Cited by 309HIV Research and TreatmentHIV/AIDS drug development and treatmentEvolution and Genetic Dynamics

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation

Open access

Temin, H M·1993·Proceedings of the National Academy of Sciences

Open this paper in CoChat — free account

Abstract

Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.

Integrity signals

Registry

Crossref · 10.1073/pnas.90.15.6900

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Frameshift Mutations and the Genetic Code
Streisinger, G., Okada, Y., Emrich, J., Newton, J., Tsugita, A., Terzaghi, E., & Inouye, M. (1966) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1966.031.01.014 · Cited by 1,400
The accuracy of reverse transcriptase from HIV-1
Roberts, J. D., Bebenek, K., & Kunkel, T. A. (1988) · Science · doi:10.1126/science.2460925 · Cited by 997
Die Molekularbiologie der Tumorviren
Sauer, G. (1977) · Die Naturwissenschaften · doi:10.1007/bf00483548 · Cited by 943
Fidelity of HIV-1 reverse transcriptase
Preston, B. D., Poiesz, B. J., & Loeb, L. A. (1988) · Science · doi:10.1126/science.2460924 · Cited by 931
Structure, Replication, and Recombination of Retrovirus Genomes: Some Unifying Hypotheses
Coffin, J. M. (1979) · Journal of General Virology · doi:10.1099/0022-1317-42-1-1 · Cited by 519
Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination.
Hu, W. S., & Temin, H. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1556 · Cited by 476
Self-citation
Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera
Albert, J., Abrahamsson, B., Nagy, K., Aurelius, E., Gaines, H., Nyström, G., & Fenyõ, É. M. (1990) · AIDS · doi:10.1097/00002030-199002000-00002 · Cited by 398
Mechanism of DNA Strand Transfer Reactions Catalyzed by HIV-1 Reverse Transcriptase
Peliska, J. A., & Benkovic, S. J. (1992) · Science · doi:10.1126/science.1279806 · Cited by 335
Specificity and Mechanism of Error-prone Replication by Human Immunodeficiency Virus-1 Reverse Transcriptase
Bębenek, K., Abbotts, J., Roberts, J. D., Wilson, S. H., & Kunkel, T. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84799-3 · Cited by 311
Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase.
Mendelman, L. V., Petruska, J. A., & Goodman, M. F. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39981-8 · Cited by 290

