Cited by 77Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsTreatment of Major Depression

Autophosphorylation of αCaMKII is not a general requirement for NMDA receptor‐dependent LTP in the adult mouse

Open access
Cooke, Sam F., Wu, Jianqun, Plattner, Florian, Errington, Michael, Rowan, Michael, Peters, Marco, Hirano, Ayumi, Bradshaw, Karl D. +3 more·2006·The Journal of Physiology

Abstract

Autophosphorylation of alpha-Ca2+/calmodulin kinase II (alphaCaMKII) at Thr286 is thought to be a general effector mechanism for sustaining transcription-independent long-term potentiation (LTP) at pathways where LTP is NMDA receptor-dependent. We have compared LTP at two such hippocampal pathways in mutant mice with a disabling point mutation at the Thr286 autophosphorylation site. We find that autophosphorylation of alphaCaMKII is essential for induction of LTP at Schaffer commissural-CA1 synapses in vivo, but is not required for LTP that can be sustained over days at medial perforant path-granule cell synapses in awake mice. At these latter synapses LTP is supported by cyclic AMP-dependent signalling in the absence of alphaCaMKII signalling. Thus, the autophosphorylation of alphaCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse.

Integrity signals

Registry

Crossref · 10.1113/jphysiol.2006.111559

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • NMDAR-dependent LTP is greatly impaired when T286 is replaced by T286A.

    “Foremost are data, now long accepted, that NMDAR-dependent LTP is greatly impaired when T286 is replaced by T286A (43, 121, 381–384).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [383]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Cooke, S. F., Wu, J., Plattner, F., Errington, M., Rowan, M., Peters, M., Hirano, A., Bradshaw, K. D., Anwyl, R., Bliss, T. V. P., & Giese, K. P.
Affiliations
  • Trinity College Dublin (IE)
  • University College London (GB)
  • National Institute for Medical Research (GB)
Corresponding author
Giese, K. Peter
Venue
The Journal of Physiology
Publisher
Wiley
Published
2006-07-21
Volume
574
Issue
3
Pages
805-818
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
OpenAlex
W2166160073
Cited by
77
References
49
Citations by year
2026: 3 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 8 · 2013: 3 · 2012: 4
FWCI
3.28
Type
journal article
Language
en
Open access
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
Ernst Schering Foundation
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
CaMKIIα, autophosphorylation, long-term potentiation, NMDA receptor, hippocampus, cAMP signaling, synaptic plasticity, mouse mutants
MeSH terms
Action Potentials, Animals, Cells, Cultured, Hippocampus, Mice, Inbred C57BL, Phosphorylation, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Mutagenesis, Site-Directed, Protein Serine-Threonine Kinases, Long-Term Potentiation, Amino Acid Substitution, Mice, Calcium-Calmodulin-Dependent Protein Kinase Kinase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review