Enhanced Amyloidogenic Processing of the β-Amyloid Precursor Protein in Gene-targeted Mice Bearing the Swedish Familial Alzheimer's Disease Mutations and a “Humanized” Aβ Sequence

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.

Schägger, H., & von Jagow, G. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90587-2 · Cited by 11,420 · see citing works

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659 · see citing works

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619 · see citing works

Manipulating the mouse embryo: A laboratory manual

Hogan, B. L. M., Costantini, F. D., & Lacy, E. (1986) · Cited by 4,460 · see citing works

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431 · see citing works

The molecular pathology of Alzheimer's disease

Selkoe, D. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90052-2 · Cited by 2,708 · see citing works

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., & Roder, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8424 · Cited by 2,328 · see citing works

Manipulating the mouse embryo: A laboratory manual

Johnson, M. (1986) · Trends in Genetics · doi:10.1016/0168-9525(86)90275-1 · Cited by 2,259 · see citing works

Altering the Genome by Homologous Recombination

Capecchi, M. R. (1989) · Science · doi:10.1126/science.2660260 · Cited by 2,037 · see citing works

Amyloid β-peptide is produced by cultured cells during normal metabolism

Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., et al. (1992) · Nature · doi:10.1038/359322a0 · Cited by 1,921 · see citing works

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., & Selkoe, D. J. (1992) · Nature · doi:10.1038/360672a0 · Cited by 1,757 · see citing works

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schiossmacher, M., Whaley, J., Swindlehurst, C., et al. (1992) · Nature · doi:10.1038/359325a0 · Cited by 1,731 · see citing works

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes

Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683 · see citing works

Rapid induction of Alzheimer A beta amyloid formation by zinc

Bush, A., Pettingell, W., Multhaup, G., d Paradis, M., Vonsattel, J., Gusella, J., Beyreuther, K., Masters, C., & Tanzi, R. (1994) · Science · doi:10.1126/science.8073293 · Cited by 1,522 · see citing works

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B., & Lannfelt, L. (1992) · Nature Genetics · doi:10.1038/ng0892-345 · Cited by 1,513 · see citing works

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

Suzuki, N., Cheung, T. T., Cai, X.-D., Odaka, A., Otvos, L., Eckman, C., Golde, T. E., & Younkin, S. G. (1994) · Science · doi:10.1126/science.8191290 · Cited by 1,471 · see citing works

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., & Ward, P. J. (1990) · Science · doi:10.1126/science.2111583 · Cited by 1,403 · see citing works

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

Goldgaber, D., Lerman, M. I., McBride, O. W., Saffiotti, U., & Gajdusek, D. C. (1987) · Science · doi:10.1126/science.3810169 · Cited by 1,333 · see citing works

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., & Mulligan, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90011-m · Cited by 1,281 · see citing works

Cardiac Malformation in Neonatal Mice Lacking Connexin43

Reaume, A. G., Sousa, P. A. D., Kulkarni, S., Langille, B. L., Zhu, D., Davies, T. C., Juneja, S. C., Kidder, G. M., & Rossant, J. (1995) · Science · doi:10.1126/science.7892609 · Cited by 1,243 · see citing works

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

Chartier-Harlin, M.-C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rossor, M., Roques, P., Hardy, J., et al. (1991) · Nature · doi:10.1038/353844a0 · Cited by 1,214 · see citing works

Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome

Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985) · Annals of Neurology · doi:10.1002/ana.410170310 · Cited by 1,159 · see citing works

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S., & Ito, H. (1988) · Nature · doi:10.1038/331530a0 · Cited by 1,083 · see citing works

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

Ponte, P. A., Gonzalez‐DeWhitt, P. A., Schilling, J., Miller, J., Hsu, D. K., Greenberg, B., Davis, K. L., Wallace, W., Lieberburg, I. M., Fuller, F. H., et al. (1988) · Nature · doi:10.1038/331525a0 · Cited by 1,050 · see citing works

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

Cai, X.-D., Golde, T. E., & Younkin, S. G. (1993) · Science · doi:10.1126/science.8424174 · Cited by 913 · see citing works

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

Mattson, M. P., Cheng, B., Culwell, A. R., Esch, F. S., Lieberburg, I. M., & Rydel, R. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90315-i · Cited by 795 · see citing works

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

Sisodia, S. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6075 · Cited by 738 · see citing works

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

Rumble, B. A., Retallack, R. W., Hilbich, C., Simms, G., Multhaup, G., Martins, R. N., Hockey, A., Montgomery, P., Beyreuther, K. T., & Masters, C. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906013202203 · Cited by 652 · see citing works

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

Busciglio, J., Gabuzda, D. H., Matsudaira, P., & Yankner, B. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2092 · Cited by 569 · see citing works

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

Seubert, P. A., Oltersdorf, T., Lee, M., Barbour, R., Blomquist, C. L., Davis, D. L., Bryant, K., Fritz, L. C., Galasko, D., Thal, L. J., et al. (1993) · Nature · doi:10.1038/361260a0 · Cited by 552 · see citing works