Show all 37 references

Sorted by citations

Items 101–200 of 309

The Role of APOBECs in Viral Replication
Xu, W. K., Byun, H., & Dudley, J. P. (2020) · Microorganisms · doi:10.3390/microorganisms8121899 · Cited by 55
Sequence Note : Coexistence of Subtypes B, F, and a B/F env Recombinant of HIV Type 1 in Buenos Aires, Argentina
MARQUINA, S., Leitner, T., Rabinovich, R., Benetucci, J. A., Libonatti, O., & Albert, J. (1996) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1996.12.1651 · Cited by 52
SIRE1, an Endogenous Retrovirus Family from Glycine max, Is Highly Homogeneous and Evolutionarily Young
Laten, H. M. (2003) · Molecular Biology and Evolution · doi:10.1093/molbev/msg142 · Cited by 51
Modification of retroviral RNA by double-stranded RNA adenosine deaminase
Hajjar, A. M., & Linial, M. L. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5878-5882.1995 · Cited by 51
Potential and limitation of UVC irradiation for the inactivation of pathogens in platelet concentrates
Terpstra, F. G., Wout, A. B. V. ’., Schuitemaker, H., Engelenburg, F. A. C. V., Dekkers, D. W. C., Verhaar, R., de Korte, D., & Verhoeven, A. J. (2007) · Transfusion · doi:10.1111/j.1537-2995.2007.01524.x · Cited by 50
New BEL-like LTR-retrotransposons in Fugu rubripes , Caenorhabditis elegans , and Drosophila melanogaster
Frame, I. G., Cutfield, J. F., & Poulter, R. T. M. (2001) · Gene · doi:10.1016/s0378-1119(00)00567-9 · Cited by 49
Uniquely Altered DNA Replication Fidelity Conferred by an Amino Acid Change in the Nucleotide Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
LEWIS, D. A., Bębenek, K., Beard, W. A., Wilson, S. H., & Kunkel, T. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.32924 · Cited by 48
HIV-1 replication cycle
Ferguson, M. R., Rojo, D. R., von Lindern, J. J., & O’Brien, W. A. (2002) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(02)00015-x · Cited by 48
Mutational studies of human immunodeficiency virus type 1 reverse transcriptase : the involvement of residues 183 and 184 in the fidelity of DNA synthesis
Bakhanashvili, M., Avidan, O., & Hizi, A. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00747-8 · Cited by 49
The Impact of Multidideoxynucleoside Resistance-Conferring Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Polymerase Fidelity and Error Specificity
Rezende, L. F., Curr, K. A., Ueno, T., Mitsuya, H., & Prasad, V. R. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.2890-2895.1998 · Cited by 49
The distribution of HIV-1 recombination breakpoints
Fan, J., Negroni, M., & Robertson, D. L. (2007) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2007.07.012 · Cited by 46
“Might as Well Jump!” Template Switching by Retroviral Reverse Transcriptase, Defective Genome Formation, and Recombination
Pathak, V. K., & Hu, W.-S. (1997) · Seminars in Virology · doi:10.1006/smvy.1997.0114 · Cited by 45
Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesis
Ji, J., Hoffmann, J., & Loeb, L. A. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.1.47 · Cited by 44
Recombination in HIV-1: Update and Implications
Quiñones‐Mateu, M. E. (2001) · Cited by 44
Population Dynamics of HIV-1 Subtype B in a Cohort of Men-Having-Sex-With-Men in Rome, Italy
Zehender, G., Ebranati, E., Lai, A., Santoro, M. M., Alteri, C., Giuliani, M., Palamara, G., Perno, C. F., Galli, M., Presti, A. L., et al. (2010) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181eb3002 · Cited by 43
The antiretrovirus drug 3'-azido-3'-deoxythymidine increases the retrovirus mutation rate
Julias, J. G., Kim, T., Arnold, G., & Pathak, V. K. (1997) · Journal of Virology · doi:10.1128/jvi.71.6.4254-4263.1997 · Cited by 43
Effects of Limiting Homology at the Site of Intermolecular Recombinogenic Template Switching during Moloney Murine Leukemia Virus Replication
Pfeiffer, J. K., & Telesnitsky, A. (2001) · Journal of Virology · doi:10.1128/jvi.75.23.11263-11274.2001 · Cited by 46
Relative Rates of Retroviral Reverse Transcriptase Template Switching during RNA- and DNA-Dependent DNA Synthesis
Bowman, R. R., Hu, W.-S., & Pathak, V. K. (1998) · Journal of Virology · doi:10.1128/jvi.72.6.5198-5206.1998 · Cited by 43
