The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis
Open accessAbstract
Apolipoprotein (apo) E, a constituent of several lipoproteins, is a ligand for the low density lipoprotein receptor, and this interaction is important for maintaining cholesterol and triglyceride homeostasis. We have used a gene replacement strategy to generate mice that express the human apoE3 isoform in place of the mouse protein. The levels of apoE mRNA in various tissues are virtually the same in the human apoE3 homozygous (3/3) mice and their littermates having the wild type mouse allele (+/+). Total cholesterol and triglyceride levels in fasted plasma from the 3/3 mice were not different from those in the +/+ mice, when maintained on a normal (low fat) chow diet. We found, however, notable differences in the distribution of plasma lipoproteins and apolipoprotein E between the two groups: beta-migrating lipoproteins and plasma apoB100 levels are decreased in the 3/3 mice, and the apoE distribution is shifted from high density lipoproteins to larger lipoprotein particles. In addition, the fractional catabolic rate of exogenously administered remnant particles without apoE was 6-fold slower in the 3/3 mice compared with the +/+ mice. When the 3/3 and +/+ animals were fed a high fat/high cholesterol diet, the 3/3 animals responded with a dramatic increase (5-fold) in total cholesterol compared with the +/+ mice (1.5-fold), and after 12 weeks on this same diet the 3/3 animals developed significantly (at least 13-fold) larger atherosclerotic plaques in the aortic sinus area t…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“To determine the gene dosage effect of human APOE3 and APOE4 on amyloid deposition, we used knock-in mouse models in which the endogenous murine Apoe gene is replaced with the APOE3 or APOE4 gene.”
From Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-β Amyloidosis (2011) · cites this paper as Sullivan et al., 1997
In the citing paper
“APOE ε2-TR or APOE ε4-TR mice retain regulatory sequences of the mouse Apoe gene and the noncoding murine exon 1 surrounding the inserted human exons 2′, 3′, and 4′ [17,18] and therefore, they express the human apoE protein at physiological levels.”
From Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice (2014) · cites this paper as [18]
In the citing paper
“APOE targeted replacement mice, which express human APOE in place of their mouse Apoe gene and which do not develop overt AD pathology28,29”
From APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice (2020) · cites this paper as [29]
In the citing paper
“These APOE TR mice were previously generated by removing and replacing the endogenous mouse Apoe gene with the human APOE gene 51,52 .”
From APOE4-drives brain bioenergetic shifts independent of Alzheimer’s disease pathology (2026) · cites this paper as [51]
In the citing paper
“APOE-TR mice, which are genetically chimeric, i.e. contain the mouse 5’ regulatory region but human exons 2–4 (Knouff et al., 1999; Sullivan et al., 1997)”
From Cholesterol and matrisome pathways dysregulated in astrocytes and microglia (2022) · cites this paper as Sullivan et al., 1997
In the citing paper
“By contrast, NHE6 ablation led to glial activation and decreased plaque load in ApoeAPOE4 (Sullivan et al., 1997) and AppNL-F (Saito et al., 2014) double knockin mice.”
From NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load (2021) · cites this paper as Sullivan et al., 1997
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
Thomas, P. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5201 · Cited by 7,937
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701
Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., & Mulligan, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90011-m · Cited by 1,281
Herz, J., Hamann, U., Rogne, S., Myklebost, O., Gausepohlꝉ, H., & Stanley, K. K. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03306.x · Cited by 955
Apolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830
Human apolipoprotein E. The complete amino acid sequence
Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34702-1 · Cited by 741
Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34954-8 · Cited by 673
Research works printed but not linked: 3
- Hallman, 1991, Am. J. Hum. Genet., 49, 338
- Chomczynski, 1987, Anal. Biochem., 162, 156, 10.1016/0003-2697(87)90021-2 · DOI
- Landis, 1987, Am. J. Physiol., 252, C805
Cited by
Sorted by citations
Items 501–576 of 576
Studying the Genetics of Complex But Common Human Diseases Using Mice
