The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The physiology of the β‐amyloid precursor protein intracellular domain AICD
Abstract
J. Neurochem. (2012) 120 (Suppl. 1), 109–124. The amyloid‐β precursor protein (βAPP) undergoes several cleavages by enzymatic activities called secretases. Numerous studies aimed at studying the biogenesis and catabolic fate of Aβ peptides, the proteinaceous component of the senile plaques that accumulate in Alzheimer’s disease‐affected brains. Relatively recently, another secretase‐mediated β‐APP‐derived catabolite called APP IntraCellular Domain (AICD) entered the game. Whether AICD corresponded to a biologically inert by‐pass product of βAPP processing or whether it could harbor its own function remained questionable. In this study, we review the mechanisms by which AICD is generated and how its production is regulated. Furthermore, we discuss the degradation mechanism underlying its rapid catabolic fate. Finally, we review putative AICD‐related functions and more particularly, the numerous studies indicating that AICD could translocate to the nucleus and control at a transcriptional level, the expression of a series of proteins involved in various functions including the control of cell death and Aβ degradation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The latter can be translocated in the nucleus and engages in transcriptional activities, which are to some extent still controversial in the AD field (reviewed in Pardossi-Piquard and Checler, 2012) (Table 1).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Pardossi-Piquard and Checler, 2012
Citations
Cites
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012
Aβ Oligomers – a decade of discovery
Walsh, D. M., & Selkoe, D. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04426.x · Cited by 1,938
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., et al. (2001) · Nature · doi:10.1038/35102591 · Cited by 1,388 · cited 1×
“Accordingly, non-steroidal anti-inflammatory drugs (Weggen et al. 2001), the antidepressant agent lithium (Phiel et al. 2003), and the tyrosine kinase inhibitor imatinib (gleevec) (Netzer et al. 2003), all inhibit Ab production without affecting NICD production.”
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.
Burdick, D., Soreghan, B., Kwon, M., Kosmoski, J., Knauer, M., Henschen, A., Yates, J., Cotman, C., & Glabe, C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48529-8 · Cited by 1,014
Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils
Khoury, J. E., Hickman, S. E., Thomas, C. A., Cao, L., Silverstein, S. C., & Loike, J. D. (1996) · Nature · doi:10.1038/382716a0 · Cited by 727
Haass, C., Lemere, C. A., Capell, A., Citron, M., Seubert, P., Schenk, D., Lannfelt, L., & Selkoe, D. J. (1995) · Nature Medicine · doi:10.1038/nm1295-1291 · Cited by 592
Kuperstein, I., Broersen, K., Benilova, I., Rozenski, J., Jonckheere, W., Debulpaep, M., Vandersteen, A., Segers‐Nolten, I., Van Der Werf, K., Subramaniam, V., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.211 · Cited by 532
Fiore, F., Zambrano, N., Minopoli, G., Donini, V., Duilio, A., & Russo, T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.30853 · Cited by 294
