The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis
Open accessAbstract
Apolipoprotein (apo) E, a constituent of several lipoproteins, is a ligand for the low density lipoprotein receptor, and this interaction is important for maintaining cholesterol and triglyceride homeostasis. We have used a gene replacement strategy to generate mice that express the human apoE3 isoform in place of the mouse protein. The levels of apoE mRNA in various tissues are virtually the same in the human apoE3 homozygous (3/3) mice and their littermates having the wild type mouse allele (+/+). Total cholesterol and triglyceride levels in fasted plasma from the 3/3 mice were not different from those in the +/+ mice, when maintained on a normal (low fat) chow diet. We found, however, notable differences in the distribution of plasma lipoproteins and apolipoprotein E between the two groups: beta-migrating lipoproteins and plasma apoB100 levels are decreased in the 3/3 mice, and the apoE distribution is shifted from high density lipoproteins to larger lipoprotein particles. In addition, the fractional catabolic rate of exogenously administered remnant particles without apoE was 6-fold slower in the 3/3 mice compared with the +/+ mice. When the 3/3 and +/+ animals were fed a high fat/high cholesterol diet, the 3/3 animals responded with a dramatic increase (5-fold) in total cholesterol compared with the +/+ mice (1.5-fold), and after 12 weeks on this same diet the 3/3 animals developed significantly (at least 13-fold) larger atherosclerotic plaques in the aortic sinus area t…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“To determine the gene dosage effect of human APOE3 and APOE4 on amyloid deposition, we used knock-in mouse models in which the endogenous murine Apoe gene is replaced with the APOE3 or APOE4 gene.”
From Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-β Amyloidosis (2011) · cites this paper as Sullivan et al., 1997
In the citing paper
“APOE ε2-TR or APOE ε4-TR mice retain regulatory sequences of the mouse Apoe gene and the noncoding murine exon 1 surrounding the inserted human exons 2′, 3′, and 4′ [17,18] and therefore, they express the human apoE protein at physiological levels.”
From Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice (2014) · cites this paper as [18]
In the citing paper
“APOE targeted replacement mice, which express human APOE in place of their mouse Apoe gene and which do not develop overt AD pathology28,29”
From APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice (2020) · cites this paper as [29]
In the citing paper
“These APOE TR mice were previously generated by removing and replacing the endogenous mouse Apoe gene with the human APOE gene 51,52 .”
From APOE4-drives brain bioenergetic shifts independent of Alzheimer’s disease pathology (2026) · cites this paper as [51]
In the citing paper
“APOE-TR mice, which are genetically chimeric, i.e. contain the mouse 5’ regulatory region but human exons 2–4 (Knouff et al., 1999; Sullivan et al., 1997)”
From Cholesterol and matrisome pathways dysregulated in astrocytes and microglia (2022) · cites this paper as Sullivan et al., 1997
In the citing paper
“By contrast, NHE6 ablation led to glial activation and decreased plaque load in ApoeAPOE4 (Sullivan et al., 1997) and AppNL-F (Saito et al., 2014) double knockin mice.”
From NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load (2021) · cites this paper as Sullivan et al., 1997
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
Thomas, P. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5201 · Cited by 7,937
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701
Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., & Mulligan, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90011-m · Cited by 1,281
Herz, J., Hamann, U., Rogne, S., Myklebost, O., Gausepohlꝉ, H., & Stanley, K. K. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03306.x · Cited by 955
Apolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830
Human apolipoprotein E. The complete amino acid sequence
Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34702-1 · Cited by 741
Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34954-8 · Cited by 673
Research works printed but not linked: 3
- Hallman, 1991, Am. J. Hum. Genet., 49, 338
- Chomczynski, 1987, Anal. Biochem., 162, 156, 10.1016/0003-2697(87)90021-2 · DOI
- Landis, 1987, Am. J. Physiol., 252, C805
Cited by
Sorted by citations
Items 401–500 of 576
Guardia-Escote, L., Basaure, P., Peris‐Sampedro, F., Biosca-Brull, J., Cabré, M., Sánchez-Santed, F., Domingo, J. L., & Colomina, M. T. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112195 · Cited by 10
Diaz, J. R., Martá-Ariza, M., Khodadadi‐Jamayran, A., Heguy, A., Tsirigos, A., Pankiewicz, J. E., Sullivan, P. M., & Sadowski, M. J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.845291 · Cited by 11
Self-citationChronic thrombin exposure results in an increase in apolipoprotein-E levels
Mhatre, M., Hensley, K., Nguyen, A., & Grammas, P. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20887 · Cited by 10
He, A., Wang, Y., Shen, Y., Dong, Z., Luo, L., Ge, X., Liu, X., Mao, Y., Zhang, T., Li, X., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-01028-4 · Cited by 9
APOE4 drives widespread changes to the hepatic proteome and alters metabolic function
Lysaker, C. R., Johnson, C. N., Csikós, V., Franczak, E., Tetlow, A. L., Benson, M. N., Thyfault, J. P., Geiger, P. C., Morris, J. K., & Wilkins, H. (2026) · iScience · doi:10.1016/j.isci.2026.115035 · Cited by 9
Boutros, S. W., Zimmerman, B., Nagy, S. C., Unni, V. K., & Raber, J. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01966-8 · Cited by 9
Guardia-Escote, L., Biosca-Brull, J., Cabré, M., Blanco, J., Mladenova-Koleva, M., Basaure, P., Pérez-Fernández, C., Sánchez-Santed, F., Domingo, J. L., & Colomina, M. T. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03555-8 · Cited by 9
Genome‐wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease
Hou, X., Heckman, M. G., Fiesel, F. C., Koga, S., Soto‐Beasley, A. I., Watzlawik, J. O., Zhao, J., Valentino, R. R., Johnson, P. W., White, L. J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70198 · Cited by 9
Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans
Beaulieu, L. M., Clancy, L., Tanrıverdi, K., Benjamin, E. J., Kramer, C. D., Weinberg, E. O., He, X., Mekasha, S., Mick, E. O., Ingalls, R. R., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131688 · Cited by 8
Mutsvunguma, L. Z., Moetlhoa, B., Edkins, A. L., Luke, G. A., Blatch, G. L., & Knox, C. M. (2011) · Cell Stress and Chaperones · doi:10.1007/s12192-011-0262-x · Cited by 9
Klein, R. C., Saini, S., Risher, M., Acheson, S. K., Fleming, R. L., Sexton, H. G., Swartzwelder, H. S., & Moore, S. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094071 · Cited by 8
The effects of the apoE4 genotype on the developing mouse retina
Maharshak, I., Salomon‐Zimri, S., Antes, R., Liraz, O., Nisgav, Y., Livnat, T., Weinberger, D., Colton, C. A., Solomon, A., & Michaelson, D. M. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.11.001 · Cited by 9
