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Cited by 227

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells.

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Yeh, W C, Bierer, B E, McKnight, S L·1995·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.92.24.11086
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Abstract

Differentiating 3T3-L1 cells express an immunophilin early during the adipocyte conversion program as described in this issue [Yeh, W.-C., Li, T.-K., Bierer, B. E. & McKnight, S. L. (1995) Proc. Natl. Acad. Sci. USA 92, 11081-11085]. The temporal expression profile of this protein, designated FK506-binding protein (FKBP) 51, is concordant with the clonal-expansion period undertaken by 3T3-L1 cells after exposure to adipogenic hormones. Having observed FKBP51 synthesis early during adipogenesis, we tested the effects of three immunosuppressive drugs--cyclosporin A, FK506, and rapamycin--on the terminal-differentiation process. Adipocyte conversion was not affected by either cyclosporin A or FK506 and yet was significantly reduced by rapamycin at drug concentrations as low as 10 nM. Clonal expansion was impeded in drug-treated cultures, as was the accumulation of cytoplasmic lipid droplets normally seen late during differentiation. Rapamycin treatment likewise inhibited the expression of CCAAT/enhancer binding protein alpha, a transcription factor required for 3T3-L1 cell differentiation. All three of these effects were reversed by high FK506 concentrations, indicating that the operative inhibitory event was mediated by an immunophilin-rapamycin complex.

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Metadata

Authors
Yeh, W. C., Bierer, B. E., & McKnight, S. L.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1995-11-21
Volume
92
Issue
24
Pages
11086-11090
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.92.24.11086
OpenAlex
W1995757037
Cited by
227
References
7
FWCI
1.89
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. https://app.cochat.ai/papers/10.1073/pnas.92.24.11086
The paper
Yeh, W. C., Bierer, B. E., & McKnight, S. L. (1995). Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.24.11086

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.