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Apolipoprotein E (APOE) genotype and the pesticide chlorpyrifos modulate attention, motivation and impulsivity in female mice in the 5-choice serial reaction time task

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ApoE4‐Driven Accumulation of Intraneuronal Oligomerized A β 42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

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Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation

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Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism

Barthelson, K., Newman, M., & Lardelli, M. T. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.049187 · Cited by 14

Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation

Johnson, L. A., Kim, H.-S., Knudson, M. J., Nipp, C. T., Yi, X., & Maeda, N. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m031435 · Cited by 13

Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer’s Disease: A Systematic Review and Meta-analysis of Preclinical Studies

Cai, J., Xie, D., Kong, F., Zhai, Z., Zhu, Z., Zhao, Y., Xu, Y., & Sun, T. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231249 · Cited by 13

Cognitive deficits in human ApoE4 knock-in mice: A systematic review and meta-analysis

van Heuvelen, M. J. G., van der Lei, M. B., Alferink, P. M., Roemers, P., & van der Zee, E. A. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115123 · Cited by 14

Investigating the plasma-liver-brain axis of omega-3 fatty acid metabolism in mouse knock-in for the human apolipoprotein E epsilon 4 allele.

Husain, M., Vachon, A., Chouinard-Watkins, R., Vandal, M., Calon, F., & Plourde, M. (2022) · Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109181 · Cited by 11

Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model

Davies, C., Tulloch, J., Yip, E., Currie, L., Colom‐Cadena, M., Wegmann, S., Hyman, B. T., Wilkins, L., Hooley, M., Tzioras, M., et al. (2023) · Brain and Neuroscience Advances · doi:10.1177/23982128231191046 · Cited by 11

Expression of human apolipoprotein E4 reduces insulin‐receptor substrate 1 expression and Akt phosphorylation in the ageing liver

Ong, Q.-R., Chan, E. S., Lim, M., & Wong, B. (2014) · FEBS Open Bio · doi:10.1016/j.fob.2014.02.011 · Cited by 12

Insulin BBB pharmacokinetics in young apoE male and female transgenic mice

Rhea, E. M., Torres, E. R. S., Raber, J., & Banks, W. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228455 · Cited by 12

Neuroinflammation drives APOE genotype-dependent differential expression of neprilysin

Graykowski, D. R., Kasparian, K., Caniglia, J. L., Gritsaeva, Y., & Cudaback, E. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577315 · Cited by 12

Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a Transgenic APOE Mouse Model: Long-Term Implications on Body Weight after a High-Fat Diet

Guardia-Escote, L., Blanco, J., Basaure, P., Biosca-Brull, J., Verkaik‐Schakel, R. N., Cabré, M., Peris‐Sampedro, F., Pérez-Fernández, C., Sánchez-Santed, F., Plösch, T., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18010184 · Cited by 12

DHA-Enriched Fish Oil Ameliorates Deficits in Cognition Associated with Menopause and the APOE4 Genotype in Rodents

Pontifex, M. G., Martinsen, A., Saleh, R. N. M., Harden, G., Fox, C., Müller, M. M., Vauzour, D., & Minihane, A. M. (2022) · Nutrients · doi:10.3390/nu14091698 · Cited by 13

ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice

Hinsdale, M. E., Sullivan, P. M., Mezdour, H., & Maeda, N. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200103-jlr200 · Cited by 12

APOE- ε4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer’s diseasePreprint

Bhattarai, P., Yılmaz, E., Cakir, E. Ö., Yüceer, H., Lee, A., Ma, Y., Çelikkaya, H., Coşacak, M. İ., Haage, V. C., Wang, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.24.634732 · Cited by 12

CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice

Greco, G. A., Rock, M. B., Amontree, M., Lanfranco, M. F., Korthas, H. T., Hong, S. H., Turner, R. S., Rebeck, G. W., & Conant, K. E. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106057 · Cited by 11

mTOR inhibition enhances synaptic and mitochondrial function in Alzheimer’s disease in an APOE genotype-dependent manner