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

Hsiao, K., Borchelt, D., Olson, K., Johannsdottir, R., Kitt, C. A., Yunis, W. S., Xu, S., Eckman, C., Younkin, S. G., Price, D., et al. (1995) · Neuron · doi:10.1016/0896-6273(95)90107-8 · Cited by 519 · see citing works

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

LaFerla, F. M., Tinkle, B. T., Bieberich, C. J., Haudenschild, C. C., & Jay, G. (1995) · Nature Genetics · doi:10.1038/ng0195-21 · Cited by 513 · see citing works

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

Hung, A. Y., Haass, C., Nitsch, R. M., Qiu, W. Q., Citron, M., Wurtman, R. J., Growdon, J. H., & Selkoe, D. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49409-x · Cited by 399 · see citing works

Formation of β-amyloid protein deposits in brains of transgenic mice

Quon, D. H., Wang, Y., Catalano, R., Scardina, J. M., Murakami, K., & Cordell, B. (1991) · Nature · doi:10.1038/352239a0 · Cited by 397 · see citing works

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.

Citron, M., Vigo-Pelfrey, C., Teplow, D. B., Miller, C., Schenk, D., Johnston, J., Winblad, B., Venizelos, N., Lannfelt, L., & Selkoe, D. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.11993 · Cited by 366 · see citing works

The pathological association between down syndrome and Alzheimer disease

Mann, D. M. A. (1988) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(88)90041-3 · Cited by 346 · see citing works

Metabolism of the “Swedish” Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells

Thinakaran, G., Teplow, D. B., Siman, R., Greenberg, B., & Sisodia, S. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9390 · Cited by 317 · see citing works

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor

Haass, C., Hung, A. Y., Selkoe, D. J., & Teplow, D. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32503-6 · Cited by 315 · see citing works

Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice

Lamb, B. T., Sisodia, S. S., Lawler, A. M., Slunt, H. H., Kitt, C. A., Kearns, W. G., Pearson, P. L., Price, D. L., & Gearhart, J. D. (1993) · Nature Genetics · doi:10.1038/ng0993-22 · Cited by 311 · see citing works

Secreted Forms of β‐Amyloid Precursor Protein Protect Against Ischemic Brain Injury

Smith‐Swintosky, V. L., Pettigrew, L. C., Craddock, S. D., Culwell, A. R., Rydel, R. E., & Mattson, M. P. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63020781.x · Cited by 284 · see citing works

Mis-sense mutation Val→Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease

Naruse, S., Igarashi, S., Aoki, K., Kaneko, K., Iihara, K., Miyatake, T., Kobayashi, H., Inuzuka, T., Shimizu, T., Kojima, T., et al. (1991) · The Lancet · doi:10.1016/0140-6736(91)91612-x · Cited by 282 · see citing works

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.

Buxbaum, J. D., Koo, E. H., & Greengard, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9195 · Cited by 272 · see citing works

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

Mucke, L., Masliah, E., Johnson, W. B., Ruppe, M. D., Alford, M. F., Rockenstein, E. M., Forss‐Petter, S., Pietropaolo, M., Mallory, M. E., & Abraham, C. R. (1994) · Brain Research · doi:10.1016/0006-8993(94)90767-6 · Cited by 265 · see citing works

Genomic organization of the human amyloid beta-protein precursor gene

Yoshikai, S.-I., Sasaki, H., Doh‐ura, K., Furuya, H., & Sakaki, Y. (1990) · Gene · doi:10.1016/0378-1119(90)90310-n · Cited by 259 · see citing works

Levels and Alternative Splicing of Amyloid β Protein Precursor (APP) Transcripts in Brains of APP Transgenic Mice and Humans with Alzheimer's Disease

Rockenstein, E. M., McConlogue, L., Tan, H. T., Power, M., Masliah, E., & Mucke, L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.47.28257 · Cited by 253 · see citing works

Research advances in Alzheimer's disease and related disorders

Iqbal, K., & Disorders, R. (1995) · Wiley eBooks · Cited by 228 · see citing works

Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.

König, G., Mönning, U., Czech, C., Prior, R., Banati, R. B., Schreiter-Gasser, U., Bauer, J., Masters, C. L., & Beyreuther, K. T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50090-4 · Cited by 217 · see citing works

Cell cycle‐dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein.

Suzuki, T., Oishi, M., Marshak, D. R., Czernik, A. J., Nairn, A. C., & Greengard, P. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06360.x · Cited by 216 · see citing works

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

Anderson, J. P., Esch, F. S., Keim, P. S., Sambamurti, K., Lieberburg, I. M., & Robakis, N. K. R. K. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90775-o · Cited by 212 · see citing works

Production of intracellular amyloid‐containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.

