The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
p140Sra-1 (Specifically Rac1-associated Protein) Is a Novel Specific Target for Rac1 Small GTPase
Open accessAbstract
Rac1 small GTPase plays pivotal roles in various cell functions such as cell morphology, cell polarity, and cell proliferation. We have previously identified IQGAP1 from bovine brain cytosol as a target for Rac1 by an affinity purification method. By using the same method, we purified a specifically Rac1-associated protein with a molecular mass of about 140 kDa (p140) from bovine brain cytosol. This protein interacted with guanosine 5'-(3-O-thio)triphosphate (GTPgammaS).glutathione S-transferase (GST)-Rac1 but not with the GDP.GST-Rac1, GTPgammaS.GST-Cdc42, or GTPgammaS.GST-RhoA. The amino acid sequences of this protein revealed that p140 is identified as a product of KIAA0068 gene. We denoted this protein as Sra-1 (Specifically Rac1-associated protein). Recombinant Sra-1 interacted with GTPgammaS.GST-Rac1 and weakly with GDP.Rac1 but not with GST-Cdc42 or GST-RhoA. The N-terminal domain of Sra-1 (1-407 amino acids) was responsible for the interaction with Rac1. Myc-tagged Sra-1 and the deletion mutant capable of interacting with Rac1, but not the mutants unable to bind Rac1, were colocalized with dominant active Rac1(Val-12) and cortical actin filament at the Rac1(Val-12)-induced membrane ruffling area in KB cells. Sra-1 was cosedimented with filamentous actin (F-actin), indicating that Sra-1 directly interacts with F-actin. These results suggest that Sra-1 is a novel and specific target for Rac1.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Indeed, GTP-Rac binds CYFIP/CYFIP1, modifying its structural conformation (Kobayashi et al., 1998; De Rubeis et al., 2013)”
From New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes (2017) · cites this paper as Kobayashi et al., 1998
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In particular, the Rac1 signaling can activate the WRC through CYFIP1 (Chen et al., 2010, Eden et al., 2002, Kobayashi et al., 1998, Schenck et al., 2003, Steffen et al., 2004).”
From CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation (2013) · cites this paper as Kobayashi et al., 1998
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Rac1 binds to two sites on CYFIP in the WAVE complex, leading to WAVE activation28,30–32.”
From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [31]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Regulation of Rabbit Skeletal Muscle Contraction
Spudich, J. A., & Watt, S. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62016-2 · Cited by 4,496
Nobes, C. D., & Hall, A. (1995) · Cell · doi:10.1016/0092-8674(95)90370-4 · Cited by 4,414
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., & Hall, A. (1992) · Cell · doi:10.1016/0092-8674(92)90164-8 · Cited by 3,616
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway
Coso, O. A., Chiariello, M., Yu, J., Teramoto, H., Crespo, P., Xu, N., Miki, T., & Gutkind, J. S. (1995) · Cell · doi:10.1016/s0092-8674(05)80018-2 · Cited by 1,629
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
Manser, E. J., Leung, T., Salihuddin, H., Zhao, Z.-S., & Lim, L. (1994) · Nature · doi:10.1038/367040a0 · Cited by 1,541
Minden, A., Lin, A., Claret, F.-X., Abo, A., & Karin, M. (1995) · Cell · doi:10.1016/s0092-8674(05)80019-4 · Cited by 1,481
The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF
Hill, C. S., Wynne, J., & Treisman, R. (1995) · Cell · doi:10.1016/s0092-8674(05)80020-0 · Cited by 1,269
Kozma, R., Ahmed, S., Best, A., & Lim, L. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.1942 · Cited by 1,021
Symons, M. H., Derry, J. M. J., Karlak, B., Jiang, S., Lemahieu, V., McCormick, F. P., Francke, U., & Abo, A. (1996) · Cell · doi:10.1016/s0092-8674(00)81050-8 · Cited by 830
Research works printed but not linked: 1
- Nishiyama, 1994, Mol. Cell. Biol., 14, 2447
Cited by
Sorted by citations
Takai, Y., Sasaki, T., & Matozaki, T. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.153 · Cited by 2,511
Rho GTPases and their effector proteins
Bishop, A. L., & Hall, A. (2000) · Biochemical Journal · doi:10.1042/bj3480241 · Cited by 2,019
Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells
Kaibuchi, K., Kuroda, S., & Amano, M. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.459 · Cited by 1,017
Self-citationThe role of the Rho GTPases in neuronal developmentPreprint
Govek, E., Newey, S. E., & Aelst, L. V. (2005) · Genes & Development · doi:10.1101/gad.1256405 · Cited by 1,030
The WASP-WAVE protein network: Connecting the membrane to the cytoskeleton.
