Cited by 561Physiological and biochemical adaptationsCancer, Hypoxia, and MetabolismPlant responses to water stress

Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis

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Gracey, Andrew Y., Troll, Joshua V., Somero, George N.·2001·Proceedings of the National Academy of Sciences

Abstract

Hypoxia is important in both biomedical and environmental contexts and necessitates rapid adaptive changes in metabolic organization. Mammals, as air breathers, have a limited capacity to withstand sustained exposure to hypoxia. By contrast, some aquatic animals, such as certain fishes, are routinely exposed and resistant to severe environmental hypoxia. Understanding the changes in gene expression in fishes exposed to hypoxic stress could reveal novel mechanisms of tolerance that may shed new light on hypoxia and ischemia in higher vertebrates. Using cDNA microarrays, we have studied gene expression in a hypoxia-tolerant burrow-dwelling goby fish, Gillichthys mirabilis. We show that a coherent picture of a complex transcriptional response can be generated for a nonmodel organism for which sequence data were unavailable. We demonstrate that: ( i ) although certain shifts in gene expression mirror changes in mammals, novel genes are differentially expressed in fish; and ( ii ) tissue-specific patterns of expression reflect the different metabolic roles of tissues during hypoxia.

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Crossref · 10.1073/pnas.98.4.1993

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  • Genes with the Hig_1_n domain are highly expressed under hypoxic stress.

    “For example, genes with the Hig_1_n (PF04588.6 in Pfam) domain were highly expressed under hypoxic stress 22,23”

    From The yak genome and adaptation to life at high altitude (2012) · cites this paper as [22]

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Authors
Gracey, A. Y., Troll, J. V., & Somero, G. N.
Affiliations
Hopkins Marine Station (US)
Venue
Proceedings of the National Academy of Sciences
Published
2001-02-13
Volume
98
Issue
4
Pages
1993-1998
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2008308093
Cited by
561
References
32
Citations by year
2026: 7 · 2025: 7 · 2024: 15 · 2023: 9 · 2022: 10 · 2021: 21 · 2020: 13 · 2019: 18 · 2018: 20 · 2017: 31 · 2016: 21 · 2015: 19 · 2014: 19 · 2013: 23 · 2012: 21
FWCI
27.02
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant responses to water stress
Keywords
hypoxia, hypoxia tolerance, Gillichthys mirabilis, gene expression profiling, transcriptional response, tissue-specific gene expression, hypoxia-ischemia
MeSH terms
Amino Acids, Animals, Hypoxia, Base Sequence, Brain, Cell Division, Glycolysis, Liver, Molecular Sequence Data, Myocardium, Oxygen, Perciformes, DNA, Complementary, Muscle, Skeletal, Gene Expression Profiling

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