Strooper, B. D., Simons, M., Multhaup, G., LEUVEN, F. V., Beyreuther, K. T., & Dotti, C. G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00176.x · Cited by 176 · see citing works

APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain

Tamaoka, A., Odaka, A., Ishibashi, Y., Usami, M., Sahara, N., Suzuki, N., Nukina, N., Mizusawa, H., Shoji, S., & Kanazawa, I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)30050-8 · Cited by 165 · see citing works

Amyloidogenicity of rodent and human βA4 sequences

Dyrks, T., Dyrks, E., Masters, C. L., & Beyreuther, K. T. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81399-k · Cited by 158 · see citing works

Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.

Strooper, B. D., Umans, L., Leuven, F. V., & BERGHE, H. V. D. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.2.295 · Cited by 152 · see citing works

Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Yamada, T., Sasaki, H., Furuya, H., Miyata, T., Goto, I., & Sakaki, Y. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90419-0 · Cited by 151 · see citing works

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.

Kammesheidt, A., Boyce, F. M., Spanoyannis, A., Cummings, B. J., Ortegón, M. E., Cotman, C. W., Vaught, J. L., & Neve, R. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10857 · Cited by 150 · see citing works

Human and rodent Alzheimer β‐amyloid peptides acquire distinct conformations in membrane‐mimicking solvents

Ötvös, L., Szendrei, G. I., Lee, V. M.-Y., & Mantsch, H. H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb19893.x · Cited by 122 · see citing works

Simple and efficient production of embryonic stem cell-embryo chimeras by coculture.

Wood, S. A., Pascoe, W. S., Schmidt, C., Kemler, R., Evans, M. J., & Allen, N. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4582 · Cited by 98 · see citing works

Intracellular Production of .beta.A4 Amyloid of Alzheimer's Disease: Modulation by Phosphoramidon and Lack of Coupling to the Secretion of the Amyloid Precursor Protein

Fuller, S. J., Storey, E., Li, Q.-X., Smith, A. I., Beyreuther, K., & Masters, C. L. (1995) · Biochemistry · doi:10.1021/bi00025a015 · Cited by 80 · see citing works

Expression of the human beta-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice.

Pearson, B. E., & Choi, T. K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.22.10578 · Cited by 77 · see citing works

Amyloid precursor protein secretion and βA4 amyloid generation are not mutually exclusive

Dyrks, T., Mönning, U., Beyreuther, K. T., & Turner, J. D. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00671-7 · Cited by 75 · see citing works

Basolateral Secretion of Amyloid Precursor Protein in Madin-Darby Canine Kidney Cells Is Disturbed by Alterations of Intracellular pH and by Introducing a Mutation Associated with Familial Alzheimer's Disease

Strooper, B. D., Craessaerts, K., Dewachter, I., Moechars, D., Greenberg, B., LEUVEN, F. V., & BERGHE, H. V. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.4058 · Cited by 63 · see citing works

Cathepsin G: Localization in human cerebral cortex and generation of amyloidogenic fragments from the β-amyloid precursor protein

Savage, M. J., Iqbal, M., Loh, T., Trusko, S. P., Scott, R. W., & Siman, R. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90490-1 · Cited by 56 · see citing works

Transgenic Mice Expressing Human β‐APP751, But Not Mice Expressing β‐APP695, Display Early Alzheimer's Disease‐like Histopathologya

Higgins, L. S., Catalano, R., Quon, D. H., & Cordell, B. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb23056.x · Cited by 50 · see citing works

Mutant and native human β-amyloid precursor proteins in transgenic mouse brain

Howland, D. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00078-s · Cited by 40 · see citing works

Transgenic mice expressing the amyloid β protein-containing carboxyl-terminal fragment of the Alzheimer amyloid precursor protein

Araki, E., Yamada, T., Takemura, K., Yamaguchi, H., Sakimura, K., Goto, I., & Sakaki, Y. (1995) · Amyloid · doi:10.3109/13506129509031894 · Cited by 4 · see citing works

Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575 · see citing works

APP mouse models for Alzheimer’s disease preclinical studies.

Sasaguri, H., Nilsson, P., Hashimoto, S., Nagata, K., Saito, T., De Strooper, B., Hardy, J., Vassar, R., Winblad, B., & Saido, T. C. (2017) · The EMBO Journal · doi:10.15252/embj.201797397 · Cited by 793 · see citing works

Practical considerations for choosing a mouse model of Alzheimer’s disease

Jankowsky, J. L., & Zheng, H. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0231-7 · Cited by 449 · see citing works

Rodent models for Alzheimer disease

Götz, J., Bodea, L., & Goedert, M. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0054-8 · Cited by 397 · see citing works

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities

Sago, H., Carlson, E. J., Smith, D. J., Kilbridge, J., Rubin, E. M., Mobley, W. C., Epstein, C. J., & Huang, T.-T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6256 · Cited by 382 · see citing works

Transgenic mouse models of Alzheimer’s disease.

