Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein

Trommsdorff, Marion; Borg, Jean-Paul; Margolis, Benjamin; Herz, Joachim

doi:10.1074/jbc.273.50.33556

Cited by 453

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Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein

Trommsdorff, Marion, Borg, Jean-Paul, Margolis, Benjamin, Herz, Joachim·1998·Journal of Biological Chemistry

DOI 10.1074/jbc.273.50.33556

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An interaction between the C-terminal domain of APP and LRP, mediated by the cytoplasmic adaptor protein Fe65, impacts APP internalization.
“In addition, an interaction between the C-terminal domain of APP and LRP, mediated by the cytoplasmic adaptor protein Fe65, impacts APP internalization (18 -23).”
From The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate (2005) · cites this paper as [23]
The Results show that distinct FE65 domains bind the cytoplasmic tails of LRP and APP, and the Discussion says FE65 could in principle link them. The paper proposes that this might affect APP trafficking or receptor endocytosis, but does not demonstrate an effect on APP internalization; its conclusion says that physiological relevance for endocytosis remains to be tested. (LLM, conf=0.90)
Experimental — accuracy not yet measured
Dab1 binds to the NPxY motif present in the cytoplasmic domains of the receptors.
“Dab1 binds to the NPxY motif present in the cytoplasmic domains of the receptors”
From The PX‐domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor (2002) · cites this paper as Trommsdorff et al., 1998
The C terminus of LRP binds to two cytosolic adapter proteins, FE65 and mammalian Disabled.
“Herz and co-workers (55) have demonstrated that the C terminus of LRP binds to two cytosolic adapter proteins, FE65 and mammalian Disabled, an observation consistent with a signaling function for the cytosolic portion of the receptor.”
From Apolipoprotein E Receptors Mediate the Effects of β-Amyloid on Astrocyte Cultures (2000) · cites this paper as [55]
LRP and other lipoprotein receptors might play a role in AD by influencing the clearance of Aβ and the processing of APP.
“Moreover, LRP and other lipopro-tein receptors might play a role in AD by influencing the clearance of amyloid ␤-protein (A␤) and the processing of APP”
From Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein (2002) · cites this paper as Trommsdorff et al., 1998
The C-terminal site of APP interacts with LRP via the adapter protein Fe65.
“Furthermore, the C-terminal site of APP interacts with LRP via the adapter protein Fe65”
From Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein (2002) · cites this paper as Trommsdorff et al., 1998

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Authors: Trommsdorff, M., Borg, J.-P., Margolis, B., & Herz, J.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1998-12
Volume: 273
Issue: 50
Pages: 33556-33560
ISSN: 0021-9258
DOI: 10.1074/jbc.273.50.33556
Cited by: 453
References: 4
Language: en
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 7979 d)

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks