Dishevelled Proteins Lead to Two Signaling Pathways

Rho GTPases and the Actin Cytoskeleton

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Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

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Wnt signaling: a common theme in animal development

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β‐catenin is a target for the ubiquitin–proteasome pathway

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XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

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The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

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A new member of the frizzled family from Drosophila functions as a Wingless receptor

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Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

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The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

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Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

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Association of the APC Gene Product with β-Catenin

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Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.

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The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

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Wnt genes

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The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

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Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling

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The role of RhoA in tissue polarity and Frizzled signalling

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A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A

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Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1

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Signal transduction by the Wnt family of ligands

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PDZ Domains: Targeting signalling molecules to sub‐membranous sites

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The dishevelled protein is modified by wingless signaling in Drosophila.Preprint

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A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled

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dishevelled is required during wingless signaling to establish both cell polarity and cell identity

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Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription

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Multiple functions of segment polarity genes in Drosophila

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Signaling by wingless in Drosophila

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Isolation and Characterization of a Mouse Homolog of the Drosophila Segment Polarity Gene dishevelled

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dishevelled is a component of the frizzled signaling pathway in Drosophila

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The genetic control of tissue polarity in Drosophila

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The genetic basis of patterned baldness in Drosophila

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Pleckstrin's repeat performance: a novel domain in G-protein signaling?

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Pleckstrin's repeat performance: a novel domain in G-protein signaling?

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Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2

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Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues.

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Temporal colinearity in expression of anterior hox genes in developing chick embryos

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The role of Wnt genes in vertebrate development

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Wnt signaling and cancer

Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183 · see citing works

The JNK signal transduction pathway

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Wnt signal transduction pathways

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A receptor for phosphatidylserine-specific clearance of apoptotic cells

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Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

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A Second Canon

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Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

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Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements

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Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

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Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1

Habas, R., Kato, Y., & He, X. (2001) · Cell · doi:10.1016/s0092-8674(01)00614-6 · Cited by 842 · see citing works

Dishevelled controls cell polarity during Xenopus gastrulation

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Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways

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Xwnt11is a target ofXenopusBrachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway

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Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation

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The casein kinase 1 family: participation in multiple cellular processes in eukaryotes

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Direct Binding of the PDZ Domain of Dishevelled to a Conserved Internal Sequence in the C-Terminal Region of Frizzled

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The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity

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Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

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JNK functions in the non‐canonical Wnt pathway to regulate convergent extension movements in vertebrates

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Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1

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DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability

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WNT-1 Signaling Inhibits Apoptosis by Activating β-Catenin/T Cell Factor–Mediated Transcription

Chen, S., D, D. C. G., You, Z., Zhang, Z., Fribley, A. M., Mayo, M. W., Kitajewski, J., & Wang, C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.1.87 · Cited by 395 · see citing works

Update on Wnt signaling in bone cell biology and bone disease

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The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos

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The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt–β-catenin signalling through Dishevelled

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Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42

Li, Z. A., Hannigan, M. O., Mo, Z., Liu, B., Lü, W., Wu, Y., Smrcka, A. V., Wu, G., Li, L., Liu, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00559-2 · Cited by 373 · see citing works

Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos

Sheldahl, L. C., Slusarski, D. C., Pandur, P., Miller, J. R., Kühl, M., & Moon, R. T. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211094 · Cited by 350 · see citing works

Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?