Elder, G. A., Gama Sosa, M. A., & De Gasperi, R. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20159 · Cited by 336 · see citing works

Mouse models of Alzheimer's disease

Hall, A. M., & Roberson, E. D. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.11.017 · Cited by 317 · see citing works

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

Larson, J., LYNCH, G. S., Games, D., & Seubert, P. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01698-4 · Cited by 274 · see citing works

Long-Term Accumulation of Amyloid-β, β-Secretase, Presenilin-1, and Caspase-3 in Damaged Axons Following Brain Trauma

Chen, X.-H., Siman, R., Iwata, A., Meaney, D. F., Trojanowski, J. Q., & Smith, D. H. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63303-2 · Cited by 271 · see citing works

Modulation of Secreted β-Amyloid Precursor Protein and Amyloid β-Peptide in Brain by Cholesterol

Howland, D., Trusko, S. P., Savage, M. J., Reaume, A. G., Lang, D. M., Hirsch, J. D., Maeda, N., Siman, R., Greenberg, B., Scott, R. W., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16576 · Cited by 254 · see citing works

Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease

Peng, S., Garzon, D. J., Marchese, M., Klein, W. L., Ginsberg, S. D., Francis, B. M., Mount, H. T. J., Mufson, E. J., Salehi, A., & Fahnestock, M. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4736-08.2009 · Cited by 216 · see citing works

Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease

Zhang, C., McNeil, E. M., Dressler, L., & Siman, R. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.09.018 · Cited by 217 · see citing works

Turnover of Amyloid β-Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester

Savage, M. J., Trusko, S. P., Howland, D. S., Pinsker, L. R., Mistretta, S., Reaume, A. G., Greenberg, B. D., Siman, R., & Scott, R. W. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01743.1998 · Cited by 213 · see citing works

Alzheimer’s Disease in the Retina: Imaging Retinal Aβ Plaques for Early Diagnosis and Therapy Assessment

Koronyo, Y., Salumbides, B. C., Black, K. L., & Koronyo‐Hamaoui, M. (2012) · Neurodegenerative Diseases · doi:10.1159/000335154 · Cited by 199 · see citing works

Animal models of Alzheimer's disease and evaluation of anti-dementia drugs

Yamada, K., & Nabeshima, T. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(00)00081-4 · Cited by 191 · see citing works

Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity

Arendt, T. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.007 · Cited by 188 · see citing works

Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior

Picciotto, M. R., & Wickman, K. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.4.1131 · Cited by 185 · see citing works

Unusual phenotypic alteration of β amyloid precursor protein (βAPP) maturation by a new Val-715 → Met βAPP-770 mutation responsible for probable early-onset Alzheimer’s disease

Ancolio, K., Dumanchin‐Njock, C., Barelli, H., Warter, J., Brice, A., Campion, D., Frébourg, T., & Checler, F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4119 · Cited by 179 · see citing works

Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer’s disease: A role for cholinergic transmission

Wisor, J. P., Edgar, D. M., Yesavage, J. A., Ryan, H. S., McCormick, C. M., Lapustea, N., & Murphy, G. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.018 · Cited by 169 · see citing works

Caveolae, Plasma Membrane Microdomains for α-Secretase-mediated Processing of the Amyloid Precursor Protein

Ikezu, T., Trapp, B. D., Song, K. S., Schlegel, A., Lisanti, M. P., & Okamoto, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10485 · Cited by 157 · see citing works

β-Amyloid Mediated Nitration of Manganese Superoxide Dismutase

Muthuswamy, A., Tangpong, J., Keller, J. N., Murphy, M. P., Markesbery, W. R., Kiningham, K. K., & Clair, D. K. S. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051223 · Cited by 143 · see citing works

An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments

Pang, K., Jiang, R., Zhang, W., Yang, Z., Li, L., Shimozawa, M., Tambaro, S., Mayer, J., Zhang, B., Li, M., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00582-x · Cited by 142 · see citing works

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

Webster, S. J., Bachstetter, A. D., & Eldik, L. J. V. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt182 · Cited by 140 · see citing works

Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature

Lathe, R., Tsitrina, A. A., & Kotelevtsev, Y. V. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-36 · Cited by 136 · see citing works

A neuronal model of Alzheimer's disease: An insight into the mechanisms of oxidative stress–mediated mitochondrial injury

Sompol, P. M., Ittarat, W., Tangpong, J., Chen, Y., Doubinskaia, I. E., Batinic-Haberle, I., Abdul, H. M., Butterfield, D. A., & Clair, D. K. S. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.044 · Cited by 134 · see citing works

Presenilin-1 P264L Knock-In Mutation: Differential Effects on Aβ Production, Amyloid Deposition, and Neuronal Vulnerability

Siman, R., Reaume, A. G., Savage, M. J., Trusko, S., Lin, Y.-G., Scott, R. W., & Flood, D. G. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08717.2000 · Cited by 133 · see citing works

FAD mutant PS-1 gene-targeted mice: increased Aβ42 and Aβ deposition without APP overproduction

Flood, D. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00330-x · Cited by 131 · see citing works

Glycogen synthase kinase 3β links neuroprotection by 17β-estradiol to key Alzheimer processes