Identification of a preferred region for recombination and mutation in HIV-1 gag
Dykes, C., Balakrishnan, M., Planelles, V., Zhu, Y., Bambara, R. A., & Demeter, L. M. (2004) · Virology · doi:10.1016/j.virol.2004.02.033 · Cited by 42
Zinc Finger Domain of Murine Leukemia Virus Nucleocapsid Protein Enhances the Rate of Viral DNA Synthesis in Vivo
Zhang, W., Hwang, C. K., Hu, W.-S., Gorelick, R. J., & Pathak, V. K. (2002) · Journal of Virology · doi:10.1128/jvi.76.15.7473-7484.2002 · Cited by 41
Evidence for the Differential Effects of Nucleocapsid Protein on Strand Transfer in Various Regions of the HIV Genome
Derebail, S. S., Heath, M. J., & DeStefano, J. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211701200 · Cited by 41
Insertions into the β3-β4 Hairpin Loop of HIV-1 Reverse Transcriptase Reveal a Role for Fingers Subdomain in Processive Polymerization
Kew, Y., Olsen, L. R., Japour, A. J., & Prasad, V. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7529 · Cited by 41
Mechanisms of Inhibition of in Vitro Dimerization of HIV Type I RNA by Sense and Antisense Oligonucleotides
Skripkin, E. A., Paillart, J., Marquet, R., BLUMENFELD, M. L., Ehresmann, B., & Ehresmann, C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.28812 · Cited by 41
The substitution rate of HIV-1 subtypes: a genomic approach
Patiño-Galindo, J. Á., & Gónzález‐Candelas, F. (2017) · Virus Evolution · doi:10.1093/ve/vex029 · Cited by 39
The Fidelity of 3′ Misinsertion and Mispair Extension During DNA Synthesis Exhibited by two Drug‐Resistant Mutants of the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 with Leu74→Val and Glu89→Gly
Rubinek, T., Bakhanashvili, M., Taube, R., Avidan, O., & Hizi, A. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00238.x · Cited by 39
Stable rearrangements of the β3–β4 hairpin loop of HIV-1 reverse transcriptase in plasma viruses from patients receiving combination therapy
Tamalet, C., Izopet, J., Koch, N., Fantini, J., & Yahi, N. (1998) · AIDS · doi:10.1097/00002030-199814000-00003 · Cited by 39
Interaction of Human Immunodeficiency Virus Nucleocapsid Protein with a Structure Mimicking a Replication Intermediate
DeStefano, J. J. (1996) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48619-x · Cited by 46
Host-Specific Modulation of the Selective Constraints Driving Human Immunodeficiency Virus Type 1 env Gene Evolution
Bagnarelli, P., Mazzola, F., Menzo, S., Montroni, M., Butini, L., & Clementi, M. (1999) · Journal of Virology · doi:10.1128/jvi.73.5.3764-3777.1999 · Cited by 38
The HIV‐1Lai RNA dimerization
Theilleux, V., Girard, F. C., Huynh‐Dinh, T., Lancelot, G., & Paoletti, J. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01292.x · Cited by 38
Base pairing among three cis-acting sequences contributes to template switching during hepadnavirus reverse transcription
Liu, N., Tian, R., & Loeb, D. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0436218100 · Cited by 37
Genetic elements of plant viruses as tools for genetic engineering
Mushegian, A. R., & Shepherd, R. J. (1995) · Microbiological Reviews · doi:10.1128/mmbr.59.4.548-578.1995 · Cited by 37
Recombination in the 5′ Leader of Murine Leukemia Virus Is Accurate and Influenced by Sequence Identity with a Strong Bias toward the Kissing-Loop Dimerization Region
Mikkelsen, J. G., Lund, A. H., Duch, M., & Pedersen, F. S. (1998) · Journal of Virology · doi:10.1128/jvi.72.9.6967-6978.1998 · Cited by 37
High rate of mismatch extension during reverse transcription in a single round of retrovirus replication.
Pulsinelli, G. A., & Temin, H. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9490 · Cited by 36
Self-citation
HIV-1 genetic recombination: experimental approaches and observations.
An, W., & Telesnitsky, A. (2002) · PubMed · Cited by 36
Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia
Baryshev, P., Bogachev, V. V., & Gashnikova, N. M. (2012) · Archives of Virology · doi:10.1007/s00705-012-1442-4 · Cited by 34
The Human T-Cell Lymphoma/Leukemia Viruses
Poiesz, B. J., Poiesz, M. J., & Choi, D. (2003) · Cancer Investigation · doi:10.1081/cnv-120016422 · Cited by 34
