Cited by 185Autism Spectrum Disorder ResearchNeuroendocrine regulation and behaviorGenetics and Neurodevelopmental Disorders

A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism

Open access
Parker, Karen J., Oztan, Ozge, Libove, Robin A., Mohsin, Noreen, Karhson, Debra S., Sumiyoshi, Raena D., Summers, Jacqueline E., Hinman, Kyle E. +6 more·2019·Science Translational Medicine

Abstract

Intranasal delivery of the neuropeptide vasopressin improves social abilities in children with autism spectrum disorder.

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Registry

Crossref · 10.1126/scitranslmed.aau7356

Cites

68 of 68 references verified0 citation errors · 0 not checkable

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  • Peripheral levels of vasopressin appear to be an accurate predictor of ASD and was effective at ameliorating social deficits when administered intranasally in a small trial.

    “Peripheral levels of vasopressin appear to be an accurate predictor of ASD and was effective at ameliorating social deficits when administered intranasally in a small trial [175, 176].”

    From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [175]

  • Intranasal vasopressin treatment considerably improved social abilities in children with autism spectrum disorder.

    “Finally, intranasal AVP treatment considerably improved social abilities in children with ASD (169).”

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Cites

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Research works printed but not linked: 5

  1. [47]Lord C, Rutter M, DiLavore PC, Risi S, Gotham K, Bishop SL, Luyster RJ, Guthrie W, Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) Manual (part 1): Modules 1–4 (Western Psychological Services, 2012).
  2. [48]Roid GH, Stanford Binet's Intelligence Scales, Fifth Edition, Technical Manual (Riverside Publishing, 2003).
  3. [68]Mead R, The Design of Experiments: Statistical Principles for Practical Applications (Cambridge Univ. Press, 1988).
  4. [70]Neter J, Kutner MH, Nachtscheim C, Wasserman W, Applied Linear Statistical Models (McGraw-Hill, ed. 4, 1996).
  5. [71]Grafen A, Hails R, Modern Statistics for the Life Sciences (Oxford Univ. Press, 2002), pp. XV, 351.

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Authors
Parker, K. J., Oztan, O., Libove, R. A., Mohsin, N., Karhson, D. S., Sumiyoshi, R. D., Summers, J. E., Hinman, K. E., Motonaga, K. S., Phillips, J. M., Carson, D. S., Fung, L. K., Garner, J. P., & Hardan, A. Y.
Affiliations
Stanford Medicine (US)
Corresponding author
Parker, Karen J.
Venue
Science Translational Medicine
Published
2019-05-08
Volume
11
Issue
491
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2943453749
Cited by
185
References
68
Citations by year
2026: 22 · 2025: 21 · 2024: 23 · 2023: 29 · 2022: 42 · 2021: 27 · 2020: 14 · 2019: 7
FWCI
13.08
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R21MH100387, T32MH019908, K08MH111750)
  • Autism Speaks (7895)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD083629, R01HD091972)
  • Stanford’s Department of Psychiatry (N/A)
  • The Teresa and Charles Michael Endowed Fund for Autism Research and Education (N/A)
  • The Child Health Research Institute (N/A)
  • The Yani Calmidis Memorial Fund for Autism Research (N/A)
  • Mosbacher Family Fund for Autism Research (N/A)
  • Bass Society (N/A)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, social dysfunction, children, anxiety symptoms, repetitive behavior, treatment tolerability, adverse events
MeSH terms
Autism Spectrum Disorder, Administration, Intranasal, Child, Female, Humans, Male, Pilot Projects, Placebos, Social Behavior, Vasopressins, Treatment Outcome

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