Goodenough, S., Schleusner, D., Pietrzik, C. U., Skutella, T., & Behl, C. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.029 · Cited by 124 · see citing works

Leveraging preclinical models for the development of Alzheimer disease therapeutics

Scearce-Levie, K. A., Sanchez, P. E., & Lewcock, J. W. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0065-9 · Cited by 118 · see citing works

Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau

Rayaprolu, S., Higginbotham, L., Bagchi, P., Watson, C. M., Zhang, T., Levey, A. I., Rangaraju, S., & Seyfried, N. T. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-00840-3 · Cited by 118 · see citing works

Cystatin C Protects Neuronal Cells from Amyloid-β-induced Toxicity

Tizón, B., Ribé, E. M., Mi, W., Troy, C. M., & Levy, E. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1291 · Cited by 114 · see citing works

Humanising the mouse genome piece by piece

Zhu, F., Nair, R., Fisher, E., & Cunningham, T. J. (2019) · Nature Communications · doi:10.1038/s41467-019-09716-7 · Cited by 110 · see citing works

Mutations in amyloid precursor protein and presenilin‐1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid β‐peptide (1–42), H2O2 and kainic acid: implications for Alzheimer's disease

Abdul, H. M., Rukhsana Sultana, A., Keller, J. N., Clair, D. K. S., Markesbery, W. R., & Butterfield, D. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03647.x · Cited by 114 · see citing works

Modeling human neurodegenerative diseases in transgenic systems

Sosa, M. A. G., Gasperi, R. D., & Elder, G. A. (2011) · Human Genetics · doi:10.1007/s00439-011-1119-1 · Cited by 107 · see citing works

Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-Dependent Progression of Alzheimer's Disease-Related Pathology

Bachstetter, A. D., Norris, C. M., Sompol, P. M., Wilcock, D. M., Goulding, D. S., Neltner, J. H., Clair, D. K. S., Watterson, D. M., & Eldik, L. J. V. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1496-12.2012 · Cited by 105 · see citing works

APP transgenic modeling of Alzheimer’s disease: mechanisms of neurodegeneration and aberrant neurogenesis

Crews, L. A., Rockenstein, E. M., & Masliah, E. (2009) · Brain Structure and Function · doi:10.1007/s00429-009-0232-6 · Cited by 107 · see citing works

APP physiological and pathophysiological functions: insights from animal models

Guo, Q., Wang, Z., Li, H., Wiese, M., & Zheng, H. (2011) · Cell Research · doi:10.1038/cr.2011.116 · Cited by 101 · see citing works

Animal models of amyloid‐β‐related pathologies in Alzheimer’s disease

Philipson, O., Lord, A., Gumucio, A., O'Callaghan, P. W., Lannfelt, L., & Nilsson, L. N. G. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07564.x · Cited by 98 · see citing works

Cognitive impairment in humanized APP×PS1 mice is linked to Aβ1–42 and NOX activation

Bruce-Keller, A. J., Gupta, S., Knight, A. G., Beckett, T. L., McMullen, J. M., Davis, P. R., Murphy, M. P., Van Eldik, L. J., St Clair, D., & Keller, J. N. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.07.012 · Cited by 96 · see citing works

Changes in Expression of Amyloid Precursor Protein and Interleukin-1β after Experimental Traumatic Brain Injury in Rats

Ciallella, J. R., Ikonomovic, M. D., Paljug, W. R., Wilbur, Y. I., Dixon, C. E., Kochanek, P. M., Marion, D. W., & DeKosky, S. T. (2002) · Journal of Neurotrauma · doi:10.1089/089771502762300229 · Cited by 94 · see citing works

A ketogenic diet improves motor performance but does not affect β-amyloid levels in a mouse model of Alzheimer's Disease

Beckett, T. L., Studzinski, C. M., Keller, J. N., Murphy, M. P., & Niedowicz, D. M. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.046 · Cited by 94 · see citing works

Brain Trauma in Aged Transgenic Mice Induces Regression of Established Aβ Deposits

Nakagawa, Y., Reed, L., Nakamura, M., McIntosh, T. K., Smith, D. H., Saatman, K. E., Raghupathi, R., Clemens, J., Saido, T. C., Lee, V. M.-Y., et al. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7375 · Cited by 91 · see citing works

Caspase inhibition therapy abolishes brain trauma-induced increases in Aβ peptide: Implications for clinical outcome

Abrahamson, E. E., Ikonomovic, M. D., Ciallella, J. R., Hope, C. E., Paljug, W. R., Isanski, B. A., Flood, D. G., Clark, R. S. B., & DeKosky, S. T. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.10.011 · Cited by 90 · see citing works

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

Sakakibara, Y., Sekiya, M., Saito, T., Saido, T. C., & Iijima, K. M. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0446-8 · Cited by 90 · see citing works

Twofold overexpression of human ?-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury

Murai, H., Pierce, J. E. S., Raghupathi, R., Smith, D. H., Saatman, K. E., Trojanowski, J. Q., Lee, V. M.-Y., Loring, J. F., Eckman, C., Younkin, S. G., et al. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980323)392:4 · Cited by 88 · see citing works

