The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Defective insulin secretion and enhanced insulin action in K ATP channel-deficient mice
Open accessAbstract
ATP-sensitive K + (K ATP ) channels regulate many cellular functions by linking cell metabolism to membrane potential. We have generated K ATP channel-deficient mice by genetic disruption of Kir6.2, which forms the K + ion-selective pore of the channel. The homozygous mice (Kir6.2 −/− ) lack K ATP channel activity. Although the resting membrane potential and basal intracellular calcium concentrations ([Ca 2+ ] i ) of pancreatic beta cells in Kir6.2 −/− are significantly higher than those in control mice (Kir6.2 +/+ ), neither glucose at high concentrations nor the sulfonylurea tolbutamide elicits a rise in [Ca 2+ ] i , and no significant insulin secretion in response to either glucose or tolbutamide is found in Kir6.2 −/− , as assessed by perifusion and batch incubation of pancreatic islets. Despite the defect in glucose-induced insulin secretion, Kir6.2 −/− show only mild impairment in glucose tolerance. The glucose-lowering effect of insulin, as assessed by an insulin tolerance test, is increased significantly in Kir6.2 −/− , which could protect Kir6.2 −/− from developing hyperglycemia. Our data indicate that the K ATP channel in pancreatic beta cells is a key regulator of both glucose- and sulfonylurea-induced insulin secretion and suggest also that the K ATP channel in skeletal muscle might be involved in insulin action.
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Cites
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Hyperpolarizing Vasodilators Activate ATP-sensitive K + Channels in Arterial Smooth Muscle
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Cited by
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Triggering and amplifying pathways of regulation of insulin secretion by glucose.
Henquin, J. C. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1751 · Cited by 1,201
Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00378-6 · Cited by 917
KATP channels as molecular sensors of cellular metabolism
Nichols, C. G. (2006) · Nature · doi:10.1038/nature04711 · Cited by 851
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
Lamkanfi, M., Mueller, J. L., Vitari, A. C., Misaghi, S., Fedorova, A., Deshayes, K., Lee, W. P., Hoffman, H. M., & Dixit, V. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903124 · Cited by 820
Metadata
- Authors
- Miki, T., Nagashima, K., Tashiro, F., Kotake, K., Yoshitomi, H., Tamamoto, A., Gonoi, T., Iwanaga, T., Miyazaki, J.-I., & Seino, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-09
- Volume
- 95
- Issue
- 18
- Pages
- 10402-10406
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2019024229
- Cited by
- 502
- References
- 28
- FWCI
- 21.83
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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