Cited by 294Alzheimer's disease research and treatmentsProtein Kinase Regulation and GTPase SignalingDementia and Cognitive Impairment Research

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The Regions of the Fe65 Protein Homologous to the Phosphotyrosine Interaction/Phosphotyrosine Binding Domain of Shc Bind the Intracellular Domain of the Alzheimer's Amyloid Precursor Protein

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Fiore, Francesca, Zambrano, Nicola, Minopoli, Giuseppina, Donini, Virgilio, Duilio, Angela, Russo, Tommaso·1995·Journal of Biological Chemistry

DOI 10.1074/jbc.270.52.30853

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Abstract

Fe65 is a protein mainly expressed in several districts of the mammalian nervous system. The search of protein sequence data banks revealed that Fe65 contains two phosphotyrosine interaction (PID) or phosphotyrosine binding (PTB) domains, previously identified in the Shc adaptor molecule. The two putative PID/PTB domains of Fe65 were used to construct glutathione S-transferase-Fe65 fusion proteins. Co-precipitation experiments demonstrated that the Fe65 PID/PTB domains interacted with several proteins of apparent molecular mass 135, 115, 105, and 51 kDa. The region of Fe65 containing the PID/PTB domains was used as a bait to screen a human brain cDNA library in yeast by the two-hybrid system. Three different cDNA clones were isolated, two of which contain overlapping segments of the cDNA encoding the COOH terminus of the Alzheimer's beta-amyloid-precursor protein (APP), that represents the short intracellular domain of this membrane protein. The third clone contains a cDNA fragment coding for the COOH terminus of the human counterpart of a mouse beta-amyloid-like precursor protein. The alignment of the three APP encoding cDNA fragments found in the screening suggests that the region of APP involved in the binding is centered on the NPTY sequence, which is analogous to that present in the intracellular domains of the growth factor receptors interacting with the PID/PTB domain of Shc.

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Authors: Fiore, F., Zambrano, N., Minopoli, G., Donini, V., Duilio, A., & Russo, T.
Affiliations: University of Naples Federico II (IT)
Corresponding author: Russo, Tommaso
ORCID: Fiore, Francesca
Zambrano, Nicola
Minopoli, Giuseppina
Duilio, Angela
Russo, Tommaso
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1995-12
Volume: 270
Issue: 52
Pages: 30853-30856
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.270.52.30853
OpenAlex: W2087496042
Cited by: 294
References: 37
Citations by year: 2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 10
FWCI: 9.48
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 9116 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
INFM-OAR (INFN Catania) (submittedVersion, cc-by)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Fe65, phosphotyrosine binding domain, Shc, amyloid precursor protein, APP intracellular domain, protein-protein interaction, yeast two-hybrid screen, GST fusion protein, Alzheimer's disease
MeSH terms: Alzheimer Disease, Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Nerve Tissue Proteins, Nuclear Proteins, Protein Binding, Amyloid beta-Protein Precursor, PC12 Cells, Sequence Homology, Amino Acid, DNA, Complementary, src Homology Domains, Phosphotyrosine, Mice, Rats

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The Regions of the Fe65 Protein Homologous to the Phosphotyrosine Interaction/Phosphotyrosine Binding Domain of Shc Bind the Intracellular Domain of the Alzheimer's Amyloid Precursor Protein

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