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Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development
Open accessAbstract
Significance: Since SARS-CoV-2 emerged in China, it has spread rapidly around the world. Effective vaccines and therapeutics for SARS-CoV-2−induced disease (coronavirus disease 2019;COVID-19) are urgently needed. We found that SARS-CoV-2 isolates replicate efficiently in the lungs of Syrian hamsters and cause severe pathological lesions in the lungs of these animals similar to commonly reported imaging features of COVID-19 patients with pneumonia. SARS-CoV-2−infected hamsters mounted neutralizing antibody responses and were protected against rechallenge with SARS-CoV-2. Moreover, passive transfer of convalescent serum to naïve hamsters inhibited virus replication in their lungs. Syrian hamsters are a useful small animal model for the evaluation of vaccines, immunotherapies, and antiviral drugs.
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Metadata
- Authors
- Imai, M., Iwatsuki-Horimoto, K., Hatta, M., Loeber, S., Halfmann, P. J., Nakajima, N., Watanabe, T., Ujie, M., Takahashi, K., Ito, M., Yamada, S., Fan, S., Chiba, S., Kuroda, M., Guan, L., Takada, K., Armbrust, T., Balogh, A., Furusawa, Y., Okuda, M., Ueki, H., Yasuhara, A., Sakai-Tagawa, Y., Lopes, T. J. S., Kiso, M., Yamayoshi, S., Kinoshita, N., Ohmagari, N., Hattori, S.-I., Takeda, M., Mitsuya, H., Krammer, F., Suzuki, T., & Kawaoka, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2020-06-22
- Volume
- 117
- Issue
- 28
- Pages
- 16587-16595
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W3036887118
- Cited by
- 1,021
- References
- 31
- FWCI
- 24.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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