The Molecular Biology of Human and Primate Spuma Retroviruses
Löchelt, M., & Flügel, R. M. (1995) · Springer eBooks · doi:10.1007/978-1-4899-1721-8_4 · Cited by 33
Review
Spada, S., Krebber, C., & Plückthun, A. (1997) · Biological Chemistry · doi:10.1515/bchm.1997.378.6.445 · Cited by 33
Hepatitis B virus genomic heterogeneity: variation between quasispecies may confound molecular epidemiological analyses of transmission incidents
Ngui, S. L., & Teo, C. G. (1997) · Journal of Viral Hepatitis · doi:10.1046/j.1365-2893.1997.00066.x · Cited by 32
Misincorporation by HIV-1 Reverse Transcriptase Promotes Recombination via Strand Transfer Synthesis
Palaniappan, C., Wisniewski, M., Wu, W., Fay, P. J., & Bambara, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22331 · Cited by 33
Higher Selection Pressure from Antiretroviral Drugs in Vivo Results in Increased Evolutionary Distance in HIV-1 pol
Günthard, H. F., Brown, A., D’Aquila, R. T., Johnson, V. A., Kuritzkes, D. R., Richman, D. D., & Wong, J. K. (1999) · Virology · doi:10.1006/viro.1999.9774 · Cited by 32
Plus strand strong‐stop DNA transfer in yeast Ty retrotransposons
Lauermann, V., & Boeke, J. D. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6603 · Cited by 32
Virtues of being faithful: can we limit the genetic variation in human immunodeficiency virus?
Drosopoulos, W. C., Rezende, L. F., Wainberg, M. A., & Prasad, V. R. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050257 · Cited by 34
Strand transfer is enhanced by mismatched nucleotides at the 3' primer terminus: a possible link between HIV reverse transcriptase fidelity and recombination
Diaz, L. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.15.3086 · Cited by 31
RNase H Activity Is Required for High-Frequency Repeat Deletion during Moloney Murine Leukemia Virus Replication
Brincat, J. L., Pfeiffer, J. K., & Telesnitsky, A. (2002) · Journal of Virology · doi:10.1128/jvi.76.1.88-95.2002 · Cited by 29
Recombination in Primeval Genomes: A Step Forward but Still a Long Leap from Maintaining a Sizable Genome
Mauro Santos, A., Zintzaras, E., & Szathm�ry, E. (2004) · Journal of Molecular Evolution · doi:10.1007/s00239-004-2642-7 · Cited by 28
Mechanistic Analysis of Pause Site-dependent and -independent Recombinogenic Strand Transfer from Structurally Diverse Regions of the HIV Genome
Derebail, S. S., & DeStefano, J. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408927200 · Cited by 29
Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine–thymine tracts
Zhang, W., Svarovskaia, E. S., Barr, R., & Pathak, V. K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152186199 · Cited by 28
Homologous interference resulting from the presence of defective particles of human immunodeficiency virus type 1
Bernier, R., & Tremblay, M. J. (1995) · Journal of Virology · doi:10.1128/jvi.69.1.291-300.1995 · Cited by 28
The primer tRNA sequence is not inherited during Ty1 retrotransposition.
Lauermann, V., & Boeke, J. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9847 · Cited by 28
Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection
Rainwater‐Lovett, K., Ziemniak, C., Watson, D. C., Luzuriaga, K., Siberry, G. K., Petru, A. M., Chen, Y., Uprety, P., McManus, M. M., Ho, Y., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170548 · Cited by 29
Efficient extension of a misaligned tRNA-primer during replication of the HIV-1 retrovirus
Das, A. T., & Berkhout, B. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.8.1319 · Cited by 27
Role of Murine Leukemia Virus Reverse Transcriptase Deoxyribonucleoside Triphosphate-Binding Site in Retroviral Replication and In Vivo Fidelity
Halvas, E. K., Svarovskaia, E. S., & Pathak, V. K. (2000) · Journal of Virology · doi:10.1128/jvi.74.22.10349-10358.2000 · Cited by 26
Differential Inhibition of polymerase and Strand-Transfer Activities of HIV-1 Reverse Transcriptase
Tillekeratne, L. M. V., Sherette, A., Fulmer, J. A., Hupe, L., HUPE, D. J., Gabbara, S., Peliska, J. A., & Hudson, R. A. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00827-7 · Cited by 26