APOE Genotype Alters Immunoglobulin Subtypes in Knock-In Mice
Zhou, Y., Zhao, W., Al‐Muhtasib, N., & Rebeck, G. W. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142184 · Cited by 9
Johnson, C. N., Lysaker, C. R., McCoin, C. S., Evans, M. R., Thyfault, J. P., Wilkins, H., Morris, J. K., & Geiger, P. C. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1486762 · Cited by 6
Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models
Wu, Y., Johnson, G., Zhao, F., Wu, Y., Zhao, G., Brown, A. J., You, S., Zou, M., & Song, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158262 · Cited by 10
Age and APOE affect L-carnitine system metabolites in the brain in the APOE-TR model
Huguenard, C. J. C., Cseresznye, A., Darcey, T. S., Nkiliza, A., Evans, J. E., Hazen, S. L., MULLAN, M. J., Crawford, F., & Abdullah, L. I. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1059017 · Cited by 9
Bonnar, O., Shaw, K., Anderle, S., Grijseels, D. M., Clarke, D., Bell, L., King, S. L., & Hall, C. N. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231172842 · Cited by 8
Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels
den Hoedt, S., Janssen, C. I. F., Astarita, G., Piomelli, D., Leijten, F. P. J., Crivelli, S. M., Verhoeven, A. J. M., de Vries, H. E., Walter, J., Martínez‐Martínez, P., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160739 · Cited by 8
ApoE4 Exacerbates Hippocampal Pathology Following Acute Brain Penetration Injury in Female Mice
Ben‐Moshe, H., Luz, I., Liraz, O., Boehm‐Cagan, A., Salomon‐Zimri, S., & Michaelson, D. M. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01397-7 · Cited by 8
Somatic gene therapy for dyslipidemias
Belalcazar, M., & Chan, L. (1999) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(99)90199-3 · Cited by 8
Lysaker, C. R., Johnson, C. N., Csikós, V., Franczak, E., Benson, M. N., Gilmore, C. A., Birky, C. J., Davis, X. C., McCoin, C. S., Smith, K. P., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.15.659811 · Cited by 8
Grenon, M. B., Papavergi, M.-T., Bathini, P., Sadowski, M. J., & Lemere, C. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115754 · Cited by 7
APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of Aging
Winter, S., Mahzarnia, A., Anderson, R. J., Han, Z. Y., Tremblay, J. T., Stout, J. A., Moon, H. S., Marcellino, D. J., Dunson, D. B., & Badea, A. (2023) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2024.110251 · Cited by 9
Hayden, E. Y., Huang, J., Charreton, M., Nuñez, S., Putman, J. N., Teter, B., Lee, J. T., Welch, A. E., Frautschy, S. A., Cole, G. M., et al. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00786-0 · Cited by 7
Twitto‐Greenberg, R., Zaltsman, S. L., Michaelson, D. M., Liraz, O., Lubitz, I., Atrakchi, D., Shemesh, C., Ashery, U., Cooper, I., Harari, A., et al. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.09.005 · Cited by 7
Apolipoprotein E loss of function: Influence on murine brain markers of physiology and pathology
Buchanan, H. M., Hull, C. E., Barraza, M. C., Delibegović, M., & Platt, B. (2022) · Aging Brain · doi:10.1016/j.nbas.2022.100055 · Cited by 7
Adams, K. J., Wilson, J. G., Millington, D. S., Moseley, M. A., Colton, C. A., Thompson, J. W., & Gottschalk, W. K. (2021) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.1c00055 · Cited by 7
Characterization of the nucleotide binding properties of the 90 kDa heat shock protein (Hsp90)
Sőti, C., & Csermely, P. (1998) · Journal of Biosciences · doi:10.1007/bf02936127 · Cited by 7
Mouse models as tools for dissecting disorders of lipoprotein metabolism
Marschang, P., & Herz, J. (2003) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084-9521(02)00169-6 · Cited by 7