Reduction in open field activity in the absence of memory deficits in the AppNL−G−F knock-in mouse model of Alzheimer’s disease

Whyte, L. S., Hemsley, K. M., Lau, A. A., Hassiotis, S., Saito, T., Saido, T. C., Hopwood, J. J., & Sargeant, T. J. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.006 · Cited by 88 · see citing works

Simvastatin therapy prevents brain trauma‐induced increases in β‐amyloid peptide levels

Abrahamson, E. E., Ikonomović, M. D., Dixon, C. E., & DeKosky, S. T. (2009) · Annals of Neurology · doi:10.1002/ana.21731 · Cited by 87 · see citing works

Potential in vivo amelioration by N‐acetyl‐L‐cysteine of oxidative stress in brain in human double mutant APP/PS‐1 knock‐in mice: Toward therapeutic modulation of mild cognitive impairment

Huang, Q.-Z., Aluise, C., Joshi, G., Sultana, R., Clair, D. S., Markesbery, W., & Butterfield, D. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22422 · Cited by 86 · see citing works

Aβ solubility and deposition during AD progression and in APP × PS-1 knock-in mice

Murphy, M. P., Beckett, T. L., Ding, Q., Patel, E., Markesbery, W. R., Clair, D. K. S., LeVine, H., & Keller, J. N. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.06.002 · Cited by 85 · see citing works

Transgenic mouse models of Alzheimer's disease

Hock, B. J., & Lamb, B. T. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02449-0 · Cited by 85 · see citing works

Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia

Niedowicz, D. M., Reeves, V. L., Platt, T. L., Köhler, K., Beckett, T. L., Powell, D. K., Lee, T., Sexton, T. R., Song, E. S., Brewer, L. D., et al. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-64 · Cited by 85 · see citing works

Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease

Wu, Z., Ciallella, J. R., Flood, D. G., O’Kane, T. M., Bozyczko‐Coyne, D., & Savage, M. J. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.02.010 · Cited by 83 · see citing works

Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age

Abdul, H. M., Rukhsana Sultana, A., Clair, D. K. S., Markesbery, W. R., & Butterfield, D. A. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.012 · Cited by 81 · see citing works

Protein Kinase C ϵ Suppresses Aβ Production and Promotes Activation of α-Secretase

Zhu, G., Wang, D., Lin, Y., McMahon, T., Koo, E. H., & Messing, R. O. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5273 · Cited by 82 · see citing works

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

Serneels, L., T’Syen, D., Pérez‐Benito, L., Theys, T., Holt, M. G., & Strooper, B. D. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00399-z · Cited by 78 · see citing works

APP transgenic mice: their use and limitations

Balducci, C., & Forloni, G. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-010-8141-7 · Cited by 79 · see citing works

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment

Webster, S. J., Van Eldik, L. J., Watterson, D. M., & Bachstetter, A. D. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.0291-15.2015 · Cited by 80 · see citing works

Insulin resistance, neuroinflammation, and Alzheimer’s disease

Najem, D., Bamji‐Mirza, M., Chang, N., Liu, Q. Y., & Zhang, W. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0050 · Cited by 75 · see citing works

A Review of the Current Mammalian Models of Alzheimer’s Disease and Challenges That Need to Be Overcome

Mckean, N. E., Handley, R. R., & Snell, R. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313168 · Cited by 76 · see citing works

Animal models in the study of the biological function of genes on human chromosome 21 and their role in the pathophysiology of Down syndrome

Kola, I. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.10.1713 · Cited by 70 · see citing works

Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice

Kawasumi, M., Chiba, T., Yamada, M., Miyamae‐Kaneko, M., Matsuoka, M., Nakahara, J., Tomita, T., Iwatsubo, T., Kato, S., Aiso, S., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03397.x · Cited by 68 · see citing works

Humanized SFTPA1 and SFTPA2 Transgenic Mice Reveal Functional Divergence of SP-A1 and SP-A2

Wang, G., Guo, X., DiAngelo, S. L., Thomas, N. J., & Floros, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.046243 · Cited by 68 · see citing works

Progress toward valid transgenic mouse models for Alzheimer’s disease

Guénette, S. Y., & Tanzi, R. E. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00042-1 · Cited by 67 · see citing works

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease

Sakakibara, Y., Sekiya, M., Saito, T., Saido, T. C., & Iijima, K. M. (2019) · BMC Neuroscience · doi:10.1186/s12868-019-0496-6 · Cited by 65 · see citing works

Transgenic animals relevant to Alzheimer’s disease

Seabrook, G. R., & Rosahl, T. W. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00170-1 · Cited by 63 · see citing works

Implanted cannula-mediated repetitive administration of Aβ25–35 into the mouse cerebral ventricle effectively impairs spatial working memory

Yamada, M., Chiba, T., Sasabe, J., Nawa, M., Tajima, H., Niikura, T., Terashita, K., Aiso, S., Kita, Y. A., Matsuoka, M., et al. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.03.026 · Cited by 61 · see citing works

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits

Tamayev, R., Matsuda, S., Fà, M., Arancio, O., & D'adamio, L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011689107 · Cited by 61 · see citing works

Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?