Sanganahalli, B. G., Mihailovic, J. M., Vekaria, H. J., Coman, D., Yackzan, A. T., Flemister, A., Aware, C. B., Wenger, K., Hubbard, W. B., Sullivan, P. G., et al. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241261942 · Cited by 12

Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis

Lloyd, G. M., Long, B., Quintin, S., Sorrentino, Z. A., Gorion, K.-M. M., Bell, B. M., Carrillo, D., Sullivan, P., Borchelt, D., & Giasson, B. I. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01623-9 · Cited by 11

High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL

Mihovilovic, M., Robinette, J. B., DeKroon, R. M., Sullivan, P. M., & Strittmatter, W. J. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600201-jlr200 · Cited by 12

The Effects of Apolipoproteins E3 and E4 on the Transforming Growth Factor-β System in Targeted Replacement Mice

Haas, A., Liraz, O., & Michaelson, D. M. (2012) · Neurodegenerative Diseases · doi:10.1159/000334902 · Cited by 11

Dose- and ApoE Isoform-Dependent Cognitive Injury after Cranial56Fe Irradiation in Female Mice

Villasana, L., Dayger, C. A., & Raber, J. (2013) · Radiation Research · doi:10.1667/rr3210.1 · Cited by 11

Isoform-dependent effects of apoE on doublecortin-positive cells and microtubule-associated protein 2 immunoreactivity following 137Cs irradiation

Villasana, L., Pfankuch, T., & Raber, J. (2010) · Radiation and Environmental Biophysics · doi:10.1007/s00411-010-0290-4 · Cited by 11

The Effect of the APOE4 Gene on Accumulation of Aβ 40 After Brain Injury Cannot Be Reversed by Increasing apoE4 Protein

Washington, P. M., & Burns, M. P. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw049 · Cited by 11

Cellular Uptake and Clearance of Oxidatively-modified Apolipoprotein E3 by Cerebral Cortex Endothelial Cells

Cruz, S., & Narayanaswami, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184582 · Cited by 11

Analysis of early effects of human APOE isoforms on Alzheimer’s disease and type III hyperlipoproteinemia pathways using knock-in rat models with humanized APP and APOE

Yesiltepe, M., Yin, T., Tambini, M., Bao, H., Pan, M., d’Abramo, C., Giliberto, L., Han, X., & D’Adamio, L. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01832-2 · Cited by 10

Apolipoprotein E Isoform-Dependent Effects on Human Amyloid Precursor Protein/Aβ-Induced Behavioral Alterations and Cognitive Impairments and Insoluble Cortical Aβ42 Levels

Holden, S. J., Kundu, P., Torres, E. R. S., Sudhakar, R., Krenik, D., Grygoryev, D., Turker, M. S., & Raber, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.767558 · Cited by 10

Amelioration of Cognitive and Olfactory System Deficits in APOE4 Transgenic Mice with DHA Treatment

González, L. M., Bourissai, A., Lessard‐Beaudoin, M., Lebel, R., Tremblay, L., Lepage, M., & Graham, R. K. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03401-z · Cited by 12

Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2.

Sullivan, P. M., Mezdour, H., Quarfordt, S. H., & Maeda, N. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2673 · Cited by 264

Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice

Ree, J. H. V., Broek, W. J. A. A. V. D., Dahlmans, V. E. H., Groot, P. H. E., Vidgeon-Hart, M., Frants, R. R., Wieringa, B., Havekes, L. M., & Hofker, M. H. (1994) · TNO Repository

Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice.

van Vlijmen, B. J. M., van den Maagdenberg, A. M. J. M., Gijbels, M. J., van der Boom, H., HogenEsch, H., Frants, R. R., Hofker, M. H., & Havekes, L. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117117 · Cited by 250

Hypomorphic Apolipoprotein E Mice

Raffaı̈, R. L., & Weisgraber, K. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111222200 · Cited by 67

Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by intramuscular injection of plasmid DNA

Rinaldi, M., Catapano, A. L., Parrella, P., Ciafrè, S. A., Signori, E., Seripa, D., Uboldi, P., Antonini, R., Ricci, G., Farace, M. G., et al. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301310 · Cited by 25