[Experimental models of cardiovascular disease].
Hernández, A. G., Ramírez-Tortosa, M. C., García, M. C. A., & García, M. D. M. (2007) · PubMed · Cited by 7
Wang, Y., Gao, Y., Wang, Y., Zhang, F., Sun, F., Wang, X., Xie, J., Xu, Z., Zhang, J., Xu, H., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70575 · Cited by 7
Evans, V. C., Graham, I. R., Athanasopoulos, T., Galley, D. J., Jackson, C. L., Simons, J. P., Dickson, G., & Owen, J. S. (2010) · Metabolism · doi:10.1016/j.metabol.2010.04.015 · Cited by 6
Biosca-Brull, J., Basaure, P., Guardia-Escote, L., Cabré, M., Blanco, J., Morales‐Navas, M., Sánchez-Santed, F., & Colomina, M. T. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116969 · Cited by 7
Obesity affects brain cortex gene expression in an APOE genotype and sex dependent manner
Pandit, H., Jones, N. S., & Rebeck, G. W. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01481-y · Cited by 6
Flexibility as a marker of early cognitive decline in humanized apolipoprotein E ε4 (ApoE4) mice
Schmitt, J., Paradis, A., Boucher, M., Andrieu, L., Barnéoud, P., & Rondi‐Reig, L. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.013 · Cited by 6
Diet enriched in omega‐3 fatty acids alleviates olfactory system deficits in APOE4 transgenic mice
Lessard‐Beaudoin, M., Gonzalez, L. M., Alotaibi, M. M., Chouinard‐Watkins, R., Plourde, M., Calon, F., & Graham, R. K. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15472 · Cited by 6
Kessler, K., Giannisis, A., Bial, G., Foquet, L., Nielsen, H. M., & Raber, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-28165-3 · Cited by 6
Rai, A., Ojiakor, O. A., & Rylett, R. J. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15904 · Cited by 6
Quantitative Trait Locus Mapping in Rice
Gouda, G., Sabarinathan, S., Gupta, M. K., Donde, R., Dash, G. K., Ponnana, M., Rajesh, N., Rathore, S. K., Pati, P., Vadde, R., et al. (2021) · Springer eBooks · doi:10.1007/978-981-16-3997-5_3 · Cited by 6
Borkowski, K., Liang, N., Zhao, N., Arnold, M., Huynh, K., Karu, N., Mahmoudiandehkordi, S., Kueider-Paisley, A., Kanekiyo, T., Bu, G., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00888-z · Cited by 7
Anderle, S., Bonnar, O., Henderson, J., Shaw, K., Chagas, A. M., McMullan, L., Webber, A., Mcgowan, K., King, S. L., & Hall, C. N. (2025) · Communications Biology · doi:10.1038/s42003-025-07585-z · Cited by 5
Human ApoE2 Endows Stronger Contractility in Rat Cardiomyocytes Enhancing Heart Function
Wu, Y., Zhao, F., Sure, V. N. L. R., Ibrahim, A. D., Yu, C., Carr, S. M., & Song, P. (2023) · Cells · doi:10.3390/cells12030347 · Cited by 5
Chaklai, A., Rhea, E. M., O’Niel, A., Babin, A., Weaver, R. R., Pemberton, S., Banks, W. A., & Raber, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-62053-8 · Cited by 5
Rueter, J., Rimbach, G. H., Treitz, C., Schloesser, A., Lüersen, K., Tholey, A., & Huebbe, P. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04706-x · Cited by 5
Role of white matter hyperintensity in effects of apolipoprotein E on cognitive injury
Raber, J., & Silbert, L. C. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1176690 · Cited by 5
Liemisa, B., Newbury, S. F., Novy, M. J., Pasato, J., Morales‐Corraliza, J., Peng, K. Y., & Mathews, P. M. (2023) · Aging Brain · doi:10.1016/j.nbas.2023.100102 · Cited by 5
Villasana, L., Akinyeke, T. O., Weber, S. J., & Raber, J. (2017) · Oncotarget · doi:10.18632/oncotarget.20603 · Cited by 5
Santino, A., Tallada, V. A., Jiménez, J., & Garzón, A. (2012) · Current Genetics · doi:10.1007/s00294-012-0376-4 · Cited by 5
Daniel, S., Sőti, C., Csermely, P., Bradley, G., & Blatch, G. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-49310-7_3 · Cited by 5