Genetics of Retrovirusesa
Temin, H. M. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb24815.x · Cited by 26
Self-citation
Capturing of host DNA by a plant retroelement: Bs1 encodes plasma membrane H+-ATPase domains
Palmgren, M. B. (1994) · Plant Molecular Biology · doi:10.1007/bf00023232 · Cited by 26
Development of an In Vivo Assay To Identify Structural Determinants in Murine Leukemia Virus Reverse Transcriptase Important for Fidelity
Halvas, E. K., Svarovskaia, E. S., & Pathak, V. K. (2000) · Journal of Virology · doi:10.1128/jvi.74.1.312-319.2000 · Cited by 26
The p66 immature precursor of HIV-1 reverse transcriptase
Sharaf, N. G., Poliner, E., Slack, R. L., Christen, M. T., Byeon, I. L., Parniak, M. A., Gronenborn, A. M., & Ishima, R. (2014) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.24594 · Cited by 25
Mutational Scan of the Human Immunodeficiency Virus Type 2 Integrase Protein
van den Ent, F. M. I., Vos, A., & Plasterk, R. H. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.5.3916-3924.1998 · Cited by 25
Cis-acting elements required for strong stop acceptor template selection during moloney murine leukemia virus reverse transcription
Topping, R. S., Demoitié, M., Shin, N.-H., & Telesnitsky, A. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.1929 · Cited by 25
The Kissing-Loop Motif Is a Preferred Site of 5′ Leader Recombination during Replication of SL3-3 Murine Leukemia Viruses in Mice
Lund, A. H., Mikkelsen, J. G., Schmidt, J., Duch, M., & Pedersen, F. S. (1999) · Journal of Virology · doi:10.1128/jvi.73.11.9614-9618.1999 · Cited by 25
Structure-Based Moloney Murine Leukemia Virus Reverse Transcriptase Mutants with Altered Intracellular Direct-Repeat Deletion Frequencies
Pfeiffer, J. K., Georgiadis, M. M., & Telesnitsky, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.20.9629-9636.2000 · Cited by 24
Enzymatic Properties of Two Mutants of Reverse Transcriptase of Human Immunodeficiency Virus Type 1 (Tyrosine 181 → Isoleucine and Tyrosine 188→ Leucine), Resistant to Nonnucleoside Inhibitors
Loya, S., Bakhanashvili, M., Tal, R., Hughes, S. H., Boyer, P. L., & HIZ, A. (1994) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1994.10.939 · Cited by 24
Kinetic analysiss of the catalysis of strand transfer from internal regions of heteropolymeric RNA templates by human immunodeficiency virus reverse transcriptase
DeStefano, J. J. (1994) · Journal of Molecular Biology · doi:10.1016/0022-2836(94)90030-2 · Cited by 24
A high rate of polymerization during synthesis of mouse mammary tumor virus DNA alleviates hypermutation by APOBEC3 proteins
Hagen, B., Kraase, M., Indiková, I., & Indik, S. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007533 · Cited by 23
Formation of chimeric DNA primer extension products by template switching onto an annealed downstream oligonucleotide.
Patel, R. J., Lin, M., Laney, M., Kurn, N., Rose, S. D., & Ullman, E. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2969 · Cited by 23
Identification of a Simian Immunodeficiency Virus Reverse Transcriptase Variant with Enhanced Replicational Fidelity in the Late Stage of Viral Infection
Diamond, T. L., Kimata, J. T., & Kim, B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102496200 · Cited by 22
Precore and X region mutants in hepatitis B virus infections among renal dialysis patients
Feitelson, M. A., Duan, L., Guo, J., Horiike, N., McIntyre, G., Blumberg, B. S., Thomas, H. C., & Carman, W. F. (1995) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.1995.tb00068.x · Cited by 22
A new peculiar DNA structure: NMR solution structure of a DNA kissing complex
Barbault, F., Huynh-Dinh, T., Paoletti, J., & Lancelot, G. (2002) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2002.10506771 · Cited by 21
Chimeric retrogenes suggest a role for the nucleolus in LINE amplification
Buzdin, A. A., Gogvadze, E. V., & Lebrun, M. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.05.034 · Cited by 19
High Fidelity of Internal Strand Transfer Catalyzed by Human Immunodeficiency Virus Reverse Transcriptase