Takenawa, T., & Suetsugu, S. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2069 · Cited by 947
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M., & Kirschner, M. W. (2002) · Nature · doi:10.1038/nature00859 · Cited by 835
PI3 Kinase Signals BCR-Dependent Mature B Cell Survival
Srinivasan, L., Sasaki, Y., Calado, D. P., Zhang, B., Paik, J. H., DePinho, R. A., Kutok, J. L., Kearney, J. F., Otipoby, K. L., & Rajewsky, K. (2009) · Cell · doi:10.1016/j.cell.2009.08.041 · Cited by 680
Neuronal polarity: from extracellular signals to intracellular mechanisms.
Arimura, N., & Kaibuchi, K. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2056 · Cited by 655
Self-citationThe Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP
Napoli, I., Mercaldo, V., Boyl, P. P., Eleuteri, B., Zalfa, F., De Rubeis, S., Di Marino, D., Mohr, E., Massimi, M., Falconi, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.031 · Cited by 609
Rac1 and Cdc42 Capture Microtubules through IQGAP1 and CLIP-170
Fukata, M., Watanabe, T., Noritake, J., Nakagawa, M., Yamaga, M., Kuroda, S., Matsuura, Y., Iwamatsu, A., Perez, F., & Kaibuchi, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00800-0 · Cited by 625
Self-citationSteering cell migration: lamellipodium dynamics and the regulation of directional persistence
Krause, M., & Gautreau, A. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3861 · Cited by 609
Chang, J.-W., Kuo, W., Lin, C.-M., Chen, W., Chan, S., Chiu, M.-F., Chang, I., Jiang, S. S., Tsai, F., Chen, C., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0253-9 · Cited by 541
The role of profilin complexes in cell motility and other cellular processes
Witke, W. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.07.003 · Cited by 540
Myoblast fusion: lessons from flies and mice
Abmayr, S. M., & Pavlath, G. K. (2012) · Development · doi:10.1242/dev.068353 · Cited by 553
Structure and control of the actin regulatory WAVE complex
Chen, Z., Borek, D., Padrick, S. B., Gomez, T. S., Metlagel, Z., Ismail, A. M., Umetani, J., Billadeau, D. D., Otwinowski, Z., & Rosen, M. K. (2010) · Nature · doi:10.1038/nature09623 · Cited by 500
Roles of Rho-family GTPases in cell polarisation and directional migration
Fukata, M., Nakagawa, M., & Kaibuchi, K. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00097-8 · Cited by 487
Self-citationFrom mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome
Bagni, C., & Greenough, W. T. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1667 · Cited by 475
Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks
Insall, R. H., & Machesky, L. M. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.08.012 · Cited by 436
Weed, S. A., Karginov, A. V., Schafer, D. A., Weaver, A. M., Kinley, A. W., Cooper, J. A., & Parsons, J. T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.1.29 · Cited by 423
Abi1 is essential for the formation and activation of a WAVE2 signalling complex
Innocenti, M., Zucconi, A., Disanza, A., Frittoli, E., Areces, L. B., Steffen, A., Stradal, T. E. B., Fiore, P. P. D., Carlier, M., & Scita, G. (2004) · Nature Cell Biology · doi:10.1038/ncb1105 · Cited by 416
Sra‐1 and Nap1 link Rac to actin assembly driving lamellipodia formation
Steffen, A., Rottner, K., Ehinger, J., Innocenti, M., Scita, G., Wehland, J., & Stradal, T. E. B. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600084 · Cited by 408
Mediation, Modulation, and Consequences of Membrane-Cytoskeleton Interactions
Doherty, G. J., & McMahon, H. T. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125912 · Cited by 378
Schenck, A., Bardoni, B., Moro, A., Bagni, C., & Mandel, J.-L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151231598 · Cited by 356
Rho GTPases, dendritic structure, and mental retardation
