Cited by 65Autism Spectrum Disorder ResearchNeuroendocrine regulation and behaviorGenetics and Neurodevelopmental Disorders

Neonatal CSF vasopressin concentration predicts later medical record diagnoses of autism spectrum disorder

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Oztan, Ozge, Garner, Joseph P., Constantino, John N., Parker, Karen J.·2020·Proceedings of the National Academy of Sciences

Abstract

Significance: Autism is a poorly understood brain disorder of childhood onset. It is characterized by social impairments and diagnosed behaviorally. Early diagnosis fosters better developmental outcomes through behavioral intervention. However, long clinic wait times to undergo behavioral evaluation contribute to delayed diagnoses and treatments. Emerging evidence indicates that low cerebrospinal fluid concentration of the “social” neuropeptide vasopressin is a marker of social impairment in children with autism. Here we report that cerebrospinal fluid vasopressin concentration is significantly lower in newborns diagnosed with autism later in childhood. These preliminary findings suggest that a biomarker of autism may be present before behavioral symptoms emerge. If replicated, this approach could be useful for assessing autism risk and facilitating early intervention in high-risk individuals.

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Crossref · 10.1073/pnas.1919050117

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33 of 33 references verified0 citation errors · 0 not checkable

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  • Peripheral levels of vasopressin appear to be an accurate predictor of ASD and was effective at ameliorating social deficits when administered intranasally in a small trial.

    “Peripheral levels of vasopressin appear to be an accurate predictor of ASD and was effective at ameliorating social deficits when administered intranasally in a small trial [175, 176].”

    From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [176]

  • Investigations in pediatric autism spectrum disorder and control samples also found decreased cerebrospinal fluid vasopressin.

    “This led to investigations in pediatric ASD and control samples that also found decreased cerebrospinal fluid AVP (167, 168).”

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Authors
Oztan, O., Garner, J. P., Constantino, J. N., & Parker, K. J.
Affiliations
  • Stanford University (US)
  • Washington University in St. Louis (US)
Corresponding author
Parker, Karen J.
Venue
Proceedings of the National Academy of Sciences
Published
2020-04-27
Volume
117
Issue
19
Pages
10609-10613
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W3020065859
Cited by
65
References
33
Citations by year
2026: 3 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 13 · 2021: 9 · 2020: 5
FWCI
5.24
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • HHS | National Institutes of Health (MH56317, HD087011)
  • Department of Psychiatry, Stanford University (Not applicable)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, vasopressin, oxytocin, neurochemical markers, early diagnosis, ADHD comorbidity, infant brain development
MeSH terms
Autism Spectrum Disorder, Arginine Vasopressin, Autistic Disorder, Female, Humans, Infant, Infant, Newborn, Male, Medical Records, Neuropeptides, Neurophysins, Oxytocin, Prospective Studies, Protein Precursors, Social Behavior, Vasopressins, Biomarkers

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