Malek, G., Mace, B. E., Saloupis, P., Schmechel, D. E., Rickman, D. W., Sullivan, P. M., & Rickman, C. B. (2007) · Springer eBooks · doi:10.1007/0-387-32442-9_17 · Cited by 5
Self-citationATP sensitive tryptophans of hsp90
Bartha, B. B., Ajtai, K., Toft, D. O., & Burghardt, T. P. (1998) · Biophysical Chemistry · doi:10.1016/s0301-4622(98)00114-8 · Cited by 5
ApoE isoform-specific differences in behavior and cognition associated with subchronic MPTP exposurePreprint
Torres, E. R. S., Boutros, S. W., Meshul, C. K., & Raber, J. (2020) · Learning & Memory · doi:10.1101/lm.052126.120 · Cited by 5
Hou, X., Heckman, M. G., Fiesel, F. C., Koga, S., Soto‐Beasley, A. I., Watzlawik, J. O., Zhao, J., Valentino, R. R., Johnson, P. W., White, L. J., et al. (2023) · medRxiv · doi:10.1101/2023.10.16.23297100 · Cited by 6
Chockanathan, U., & Padmanabhan, K. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15636 · Cited by 6
The Dynamic SUMOylation Changes and Their Potential Role in the Senescence of APOE4 Mice
Xu, Y., Cai, W., Sang, S., Cheng, X., Jin, B., Zhao, X., & Zhong, C. (2023) · Biomedicines · doi:10.3390/biomedicines12010016 · Cited by 4
Peng, K. Y., Liemisa, B., Pasato, J., D’Acunzo, P., Pawlik, M., Heguy, A., Penikalapati, S. C., Labuza, A., Pidikiti, H., Alldred, M. J., et al. (2024) · Traffic · doi:10.1111/tra.12937 · Cited by 4
Peris‐Sampedro, F., Guardia-Escote, L., Basaure, P., Cabré, M., & Colomina, M. T. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112552 · Cited by 5
Novy, M. J., Newbury, S. F., Liemisa, B., Morales‐Corraliza, J., Alldred, M. J., Ginsberg, S. D., & Mathews, P. M. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.10.015 · Cited by 4
Londoño, C. A., DeKroon, R. M., Mocanu, M., Booe, J., Winnik, W., Swank, A., Osorio, C., Hamlett, E. D., & Álzate, Ó. (2012) · Electrophoresis · doi:10.1002/elps.201200219 · Cited by 4
Correction: In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS
Wildsmith, K. R., Basak, J. M., Patterson, B. W., Pyatkivskyy, Y., Kim, J., Yarasheski, K. E., Wang, J. X., Mawuenyega, K. G., Jiang, H., Parsadanian, M., et al. (2012) · PLoS ONE · doi:10.1371/annotation/9bd329b7-cdea-45ec-a4aa-a173855dc0b9 · Cited by 4
NHE6-Depletion Corrects ApoE4-Mediated Synaptic Impairments and Reduces Amyloid Plaque LoadPreprint
Pohlkamp, T., Xian, X., Wong, C. H. Y., Durakoglugil, M. S., Werthmann, G. C., Saido, T., Evers, B. M., White, C. L., Connor, J., Hammer, R. E., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.22.436385 · Cited by 4
Richards, S. E. V., Yang, M., Deik, A. A., & Ricq, E. L. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04463-2 · Cited by 3
Labuza, A., Pidikiti, H., Alldred, M. J., Ibrahim, K. W., Peng, K. Y., Pasato, J., Heguy, A., Mathews, P. M., & Ginsberg, S. D. (2025) · Brain Sciences · doi:10.3390/brainsci15101117 · Cited by 4
Wang, Y., Liu, H., Ye, Y., Fang, W., Lin, A., Dai, X., Ye, Q., Chen, X., & Zhang, J. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02093-3 · Cited by 4
Cho, J., Alexander, K. L., Ferrell, J. L., Johnson, L. A., Estus, S., & D’Orazio, S. E. F. (2023) · Infection and Immunity · doi:10.1128/iai.00251-23 · Cited by 3
Taylor, C. E., Mendenhall, L. E., Sunshine, M. D., Wilson, J. N., Calulot, C. M., Sun, R. C., Johnson, L. A., & Alilain, W. J. (2024) · Journal of Neurophysiology · doi:10.1152/jn.00255.2023 · Cited by 3
O’Niel, A., Pederson, A., Saltontall, E., Nguyen, K., Pantoja, M., Chaudhari, M., Sandholm, P., Yoon, E., Harrison, H. F., Boutros, S. W., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1473366 · Cited by 3
Baer, L., Barthelson, K., Postlethwait, J. H., Adelson, D. L., Pederson, S., & Lardelli, M. T. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011868 · Cited by 3