Dubal, D. B., Broestl, L., & Worden, K. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-24 · Cited by 58 · see citing works

Enhanced -secretase processing alters APP axonal transport and leads to axonal defects

Rodrigues, E. M., Weissmiller, A. M., & Goldstein, L. S. B. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds297 · Cited by 55 · see citing works

Time sequence of oxidative stress in the brain from transgenic mouse models of Alzheimer's disease related to the amyloid-β cascade

Belkacemi, A., & Ramassamy, C. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.020 · Cited by 49 · see citing works

Guinea Pigs as a Nontransgenic Model for APP Processing in Vitro and in Vivo

Beck, M., Bigl, V., & Roßner, S. (2003) · Neurochemical Research · doi:10.1023/a:1022850113083 · Cited by 45 · see citing works

Proteomic analysis of brain proteins in APP/PS‐1 human double mutant knock‐in mice with increasing amyloid β‐peptide deposition: Insights into the effects of in vivo treatment with N‐acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer's disease

Robinson, R. A. S., Gururaj Joshi, A., Huang, Q., Rukhsana Sultana, A., Baker, A. S., Cai, J., Pierce, W. M. J., Clair, D. K. S., Markesbery, W. R., & Butterfield, D. A. (2011) · PROTEOMICS · doi:10.1002/pmic.201000523 · Cited by 46 · see citing works

Transgenic models of Alzheimer's disease: Better utilization of existing models through viral transgenesis

Platt, T. L., Reeves, V. L., & Murphy, M. P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.04.017 · Cited by 46 · see citing works

Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease (Erratum)

Chouliaras, L., Sierksma, A. S. R., Kenis, G., Prickaerts, J., Lemmens, M. A. M., Brasnjevic, I., van Donkelaar, E. L., Martínez‐Martínez, P., Losen, M. H., Baets, M. H. D., et al. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/356862 · Cited by 44 · see citing works

Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice

Subaiea, G. M., Adwan, L. I., Ahmed, A. H., Stevens, K. E., & Zawia, N. H. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.002 · Cited by 44 · see citing works

Rank-Order of Potencies for Inhibition of the Secretion of Aβ40 and Aβ42 Suggests That Both Are Generated by a Single γ-Secretase

Durkin, J. T., Murthy, S., Husten, E. J., Trusko, S. P., Savage, M. J., Rotella, D. P., Greenberg, B., & Siman, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20499 · Cited by 43 · see citing works

Age-related loss of phospholipid asymmetry in APP /APP x PS-1 /PS-1 human double mutant knock-in mice: Relevance to Alzheimer disease

Lange, M. L. B., Clair, D. K. S., Markesbery, W. R., Studzinski, C. M., Murphy, M. P., & Butterfield, D. A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.01.004 · Cited by 41 · see citing works

Proteomic identification of specifically carbonylated brain proteins in APPNLh/APPNLh×PS-1P264L/PS-1P264L human double mutant knock-in mice model of Alzheimer disease as a function of age

Sultana, R., Robinson, R. A. S., Di Domenico, F., Abdul, H. M., Clair, D. K. S., Markesbery, W. R., Cai, J., Pierce, W. M., & Butterfield, D. A. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.06.015 · Cited by 41 · see citing works

Modeling Alzheimer’s Disease in Mouse without Mutant Protein Overexpression: Cooperative and Independent Effects of Aβ and Tau

Guo, Q., Li, H., Cole, A. L., Hur, J., Li, Y., & Zheng, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080706 · Cited by 38 · see citing works

Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels

Köhler, C., Ebert, U., Baumann, K., & Schröder, H. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.04.009 · Cited by 37 · see citing works

Gavage of D-Ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice

Wu, B., Yan, W., Wang, Y., Su, T., Zhou, L., Liu, Y., & He, R. (2015) · Oncotarget · doi:10.18632/oncotarget.6021 · Cited by 36 · see citing works

Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain

Siman, R., & Salidas, S. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.028 · Cited by 33 · see citing works

PS Dependent APP Cleavage Regulates Glucosylceramide Synthase and is Affected in Alzheimer's Disease

Grimm, M. O. W., Hundsdörfer, B., Grösgen, S., Mett, J., Zimmer, V. C., Stahlmann, C. P., Haupenthal, V. J., Rothhaar, T. L., Lehmann, J., Pätzold, A. J., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000362987 · Cited by 31 · see citing works

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Steffen, J., Krohn, M., Schwitlick, C., Brüning, T., Paarmann, K., Pietrzik, C. U., Biverstål, H., Jansone, B., Langer, O., & Pahnke, J. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0448-2 · Cited by 31 · see citing works