Newey, S. E., Velamoor, V., Govek, E., & Van Aelst, L. (2005) · Journal of Neurobiology · doi:10.1002/neu.20153 · Cited by 351
The comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13
Hogart, A., Wu, D., LaSalle, J. M., & Schanen, N. C. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.08.011 · Cited by 361
Molecular mechanisms of dendritic spine development and remodeling
Ethell, I. M., & Pasquale, E. B. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.02.003 · Cited by 367
Kunda, P., Craig, G., Dominguez, V., & Baum, B. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.005 · Cited by 341
Aspenström, P. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80011-8 · Cited by 326
Schenck, A., Bardoni, B., Langmann, C., Harden, N., Mandel, J.-L., & Giangrande, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00354-4 · Cited by 316
Rho proteins, mental retardation and the cellular basis of cognition
Ramakers, G. J. A. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02118-4 · Cited by 374
De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.039 · Cited by 296
Regulation of actin dynamics by WASP and WAVE family proteins
Stradal, T. E. B., Rottner, K., Disanza, A., Confalonieri, S., Innocenti, M., & Scita, G. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.04.007 · Cited by 286
Activation of the WAVE Complex by Coincident Signals Controls Actin Assembly
Lebensohn, A. M., & Kirschner, M. W. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.10.024 · Cited by 263
Protein complexes regulating Arp2/3-mediated actin assembly
Stradal, T. E. B., & Scita, G. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.12.003 · Cited by 267
Phosphorylation by Rho Kinase Regulates CRMP-2 Activity in Growth Cones
Arimura, N., Ménager, C., Kawano, Y., Yoshimura, T., Kawabata, S., Hattori, A., Fukata, Y., Amano, M., Goshima, Y., Inagaki, M., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.9973-9984.2005 · Cited by 267
Self-citationPhysical Mechanisms of Signal Integration by WASP Family Proteins
Padrick, S. B., & Rosen, M. K. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.060407.135452 · Cited by 254
CRMP-2 Is Involved in Kinesin-1-Dependent Transport of the Sra-1/WAVE1 Complex and Axon Formation
Kawano, Y., Yoshimura, T., Tsuboi, D., Kawabata, S., Kaneko-Kawano, T., Shirataki, H., Takenawa, T., & Kaibuchi, K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.9920-9935.2005 · Cited by 241
Self-citationYoon, K.-J., Nguyen, H. N., Ursini, G., Zhang, F., Kim, N.-S., Wen, Z., Makri, G., Nauen, D., Shin, J. H., Park, Y., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.05.003 · Cited by 240
Purification and architecture of the ubiquitous Wave complex
Gautreau, A. M., Ho, H. H., Li, J., Steen, H., Gygi, S. P., & Kirschner, M. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400628101 · Cited by 247
Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes
Innocenti, M., Gerboth, S., Rottner, K., Lai, F. P. L., Hertzog, M., Stradal, T. E. B., Frittoli, E., Didry, D., Polo, S., Disanza, A., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1304 · Cited by 236
Cdc42 and Rac1 Regulate the Interaction of IQGAP1 with β-Catenin
Fukata, M., Kuroda, S., Nakagawa, M., Kawajiri, A., Itoh, N., Shoji, I., Matsuura, Y., Yonehara, S., Fujisawa, H., Kikuchi, A., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26044 · Cited by 221
Self-citationChai, J.-H., Locke, D. P., Greally, J. M., Knoll, J. H. M., Ohta, T., Dunai, J., Yavor, A., Eichler, E. E., & Nicholls, R. D. (2003) · The American Journal of Human Genetics · doi:10.1086/378816 · Cited by 218
Pan, F., Aldridge, G. M., Greenough, W. T., & Gan, W.-B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012496107 · Cited by 208
Williams, C. L. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(03)00098-6 · Cited by 211