DeStefano, J. J., Ghosh, J., Prasad, B., & Raja, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1483 · Cited by 21
The Drosophila micropia Retrotransposon Encodes a Testis-Specific Antisense RNA Complementary to Reverse Transcriptase
Lankenau, S., Corces, V. G., & Lankenau, D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1764-1775.1994 · Cited by 20
Co-evolving infectivity and expression patterns drive the diversification of endogenous retroviruses
Senti, K.-A., Rafanel, B., Handler, D., Kosiol, C., Schlötterer, C., & Brennecke, J. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00471-8 · Cited by 31
Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success
Mcintyre, G. J., Yu, Y. H., Tran, A., Jaramillo, A. B., Arndt, A. J., Millington, M., Boyd, M. P., Elliott, F. A., Shen, S., Murray, J. M., et al. (2009) · Virology Journal · doi:10.1186/1743-422x-6-184 · Cited by 19
Hairpin-induced tRNA-mediated (HITME) recombination in HIV-1
Konstantinova, P. S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl226 · Cited by 19
Recombination analysis and structure prediction show correlation between breakpoint clusters and RNA hairpins in the pol gene of human immunodeficiency virus type 1 unique recombinant forms
Galli, A., Lai, A., Corvasce, S., Saladini, F., Riva, C., Dehò, L., Caramma, I., Franzetti, M., Romanó, L., Galli, M., et al. (2008) · Journal of General Virology · doi:10.1099/vir.0.2008/003418-0 · Cited by 19
Yeast Retrotransposon Ty4: The Majority of the Rare Transcripts Lack a U3-R Sequence
Hug, A. M., & Feldmann, H. M. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.12.2338 · Cited by 19
Retroviral vector design studies toward hematopoietic stem cell gene therapy for mucopolysaccharidosis type I
Pan, D., Aronovich, E. L., McIvor, R. S., & Whitley, C. B. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301298 · Cited by 18
Reverse transcription of the yeast ty1 retrotransposon: the mode of first strand transfer is either intermolecular or intramolecular 1 1Edited by M. Yaniv
Wilhelm, M. L., Boutabout, M., Heyman, T., & Wilhelm, F. X. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.2723 · Cited by 18
Differences in Mutagenesis During Minus Strand, Plus Strand and Strand Transfer (Recombination) Synthesis of the Hiv-1 Nef Gene in Vitro
Wu, W., Palaniappan, C., Bambara, R. A., & Fay, P. J. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.9.1710 · Cited by 17
Effect of the Murine Leukemia Virus Extended Packaging Signal on the Rates and Locations of Retroviral Recombination
Anderson, J. A., Pathak, V. K., & Hu, W.-S. (2000) · Journal of Virology · doi:10.1128/jvi.74.15.6953-6963.2000 · Cited by 17
Mutations in the RNase H Primer Grip Domain of Murine Leukemia Virus Reverse Transcriptase Decrease Efficiency and Accuracy of Plus-Strand DNA Transfer
Mbisa, J. L., Nikolenko, G. N., & Pathak, V. K. (2004) · Journal of Virology · doi:10.1128/jvi.79.1.419-427.2005 · Cited by 16
Unusual genomic features of a badnavirus infecting mulberry
Chiumenti, M., Morelli, M., Stradis, A. D., Elbeaino, T., Stavolone, L., & Minafra, A. (2016) · Journal of General Virology · doi:10.1099/jgv.0.000600 · Cited by 15
A New Mechanism of Retrogene Formation in Mammalian Genomes: In Vivo Recombination during RNA Reverse Transcription
Gogvadze, E. V., & Buzdin, A. A. (2005) · Molecular Biology · doi:10.1007/s11008-005-0045-5 · Cited by 14
Retrovirus Reverse Transcriptases Containing a Modified YXDD Motif
Sharma, P. L., Nurpeisov, V., & Schinazi, R. F. (2005) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020501600303 · Cited by 13
Mutations in the SIV env and the M13 lacZa gene generatedin vitro by reverse transcriptases and DNA polymerases
Stuke, A. W., Ahmad-Omar, O., Hoefer, K., Hunsmann, G., & Jentsch, K. D. (1997) · Archives of Virology · doi:10.1007/s007050050148 · Cited by 14
In Vitro Strand Transfer from Broken RNAs Results in Mismatch but Not Frameshift Mutations
DeStefano, J. J., Raja, A., & Cristofaro, J. V. (2000) · Virology · doi:10.1006/viro.2000.0533 · Cited by 14
Extended Minus-Strand DNA as Template for R-U5-Mediated Second-Strand Transfer in Recombinational Rescue of Primer Binding Site-Modified Retroviral Vectors