Maeda, N., & Smithies, O. (2000) · Springer eBooks · doi:10.1007/978-0-387-21628-7_22 · Cited by 1
Self-citationApolipoprotein E: Structural and Functional Interactions with Amyloid β
Stine, W. B., & LaDu, M. J. (2005) · Wiley eBooks · doi:10.1002/9783527619344.ch10 · Cited by 1
GENETIC ANALYSIS OF ISCHEMIC STROKE AND PREDISPOSING CAROTID ARTERY STENOSIS
Kostulas, K. (2007) · Cited by 1
Barthelson, K., Newman, M., & Lardelli, M. T. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.16.431539 · Cited by 1
Bonnar, O., Shaw, K., Grijseels, D. M., Clarke, D., Bell, L., Anderle, S., King, S. L., & Hall, C. N. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.26.445731 · Cited by 1
Vastrad, B. M., Pattanashetti, S., & Vastrad, C. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.13.618070 · Cited by 1
APOE4 alters the lipid droplet proteome and modulates droplet dynamicsPreprint
Friday, C. M., Stephens, I. O., Smith, C. T., Lee, S., Satish, D., Devanney, N. A., Cohen, S., Morganti, J. M., Gordon, S. M., & Johnson, L. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.16.628710 · Cited by 1
Prescott, E. E., Wei, J., Garland, E. F., Urbanek, A. N., Capriglia, F., Molenkamp, W. H., Rhodes, D. P., Heywood, L. D., Schwartzentruber, A., Stephen, E., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.17.676873 · Cited by 1
Schmechel, D. E., Xu, P., Gilbert, J. R., & Roses, A. D. (1999) · Springer eBooks · doi:10.1007/978-1-4615-4887-4_10 · Cited by 1
Mechanisms underlying the atherosclerosis risk associated with apolipoprotein E isoforms in humans
Altenburg, M. K. (2007) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/c6pc-dx08
Koutseff, A. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique)
Biomolecular studies in Alzheimer’s Disease models: investigations in vitro and in vivo
Lattanzio, F. (2013) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/5507
Chapter 5.1 Microdialysis in genetically altered animals
Sotnikova, T. D., & Gainetdinov, R. R. (2006) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(06)16021-x
Granic, A. (2011) · Digital Commons - University of South Florida (University of South Florida)
Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
Basak, J. M. (2014) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7dz06bk
Biologie, A. F., & Dieckmann, M. (2010)
Rodriguez, G. A. (2014) · DigitalGeorgetown (Georgetown University Library)
Les animaux génétiquement modifiés
Baroukh, N., Vergnes, L., Ostos, M. A., Zakin, M. M., & Ochoa, A. (2000) · Annales de l Institut Pasteur / Actualités · doi:10.1016/s0924-4204(00)80017-7
Slim, K. (2015) · UEA Digital Repository (University of East Anglia)
Apolipoprotein E and Mitochondria-associated Endoplasmic Reticulum Dysfunction
Tambini, M. D. (2016)
Fibrin Formation and Dissolution in the Progression of Amyloid-Beta Pathology in Alzheimer's Disease
Paul, J. (2025) · Digital Commons - RU (Rockefeller University) · doi:10.48496/m50g-qv97
Alzheimer’s Disease Therapeutics Targeting Apolipoprotein E
Liao, F., & Holtzman, D. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802173-6.00010-1
Albrecht, M. A., & Foster, J. K. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3777-6_7
How Can we Know What the Latest Findings Mean?
Kohlmeier, M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385900-6.00006-x
Sampedro, F. P. (2016) · TDX (Tesis Doctorals en Xarxa)
Chaperone Action in Folding Newly-Translated Cytosolic Proteins in Bacteria and Eukaryotes
Horwich, A. L. (1998) · Springer eBooks · doi:10.1007/978-3-642-51463-0_4
Estrogen Receptor β Regulates Brain Signaling Involved in Depression
Chhibber, A. (2016) · KU ScholarWorks (The University of Kansas)
APOE2 promotes longevity independent of Alzheimer’s diseasePreprint
Shinohara, M., Kanekiyo, T., Tachibana, M., Kurti, A., Shinohara, M., Fu, Y., Zhao, J., Han, X., Sullivan, P. M., Rebeck, W. G., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.31.255141
Self-citationThe interactive impact of omega-3 fatty acids, APOE genotype and sex hormones on cognition
Pontifex, M. G. (2020) · UEA Digital Repository (University of East Anglia)
Strattan, L. E. (2021) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2021.097
Modelling of ischemic stroke : focus on co-morbidities and therapeutic intervention
Dhungana, H. (2014) · UEF eRepo (University of Eastern Finland)
The APOE4 Mouse as a Model of Chemotherapy-induced Cognitive Impairments and Senescence
Demby, T. C. (2021) · DigitalGeorgetown (Georgetown University Library)
Faculty Opinions recommendation of Direct transcriptional effects of apolipoprotein E.
