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Birth delivery mode alters perinatal cell death in the mouse brain

Castillo-Ruiz, Alexandra, Mosley, Morgan, Jacobs, Andrew J., Hoffiz, Yarely C., Forger, Nancy G.·2018·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1811962115
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Abstract

Significance: The rate of cesarean section (C-section) delivery worldwide far exceeds the World Health Organization’s recommended rate. C-section delivery has been linked to behavioral effects in the offspring. This suggests effects on the brain, but human studies are confounded by the medical complications, altered birth timing, and maternal factors associated with C-section delivery. We addressed these limitations in a carefully controlled study in mice. Vaginally-born offspring exhibited an acute decrease in cell death across the brain that was absent in C-section–born mice. C-section delivery also was associated with softer vocalizations, as well as with a reduction in at least one neuronal cell type and increased body weight at weaning. Thus, birth mode has acute effects on neurodevelopment that may lead to lasting changes in the brain and behavior.

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  • In animal models, delivery by C-section leads to transient alterations in neural development including decreased dendritic arborization and increased neuronal cell death at birth.

    “In animal models, delivery by C-section leads to transient alterations in the neural development including decreased dendritic arborization (Chiesa et al., 2018;Juarez et al., 2008) and increased neuronal cell death at birth (Castillo-Ruiz et al., 2018).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Castillo-Ruiz et al., 2018

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Research works printed but not linked: 7

  1. [3]Tribe RM, et al. (March 13, 2018) Parturition and the perinatal period: Can mode of delivery impact on the future health of the neonate? J Physiol , 10.1113/JP275429. · DOI
  2. [4]Curran EA, et al. (2015) Research review. Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: A systematic review and meta-analysis. J Child Psychol Psychiatry 56:500 -508.
  3. [7]Stinson LF, Payne MS, Keelan JA (2018) A critical review of the bacterial baptism hypothesis and the impact of cesarean delivery on the infant microbiome. Front Med (Lausanne) 5:135.
  4. [12]Chiesa M, et al. (May 16, 2018) Term or preterm cesarean section delivery does not lead to long-term detrimental consequences in mice. Cereb Cortex , 10.1093/cercor/bhy112. · DOI · Paper page
  5. [25]Hofer MA, Shair HN, Brunelli SA (2002) Ultrasonic vocalizations in rat and mouse pups. Curr Protoc Neurosci Chapter 8:Unit 8.14.
  6. [55]Mavani GP, DeVita MV, Michelis MF (2015) A review of the nonpressor and nonantidiuretic actions of the hormone vasopressin. Front Med (Lausanne) 2:19.
  7. [59]Darmasseelane K, Hyde MJ, Santhakumaran S, Gale C, Modi N (2014) Mode of delivery and offspring body mass index, overweight and obesity in adult life: A systematic review and meta-analysis. PLoS One 9:e87896.

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Authors
Castillo-Ruiz, A., Mosley, M., Jacobs, A. J., Hoffiz, Y. C., & Forger, N. G.
Affiliations
Neuroscience Institute, Georgia State University, Atlanta, GA 30302
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2018-10-15
Volume
115
Issue
46
Pages
11826-11831
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1811962115
Cited by
65
References
4
Language
en
Licence
www.pnas.org/site/aboutpnas/licenses.xhtml (vor, 182 d)
Funders
National Science Foundation (IOS-1743673)

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