Wolfe, M. S., Xia, W., Moore, C. L., Leatherwood, D. D., Ostaszewski, B., Rahmati, T., Donkor, I. O., & Selkoe, D. J. (1999) · Biochemistry · doi:10.1021/bi982562p · Cited by 289
Presenilin-Dependent -Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer's Disease
Alves da Costa, C., Sunyach, C., Pardossi-Piquard, R., Sevalle, J., Vincent, B., Boyer, N., Kawarai, T., Girardot, N., St. George-Hyslop, P., & Checler, F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0651-06.2006 · Cited by 168
Self-citation
Flagged first, then by citations
Research works printed but not linked: 191
- 10.1002/jnr.21690 · DOI
- 10.1128/MCB.26.10.3917-3934.2006 · DOI
- 10.1042/BJ20041387 · DOI
- 10.1074/jbc.M401925200 · DOI
- 10.1038/ncb1101-1030 · DOI
- 10.1126/science.7716513 · DOI
- 10.1016/S0092-8674(02)00809-7 · DOI
- 10.1083/jcb.200212085 · DOI
- 10.1128/MCB.01280-06 · DOI
- 10.3233/JAD-2011-110746 · DOI
- 10.1007/s00018-008-7462-2 · DOI
- 10.1038/embor.2008.222 · DOI
- 10.1074/jbc.M110.141390 · DOI
- 10.1523/JNEUROSCI.22-17-07340.2002 · DOI
- 10.1016/j.bbamcr.2010.12.005 · DOI
- 10.1074/jbc.C300016200 · DOI
- 10.1016/j.febslet.2009.09.009 · DOI
- 10.1074/jbc.M601660200 · DOI
- 10.1128/MCB.16.11.6229 · DOI · Paper page
- 10.1038/nrm2009 · DOI · Paper page
- 10.1093/hmg/5.10.1589 · DOI
- 10.1016/S0092-8674(00)80675-3 · DOI · Paper page
- 10.1016/j.neurobiolaging.2004.06.013 · DOI · Paper page
- 10.1074/jbc.M507401200 · DOI
- 10.1111/j.1460-9568.2010.07376.x · DOI
- 10.1126/science.1058783 · DOI · Paper page
- 10.1042/BJ20060847 · DOI
- 10.5483/BMBRep.2010.43.10.656 · DOI
- 10.1128/MCB.02393-05 · DOI · Paper page
- 10.1046/j.1471-4159.1995.65041431.x · DOI · Paper page
- 10.1046/j.1471-4159.2001.00244.x · DOI
- 10.2174/156720507781788945 · DOI
- 10.1159/000283483 · DOI
- 10.1016/j.neuron.2007.01.023 · DOI
- 10.1074/jbc.M205093200 · DOI
- 10.1038/nature04667 · DOI
- 10.1073/pnas.91.25.11993 · DOI · Paper page
- 10.1074/jbc.M500621200 · DOI
- 10.1042/bj3300513 · DOI
- 10.1046/j.1471-4159.2001.00513.x · DOI
- 10.1242/jcs.051169 · DOI
- 10.1007/s00401-009-0532-1 · DOI · Paper page
- 10.1074/jbc.M111571200 · DOI
- 10.1091/mbc.e07-01-0035 · DOI
- 10.1002/jcp.20305 · DOI
- 10.1074/jbc.M803108200 · DOI
- 10.1038/ncb0502-e110b · DOI
- 10.1073/pnas.0230450100 · DOI
- 10.1091/mbc.E08-09-0969 · DOI
- 10.1021/bi052412w · DOI
- 10.1021/bi049399k · DOI
- Gandy S., 2005, The role of cerebral amyloid β accumulation in common forms of Alzheimer’s disease, J. Clin. Invest., 115, 1121
- 10.1073/pnas.261463298 · DOI
- 10.1038/sj.emboj.7601031 · DOI
- 10.1073/pnas.0907652106 · DOI · Paper page
- 10.1016/S0006-291X(84)80190-4 · DOI · Paper page
- 10.1242/jcs.048090 · DOI
- 10.1242/jcs.01263 · DOI
- 10.1074/jbc.C100357200 · DOI
- 10.1073/pnas.93.20.10832 · DOI
- 10.1016/S0896-6273(01)00496-2 · DOI · Paper page
- Ha S., 2010, Association of AICD and Fe65 with Hirano bodies reduces transcriptional activation and initiation of apoptosis, Neurobiol. Aging
- 10.1371/journal.pone.0008840 · DOI · Paper page
- 10.3233/JAD-2011-101065 · DOI · Paper page
- 10.1074/jbc.M611324200 · DOI
- 10.1074/jbc.M414359200 · DOI
- 10.1111/j.1471-4159.2007.04627.x · DOI
- 10.1126/science.1566067 · DOI · Paper page
- 10.1074/jbc.M502861200 · DOI
- 10.1038/nature09325 · DOI
