Cited by 182Peroxisome Proliferator-Activated ReceptorsRegulation of Appetite and ObesityAdipose Tissue and Metabolism

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PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue

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Lee, Y., Yu, X., Gonzales, F., Mangelsdorf, D. J., Wang, May-Yun, Richardson, C., Witters, L. A., Unger, R. H.·2002·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.182420899PMC PMC129357

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Abstract

Adenovirus-induced hyperleptinemia causes rapid disappearance of body fat in normal rats, presumably by up-regulating fatty acid oxidation within white adipocytes. To determine the role of peroxisomal proliferation-activated receptor (PPAR)α expression, which was increased during the rapid loss of fat, we infused adenovirus–leptin into PPARα −/− and PPARα +/+ mice. Despite similar degrees of hyperleptinemia and reduction in food intake, epididymal fat pad weight declined 55% in wild-type but only 6% in PPARα −/− mice; liver triacylglycerol fell 39% in the wild-type group but was unchanged in PPAR −/− mice. Carnitine palmitoyl transferase-1 mRNA rose 52% in the wild-type mice but did not increase in PPARα −/− mice. PPARγ coactivator-1α rose 3-fold in the fat and 46% in the liver of wild-type mice but was unchanged in PPARα −/− mice. Although AMP-activated protein kinase could not be implicated in the lipopenic actions of hyperleptinemia, acetyl CoA carboxylase protein was reduced in the liver of wild-type but not in PPARα −/− mice. Thus, in PPARα −/− mice, up-regulation of carnitine palmitoyl transferase-1 mRNA in fat, down-regulation of acetyl CoA carboxylase in liver, and up-regulation of PPARγ coactivator-1α mRNA in both tissues are abolished, as is the reduction in their triacylglycerol content.

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Authors: Lee, Y., Yu, X., Gonzales, F., Mangelsdorf, D. J., Wang, M.-Y., Richardson, C., Witters, L. A., & Unger, R. H.
Affiliations: Dartmouth College (US)
ORCID: Yu, X.
Mangelsdorf, D. J.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2002-08-23
Volume: 99
Issue: 18
Pages: 11848-11853
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.182420899
PMC: PMC129357
OpenAlex: W1975015881
Cited by: 181
References: 20
Citations by year: 2025: 2 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 2 · 2015: 7 · 2014: 8 · 2013: 8 · 2012: 7
FWCI: 4.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
U.S. Department of Veterans Affairs
National Institute of Diabetes and Digestive and Kidney Diseases (P01DK058398, DK-35712, DK-58398, DK 02700, K08DK002700, R01DK035712, R01DK002700)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: PPARα, hyperleptinemia, leptin, adipose tissue, liver, fatty acid oxidation, PPARγ coactivator-1α, acetyl-CoA carboxylase, triglycerides, AMPK, adipocyte lipolysis, adipose tissue atrophy
MeSH terms: Adipose Tissue, Animals, Base Sequence, Lipolysis, Liver, Multienzyme Complexes, Oxidation-Reduction, Phosphorylation, Transcription Factors, Triglycerides, Gene Expression Regulation, Enzymologic, Polymerase Chain Reaction, Protein Serine-Threonine Kinases, DNA Primers, Receptors, Cytoplasmic and Nuclear, Mice, Knockout, Leptin, Mice, AMP-Activated Protein Kinases

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PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue

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