Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 427

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Blue Light-induced Reactivity of Retinal Age Pigment

Open access
Rózanowska, Malgorzata, Jarvis-Evans, John, Korytowski, Witold, Boulton, Mike E., Burke, Janice M., Sarna, Tadeusz·1995·Journal of Biological Chemistry
DOI 10.1074/jbc.270.32.18825
Open this paper in CoChat — free account

Abstract

Exposure of the eye to intense light, particularly blue light, can cause irreversible, oxygen-dependent damage to the retina. However, no key chromophores that trigger such photooxidative processes have been identified yet. We have found that illumination of human retinal pigment epithelium (RPE) cells with light induces significant uptake of oxygen that is both wavelength- and age-dependent. Analysis of photoreactivity of RPE cells and their age pigment lipofuscin indicates that the observed photoreactivity in RPE cells is primarily due to the presence of lipofuscin, which, under aerobic conditions, generates several oxygen-reactive species including singlet oxygen, superoxide anion, and hydrogen peroxide. We have also found that lipofuscin-photosensitized aerobic reactions lead to enhanced lipid peroxidation as measured by accumulation of lipid hydroperoxides and malondialdehyde in illuminated pigment granules. Hydrogen peroxide is only a minor product of aerobic photoexcitation of lipofuscin. We postulate that lipofuscin is a potential photosensitizer that may increase the risk of retinal photodamage and contribute to the development of age-related maculopathy.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1074/jbc.270.32.18825

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 26

  1. Young, 1988, Surv. Ophthalmol., 32, 265, 10.1016/0039-6257(88)90174-9 · DOI · Paper page
  2. Yannuzzi, 1987, Trans. Am. Ophthalmol. Sci., 85, 120
  3. Jaffe, 1988, Ophthalmology, 95, 1130, 10.1016/S0161-6420(88)33065-4 · DOI
  4. Taylor, 1992, Arch. Ophthalmol., 110, 99, 10.1001/archopht.1992.01080130101035 · DOI · Paper page
  5. Vinding, 1992, Acta Ophthalmol., 70, 66, 10.1111/j.1755-3768.1992.tb02093.x · DOI · Paper page
  6. Green, 1985, Ophthalmology, 92, 615, 10.1016/S0161-6420(85)33993-3 · DOI · Paper page
  7. Sarna, 1992, J. Photochem. Photobiol. B Biol., 12, 215, 10.1016/1011-1344(92)85027-R · DOI · Paper page
  8. Weiter, 1986, Invest. Ophthalmol. Vis. Sci., 27, 145
  9. Boulton, 1993, J. Photochem. Photobiol. B Biol., 19, 201, 10.1016/1011-1344(93)87085-2 · DOI · Paper page
  10. Burke, 1988, Invest. Ophthalmol. Vis. Sci., 29, 1784
  11. Lowry, 1951, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 · DOI · Paper page
  12. Boulton, 1990, Vis. Res., 9, 1291, 10.1016/0042-6989(90)90003-4 · DOI · Paper page
  13. Enochs, 1993, Pigment Cell Res., 6, 91, 10.1111/j.1600-0749.1993.tb00587.x · DOI
  14. Halpern, 1990, J. Magn. Reson., 90, 40
  15. Sarna, 1980, Arch. Biochem. Biophys., 200, 140, 10.1016/0003-9861(80)90340-9 · DOI
  16. Korytowski, 1987, Photochem. Photobiol., 45, 185, 10.1111/j.1751-1097.1987.tb05362.x · DOI · Paper page
  17. Rosen, 1985, Adv. Free Radical Biol. Med., 1, 345, 10.1016/8755-9668(85)90012-2 · DOI
  18. Pryor, 1984, Methods Enzymol., 105, 293, 10.1016/S0076-6879(84)05037-0 · doi:10.1016/s0076-6879(84)05037-0
  19. Draper, 1993, Free Radical Biol. Med., 15, 353, 10.1016/0891-5849(93)90035-S · DOI · Paper page
  20. Girotti, 1990, Photochem. Photobiol., 51, 497, 10.1111/j.1751-1097.1990.tb01744.x · DOI · Paper page
  21. Korytowski, 1993, Anal. Biochem., 213, 111, 10.1006/abio.1993.1393 · doi:10.1006/abio.1993.1393
  22. Buettner, 1987, Free Radical Biol. Med., 3, 259, 10.1016/S0891-5849(87)80033-3 · DOI · Paper page
  23. Gutteridge, 1983, J. Appl. Biochem., 5, 293
  24. Feeney-Burns, 1984, Invest. Ophthalmol. Vis. Sci., 25, 195
  25. Bielski, 1991, Int. J. Radiat. Biol., 59, 291, 10.1080/09553009114550301 · DOI
  26. Bielski, 1983, J. Biol. Chem., 258, 4759, 10.1016/S0021-9258(18)32488-8 · DOI · Paper page

Cited by

See all 427

Metadata

Authors
Rózanowska, M., Jarvis-Evans, J., Korytowski, W., Boulton, M. E., Burke, J. M., & Sarna, T.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1995-08
Volume
270
Issue
32
Pages
18825-18830
ISSN
0021-9258 (ISSN-L)
DOI
10.1074/jbc.270.32.18825
OpenAlex
W1512942014
Cited by
427
References
1
FWCI
8.86
Type
journal article
Language
en
Open access
hybrid
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Blue Light-induced Reactivity of Retinal Age Pigment. https://app.cochat.ai/papers/10.1074/jbc.270.32.18825
The paper
Rózanowska, M., Jarvis-Evans, J., Korytowski, W., Boulton, M. E., Burke, J. M., & Sarna, T. (1995). Blue Light-induced Reactivity of Retinal Age Pigment. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.270.32.18825

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.