In utero MRI identifies consequences of early-gestation alcohol drinking on fetal brain development in rhesus macaques
Open accessAbstract
One factor that contributes to the high prevalence of fetal alcohol spectrum disorder (FASD) is binge-like consumption of alcohol before pregnancy awareness. It is known that treatments are more effective with early recognition of FASD. Recent advances in retrospective motion correction for the reconstruction of three-dimensional (3D) fetal brain MRI have led to significant improvements in the quality and resolution of anatomical and diffusion MRI of the fetal brain. Here, a rhesus macaque model of FASD, involving oral self-administration of 1.5 g/kg ethanol per day beginning prior to pregnancy and extending through the first 60 d of a 168-d gestational term, was utilized to determine whether fetal MRI could detect alcohol-induced abnormalities in brain development. This approach revealed differences between ethanol-exposed and control fetuses at gestation day 135 (G135), but not G110 or G85. At G135, ethanol-exposed fetuses had reduced brainstem and cerebellum volume and water diffusion anisotropy in several white matter tracts, compared to controls. Ex vivo electrophysiological recordings performed on fetal brain tissue obtained immediately following MRI demonstrated that the structural abnormalities observed at G135 are of functional significance. Specifically, spontaneous excitatory postsynaptic current amplitudes measured from individual neurons in the primary somatosensory cortex and putamen strongly correlated with diffusion anisotropy in the white matter tracts that connect these structures. These findings demonstrate that exposure to ethanol early in gestation perturbs development of brain regions associated with motor control in a manner that is detectable with fetal MRI.
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MRI studies showed reductions in brainstem as well as cerebellum volume in a primate FAS model and a sex-dependent change in functional connectivity and metabolism in prefrontal areas in a rat FAS model.
“MRI studies showed reductions in brainstem as well as cerebellum volume in a primate FAS model and a sex-dependent change in functional connectivity and metabolism in prefrontal areas in a rat FAS model [317, 318].”
From Development of prefrontal cortex (2022) · cites this paper as [318]
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Hougaard, K. S., & Hansen, Å. M. (2007) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2007.02.003 · Cited by 21 · see citing works
Jimenez, V. A., Wang, X., Newman, N., Walter, N. A. R., Gonzales, S. W., Lo, J. O.-T., Ford, M. M., Carlson, V. C. C., Grant, K. A., & Kroenke, C. D. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13938 · Cited by 11 · see citing works
Self-citationYazdani-Brojeni, P., Motz, M., & Koren, G. (2009) · PubMed · Cited by 10 · see citing works
Moore, T. E., & Gagnier, K. R. (2010) · The Corsini Encyclopedia of Psychology · doi:10.1002/9780470479216.corpsy0354 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
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Cited by
Sorted by citations
Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
“MRI studies showed reductions in brainstem as well as cerebellum volume in a primate FAS model and a sex-dependent change in functional connectivity and metabolism in prefrontal areas in a rat FAS model [317, 318].”
Background
- Authors
- Wang, X., Cuzon Carlson, V. C., Studholme, C., Newman, N., Ford, M. M., Grant, K. A., & Kroenke, C. D.
- Affiliations
- Oregon National Primate Research Center (US)
- Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006;
- University of Washington (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2020-04-20
- Volume
- 117
- Issue
- 18
- Pages
- 10035-10044
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC7211988
- OpenAlex
- W3016443736
- Cited by
- 31
- References
- 91
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 1
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (AA021981, AA019431)
- HHS | NIH | NIH Office of the Director (OD011092)
- HHS | NIH | National Institute of Neurological Disorders and Stroke (NS055064)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- fetal alcohol spectrum disorders, prenatal alcohol exposure, fetal brain development, rhesus macaque model, fetal MRI, diffusion MRI, white matter anisotropy, brainstem volume, spontaneous excitatory postsynaptic currents, primary somatosensory cortex, putamen, motor control, early pregnancy
- MeSH terms
- Alcohol Drinking, Ethanol, Animals, Brain, Disease Models, Animal, Female, Fetus, Humans, Macaca mulatta, Pregnancy, Prenatal Exposure Delayed Effects, Retrospective Studies, Diffusion Magnetic Resonance Imaging, Fetal Development, Fetal Alcohol Spectrum Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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