- 10.1371/journal.pbio.0060257 · DOI · Paper page
- 10.1016/j.molbrainres.2005.02.013 · DOI · Paper page
- Hong Y., 2011, The impact of amyloid precursor protein signalling and histone deacetylase inhibition on neprilysin expression in human prostate cells, Int. J. Cancer
- 10.1016/j.bbrc.2007.06.186 · DOI
- 10.1096/fj.09-140012 · DOI
- 10.1007/s11064-005-7952-7 · DOI
- 10.1074/jbc.C200711200 · DOI
- 10.1083/jcb.200809151 · DOI
- Iwatsubo T., 1996, Full‐length amyloid‐β(1‐42(43)) and amino‐terminally modified and truncated amyloid‐β42(43) deposit in diffuse plaques, Am. J. Pathol., 149, 1823
- 10.1093/hmg/ddm039 · DOI
- 10.1074/jbc.M513453200 · DOI
- 10.1523/JNEUROSCI.23-13-05425.2003 · DOI
- 10.1016/j.bbrc.2007.06.022 · DOI
- 10.1074/jbc.M210179200 · DOI
- 10.1096/fj.03-0106fje · DOI · Paper page
- 10.1074/jbc.M412938200 · DOI
- 10.1074/jbc.C100447200 · DOI
- 10.1074/jbc.M203372200 · DOI · Paper page
- 10.1074/jbc.M306403200 · DOI · Paper page
- 10.1016/j.neurobiolaging.2011.06.012 · DOI
- 10.1016/j.neurobiolaging.2008.03.001 · DOI
- 10.1242/jcs.115.6.1095 · DOI
- 10.1073/pnas.93.4.1683 · DOI
- 10.1074/jbc.M700356200 · DOI · Paper page
- Kume H., 2004, Intracellular domain generation of amyloid precursor protein by ε‐cleavage depends on C‐terminal fragment by a‐secretase cleavage, Int. J. Mol. Med., 13, 121
- 10.1111/j.1471-4159.2005.03528.x · DOI
- 10.1074/jbc.M302659200 · DOI
- 10.1242/jcs.00734 · DOI
- 10.1152/ajpcell.00037.2008 · DOI
- 10.1074/jbc.M611449200 · DOI
- 10.1016/j.neuron.2007.08.008 · DOI · Paper page
- 10.2174/156802608783334060 · DOI
- 10.1038/74656 · DOI
- 10.1016/j.cell.2003.08.008 · DOI
- 10.1128/MCB.25.20.9040-9053.2005 · DOI
- 10.1074/jbc.M702535200 · DOI
- 10.1073/pnas.82.12.4245 · DOI · Paper page
- 10.1074/jbc.M201979200 · DOI · Paper page
- 10.1016/j.bbrc.2007.05.062 · DOI
- 10.1016/S0014-5793(96)01128-3 · DOI
- 10.1074/jbc.M301360200 · DOI
- 10.1016/j.tins.2006.03.001 · DOI
- 10.1073/pnas.112686799 · DOI
- 10.1091/mbc.E06-04-0283 · DOI
- 10.1016/j.pneurobio.2008.05.002 · DOI
- 10.1093/hmg/ddh054 · DOI
- 10.1111/j.1365-2443.2006.00968.x · DOI
- 10.1016/j.neulet.2008.08.034 · DOI
- 10.1073/pnas.1534745100 · DOI
- 10.1126/science.1065412 · DOI
- 10.1016/j.neurobiolaging.2006.06.023 · DOI
- 10.1016/S0092-8674(00)81667-0 · DOI
- 10.1046/j.0014-2956.2001.02465.x · DOI
- 10.1186/1750-1326-1-3 · DOI
- 10.1016/j.gene.2010.11.014 · DOI
- 10.2174/156720508786898514 · DOI
- 10.1096/fj.04-2637fje · DOI · Paper page
- 10.1083/jcb.200108159 · DOI
- 10.1016/j.cell.2006.09.026 · DOI
- 10.1016/j.bbrc.2006.09.162 · DOI
- 10.1016/j.neuron.2005.04.008 · DOI
- 10.1111/j.1471-4159.2006.03822.x · DOI
- 10.1016/j.neuron.2007.01.024 · DOI
- 10.3233/JAD-2000-23-408 · DOI
- 10.1038/35074581 · DOI
- 10.1038/nature01640 · DOI
- 10.1007/978-1-60761-744-0_7 · DOI
- 10.1523/JNEUROSCI.1575-04.2005 · DOI · Paper page
- 10.1074/jbc.M110.145334 · DOI
- 10.1073/pnas.0603838103 · DOI · Paper page
- 10.3233/JAD-2007-11311 · DOI
- 10.1016/j.brainresrev.2006.04.005 · DOI
- 10.1073/pnas.102192599 · DOI
- 10.1242/jcs.01323 · DOI
- 10.1083/jcb.200505078 · DOI
- 10.1038/sj.onc.1207955 · DOI
- 10.1093/embo-reports/kve180 · DOI
- 10.1074/jbc.M211161200 · DOI
- 10.1074/jbc.M208110200 · DOI
