Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

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Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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Surface location and high affinity for calcium of a 500‐kd liver membrane protein closely related to the LDL‐receptor suggest a physiological role as lipoprotein receptor.

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Abnormal lipoprotein receptor‐binding activity of the human E apoprotein due to cysteine‐arginine interchange at a single site

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Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo

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Models of retinal diseases and their applicability in drug discovery

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Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease

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CYP2E1 Degradation by in Vitro Reconstituted Systems: Role of the Molecular Chaperone hsp90

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A simple, efficient tool for assessment of mice after unilateral cortex injury

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Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response

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Apolipoprotein E Isoform-Specific Effects on Lipoprotein Receptor Processing

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Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment‐associated cytotoxicity

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Independent effects of APOE on cholesterol metabolism and brain A levels in an Alzheimer disease mouse model

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Reelin and apoE actions on signal transduction, synaptic function and memory formation

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APOE4 genotype exacerbates the impact of menopause on cognition and synaptic plasticity in APOE‐TR mice

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Treatment with a γ-Ketoaldehyde Scavenger Prevents Working Memory Deficits in hApoE4 Mice

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APOEgenotype-dependent modulation of astrocyte chemokine CCL3 production

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Aortic Constriction Exacerbates Atherosclerosis and Induces Cardiac Dysfunction in Mice Lacking Apolipoprotein E

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Sialylated Human Apolipoprotein E (apoEs) Is Preferentially Associated with Neuron-Enriched Cultures from APOE Transgenic Mice

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Harmful Effects of Increased LDLR Expression in Mice With Human APOE*4 But Not APOE*3

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NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

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Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice

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Neuroimmunometabolism: A New Pathological Nexus Underlying Neurodegenerative Disorders

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Administration of COG1410 Reduces Axonal Amyloid Precursor Protein Immunoreactivity and Microglial Activation after Controlled Cortical Impact in Mice

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APOE genotype and postnatal chlorpyrifos exposure modulate gut microbiota and cerebral short-chain fatty acids in preweaning mice

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APOE genetics influence murine gut microbiome

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The challenge of modeling macular degeneration in mice

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A multi‐hit hypothesis for an APOE4 ‐dependent pathophysiological state

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Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice

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Human Apolipoprotein E4 Worsens Acute Axonal Pathology but Not Amyloid-β Immunoreactivity After Traumatic Brain Injury in 3×TG-AD Mice

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Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcumin

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Uses for humanised mouse models in precision medicine for neurodegenerative disease

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Apolipoprotein E2 Accentuates Postprandial Inflammation and Diet-Induced Obesity to Promote Hyperinsulinemia in Mice

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Presence of the apolipoprotein E-ε4 allele is associated with an increased risk of sepsis progression

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Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice

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Influence of Matrix Metallopeptidase 9 on Beta-Amyloid Elimination Across the Blood-Brain Barrier

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Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice

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The effect of dietary fat consumption on Alzheimer’s disease pathogenesis in mouse models

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Effect of human apolipoprotein E genotype on the pathogenesis of experimental ocular HSV-1

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ApoE genotype-specific inhibition of apoptosis

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Human iPSC application in Alzheimer’s disease and tau-related neurodegenerative diseases

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ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer’s disease mouse model

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ApoE mimetic improves pathology and memory in a model of Alzheimer’s disease

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ApoE4-dependent Aβ-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum

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Human LDL Receptor Enhances Sequestration of ApoE4 and VLDL Remnants on the Surface of Hepatocytes but Not Their Internalization in Mice

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Apolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity

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Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele

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Sulforaphane Potentiates the Efficacy of 17-Allylamino 17-Demethoxygeldanamycin Against Pancreatic Cancer Through Enhanced Abrogation of Hsp90 Chaperone Function

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Behavioral phenotype and BDNF differences related to apoE isoforms and sex in young transgenic mice

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Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent manner

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The ε3 and ε4 Alleles of Human APOE Differentially Affect Tau Phosphorylation in Hyperinsulinemic and Pioglitazone Treated Mice

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The contribution of cholesterol and epigenetic changes to the pathophysiology of breast cancer

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High-Fat Diets in Animal Models of Alzheimer’s Disease: How Can Eating Too Much Fat Increase Alzheimer’s Disease Risk?