Mlodzik, M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02770-1 · Cited by 341 · see citing works

Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

Li, X., Liu, P., Liu, W., Maye, P. F., Zhang, J., Zhang, Y., Hurley, M. M., Guo, C., Boskey, A. L., Sun, L., et al. (2005) · Nature Genetics · doi:10.1038/ng1614 · Cited by 341 · see citing works

Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural developmentPreprint

Baker, J. C., Beddington, R. S. P., & Harland, R. M. (1999) · Genes & Development · doi:10.1101/gad.13.23.3149 · Cited by 337 · see citing works

Roles of Wnt proteins in neural development and maintenance

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Runnin' with the Dvl: Proteins That Associate with Dsh/Dvl and Their Significance to Wnt Signal Transduction

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Wnt/Beta-Catenin/Tcf Signaling: A Critical Pathway in Gastrointestinal Tumorigenesis

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Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis

Rothbächer, U., Laurent, M. N., Deardorff, M. A., Klein, P. S., Cho, K. W. Y., & Fraser, S. E. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.1010 · Cited by 299 · see citing works

Wnt signaling in triple-negative breast cancer

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Wnt signaling function in Alzheimer’s disease

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The Wnt Antagonist sFRP1 in Colorectal Tumorigenesis

Caldwell, G. M., Jones, C., Gensberg, K., Jan, S., Hardy, R. G., Byrd, P. J., Chughtai, S., Wallis, Y., Matthews, G. M., & Morton, D. G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1346 · Cited by 281 · see citing works

Dishevelled: at the crossroads of divergent intracellular signaling pathways

Boutros, M., & Mlodzik, M. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00046-5 · Cited by 275 · see citing works

Regulation of β-Catenin Signaling in the Wnt Pathway

Kikuchi, A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1860 · Cited by 253 · see citing works

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

Sun, T., Lu, B., Feng, J., Reinhard, C., Jan, Y. N., Fantl, W. J., & Williams, L. T. (2001) · Nature Cell Biology · doi:10.1038/35083016 · Cited by 255 · see citing works

Frizzled signalling and cell polarisation inDrosophilaand vertebrates

Strutt, D. I. (2003) · Development · doi:10.1242/dev.00695 · Cited by 243 · see citing works

Regulation of AChR Clustering by Dishevelled Interacting with MuSK and PAK1

Luo, Z., Wang, Q., Zhou, J., Wang, J., Luo, Z., Liu, M., He, X., Wynshaw-Boris, A. J., Xiong, W., Lu, B., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00783-3 · Cited by 238 · see citing works

Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabiLization of β-catenin–TCF interaction

Gan, X., Wang, J., Xi, Y., Wu, Z., Li, Y.-P., & Li, L. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710050 · Cited by 235 · see citing works

An Antagonist of Dishevelled Protein-Protein Interaction Suppresses β-Catenin–Dependent Tumor Cell Growth

Fujii, N., You, L., Xu, Z., Uematsu, K., Shan, J., He, B., Mikami, I., Edmondson, L. R., Neale, G. A. M., Zheng, J., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2726 · Cited by 232 · see citing works

Wnt / β-Catenin Signaling Pathway as Novel Cancer Drug Targets

Luu, H. H., Zhang, R., Haydon, R. C., Rayburn, E. R., Kang, Q., Si, W., Park, J. K., Wang, H., Peng, Y., Jiang, W., et al. (2004) · Current Cancer Drug Targets · doi:10.2174/1568009043332709 · Cited by 232 · see citing works

Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled

Tauriello, D. V. F., Jordens, I., Kirchner, K., Slootstra, J. W., Kruitwagen, T., Bouwman, B. A. M., Noutsou, M., Rüdiger, S., Schwamborn, K., Schambony, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114802109 · Cited by 227 · see citing works

Alternative Wnt Pathways and ReceptorsPreprint

van Amerongen, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007914 · Cited by 220 · see citing works

Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling

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Antagonistic regulation of convergent extension movements in Xenopus by Wnt/β-catenin and Wnt/Ca2+ signaling

Kühl, M., Geis, K., Sheldahl, L. C., Pukrop, T., Moon, R. T., & Wedlich, D. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00416-6 · Cited by 219 · see citing works

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

Tauriello, D. V. F., Haegebarth, A., Kuper, I., Edelmann, M. J., Henraat, M., van Dijk, M. R., Kessler, B. M., Clevers, H. C., & Maurice, M. M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.035 · Cited by 218 · see citing works

Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways

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