Rujescu, D., & Jung, M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726091077.793558447
Dorrance, A. M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734038755.793557090
Mak, T. W., Penninger, J. M., Roder, J., Rossant, J., & Saunders, M. E. (1998) · Elsevier eBooks · doi:10.1016/b978-012466044-1/50027-2
Taylor, C. E., Mendenhall, L. E., Sunshine, M. D., Wilson, J. N., Calulot, C. M., Sun, R. C., Johnson, L. A., & Alilain, W. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.03.502692
Apolipoprotein E Isoform-Related Translational Measures in PTSD Research
Torres, E. R. S., DeBarber, A. E., & Raber, J. (2023) · Neuromethods · doi:10.1007/978-1-0716-3218-5_8
The establishment and application of animal models for neurodegenerative diseases
Pan, J., Zhang, L., Wang, Q., Zhao, D., Huang, Z., Wei, C., Ma, X., & Qin, C. L. (2023) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2023-0764
Roubeix, C., Nous, C., Augustin, S., Ronning, K. E., Mathis, T., Blond, F., Lagouge-Roussey, P., Crespo‐Garcia, S., Sullivan, P. M., Gautier, E. L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25017793
Self-citationChan, D., Spires‐Jones, T. L., Provenzano, F. A., Glennon, E. B. C., & Duff, K. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0020
NaviGraph: A graph-based framework for multimodal analysis of spatial decision-makingPreprint
Koren-Iton, A., Iton, E., Bikovski, L., Michaelson, D. M., & Blinder, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.18.654725
Thorwald, M. A., Cacciottolo, M., Hou, X., Morgan, T. E., & Finch, C. E. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251386812
Ringland, C., Schweig, J. E., Eisenbaum, M., Paris, D., Ait‐Ghezala, G., Mullan, M., Crawford, F., Abdullah, L. I., & Bachmeier, C. (2021) · Figshare · doi:10.6084/m9.figshare.14677003
Wang, S., Li, B., Solomon, V. A., Fonteh, A. N., Rapoport, S. I., Bennett, D. A., Arvanitakis, Z., Chui, H. C., Sullivan, P. M., & Yassine, H. N. (2022) · Figshare · doi:10.6084/m9.figshare.20080941
Self-citationFarmer, B. C., Williams, H. C., Devanney, N. A., Piron, M. A., Nation, G. K., Carter, D. J., Walsh, A. E., Khanal, R., Young, L. E. A., Kluemper, J. C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16575414
Wang, S., Li, B., Solomon, V. A., Fonteh, A. N., Rapoport, S. I., Bennett, D. A., Arvanitakis, Z., Chui, H. C., Sullivan, P. M., & Yassine, H. N. (2022) · Figshare · doi:10.6084/m9.figshare.20080938
Self-citationWilliams, T., Bathe, T., Vo, Q., Sacilotto, P., McFarland, K., Ruiz, A. J., Hery, G. P., Sullivan, P. M., Borchelt, D. R., Prokop, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23543276
Self-citationWilliams, T., Bathe, T., Vo, Q., Sacilotto, P., McFarland, K., Ruiz, A. J., Hery, G. P., Sullivan, P. M., Borchelt, D. R., Prokop, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23543279
Self-citationWang, S., Li, B., Solomon, V. A., Fonteh, A. N., Rapoport, S. I., Bennett, D. A., Arvanitakis, Z., Chui, H. C., Miller, C. A., Sullivan, P. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14442868
Self-citationLloyd, G. M., Long, B., Quintin, S. S., Sorrentino, Z. A., Gorion, K.-M. M., Bell, B. M., Carrillo, D., Sullivan, P. M., Borchelt, D. B., & Giasson, B. I. (2024) · Figshare · doi:10.6084/m9.figshare.26606044
Self-citationWilliams, T., Bathe, T., Vo, Q., Sacilotto, P., McFarland, K., Ruiz, A. J., Hery, G. P., Sullivan, P. M., Borchelt, D. R., Prokop, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23543273
Self-citationWilliams, T., Bathe, T., Vo, Q., Sacilotto, P., McFarland, K., Ruiz, A. J., Hery, G. P., Sullivan, P. M., Borchelt, D. R., Prokop, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23543264
Self-citationAdditional file 12 of Impact of APOE genotype on prion-type propagation of tauopathy
Williams, T., Ruiz, A. J., Ruiz, A. M., Vo, Q., Tsering, W., Xu, G., McFarland, K., Giasson, B. I., Sullivan, P. M., Borchelt, D. R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19619142
Self-citationWilliams, T., Bathe, T., Vo, Q., Sacilotto, P., McFarland, K., Ruiz, A. J., Hery, G. P., Sullivan, P. M., Borchelt, D. R., Prokop, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23543267
Self-citationWilliams, T., Bathe, T., Vo, Q., Sacilotto, P., McFarland, K. N., Ruiz, A. J., Hery, G. P., Sullivan, P. M., Borchelt, D. R., Prokop, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23543261
