Sleep and inflammatory markers in different psychiatric disorders
Open accessAbstract
Many psychiatric disorders, like schizophrenia, affective disorders, addictions and different forms of dementia are associated with sleep disturbances. In the etiology and course of those diseases inflammatory processes are regarded to be an increasingly important factor. They are also a frequently discussed element of the pathology of sleep. In this literature review reports on correlations between poor sleep and inflammatory responses in various psychiatric conditions are discussed. The link between schizophrenia, affective disorders and inflammatory cytokines is a complex phenomenon, which has been already confirmed in a number of studies. However, the presence of sleep deficits in those conditions, being a common symptom of depression and psychoses, can be an additional factor having a considerable impact on the immunological processes in mental illnesses. In the analyzed data, a number of studies are presented describing the role of inflammatory markers in sleep disturbances and psychopathological symptoms of affective, psychotic, neurogenerative and other disorders. Also attention is drawn to possible implications for their treatment. Efforts to use, e.g., anti-inflammatory agents in psychiatry in the context of their impact on sleep are reported. The aspect of inflammatory markers in the role of sleep deprivation as the treatment method in major depressive disorder is also discussed. A general conclusion is drawn that the improvement of sleep quality plays a crucial role in the care for psychiatric patients.
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Poor sleep has pro-inflammatory effects in humans.
“both of these factors have also been shown to have pro-inflammatory effects in humans 110,111 .”
From A meta-review of "lifestyle psychiatry": the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders (2020) · cites this paper as [110]
Smoking has pro-inflammatory effects in humans.
“both of these factors have also been shown to have pro-inflammatory effects in humans 110,111 .”
From A meta-review of "lifestyle psychiatry": the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders (2020) · cites this paper as [110]
The Results and Discussion passages address sleep disturbance and inflammatory markers, not smoking. Searches for smoking, cigarettes, tobacco, and nicotine found no passage in our copy addressing whether smoking has pro-inflammatory effects in humans. (LLM, conf=0.72)
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Qualidade do sono, variáveis pessoais e laborais e hábitos de vida de enfermeiros hospitalares
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Sleep Disturbances and Depression Levels among General Indonesian Population: A National Survey
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An Overview of the Relationship Between Meal Timing and Sleep
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The Effects of Circadian Rhythm Disruption towards Metabolic Stress and Mental Health: A Review
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Associations between neurological soft signs, chronotype and sleep quality in schizophrenia
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Nutritional Therapies, Exercise, and Diet for Mental Disorders
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Pills or Sleep Deprivation? Sleep-Deprivation as a Therapeutic Option Intervention in Psychiatry
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Neurobehavioral and physiological changes in pregnant rats following REM sleep deprivation model
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- Authors
- Krysta, K., Krzystanek, M., Bratek, A., & Krupka-Matuszczyk, I.
- Affiliations
- Medical University of Silesia (PL)
- Corresponding author
- Krysta, Krzysztof
- Venue
- Journal of Neural Transmission
- Published
- 2015-12-09
- Volume
- 124
- Issue
- S1
- Pages
- 179-186
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- PMC
- PMC5281642
- OpenAlex
- W2290282548
- Cited by
- 53
- References
- 76
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 8 · 2019: 4 · 2018: 6 · 2015: 1
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Neural Transmission (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep disorders, inflammatory markers, cytokines, schizophrenia, mood disorders, depression, psychosis, dementia, sleep deprivation, anti-inflammatory agents, sleep quality, psychiatric treatment
- MeSH terms
- Animals, Mental Disorders, Humans, Sleep
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