Drebrin in Alzheimer’s Disease

Ishizuka, Y., & Hanamura, K. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-4-431-56550-5_12 · Cited by 30 · see citing works

Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease

Chouliaras, L., Sierksma, A. S. R., Kenis, G., Prickaerts, J., Lemmens, M. A. M., Brasnjevic, I., van Donkelaar, E. L., Martínez‐Martínez, P., Losen, M. H., Baets, M. H. D., et al. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/859101 · Cited by 30 · see citing works

Thiorphan-induced neprilysin inhibition raises amyloid β levels in rabbit cortex and cerebrospinal fluid

Newell, A., Sue, L. I., Scott, S., Rauschkolb, P. K., Walker, D. G., Potter, P. E., & Beach, T. G. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00902-9 · Cited by 29 · see citing works

Transgenic Animals in Alzheimer's Disease Research

Sturchler, C., & Sommer, B. (1999) · Reviews in the Neurosciences · doi:10.1515/revneuro.1999.10.1.15 · Cited by 29 · see citing works

Retinal Manifestations of Alzheimer’s Disease

Dehabadi, M. H., Davis, B. M., Wong, T. K. Y., & Cordeiro, M. F. (2014) · Neurodegenerative Disease Management · doi:10.2217/nmt.14.19 · Cited by 27 · see citing works

Of mice and men: more neurobiology in dementia

Codita, A., Winblad, B. G., & Mohammed, A. H. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000245757.06374.6a · Cited by 28 · see citing works

Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein‐specific antibodies

Höfling, C., Morawski, M., Zeitschel, U., Zanier, E. R., Moschke, K., Serdaroglu, A., Canneva, F., von Hörsten, S., Simoni, M. G. D., Forloni, G., et al. (2016) · Aging Cell · doi:10.1111/acel.12508 · Cited by 26 · see citing works

Generation of mice expressing the human glucagon receptor with a direct replacement vector

Shiao, L., Cascieri, M. A., Trumbauer, M. E., Chen, H., & Sullivan, K. A. (1999) · Transgenic Research · doi:10.1023/a:1008922521461 · Cited by 26 · see citing works

Complexity of Sex Differences and Their Impact on Alzheimer’s Disease

Kadlecová, M., Freude, K., & Haukedal, H. (2023) · Biomedicines · doi:10.3390/biomedicines11051261 · Cited by 26 · see citing works

Animal Models of Alzheimer’s Disease

Newman, M., Kretzschmar, D., Khan, I., Chen, M., Verdile, G., & Lardelli, M. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00040-1 · Cited by 24 · see citing works

Stability of the distribution of spines containing drebrin A in the sensory cortex layer I of mice expressing mutated APP and PS1 genes

Mahadomrongkul, V., Huerta, P. T., Shirao, T., & Aoki, C. J. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.012 · Cited by 24 · see citing works

Cerebral Blood Flow Changes after Brain Injury in Human Amyloid-Beta Knock-in Mice

Abrahamson, E., Foley, L., DeKosky, S., Hitchens, T., Ho, C., Kochanek, P., & Ikonomovic, M. (2013) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2013.24 · Cited by 20 · see citing works

Guinea-pig primary cell cultures provide a model to study expression and amyloidogenic processing of endogenous amyloid precursor protein

Beck, M., Brückner, M. K., Holzer, M., Kaap, S., Pannicke, T., Arendt, T., & Bigl, V. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00390-5 · Cited by 21 · see citing works

Context dependent function of APPb enhancer identified using enhancer trap-containing BACs as transgenes in zebrafish

Shakes, L. A., Malcolm, T. L., Allen, K. L., De, S., Harewood, K. R., & Chatterjee, P. K. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn628 · Cited by 20 · see citing works

Beta Amyloid Differently Modulate Nicotinic and Muscarinic Receptor Subtypes which Stimulate in vitro and in vivo the Release of Glycine in the Rat Hippocampus

Zappettini, S., Grilli, M., Olivero, G., Mura, E., Preda, S., Govoni, S. M., Salamone, A., & Marchi, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00146 · Cited by 20 · see citing works

Mouse models of neurological disorders—A comparison of heritable and acquired traits

Harper, A. J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.05.009 · Cited by 21 · see citing works

Proteolytical processing of mutated human amyloid precursor protein in transgenic mice

Czech, C., Delaère, P., Macq, A. F., Reibaud, M., Dreisler, S., Touchet, N., Schombert, B., Mazadier, M., Mercken, L., Theisen, M., et al. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00039-9 · Cited by 36 · see citing works

Mutant and native human β-amyloid precursor proteins in transgenic mouse brain

Howland, D. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00078-s · Cited by 40 · see citing works

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor

Haass, C., Hung, A. Y., Selkoe, D. J., & Teplow, D. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32503-6 · Cited by 315 · see citing works

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

Serneels, L., T’Syen, D., Pérez‐Benito, L., Theys, T., Holt, M. G., & Strooper, B. D. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00399-z · Cited by 78 · see citing works

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507 · see citing works