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Cited by 77

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response

Sitz, Justine, Blanchet, Sophie Anne, Gameiro, Steven F., Biquand, Elise, Morgan, Tia M., Galloy, Maxime, Dessapt, Julien, Lavoie, Elise G., Blondeau, Andréanne, Smith, Brandon C., Mymryk, Joe S., Moody, Cary A., Fradet-Turcotte, Amélie·2019·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1906102116
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Abstract

Significance: Human papillomaviruses (HPVs) cause 5% of all cancers, including cervical cancers and a growing number of oropharyngeal cancers, which are reaching epidemic proportion. While HPV oncogenes promote the acquisition of cancer hallmarks such as sustained proliferation and resistance to cell death by targeting the p53 and pRb pathways, the mechanism by which they induce genomic instability leading to cellular transformation remains largely unknown. This paper describes how the HPV oncoprotein E7 directly impedes the cellular response to DNA double-strand breaks by interacting with a previously uncharacterized domain of the E3 ubiquitin ligase RNF168. As the function of RNF168 is essential for proper DNA repair, our findings reveal a mechanism by which HPV induces genomic instability and fuels cancer progression.

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Research works printed but not linked: 67

  1. 10.1016/S1470-2045(12)70137-7 · DOI
  2. 10.1016/j.chom.2014.02.011 · DOI
  3. 10.1016/j.virol.2004.03.033 · DOI
  4. 10.1002/rmv.1822 · DOI
  5. 10.1200/JCO.2015.61.6995 · DOI
  6. 10.3747/co.20.1375 · DOI
  7. 10.1515/hsz-2017-0113 · DOI · Paper page
  8. 10.3390/v7052450 · DOI
  9. 10.1146/annurev-virology-092917-043534 · DOI
  10. 10.1128/JVI.00247-12 · DOI
  11. 10.1371/journal.ppat.1000605 · DOI · Paper page
  12. 10.1371/journal.ppat.1003777 · DOI
  13. 10.1371/journal.ppat.1000397 · DOI · Paper page
  14. 10.1128/JVI.00517-14 · DOI
  15. 10.1128/JVI.02495-15 · DOI
  16. 10.1128/mBio.00064-18 · DOI
  17. 10.1016/j.cell.2011.02.013 · DOI · Paper page
  18. 10.1016/0092-8674(93)90493-A · DOI
  19. 10.15252/embj.201592595 · DOI
  20. 10.1098/rstb.2016.0280 · DOI
  21. 10.1016/j.cell.2012.08.005 · DOI
  22. 10.7554/eLife.23872 · DOI
  23. 10.1016/j.molcel.2017.04.009 · DOI
  24. 10.1038/nature18951 · DOI
  25. 10.15252/embr.201847560 · DOI
  26. 10.1371/journal.pgen.1001381 · DOI
  27. 10.1016/j.cell.2008.12.042 · DOI
  28. 10.1016/j.cell.2012.06.039 · DOI
  29. 10.1158/2159-8290.CD-12-0095 · DOI · Paper page
  30. 10.1126/scisignal.2004088 · DOI · Paper page
  31. 10.1093/emboj/17.6.1768 · DOI
  32. 10.1038/ncb2201 · DOI
  33. 10.1083/jcb.201011083 · DOI
  34. 10.1038/s41556-019-0293-6 · DOI
  35. 10.1128/JVI.01002-12 · DOI
  36. 10.1016/j.molcel.2010.05.020 · DOI · Paper page
  37. 10.1038/onc.2015.268 · DOI
  38. 10.1128/JVI.78.7.3533-3541.2004 · DOI
  39. 10.1038/sj.emboj.7600651 · DOI · Paper page
  40. 10.1016/j.virol.2013.04.013 · DOI
  41. 10.1128/JVI.00643-11 · DOI · Paper page
  42. 10.1186/s12985-018-1086-4 · DOI
  43. 10.1016/j.molcel.2018.07.011 · DOI
  44. 10.1073/pnas.212519499 · DOI
  45. 10.1016/j.molcel.2018.12.010 · DOI
  46. 10.7554/eLife.20922 · DOI
  47. 10.1016/j.coviro.2018.08.017 · DOI
  48. 10.1038/emboj.2009.400 · DOI
  49. 10.1371/journal.ppat.1002084 · DOI
  50. 10.1016/j.molcel.2012.02.004 · DOI
  51. 10.1016/j.virol.2019.03.001 · DOI
  52. 10.1371/journal.pgen.1004178 · DOI
  53. 10.1128/JVI.00262-18 · DOI
  54. 10.1093/nar/gkt729 · DOI
  55. 10.1101/gad.1735109 · DOI
  56. 10.1038/ncb2017 · DOI · Paper page
  57. 10.1038/nrc2886 · DOI
  58. 10.1038/emboj.2012.47 · DOI
  59. 10.1128/JVI.01318-17 · DOI
  60. 10.1128/JVI.00881-07 · DOI · Paper page
  61. 10.1128/JVI.01012-17 · DOI
  62. 10.1093/nar/gkv336 · DOI
  63. 10.1016/j.cell.2017.08.001 · DOI
  64. R. Wilson, L. A. Laimins, Differentiation of HPV-containing cells using organotypic “raft” culture or methylcellulose. Methods Mol. Med. 119, 157–169 (2005).
  65. 10.1128/JVI.77.5.2819-2831.2003 · DOI
  66. 10.1093/nar/gkv993 · DOI
  67. 10.3390/v9090252 · DOI

Cited by

Metadata

Authors
Sitz, J., Blanchet, S. A., Gameiro, S. F., Biquand, E., Morgan, T. M., Galloy, M., Dessapt, J., Lavoie, E. G., Blondeau, A., Smith, B. C., Mymryk, J. S., Moody, C. A., & Fradet-Turcotte, A.
Affiliations
  • Oncology Division, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval Research Center, Québec, QC, Canada G1R 1S3;
  • Department of Microbiology & Immunology, The University of Western Ontario, London, ON, Canada N6A 3K7;
  • Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
  • Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
ORCID
Fradet-Turcotte, Amélie
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2019-09-09
Volume
116
Issue
39
Pages
19552-19562
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1906102116
Cited by
77
References
9
Language
en
Licence
www.pnas.org/site/aboutpnas/licenses.xhtml (vor, 182 d)
Funders
  • Gouvernement du Canada | CIHR | Institute of Cancer Research (152948)
  • Gouvernement du Canada | CIHR | Institute of Infection and Immunity (142491)
  • Cancer Research Society (19590)
  • HHS | NIH | National Cancer Institute (CA181581, CA226523)

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