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APOE3, but Not APOE4, Bone Marrow Transplantation Mitigates Behavioral and Pathological Changes in a Mouse Model of Alzheimer Disease

Yang, Y. J., Cudaback, E., Jorstad, N. L., Hemingway, J. F., Hagan, C. E., Melief, E. J., Li, X., Yoo, T., Khademi, S. B., Montine, K. S., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.05.009 · Cited by 37

ERβ and ApoE isoforms interact to regulate BDNF–5-HT2A signaling and synaptic function in the female brain

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Doubling expression of the low density lipoprotein receptor by truncation of the 3′-untranslated region sequence ameliorates type iii hyperlipoproteinemia in mice expressing the human apoe2 isoform

Knouff, C., Malloy, S., Wilder, J., Altenburg, M. K., & Maeda, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009423200 · Cited by 28

Profiling Brain and Plasma Lipids in Human APOE ε2, ε3, and ε4 Knock-in Mice Using Electrospray Ionization Mass Spectrometry

Sharman, M. J., Shui, G., Fernandis, A. Z., Lim, W. L. F., Berger, T., Hone, E., Taddei, K., Martins, I. J., Ghiso, J., Buxbaum, J. D., et al. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1348 · Cited by 35

ApoE4 Delays Dendritic Spine Formation during Neuron Development and Accelerates Loss of Mature Spines in Vitro

Nwabuisi‐Heath, E., Rebeck, G. W., LaDu, M. J., & Yu, C. (2013) · ASN NEURO · doi:10.1042/an20130043 · Cited by 38

Apolipoprotein E4 causes early olfactory network abnormalities and short-term olfactory memory impairments

Peng, K. Y., Mathews, P. M., Levy, E., & Wilson, D. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.12.004 · Cited by 37

Relevance of transgenic mouse models for Alzheimer's disease

Tai, L. M., Weng, J. M., LaDu, M. J., & Brady, S. T. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.07.007 · Cited by 39

A Novel Selective PKR Inhibitor Restores Cognitive Deficits and Neurodegeneration in Alzheimer Disease Experimental Models

Lopez‐Grancha, M., Bernardelli, P., Moindrot, N., Genet, E., Vincent, C., Roudières, V., Krick, A., Sabuco, J.-F., Machnik, D., Ibghi, D., et al. (2021) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.121.000590 · Cited by 34

ApoE isoform‐dependent deficits in extinction of contextual fear conditioning

Olsen, R. H. J., Agam, M., Davis, M. J., & Raber, J. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00833.x · Cited by 35

The neurobiology of APOE in schizophrenia and mood disorders

Gibbons, A. S. (2010) · Frontiers in bioscience · doi:10.2741/3729 · Cited by 35

Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ɛ3 and ɛ4 knock-in mice

Lim, W. L. F., Lam, S. M., Shui, G., Mondal, A., Ong, D., Duan, X., Creegan, R., Martins, I. J., Sharman, M. J., Taddei, K., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.012 · Cited by 37

A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice

Blain, J., Sullivan, P. M., & Poirier, J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.08.010 · Cited by 37

Hippocampus-related cognitive impairments in young apoE4 targeted replacement mice

Salomon-Zimri, S., Boehm-Cagan, A., Liraz, O., & Michaelson, D. M. (2013) · Neurodegenerative Diseases · doi:10.1159/000354777 · Cited by 34

APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice

Pankiewicz, J. E., Baquero-Buitrago, J., Sanchez, S., Lopez-Contreras, J., Kim, J., Sullivan, P. M., Holtzman, D. M., & Sadowski, M. J. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0156-1 · Cited by 34

The Impact of Apolipoprotein E (APOE) Epigenetics on Aging and Sporadic Alzheimer’s Disease

Lozupone, M., Dibello, V., Sardone, R., Castellana, F., Zupo, R., Lampignano, L., Bortone, I., Daniele, A., Bellomo, A., Solfrizzi, V., et al. (2023) · Biology · doi:10.3390/biology12121529 · Cited by 39

Chronic exposure to chlorpyrifos triggered body weight increase and memory impairment depending on human apoE polymorphisms in a targeted replacement mouse model

