Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis
Open accessAbstract
Hypoxia is important in both biomedical and environmental contexts and necessitates rapid adaptive changes in metabolic organization. Mammals, as air breathers, have a limited capacity to withstand sustained exposure to hypoxia. By contrast, some aquatic animals, such as certain fishes, are routinely exposed and resistant to severe environmental hypoxia. Understanding the changes in gene expression in fishes exposed to hypoxic stress could reveal novel mechanisms of tolerance that may shed new light on hypoxia and ischemia in higher vertebrates. Using cDNA microarrays, we have studied gene expression in a hypoxia-tolerant burrow-dwelling goby fish, Gillichthys mirabilis. We show that a coherent picture of a complex transcriptional response can be generated for a nonmodel organism for which sequence data were unavailable. We demonstrate that: ( i ) although certain shifts in gene expression mirror changes in mammals, novel genes are differentially expressed in fish; and ( ii ) tissue-specific patterns of expression reflect the different metabolic roles of tissues during hypoxia.
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Genes with the Hig_1_n domain are highly expressed under hypoxic stress.
“For example, genes with the Hig_1_n (PF04588.6 in Pfam) domain were highly expressed under hypoxic stress 22,23”
From The yak genome and adaptation to life at high altitude (2012) · cites this paper as [22]
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- Authors
- Gracey, A. Y., Troll, J. V., & Somero, G. N.
- Affiliations
- Hopkins Marine Station (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-02-13
- Volume
- 98
- Issue
- 4
- Pages
- 1993-1998
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC29370
- OpenAlex
- W2008308093
- Cited by
- 561
- References
- 32
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 15 · 2023: 9 · 2022: 10 · 2021: 21 · 2020: 13 · 2019: 18 · 2018: 20 · 2017: 31 · 2016: 21 · 2015: 19 · 2014: 19 · 2013: 23 · 2012: 21
- FWCI
- 27.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant responses to water stress
- Keywords
- hypoxia, hypoxia tolerance, Gillichthys mirabilis, gene expression profiling, transcriptional response, tissue-specific gene expression, hypoxia-ischemia
- MeSH terms
- Amino Acids, Animals, Hypoxia, Base Sequence, Brain, Cell Division, Glycolysis, Liver, Molecular Sequence Data, Myocardium, Oxygen, Perciformes, DNA, Complementary, Muscle, Skeletal, Gene Expression Profiling
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