Mikkelsen, J. G., Lund, A. H., Dybkær, K., Duch, M., & Pedersen, F. S. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.2519-2525.1998 · Cited by 14
APOBEC3 Host Restriction Factors of HIV-1 Can Change the Template Switching Frequency of Reverse Transcriptase
Adolph, M. B., Ara, A., & Chelico, L. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.02.015 · Cited by 12
Comparisons of Defective HTLV-I Proviruses Predict the Mode of Origin and Coding Potential of Internally Deleted Genomes
Hill, S. A., Shuh, M., & Derse, D. (1999) · Virology · doi:10.1006/viro.1999.9922 · Cited by 13
The Effect of Increased Processivity on Overall Fidelity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
Rezende, L. F., Kew, Y., & Prasad, V. R. (2001) · Journal of Biomedical Science · doi:10.1007/bf02256413 · Cited by 13
Use of Sequence Data Generated in the Bayer TruGene Genotyping Assay To Recognize and Characterize Non-Subtype-B Human Immunodeficiency Virus Type 1 Strains
Hirigoyen, D., & Cartwright, C. P. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.10.5263-5271.2005 · Cited by 13
Therapeutic potential of retroviral vectors
Hawley, R. G. (1996) · Transfusion Science · doi:10.1016/0955-3886(95)00053-4 · Cited by 13
Determinants of Active-Site Inhibitor Interaction with HIV-1 RNase H
Xi, Z., Wang, Z., Sarafianos, S. G., Myshakina, N. S., & Ishima, R. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00300 · Cited by 12
Transduction of Cellular Sequence by a Human Immunodeficiency Virus Type 1-Derived Vector
Sun, G., O’Neil, P. K., Yu, H., Ron, Y., Preston, B. D., & Dougherty, J. P. (2001) · Journal of Virology · doi:10.1128/jvi.75.23.11902-11906.2001 · Cited by 12
Copackaging of different-sized retroviral genomic RNAs: little effect on retroviral replication or recombination
Jones, J. S., Allan, R. W., Seufzer, B. J., & Temin, H. M. (1994) · Journal of Virology · doi:10.1128/jvi.68.6.4097-4103.1994 · Cited by 12
Self-citation
In search of a function for the most frequent naturally-occurring length polymorphism (MFNLP) of the HIV-1 LTR: Retaining functional coupling, of Nef and RBF-2, at RBEIII?
Estable, M. C. (2007) · International Journal of Biological Sciences · doi:10.7150/ijbs.3.318 · Cited by 11
DNA Integration by Ty Integrase in yku70Mutant Saccharomyces cerevisiae Cells
Kiechle, M., Friedl, A. A., Manivasakam, P., Eckardt‐Schupp, F., & Schiestl, R. H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8836-8844.2000 · Cited by 11
Unique insertion sequence and pattern of CD4 expression in variants selected with immunotoxins from human immunodeficiency virus type 1-infected T cells
Fang, H., & Pincus, S. H. (1995) · Journal of Virology · doi:10.1128/jvi.69.1.75-81.1995 · Cited by 11
Insertions in the β3–β4 loop of reverse transcriptase of human immunodeficiency virus type 1 and their mechanism of action, influence on drug susceptibility and viral replication capacity
Eggink, D., Huigen, M. C. D. G., Boucher, C. A., Götte, M., & Nijhuis, M. (2007) · Antiviral Research · doi:10.1016/j.antiviral.2007.03.001 · Cited by 10

Authors: Temin, H. M.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Temin, H M
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1993-08
Volume: 90
Issue: 15
Pages: 6900-6903
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.90.15.6900
PMC: PMC47042
OpenAlex: W2087946368
Cited by: 309
References: 37
Citations by year: 2026: 2 · 2025: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 4 · 2013: 7 · 2012: 7
FWCI: 6.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p30ca007175-36)
U.S. Public Health Service (CA-07175)
National Cancer Institute (CA-22443, CA-07175, P01CA022443)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: strand transfer, human immunodeficiency virus, growing points, retroviral replication
MeSH terms: Mutation, Recombination, Genetic, Retroviridae, RNA-Directed DNA Polymerase, RNA, Viral, Templates, Genetic, Genetic Variation, Virus Replication, Sequence Deletion

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks