in ADHD. We map the brain’s functional architecture in 205 young adults followed clinically since childhood. We find clinically significant inattention persisting from childhood has a disruptive effect on the functional connections within and between the brain’s major networks. These disruptions are similar whether defined through direct observation of neuronal activity or measures of hemodynamic change. By contrast, adults who remit from childhood ADHD showed typical brain connectivity, suggesting convergence toward typical brain function may underpin recovery.
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Studies of individuals with ADHD report reduced segregation of DMN-FPN networks in children, adolescents, and adults.
“Specifically, studies of individuals with ADHD report reduced segregation of DMN-FPN networks in children, adolescents, and adults (Kessler et al., 2014; Sudre et al., 2017)”
From Investigating functional brain network integrity using a traditional and novel categorical scheme for neurodevelopmental disorders (2019) · cites this paper as Sudre et al., 2017
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“Specifically, studies of individuals with ADHD report reduced segregation of DMN-FPN networks in children, adolescents, and adults (Kessler et al., 2014; Sudre et al., 2017), but results from within-network connectivity studies are less coherent.”
- Authors
- Sudre, G., Szekely, E., Sharp, W., Kasparek, S., & Shaw, P.
- Affiliations
- National Institutes of Health (US)
- Section on Neurobehavioral and Clinical Research, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-10-16
- Volume
- 114
- Issue
- 44
- Pages
- 11787-11792
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5676882
- OpenAlex
- W2766185528
- Cited by
- 93
- References
- 53
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 12 · 2020: 42 · 2019: 12 · 2018: 6 · 2016: 1
- FWCI
- 13.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- attention deficit hyperactivity disorder, functional connectivity, default mode network, inattention, adult outcomes, remission, cognitive control, neurobiology of ADHD, longitudinal follow-up
- MeSH terms
- Adult, Attention, Attention Deficit Disorder with Hyperactivity, Brain, Brain Mapping, Cognition Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways, Magnetoencephalography, Young Adult, Multimodal Imaging
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