Cardiovascular DiseaseMouse Models of Atherosclerosis
MAEDA, N., CGIVENS, R., & LReddick, R. (2007) · Elsevier eBooks · doi:10.1016/b978-012369454-6/50070-4 · Cited by 3
Self-citationAPOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of AgingPreprint
Winter, S., Mahzarnia, A., Anderson, R. J., Han, Z. Y., Tremblay, J. T., Stout, J. A., Moon, H. S., Marcellino, D. J., Dunson, D. B., & Badea, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.04.560954 · Cited by 3
O’Niel, A., Parkins, C. J., Pederson, A., Saltonstall, E., Bunnell, E., Aggarwal, R., Sandholm, P., Kessler, K., Harrison, H. F., Smith, J. R., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1600119 · Cited by 2
Nazareth, M., Duck, S. A., Fassinger, A., Elmore, G., Pinto, C., Nugent, M., Pierre, M. S., Lechner, C., Jantzie, L. L., Northington, F. J., et al. (2025) · Developmental Neuroscience · doi:10.1159/000548432 · Cited by 2
Lee, S. M., Kim, J. W., Jeong, Y.-H., Kim, S. E., Kim, Y. J., Moon, S. J., Lee, J., Kim, K. J., Kim, M., & Kang, M. (2014) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2014.14222 · Cited by 2
Simmons, K. E., Healey, K. L., Li, Q., Moore, S. D., & Klein, R. C. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14717 · Cited by 2
Amyloid β-Peptide Effects on Glucose Regulation Are Dependent on Apolipoprotein E Genotype
Sung, J. H., Ou, Y., & Barger, S. W. (2023) · eNeuro · doi:10.1523/eneuro.0376-22.2023 · Cited by 2
Gottschalk, W. K., Mahon, S., Hodgson, D., Barrera, J., Hill, D., Wei, A. L., Kumar, M., Dai, K. Z., Anderson, L., Mihovilovic, M., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230451 · Cited by 2
Fagla, B. M., York, J. M., Christensen, A., Rosa, C. D., Balu, D., Pike, C. J., Tai, L. M., & Buhimschi, I. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-66489-w · Cited by 2
Calon, F. (2014) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2014.03.003 · Cited by 4
Molecular dynamics analyses of the dissociation process of ADP from Hsp90
Kawaguchi, K., Takagi, H., Iwayama, M., Nishimura, M., Miyakawa, T., Saito, H., Takasu, M., & Nagao, H. (2012) · International Journal of Quantum Chemistry · doi:10.1002/qua.24229 · Cited by 2
Rueter, J., Rimbach, G. H., & Huebbe, P. (2023) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2023.194942 · Cited by 2
Experimental Models of Oxidative Stress Related to Cardiovascular Diseases and Diabetes
Mesa, M. D., Aguilera, C. M., & Gil, Á. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-956-7_2 · Cited by 2
Malek, G., Yao, P., & Choudhary, M. (2020) · Topics in medicinal chemistry · doi:10.1007/7355_2020_93 · Cited by 2
Malek, G., Jamison, J. A., Mace, B. E., Sullivan, P. M., & Rickman, C. B. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-74904-4_18 · Cited by 2
Self-citationPerturbed Brain Energy Metabolism in Alzheimer’s Disease and Diabetes
Wu, L. (2017) · KU ScholarWorks (University of Kansas) · Cited by 2
APOE4 Regulates Synaptic Function by Directly Modulating the SNARE Complex AssemblyPreprint
Chen, F., Chen, Y., Chen, H., Wang, Y., Wei, W., Cai, Y., Liang, C., Cao, H., Chen, X., Ji, Y., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-380304/v1 · Cited by 3
Imaging Biomarkers for Alzheimer's Disease Using Magnetic Resonance Microscopy
Badea, A., Stout, J. A., Anderson, R. J., Cofer, G. P., Duan, L. L., & Vogelstein, J. T. (2022) · Wiley eBooks · doi:10.1002/9783527827244.ch13 · Cited by 2
Yılmaz, E., Chen, K. W., Cakir, E. Ö., Bhattarai, P., Liu, M., Ciener, B., Qiao, M., Lantigua, R., Medrano, M. Z., Rivera, D., et al. (2025) · medRxiv · doi:10.1101/2025.05.21.25328040 · Cited by 4
APOE4-drives brain bioenergetic shifts independent of Alzheimer’s disease pathology