NIPA1 gene mutations cause autosomal dominant hereditary spastic paraplegia (SPG6)
Rainier, S., Chai, J.-H., Tokarz, D., Nicholls, R. D., & Fink, J. K. (2003) · The American Journal of Human Genetics · doi:10.1086/378817 · Cited by 207
The CRMP Family of Proteins and Their Role in Sema3A Signaling
Schmidt, E. F., & Strittmatter, S. M. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-70956-7_1 · Cited by 206
The role of Rho GTPases in disease development
Boettner, B., & Van Aelst, L. (2002) · Gene · doi:10.1016/s0378-1119(02)00426-2 · Cited by 229
Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Grossman, A. W., Aldridge, G. M., Weiler, I. J., & Greenough, W. T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1790-06.2006 · Cited by 177
Weiner, O. D., Rentel, M., Ott, A., Brown, G. E., Jedrychowski, M. P., Yaffe, M. B., Gygi, S. P., Cantley, L. C., Bourne, H. R., & Kirschner, M. W. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040038 · Cited by 185
Disanza, A., Steffen, A., Hertzog, M., Frittoli, E., Rottner, K., & Scita, G. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4472-6 · Cited by 171
FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts
Castets, M., Schaeffer, C., Bechara, E., Schenck, A., Khandjian, E. W., Luche, S., Moine, H., Rabilloud, T., Mandel, J.-L., & Bardoni, B. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi077 · Cited by 162
Derivery, E., & Gautreau, A. M. (2010) · BioEssays · doi:10.1002/bies.200900123 · Cited by 161
PIR121 Regulates Pseudopod Dynamics and SCAR Activity in Dictyostelium
Blagg, S. L., Stewart, M., Sambles, C., & Insall, R. H. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00580-3 · Cited by 150
Regulation of the actin cytoskeleton by PIP2 in cytokinesis
Logan, M. R., & Mandato, C. A. (2006) · Biology of the Cell · doi:10.1042/bc20050081 · Cited by 150
Steffen, A., Ladwein, M., Dimchev, G. A., Hein, A., Schwenkmezger, L., Arens, S., Ladwein, K. I., Holleboom, J. M., Schur, F. K. M., Small, J. V., et al. (2013) · Journal of Cell Science · doi:10.1242/jcs.118232 · Cited by 157
Regulation of WASP/WAVE proteins
Bompard, G., & Caron, E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403127 · Cited by 148
Order or chaos? An evaluation of the regulation of protein kinase CK2
Olsten, M. E. K., & Litchfield, D. W. (2004) · Biochemistry and Cell Biology · doi:10.1139/o04-116 · Cited by 141
Rac1‐induced cell migration requires membrane recruitment of the nuclear oncogene SET
ten Klooster, J. P., Leeuwen, I. V., Scheres, N., Anthony, E. C., & Hordijk, P. L. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601518 · Cited by 140
WAVE regulatory complex activation by cooperating GTPases Arf and Rac1
Koronakis, V., Hume, P. J., Humphreys, D., Liu, T., Hørning, O., Jensen, O. N., & McGhie, E. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107666108 · Cited by 138
Feedback signaling controls leading-edge formation during chemotaxis
Charest, P. G., & Firtel, R. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.06.016 · Cited by 133
Basu, D., El‐Assal, S. E., Le, J., Mallery, E. L., & Szymanski, D. B. (2004) · Development · doi:10.1242/dev.01307 · Cited by 129
Bardoni, B., & Mandel, J. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00300-3 · Cited by 129
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegansPreprint
Soto, M. C., Qadota, H., Kasuya, K., Inoue, M., Tsuboi, D., Mello, C. C., & Kaibuchi, K. (2002) · Genes & Development · doi:10.1101/gad.955702 · Cited by 129
Self-citationDavenport, E. C., Szulc, B. R., Drew, J., Taylor, J., Morgan, T., Higgs, N. F., López-Doménech, G., & Kittler, J. T. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.092 · Cited by 125
CNV biology in neurodevelopmental disorders