Peris‐Sampedro, F., Basaure, P., Reverte, I., Cabré, M., Domingo, J. L., & Colomina, M. T. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.03.006 · Cited by 34

Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease

Yang, Y., Keene, C. D., Peskind, E. R., Galasko, D. R., Hu, S., Cudaback, E., Wilson, A. M., Li, G., Yu, C., Montine, K. S., et al. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000207 · Cited by 35

APOE Genotype Affects Outcome in a Murine Model of Sepsis: Implications for a New Treatment Strategy

Wang, H., Christensen, D. J., Vitek, M. P., Sullivan, P. M., & Laskowitz, D. T. (2009) · Anaesthesia and Intensive Care · doi:10.1177/0310057x0903700111 · Cited by 34

Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice

Lattanzio, F., Carboni, L., Carretta, D., Rimondini, R., Candeletti, S., & Romualdi, P. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.017 · Cited by 34

Apolipoprotein E4 Exaggerates Diabetic Dyslipidemia and Atherosclerosis in Mice Lacking the LDL Receptor

Johnson, L. A., Arbonés-Mainar, J. M., Fox, R. G., Pendse, A. A., Altenburg, M. K., Kim, H., & Maeda, N. (2011) · Diabetes · doi:10.2337/db11-0466 · Cited by 34

APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses

Friday, C. M., Stephens, I. O., Smith, C. T., Lee, S., Satish, D., Devanney, N. A., Cohen, S., Morganti, J. M., Gordon, S. M., & Johnson, L. A. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106983 · Cited by 33

The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer

McDonnell, D. P., Chang, C.-Y., & Nelson, E. R. (2014) · Climacteric · doi:10.3109/13697137.2014.966949 · Cited by 33

The Role of Upregulated APOE in Alzheimer's Disease Etiology

Gottschalk, W. K., & Mihovilovic, M. (2016) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000209 · Cited by 33

Human APOE genotype affects intraneuronal A 1-42 accumulation in a lentiviral gene transfer model

Zhao, W., Dumanis, S. B., Tamboli, I. Y., Rodriguez, G. A., Jo LaDu, M., Moussa, C. E. H., & William Rebeck, G. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt525 · Cited by 32

Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo

Dieckmann, M., Beil, F. T., Mueller, B., Bartelt, A., Marshall, R. P., Koehne, T., Amling, M., Ruether, W., Cooper, J. A., Humphries, S. E., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1757 · Cited by 34

Apolipoprotein E is found in astrocytes but not in microglia in the normal mouse brain

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Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment

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Astragaloside IV Prevents Cardiac Remodeling in the Apolipoprotein E-Deficient Mice by Regulating Cardiac Homeostasis and Oxidative Stress

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Human Apolipoprotein E4 Targeted Replacement Mice Show Increased Prevalence of Intracerebral Hemorrhage Associated with Vascular Amyloid Deposition

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Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner

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Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology

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Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice

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The Modulating Effect of Mechanical Changes in Lipid Bilayers Caused by ApoE-Containing Lipoproteins on Aβ Induced Membrane Disruption

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Interaction Between Sex and Apolipoprotein E Genetic Background in a Murine Model of Intracerebral Hemorrhage

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ApoE isoform modulates effects of cranial 56Fe irradiation on spatial learning and memory in the water maze

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Identification and modification of amyloid-independent phenotypes of APOE4 mice

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APOE Genotype Specific Effects on the Early Neurodegenerative Sequelae Following Chronic Repeated Mild Traumatic Brain Injury

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Long term effects of murine postnatal exposure to decabromodiphenyl ether (BDE-209) on learning and memory are dependent upon APOE polymorphism and age

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ApoE4 Induces Synaptic and ERG Impairments in the Retina of Young Targeted Replacement ApoE4 Mice

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Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules

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Characterization of plant p23-like proteins for their co-chaperone activities

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A mouse model of chemotherapy-related cognitive impairments integrating the risk factors of aging and APOE4 genotype

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The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype

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Blockade of nicotinic acetylcholine receptors suppresses hippocampal long‐term potentiation in wild‐type but not ApoE4 targeted replacement mice

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Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice.

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Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by intramuscular injection of plasmid DNA

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