Lysaker, C. R., Johnson, C. N., Csikos, V., Franczak, E., Benson, M., Gilmore, C. A., Birky, C. J., Davis, X., McCoin, C. S., Smith, K. P., et al. (2026) · npj Dementia · doi:10.1038/s44400-026-00105-8 · Cited by 1
Singh, T., Bridgeman, E., Baker, A. J., Noblet, H. A., Yang, K. Y., Kang, S., Lim, K. H., Lee, S. S., Amundsen, N. M., Lee, Y., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107246 · Cited by 1
Guardia-Escote, L., Biosca-Brull, J., Blanco, J., Cabré, M., Basaure, P., Pérez-Fernández, C., Sánchez-Santed, F., Domingo, J. L., & Colomina, M. T. (2025) · NeuroToxicology · doi:10.1016/j.neuro.2025.07.004 · Cited by 1
Sambhariya, W. S., Rickman, C. B., D'Amore, P. A., Corradetti, G., Hageman, G. S., Howell, G. R., Marola, O. J., Phatnani, H. P., Philp, N. J., Sinha, D., et al. (2026) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2026.101449 · Cited by 1
Wang, N., Yu, G., Wang, Z., Alnobani, A., Jeevaratnam, S., Zhang, X., McReynolds, M. G., Chang, Y., Qi, F., Tauer, W., et al. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00940-6 · Cited by 1
Luo, N., Pandit, H., Kalra, S., Tran, E., Mandelblatt, J. S., Vicini, S., & Rebeck, G. W. (2026) · PLoS ONE · doi:10.1371/journal.pone.0343276 · Cited by 1
Hui, D. Y., Alagarsamy, J., Haller, A. M., Medvedovic, M., & Jaeschke, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125619 · Cited by 1
Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease
Bhattarai, P., Yılmaz, E., Cakir, E. Ö., Tayran, H., Haq, I., Murphy, D., Keller, J. N., Grand, Q. L., Eschbach, J., Çelikkaya, H., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01204-0 · Cited by 1
APOE-Based Models of “Pre-Dementia”
Sullivan, P. M. (2010) · Neuromethods · doi:10.1007/978-1-60761-898-0_22 · Cited by 1
Self-citationBassett, C. N., Swift, L. L., Montine, K. S., Markesbery, W. R., & Montine, T. J. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4103 · Cited by 1
Insights into synaptic function from mouse models of human cognitive disorders
Banko, J. L., Trotter, J. H., & Weeber, E. J. (2010) · Future Neurology · doi:10.2217/fnl.10.80 · Cited by 1
Entropy estimation within in vitro neural-astrocyte networks as a measure of development instability
Teneggi, J., Chen, X., Balu, A., Barrett, C., Grisolia, G., Lucia, U., & Dzakpasu, R. (2021) · Physical review. E · doi:10.1103/physreve.103.042412 · Cited by 1
Pratt, W. B., Morishima, Y., & Osawa, Y. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6401-2_1 · Cited by 1
Metadata
- Authors
- Sullivan, P. M., Mezdour, H., Aratani, Y., Knouff, C., Najib, J., Reddick, R. L., Quarfordt, S. H., & Maeda, N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Duke Medical Center (US)
- Corresponding author
- Maeda, Nobuyo
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 272
- Issue
- 29
- Pages
- 17972-17980
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2011885704
- Cited by
- 575
- References
- 48
- Citations by year
- 2026: 17 · 2025: 26 · 2024: 25 · 2023: 39 · 2022: 28 · 2021: 32 · 2020: 31 · 2019: 21 · 2018: 12 · 2017: 20 · 2016: 27 · 2015: 22 · 2014: 29 · 2013: 21 · 2012: 29
- FWCI
- 15.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Heart, Lung, and Blood Institute (HL 42630)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- apolipoprotein E, APOE3, gene replacement, transgenic mice, hypercholesterolemia, atherosclerosis, serum lipoproteins, apolipoprotein B-100, high-fat diet, LDL receptor, cholesterol homeostasis, aortic plaque
- MeSH terms
- Alleles, Animals, Apolipoproteins E, Arteriosclerosis, Cholesterol, Diet, Atherogenic, Female, Homozygote, Humans, Hypercholesterolemia, Cholesterol, HDL, Male, Mice, Transgenic, Stem Cells, Triglycerides, Restriction Mapping, Mice, Apolipoprotein E3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
