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Cited by 121Sleep and Wakefulness ResearchHIV Research and TreatmentSleep and related disorders

Sleep electroencephalogram delta-frequency amplitude, night plasma levels of tumor necrosis factor alpha, and human immunodeficiency virus infection.

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Darko, D F, Miller, J C, Gallen, C, White, J, Koziol, J, Brown, S J, Hayduk, R, Atkinson, J H +2 more·1995·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.92.26.12080PMC PMC40300
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Abstract

We tested the hypothesis that increases in tumor necrosis factor alpha (TNF-alpha) induced by human immunodeficiency virus (HIV) are associated with the increases in slow-wave sleep seen in early HIV infection and the decrease with sleep fragmentation seen in advanced HIV infection. Nocturnal sleep disturbances and associated fatigue contribute to the disability of HIV infection. TNF-alpha causes fatigue in clinical use and promotes slow-wave sleep in animal models. With slow progress toward a vaccine and weak effects from current therapies, efforts are directed toward extending productive life of HIV-infected individuals and shortening the duration of disability in terminal illness. We describe previously unrecognized nocturnal cyclic variations in plasma levels of TNF-alpha in all subjects. In 6 of 10 subjects (1 control subject, 3 HIV-seropositive patients with CD4+ cell number > 400 cells per microliters, and 2 HIV-positive patients with CD4+ cell number < 400 cells per microliters), these fluctuations in TNF-alpha were coupled to the known rhythm of electroencephalogram delta amplitude (square root of power) during sleep. This coupling was not present in 3 HIV-positive subjects with CD4+ cell number < 400 cells per microliters and 1 control subject. In 5 HIV subjects with abnormally low CD4+ cell counts ( < 400 cells per microliters), the number of days since seroconversion correlated significantly with low correlation between TNF-alpha and delta amplitude. We conclude that a previously unrecognized normal, physiological coupling exists between TNF-alpha and delta amplitude during sleep and that the lessened likelihood of this coupling in progressive HIV infection may be important in understanding fatigue-related symptoms and disabilities.

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Authors
Darko, D. F., Miller, J. C., Gallen, C., White, J., Koziol, J., Brown, S. J., Hayduk, R., Atkinson, J. H., Assmus, J., & Munnell, D. T.
Affiliations
Scripps Research Institute (US)
ORCID
Miller, J C
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1995-12-19
Volume
92
Issue
26
Pages
12080-12084
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.92.26.12080
PMC
PMC40300
OpenAlex
W2118624908
Cited by
121
References
8
Citations by year
2025: 3 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2014: 2 · 2013: 7 · 2012: 10
FWCI
1.91
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r29mh042762-01a1, Z99 NS999999, RR00827, RR00833, MH47680, MH45294)
  • U.S. Navy
  • National Institute on Alcohol Abuse and Alcoholism
  • National Institute of Mental Health (P50MH047680, MH-42762)
  • National Institute of Neurological Disorders and Stroke
  • National Center for Research Resources (M01RR000833, M01RR000827)
  • U.S. Army Medical Research and Development Command
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
HIV infection, TNF-α, sleep EEG, slow-wave sleep, CD4 count, seroconversion, fatigue, sleep fragmentation
MeSH terms
Adult, Animals, Delta Rhythm, HIV Seropositivity, Humans, Male, Reference Values, Sleep, Time Factors, Tumor Necrosis Factor-alpha, HIV Seronegativity

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