The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.
Open accessAbstract
NF-kappa B/Rel transcription factors are central regulators of mammalian immunity and are also implicated in the induction of cecropins and other antibacterial peptides in insects. We identified the gene for Relish, a compound Drosophila protein that, like mammalian p105 and p100, contains both a Rel homology domain and an I kappa B-like domain. Relish is strongly induced in infected flies, and it can activate transcription from the Cecropin A1 promoter. A Relish transcript is also detected in early embryos, suggesting that it acts in both immunity and embryogenesis. The presence of a compound Rel protein in Drosophila indicates that similar proteins were likely present in primordial immune systems and may serve unique signaling functions.
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Cites
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
Cited by
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
The immune response of Drosophila
Hoffmann, J. A. (2003) · Nature · doi:10.1038/nature02021 · Cited by 1,553
McKay, L. I., & Cidlowski, J. A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0375 · Cited by 805
An ancient system of host defense
Medzhitov, R., & Janeway, C. A. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80024-1 · Cited by 327
Population Genetics of the Nomenspecies Enterobacter cloacae
Hoffmann, H., & Roggenkamp, A. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.9.5306-5318.2003 · Cited by 306
Functional Dissection of an Innate Immune Response by a Genome-Wide RNAi Screen
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The Two NF-κB Pathways Regulating Bacterial and WSSV Infection of Shrimp
Li, C., Wang, S., & He, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01785 · Cited by 230
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Metadata
- Authors
- Dushay, M. S., Asling, B., & Hultmark, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-09-17
- Volume
- 93
- Issue
- 19
- Pages
- 10343-10347
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1968219928
- Cited by
- 373
- References
- 1
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- green
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