The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
O 2 availability impacts iron homeostasis in Escherichia coli
Abstract
Significance: Our understanding of how cells regulate intracellular iron pools has been largely shaped by studying cells grown under aerobic conditions, in which the barrier to iron acquisition is dominated by O 2 -dependent insolubility. However, less is known about how bacteria meet their iron demands in the O 2 -limiting or anaerobic environments that are common to many ecosystems and reflective of the ancient atmosphere of early Earth. Because the transcription factor ferric-uptake regulator (Fur) plays a central role in controlling iron homeostasis in many bacterial species, we use Fur activity as a surrogate for understanding how anaerobiosis alters iron homeostasis. Our finding that levels of active Fur are increased during anaerobiosis emphasizes fundamental differences in bacterial iron requirements between aerobic and anaerobic growth conditions.
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“In E. coli, Fe(II) uptake systems are under the control of Fur and Fnr such that their expression is controlled by Fe and oxygen levels.79”
From Bacterial Responses to Iron Withholding by Calprotectin (2021) · cites this paper as [79]
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BackgroundMetalloproteins and metal sensing
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Characterization of the ferrous iron uptake system of Escherichia coli
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Functional specialization within the Fur family of metalloregulators
Lee, J.-W., & Helmann, J. D. (2007) · BioMetals · doi:10.1007/s10534-006-9070-7 · Cited by 432 · cited 1×
“When iron is available, each subunit of a Fur dimer binds one molecule of Fe ion (7, 8).”
BackgroundRecognition of DNA by Fur: a Reinterpretation of the Fur Box Consensus Sequence
Baichoo, N., & Helmann, J. D. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.21.5826-5832.2002 · Cited by 282 · cited 1×
“In this Fe-bound form, Fur exhibits increased affinity for specific DNA sequences [referred to a Fur boxes (9, 10)] and represses transcription of many iron assimilation pathways.”
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Cited by
Bacterial iron detoxification at the molecular level
Bradley, J. M., Svistunenko, D. A., Wilson, M. T., Hemmings, A. M., Moore, G. R., & Le Brun, N. E. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.007746 · Cited by 140
Fontenot, C. R., Tasnim, H., Valdes, K. A., Popescu, C. V., & Ding, H. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014814 · Cited by 74
Meddling with metal sensors: Fur-Family proteins as signaling hubs
Steingard, C. H., & Helmann, J. D. (2023) · Journal of Bacteriology · doi:10.1128/jb.00022-23 · Cited by 59
Multiple prebiotic metals mediate translation
Bray, M. S., Lenz, T. K., Haynes, J. W., Bowman, J. C., Petrov, A. S., Reddi, A. R., Hud, N. V., Williams, L. D., & Glass, J. B. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803636115 · Cited by 58
Brawley, H. N., Kreinbrink, A. C., Hierholzer, J. D., Vali, S. W., & Lindahl, P. A. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c06625 · Cited by 30
Metadata
- Authors
- Beauchene, N. A., Mettert, E. L., Moore, L. J., Keleş, S., Willey, E. R., & Kiley, P. J.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-10-30
- Volume
- 114
- Issue
- 46
- Pages
- 12261-12266
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 95
- References
- 11
- Language
- en
- Funders
- HHS | National Institutes of Health (GM045844, GM115894)
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