Takumi, T., & Tamada, K. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.12.004 · Cited by 121
Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTor
Oguro-Ando, A., Rosensweig, C., Herman, E., Nishimura, Y., Werling, D., Bill, B. R., Berg, J. M., Gao, F., Coppola, G., Abrahams, B. S., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.124 · Cited by 117
Structure and function of Rho-type molecular switches in plants
Berken, A., & Wittinghofer, A. (2008) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2007.12.008 · Cited by 114
On the Rho'd: The regulation of membrane protrusions by Rho‐GTPases
Ladwein, M., & Rottner, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.04.033 · Cited by 114
The FMRP regulon: from targets to disease convergence
Fernández, E., Rajan, N., & Bagni, C. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00191 · Cited by 117
Le, J., Mallery, E. L., Zhang, C., Brankle, S., & Szymanski, D. B. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.061 · Cited by 109
Clearance of apoptotic cells in Caenorhabditis elegans
Mangahas, P. M., & Zhou, Z. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.12.005 · Cited by 104
Rakeman, A. S., & Anderson, K. V. (2006) · Development · doi:10.1242/dev.02473 · Cited by 107
The fragile X syndrome: From molecular genetics to neurobiology
Willemsen, R., Oostra, B. A., Bassell, G. J., & Dictenberg, J. B. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20010 · Cited by 106
Rho-linked genes and neurological disorders
Kasri, N. N., & Aelst, L. V. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0385-1 · Cited by 106
The Wave complex is intrinsically inactive
Derivery, E., Lombard, B., Loew, D., & Gautreau, A. M. (2009) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20342 · Cited by 114
Anitei, M., Stange, C., Parshina, I., Baust, T., Schenck, A., Raposo, G., Kirchhausen, T., & Hoflack, B. (2010) · Nature Cell Biology · doi:10.1038/ncb2034 · Cited by 102
Hoshino, M., Sone, M., Fukata, M., Kuroda, S., Kaibuchi, K., Nabeshima, Y.-I., & Hama, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17837 · Cited by 102
Self-citationNovel Mechanism of the Co-regulation of Nuclear Transport of SmgGDS and Rac1
Lanning, C. C., Ruiz-Velasco, R., & Williams, C. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211286200 · Cited by 99
Piazzon, N., Rage, F., Schlotter, F., Moine, H., Branlant, C., & Massenet, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707304200 · Cited by 107
Whole Exome Sequencing in Females with Autism Implicates Novel and Candidate Genes
Butler, M. G., Rafi, S. K., Hossain, W. A., Stephan, D. A., & Manzardo, A. M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16011312 · Cited by 93
Phosphoregulation of the WAVE regulatory complex and signal integration
Mendoza, M. C. (2013) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2013.01.007 · Cited by 94
SCAR knockouts in Dictyostelium : WASP assumes SCAR’s position and upstream regulators in pseudopods
Veltman, D. M., King, J., Machesky, L. M., & Insall, R. H. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201205058 · Cited by 91
Arabidopsis GNARLED Encodes a NAP125 Homolog that Positively Regulates ARP2/3
El‐Assal, S. E., Le, J., Basu, D., Mallery, E. L., & Szymanski, D. B. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.062 · Cited by 91
The Fragile X mental retardation protein
Bardoni, B., Schenck, A., & Mandel, J. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00647-5 · Cited by 91
Kette regulates actin dynamics and genetically interacts with Wave and Wasp
Bogdan, S., & Klämbt, C. (2003) · Development · doi:10.1242/dev.00663 · Cited by 89
Brembu, T., Winge, P., Seem, M., & Bones, A. M. (2004) · The Plant Cell · doi:10.1105/tpc.104.023739 · Cited by 90
