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Cited by 85

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding

Sun, Xun, Dyson, H. Jane, Wright, Peter E.·2021·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.2021456118
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Abstract

Significance: The transcription factor p53 is a master tumor suppressor that controls the cellular response to genotoxic stress. Following DNA damage, p53 is activated by phosphorylation at multiple sites in the intrinsically disordered N-terminal transactivation domain. In particular, the phosphorylation status of Thr55 controls both activation and termination of p53-mediated transcriptional programs during different stages of the cellular DNA damage response. Here we show that Thr55 functions as a phosphorylation-dependent regulatory switch that modulates synergistic intramolecular interactions between the disordered transactivation domain and the structured DNA-binding domain. The strength of these interactions is fine-tuned by the intervening proline-rich domain and is enhanced by Thr55 phosphorylation, resulting in autoinhibition of p53 binding to promoters that regulate cell cycle arrest and apoptosis.

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Research works printed but not linked: 60

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Metadata

Authors
Sun, X., Dyson, H. J., & Wright, P. E.
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2020-12-28
Volume
118
Issue
1
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.2021456118
Cited by
85
References
8
Language
en
Licence
www.pnas.org/site/aboutpnas/licenses.xhtml (vor, 175 d)
Funders
HHS | NIH | National Institute of General Medical Sciences (GM075995, GM131693)

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CoChat. (2026). Citation check: A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding. https://app.cochat.ai/papers/10.1073/pnas.2021456118
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Sun, X., Dyson, H. J., & Wright, P. E. (2021). A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2021456118

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.