Cited by 200Pancreatic function and diabetesTissue Engineering and Regenerative MedicineHydrogels: synthesis, properties, applications

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Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes

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An, Duo, Chiu, Alan, Flanders, James A., Song, Wei, Shou, Dahua, Lu, Yen-Chun, Grunnet, Lars G., Winkel, Louise, Ingvorsen, Camilla, Christophersen, Nicolaj Strøyer, Fels, Johannes Josef, Sand, Fredrik Wolfhagen, Ji, Yewei, Qi, Ling, Pardo, Yehudah, Luo, Dan, Silberstein, Meredith, Fan, Jintu, Ma, Minglin·2018·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1708806115PMC PMC5777032

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Abstract

Significance: Cell encapsulation holds great potential as a better treatment for type 1 diabetes. An encapsulation system that is scalable to a clinically relevant capacity and can be retrieved or replaced whenever needed is highly desirable for clinical applications. Here we report a cell encapsulation device that is readily scalable and conveniently retrievable through a minimally invasive laparoscopic procedure. We demonstrated its mechanical robustness and facile mass transfer as well as its durable function in diabetic mice. We further showed, as a proof of concept, its scalability and retrievability in dogs. We believe this encapsulation device may contribute to a cellular therapy for type 1 diabetes and potentially other endocrine disorders and hormone-deficient diseases.

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Authors: An, D., Chiu, A., Flanders, J. A., Song, W., Shou, D., Lu, Y.-C., Grunnet, L. G., Winkel, L., Ingvorsen, C., Christophersen, N. S., Fels, J. J., Sand, F. W., Ji, Y., Qi, L., Pardo, Y., Luo, D., Silberstein, M., Fan, J., & Ma, M.
Affiliations: Cornell University (US)
Novo Nordisk (Denmark) (DK)
University of Michigan (US)
Chinese Academy of Sciences (CN)
ORCID: An, Duo
Flanders, James A.
Song, Wei
Shou, Dahua
Ingvorsen, Camilla
Christophersen, Nicolaj Strøyer
Fels, Johannes Josef
Sand, Fredrik Wolfhagen
Ji, Yewei
Qi, Ling
Pardo, Yehudah
Luo, Dan
Silberstein, Meredith
Fan, Jintu
Ma, Minglin
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-12-26
Volume: 115
Issue: 2
Pages: E263-E272
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1708806115
PMC: PMC5777032
OpenAlex: W2776885898
Cited by: 200
References: 0
Citations by year: 2026: 10 · 2025: 10 · 2024: 26 · 2023: 32 · 2022: 22 · 2021: 31 · 2020: 25 · 2019: 32 · 2018: 12
FWCI: 19.34
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.pnas.org/site/aboutpnas/licenses.xhtml (vor, 182 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020572)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords: type 1 diabetes, islet transplantation, alginate hydrogel, in situ crosslinking, immunoprotection, retrievability, scalability, human islets, rat islets, cell therapy, C57BL/6 mice, SCID/beige mice
MeSH terms: Alginates, Animals, Diabetes Mellitus, Experimental, Dimethylformamide, Dogs, Hexuronic Acids, Humans, Islets of Langerhans, Islets of Langerhans Transplantation, Mice, SCID, Polymethyl Methacrylate, Hydrogels, Glucuronic Acid, Mice, Rats, Cell- and Tissue-Based Therapy

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Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes

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