- 10.1073/pnas.0437908100 · DOI
- 10.1634/stemcells.2008-0010 · DOI
- 10.1016/j.bbrc.2007.04.100 · DOI
- 10.1074/jbc.M308424200 · DOI
- 10.1161/CIRCRESAHA.107.169805 · DOI
- 10.1152/physrev.2001.81.2.741 · DOI · Paper page
- 10.1111/j.1471-4159.2009.06131.x · DOI
- 10.1073/pnas.1230693100 · DOI
- 10.1242/jcs.060830 · DOI
- 10.1124/pr.54.3.469 · DOI
- 10.1111/j.1471-4159.2009.06067.x · DOI
- 10.1038/nature01506 · DOI
- 10.1096/fj.03-1070fje · DOI
- 10.1074/jbc.C300239200 · DOI
- 10.1016/S0896-6273(01)00476-7 · DOI
- 10.1046/j.1471-4159.1999.0731584.x · DOI
- 10.1097/00005072-199902000-00010 · DOI
- 10.1186/1750-1326-1-2 · DOI
- 10.1074/jbc.M805894200 · DOI
- 10.1093/hmg/ddr033 · DOI
- 10.1523/JNEUROSCI.3657-09.2009 · DOI · Paper page
- 10.1002/jcp.21743 · DOI
- 10.1007/s11064-007-9449-z · DOI
- 10.1016/j.nbd.2006.09.019 · DOI
- 10.1016/j.neurobiolaging.2009.09.002 · DOI
- 10.1073/pnas.0509822102 · DOI
- 10.1021/bi015794o · DOI
- Weihofen A., 2003, Intramembrane‐cleaving proteases: controlled liberation of proteins and bioactive peptides, Trends Biochem. Sci., 13, 71
- 10.1074/jbc.M706024200 · DOI
- 10.1128/MCB.24.1.454-464.2004 · DOI
- 10.1038/nn898 · DOI
- 10.1002/jnr.10776 · DOI
- 10.1038/19077 · DOI
- 10.1074/jbc.M414648200 · DOI
- 10.1038/sj.cdd.4401928 · DOI
- 10.1038/embor.2010.210 · DOI
- 10.1016/j.bbrc.2008.09.090 · DOI
- 10.1074/jbc.C100410200 · DOI
- 10.1074/jbc.273.32.20128 · DOI
- 10.1186/1750-1326-2-15 · DOI
- 10.3233/JAD-2009-0970 · DOI
- 10.1074/jbc.M405608200 · DOI
Cited by
Sorted by citations
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., Cedazo-Minguez, A., Dubois, B., Edvardsson, D., Feldman, H., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00062-4 · Cited by 1,676
Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection
Marcocci, M. E., Napoletani, G., Protto, V., Kolesova, O., Piacentini, R., Li Puma, D. D., Lomonte, P., Grassi, C., Palamara, A. T., & De Chiara, G. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.03.003 · Cited by 303
Mitophagy in Alzheimer’s disease: Molecular defects and therapeutic approaches
Mary, A., Eysert, F., Checler, F., & Chami, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01631-6 · Cited by 244
Self-citationLauritzen, I., Pardossi-Piquard, R., Bauer, C., Brigham, E., Abraham, J.-D., Ranaldi, S., Fraser, P., St-George-Hyslop, P., Le Thuc, O., Espin, V., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2775-12.2012 · Cited by 201
“Although AICD can theoretically be produced in both amyloidogenic and nonamyloidogenic pathways (Konietzko, 2012; Pardossi-Piquard and Checler, 2012), we and others have shown that AICD is preferentially derived from C99 in the amyloidogenic pathway (Goodger et al., 2009; Belyaev et al., 2010;…”
BackgroundSelf-citationSuccessful therapies for Alzheimer’s disease: why so many in animal models and none in humans?
Franco, R., & Cedazo-Minguez, A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00146 · Cited by 183
Metadata
- Authors
- Pardossi‐Piquard, R., & Checler, F.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2011-11-28
- Volume
- 120
- Issue
- s1
- Pages
- 109-124
- ISSN
- 0022-3042
- 1471-4159
- Cited by
- 159
- References
- 14
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