Self-citationRoubeix, C., Nous, C., Augustin, S., Ronning, K. E., Mathis, T., Blond, F., Lagouge-Roussey, P., Crespo‐Garcia, S., Sullivan, P. M., Gautier, E. L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25017933
Self-citationVitek, M. P., Brown, C. M., & Colton, C. A. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_57-1
Tri-AD: Hippocampal cell-type-specific responses to age, sex and APOE genotypePreprint
Li, Y., Hao, Y., Serras, C. P., Yao, L., Liang, Z., Almonte-Loya, A., Blumenfeld, J. R., Suan, K., Yoon, S. Y., Grone, B. P., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.03.691944
Mouse models elucidating the role of apolipoprotein E in neurological conditions
Torres, E. R. S., & Raber, J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29090-9.00001-5
Role of apolipoprotein E4 in alzheimer’s disease pathogenesis and emerging therapeutic strategies
Natarajan, S., & Saraswathy, S. D. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01761-0
APOE genotype differentially modulates prion pathology in a mouse model
Lizińczyk, A. M., Pankiewicz, J. E., Cullina, W. L., Franco, L. A., Sullivan, P. M., & Sadowski, M. J. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02207-5
Self-citationRaber, J., & Nielsen, H. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_41-1
Vitek, M. P., Brown, C. M., & Colton, C. A. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_57
Raber, J., & Nielsen, H. M. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_41
Frosina, M., Maurotti, S., Castagna, A., Montalcini, T., Pujia, A., & Tirinato, L. (2026) · MedComm · doi:10.1002/mco2.70789
APOE4-Expressing Astrocytes Exhibit Parkinson’s Disease–Related Pathology
Nechushtai, L., Anna, P., Roni, H., Daniel, M. M., Dan, F., & Pinkas‐Kramarski, R. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05996-5 · Cited by 1
Zhang, X., Zhuang, D., Lai, C., Zheng, C., Soh, Z. D., Wagner, S. K., Cai, V. Y., Yang, Z., Wang, S., Geng, X., et al. (2026) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2026.101504
A review of animal models of vascular dementia
Song, Y., & Chen, Y. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12401-w
Ledesma‐Corvi, S., Blankers, S. A., McGovern, A. J., Towriss, M., Kim, J. S., Ciernia, A. V., & Galea, L. A. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.31.748388
Bunnell, E., Saltonstall, E., Shanava, E., O’Niel, A., Pederson, A., Marla, S., Llamas, M. L. S., Garg, I., Chaudhari, M., Vodapally, S., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1899626
Human brain cellular xenografts in neuroimmunology and beyond
Fattorelli, N., Martínez‐Muriana, A., Perry, V. H., & Mancuso, R. (2026) · Immunity · doi:10.1016/j.immuni.2026.09.024
Non-alcoholic steatohepatitis : second hit or strike out?
Wouters, K. (2008) · Research Publications (Maastricht University) · doi:10.26481/dis.20081203kw
Metadata
- Authors
- Sullivan, P. M., Mezdour, H., Aratani, Y., Knouff, C., Najib, J., Reddick, R. L., Quarfordt, S. H., & Maeda, N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Duke Medical Center (US)
- Corresponding author
- Maeda, Nobuyo
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 272
- Issue
- 29
- Pages
- 17972-17980
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2011885704
- Cited by
- 575
- References
- 48
- Citations by year
- 2026: 17 · 2025: 26 · 2024: 25 · 2023: 39 · 2022: 28 · 2021: 32 · 2020: 31 · 2019: 21 · 2018: 12 · 2017: 20 · 2016: 27 · 2015: 22 · 2014: 29 · 2013: 21 · 2012: 29
- FWCI
- 15.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Heart, Lung, and Blood Institute (HL 42630)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- apolipoprotein E, APOE3, gene replacement, transgenic mice, hypercholesterolemia, atherosclerosis, serum lipoproteins, apolipoprotein B-100, high-fat diet, LDL receptor, cholesterol homeostasis, aortic plaque
- MeSH terms
- Alleles, Animals, Apolipoproteins E, Arteriosclerosis, Cholesterol, Diet, Atherogenic, Female, Homozygote, Humans, Hypercholesterolemia, Cholesterol, HDL, Male, Mice, Transgenic, Stem Cells, Triglycerides, Restriction Mapping, Mice, Apolipoprotein E3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
