Neonatal CSF vasopressin concentration predicts later medical record diagnoses of autism spectrum disorder
Open accessAbstract
Significance: Autism is a poorly understood brain disorder of childhood onset. It is characterized by social impairments and diagnosed behaviorally. Early diagnosis fosters better developmental outcomes through behavioral intervention. However, long clinic wait times to undergo behavioral evaluation contribute to delayed diagnoses and treatments. Emerging evidence indicates that low cerebrospinal fluid concentration of the “social” neuropeptide vasopressin is a marker of social impairment in children with autism. Here we report that cerebrospinal fluid vasopressin concentration is significantly lower in newborns diagnosed with autism later in childhood. These preliminary findings suggest that a biomarker of autism may be present before behavioral symptoms emerge. If replicated, this approach could be useful for assessing autism risk and facilitating early intervention in high-risk individuals.
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Peripheral levels of vasopressin appear to be an accurate predictor of ASD and was effective at ameliorating social deficits when administered intranasally in a small trial.
“Peripheral levels of vasopressin appear to be an accurate predictor of ASD and was effective at ameliorating social deficits when administered intranasally in a small trial [175, 176].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [176]
Investigations in pediatric autism spectrum disorder and control samples also found decreased cerebrospinal fluid vasopressin.
“This led to investigations in pediatric ASD and control samples that also found decreased cerebrospinal fluid AVP (167, 168).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [167]
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Oztan, O., Talbot, C. F., Argilli, E., Maness, A. C., Simmons, S. M. V., Mohsin, N., Rosso, L. A. D., Garner, J. P., Sherr, E. H., Capitanio, J. P., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14936229
Self-citationToya, A., Fukada, M., Aoki, E., Matsuki, T., Ueda, M., Eda, S., Hashizume, Y., Iio, A., Masaki, S., & Nakayama, A. (2023) · Figshare · doi:10.6084/m9.figshare.26566856
Toya, A., Fukada, M., Aoki, E., Matsuki, T., Ueda, M., Eda, S., Hashizume, Y., Iio, A., Masaki, S., & Nakayama, A. (2023) · Figshare · doi:10.6084/m9.figshare.26566853
Circuit logic of oxytocin and vasopressin complementary actions
Jeanneteau, F. D., Chakraborty, P., Petitjean, H., & Charlet, A. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1875731
- Authors
- Oztan, O., Garner, J. P., Constantino, J. N., & Parker, K. J.
- Affiliations
- Stanford University (US)
- Washington University in St. Louis (US)
- Corresponding author
- Parker, Karen J.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2020-04-27
- Volume
- 117
- Issue
- 19
- Pages
- 10609-10613
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC7229671
- OpenAlex
- W3020065859
- Cited by
- 65
- References
- 33
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 13 · 2021: 9 · 2020: 5
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | National Institutes of Health (MH56317, HD087011)
- Department of Psychiatry, Stanford University (Not applicable)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, vasopressin, oxytocin, neurochemical markers, early diagnosis, ADHD comorbidity, infant brain development
- MeSH terms
- Autism Spectrum Disorder, Arginine Vasopressin, Autistic Disorder, Female, Humans, Infant, Infant, Newborn, Male, Medical Records, Neuropeptides, Neurophysins, Oxytocin, Prospective Studies, Protein Precursors, Social Behavior, Vasopressins, Biomarkers
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