Domínguez-Iturza, N., Lo, A. C., Shah, D., Armendáriz, M., Vannelli, A., Mercaldo, V., Trusel, M., Li, K. W., Gastaldo, D., Santos, A. R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11203-y · Cited by 96
Bongmba, O. Y. N., Martinez, L. A., Elhardt, M. E., Butler, K., & Tejada-Simon, M. V. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.020 · Cited by 91
Moon, J., Beaudin, A. E., Verosky, S. C., Driscoll, L. L., Weiskopf, M., Levitsky, D. A., Crnic, L. S., & Strupp, B. J. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.6.1367 · Cited by 91
Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis
Kotelevets, L., & Chastre, E. (2020) · Cancers · doi:10.3390/cancers12030665 · Cited by 92
Cyfip1 is a putative invasion suppressor in epithelial cancers
Silva, J. M., Ezhkova, E., Silva, J., Heart, S., Castillo, M., Campos, Y., Castro, V., Bonilla, F., Cordon-Cardo, C., Muthuswamy, S. K., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.013 · Cited by 87
Santos, A. R., Kanellopoulos, A. K., & Bagni, C. (2014) · Learning & Memory · doi:10.1101/lm.035956.114 · Cited by 91
Lamellipodia are crucial for haptotactic sensing and response
King, S. J., Asokan, S. B., Haynes, E. M., Zimmerman, S. P., Rotty, J. D., Alb, J. G., Tagliatela, A. C., Blake, D. R., Lebedeva, I. P., Marston, D., et al. (2016) · Journal of Cell Science · doi:10.1242/jcs.184507 · Cited by 87
Cryptic Rac-binding and p21 -activated Kinase Phosphorylation Sites of NADPH Oxidase Component p67
Ahmed, S., Prigmore, E., Govind, S., Veryard, C., Kozma, R., Wientjes, F. B., Segal, A. W., & Lim, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15693 · Cited by 85
Rho proteins, mental retardation and the neurobiological basis of intelligence
van Galen, E., & Ramakers, G. J. A. (2004) · Progress in brain research · doi:10.1016/s0079-6123(04)47022-8 · Cited by 87
WASP and WAVE family proteins: Friends or foes in cancer invasion?
Kurisu, S., & Takenawa, T. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01654.x · Cited by 84
Regulation of Cytoskeletal Dynamics at the Immune Synapse: New Stars Join the Actin Troupe
Billadeau, D. D., & Burkhardt, J. K. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00491.x · Cited by 80
Quinlan, M. P., & Hyatt, J.-P. (1999) · PubMed · Cited by 79
Free Brick1 Is a Trimeric Precursor in the Assembly of a Functional Wave Complex
Derivery, E., Fink, J., Martin, D., Houdusse, A., Piel, M., Stradal, T. E. B., Louvard, D., & Gautreau, A. M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002462 · Cited by 82
Burianek, L. E., & Soderling, S. H. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.12.005 · Cited by 83
Metadata
- Authors
- Kobayashi, K., Kuroda, S., Fukata, M., Nakamura, T., Nagase, T., Nomura, N., Matsuura, Y., Yoshida-Kubomura, N., Iwamatsu, A., & Kaibuchi, K.
- Affiliations
- Nara Institute of Science and Technology (JP)
- Japan Science and Technology Agency (JP)
- Hiroshima University (JP)
- Kazusa DNA Research Institute (JP)
- National Institute of Infectious Diseases (JP)
- Kirin (Japan) (JP)
- Corresponding author
- Kaibuchi, Kozo
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 273
- Issue
- 1
- Pages
- 291-295
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2032419047
- Cited by
- 244
- References
- 32
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 6 · 2014: 9 · 2013: 8 · 2012: 10
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Mitsubishi Foundation
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- Rac1, small GTPases, GTP binding, IQGAP1, F-actin binding, cortical actin, ruffles, cell morphology
- MeSH terms
- Amino Acid Sequence, Animals, Carrier Proteins, Cattle, Molecular Sequence Data, Recombinant Proteins, Substrate Specificity, GTP-Binding Proteins, rac GTP-Binding Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
