Risk factor analysis for atrophic and exudative age‐related macular degeneration: An epidemiological study of 1000 aged individuals
Abstract
The relationship between age-related macular degeneration and cardiovascular risk factors and certain life-style factors, collected in the Copenhagen City Heart Study (1981-83), was studied by multiple logistic regression analysis. The ophthalmological study sample comprised 1000 randomly selected persons aged 60 to 80 years. Separate analyses were made for the atrophic and the exudative forms of age-related macular degeneration. Among all the possible risk factors analysed, only three factors were significantly associated with macular degeneration. Age was associated with both atrophic and exudative macular degeneration (P less than 0.01). Among smokers who inhaled, the risk of atrophic maculopathy was 2.5 times higher than among non-smokers (P less than 0.01), whereas the use of hypnotics increased the risk of exudative maculopathy by 3.4 times (P less than 0.01).
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Cigarette smoking is a risk factor for age-related macular degeneration, confirmed by case-control, population-based, and prospective studies.
“Results from a number of case-control studies,28–33 population-based studies,34–36 and prospective studies of both physicians37 and nurses38 strongly confirm cigarette smoking as a risk factor for age-related macular degeneration.”
From Age-related macular degeneration (2008) · cites this paper as [31]
The neovascular form of age-related macular degeneration was highest in Chinese individuals, compared with white people.
“The neovascular form of age-related macular degeneration was highest in Chinese individuals, compared with white people.31”
From Age-related macular degeneration (2008) · cites this paper as [31]
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- Authors
- Vinding, T., Appleyard, M., Nyboe, J., & Jensen, G.
- Affiliations
- Rigshospitalet (DK)
- Corresponding author
- Vinding, T.
- Venue
- Acta Ophthalmologica
- Publisher
- Wiley
- Published
- 1992-02
- Volume
- 70
- Issue
- 1
- Pages
- 66-72
- ISSN
- 0001-639X (ISSN-L)
- 1755-375X
- 1755-3768
- OpenAlex
- W2002558743
- Cited by
- 117
- References
- 24
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Ophthalmologica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- age-related macular degeneration, atrophic macular degeneration, neovascular age-related macular degeneration, risk factors, cardiovascular risk factors, lifestyle factors, smoking, hypnotic use, older adults, Copenhagen City Heart Study
- MeSH terms
- Aged, Aged, 80 and over, Atrophy, Denmark, Exudates and Transudates, Female, Humans, Hypnotics and Sedatives, Macula Lutea, Macular Degeneration, Male, Middle Aged, Random Allocation, Regression Analysis, Risk Factors, Smoking, Odds Ratio
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