Physiological Levels of Mammalian Uncoupling Protein 2 Do Not Uncouple Yeast Mitochondria

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UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation

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Superoxide Activates Mitochondrial Uncoupling Protein 2 from the Matrix Side

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Physiological Increases in Uncoupling Protein 3 Augment Fatty Acid Oxidation and Decrease Reactive Oxygen Species Production Without Uncoupling Respiration in Muscle Cells

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Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization

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No Evidence for a Basal, Retinoic, or Superoxide-induced Uncoupling Activity of the Uncoupling Protein 2 Present in Spleen or Lung Mitochondria

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Regulation of Cellular Oncosis by Uncoupling Protein 2

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Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers

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Activating ω-6 Polyunsaturated Fatty Acids and Inhibitory Purine Nucleotides Are High Affinity Ligands for Novel Mitochondrial Uncoupling Proteins UCP2 and UCP3

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Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages

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Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARα-mediated pathway

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UCP2-dependent Proton Leak in Isolated Mammalian Mitochondria

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Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species

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Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis

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Uncoupling protein-2 and non-alcoholic fatty liver disease

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Mitochondrial Uncoupling Protein-2 Mediates Steatotic Liver Injury following Ischemia/Reperfusion

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An ancient look at UCP1

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Population Genetic Analysis of the Uncoupling Proteins Supports a Role for UCP3 in Human Cold Resistance

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Long-term high-fat feeding induces greater fat storage in mice lacking UCP3

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Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice

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Nutritional Manipulation of Fetal Adipose Tissue Deposition and Uncoupling Protein 1 Messenger RNA Abundance in the Sheep: Differential Effects of Timing and Duration

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Glucose induces and leptin decreases expression of uncoupling protein‐2 mRNA in human islets

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Reduced Body Weight and Increased Energy Expenditure in Transgenic Mice Over-Expressing Soluble Leptin Receptor

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Respiratory uncoupling by UCP1 and UCP2 and superoxide generation in endothelial cell mitochondria

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UCP2 as a Cancer Target through Energy Metabolism and Oxidative Stress Control

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Functional Characterization of a Drosophila Mitochondrial Uncoupling Protein

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Ontogeny and nutritional manipulation of mitochondrial protein abundance in adipose tissue and the lungs of postnatal sheep

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Fasting, lipid metabolism, and triiodothyronine in rat gastrocnemius muscle: interrelated roles of uncoupling protein 3, mitochondrial thioesterase, and coenzyme Q

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HDMCP uncouples yeast mitochondrial respiration and alleviates steatosis in L02 and hepG2 cells by decreasing ATP and H2O2 levels: A novel mechanism for NAFLD

Jin, X., Yang, Y., Chen, K., Lv, Z., Zheng, L., Liu, Y.-P., Chen, S., Yu, C., Jiang, X., Zhang, C., et al. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.10.034 · Cited by 42 · see citing works

Decrease of intracellular ATP content downregulated UCP2 expression in mouse hepatocytes

Cheng, G., Polito, C. C., Haines, J. K., Shafizadeh, S. F., Fiorini, R. N., Zhou, X., Schmidt, M. G., & Chavin, K. D. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01409-8 · Cited by 41 · see citing works

Role of lipid-derived mediators in skeletal muscle insulin resistance

Taube, A., Eckardt, K., & Eckel, J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00241.2009 · Cited by 40 · see citing works

Two-stage evolution of mammalian adipose tissue thermogenesis

Keipert, S., Gaudry, M. J., Kutschke, M., Keuper, M., Rosa, M. A. S. D., Cheng, Y., Kuhn, J. M. M., Laterveer, R., Cotrim, C. A., Giere, P., et al. (2024) · Science · doi:10.1126/science.adg1947 · Cited by 39 · see citing works

Mitochondrial proton leak in obesity-resistant and obesity-prone mice

Fink, B. D., Herlein, J. A., Almind, K., Cinti, S., Kahn, C. R., & Sivitz, W. I. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00478.2007 · Cited by 40 · see citing works

UCP2/3 — likely to be fundamental for mitochondrial Ca2+ uniport

Trenker, M., Fertschai, I., Malli, R., & Graier, W. F. (2008) · Nature Cell Biology · doi:10.1038/ncb1108-1237 · Cited by 37 · see citing works

Protein-mediated energy-dissipating pathways in mitochondria

Starkov, A. A. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.08.015 · Cited by 37 · see citing works

Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid

Zhao, L., Wang, S., Zhu, Q., Wu, B., Liu, Z., OuYang, B., & Chou, J. J. (2017) · Structure · doi:10.1016/j.str.2017.07.005 · Cited by 33 · see citing works

Exhaustive Training Increases Uncoupling Protein 2 Expression and Decreases Bcl-2/Bax Ratio in Rat Skeletal Muscle

Liu, W. Y., He, W., & Li, H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/780719 · Cited by 32 · see citing works

Fatty acid activation of the uncoupling proteins requires the presence of the central matrix loop from UCP1

Jiménez-Jiménez, J., Ledesma, A., Zaragoza, P., González‐Barroso, M. M., & Rial, E. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.027 · Cited by 30 · see citing works

Nucleotide binding to human uncoupling protein-2 refolded from bacterial inclusion bodies

Jekabsons, M. B., Echtay, K. S., & Brand, M. D. (2002) · Biochemical Journal · doi:10.1042/bj20020469 · Cited by 29 · see citing works

Characterization of the differential expression of uncoupling protein 2 and ROS production in differentiated mouse macrophage-cells (Mm1) and the progenitor cells (M1)

Nishio, K., Qiao, S., & Yamashita, H. (2005) · The Histochemical Journal · doi:10.1007/s10735-004-2915-x · Cited by 29 · see citing works

Adrenoceptors, Uncoupling Proteins, and Energy Expenditure

Collins, S., Cao, W., Daniel, K. W., Dixon, T. M., Medvedev, A. V., Onuma, H., & Surwit, R. S. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122601104 · Cited by 28 · see citing works

Reconstitution of novel mitochondrial uncoupling proteins UCP2 and UCP3

Žáčkova, M., & Ježek, P. (2002) · Bioscience Reports · doi:10.1023/a:1016009022186 · Cited by 25 · see citing works

Nutritional manipulation between early to mid-gestation: effects on uncoupling protein-2, glucocorticoid sensitivity, IGF-I receptor and cell proliferation but not apoptosis in the ovine placenta

Gnanalingham, M. G., Williams, P. M., Wilson, V. G., Bispham, J., Hyatt, M. A., Pellicano, A. J., Budge, H., Stephenson, T. J., & Symonds, M. E. (2007) · Reproduction · doi:10.1530/rep-06-0369 · Cited by 25 · see citing works

Mitochondrial carriers in inflammation induced by bacterial endotoxin and cytokines

Iacobazzi, V., Infantino, V., Castegna, A., Menga, A., Palmieri, E. M., Convertini, P., & Palmieri, F. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0260 · Cited by 21 · see citing works

Fatty acids do not activate UCP2 in pancreatic beta cells: comparison with UCP1

Galetti, S., Sarre, A., Perreten, H., Produit-Zengaffinen, N., Muzzin, P., & Assimacopoulos‐Jeannet, F. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0548-8 · Cited by 19 · see citing works

Alleviation of ischemia/reperfusion injury in ob/ob mice by inhibiting UCP-2 expression in fatty liver

Wan, C., Wang, C., Liu, T., Cheng, R., & Wang, H. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.590 · Cited by 19 · see citing works

Absence of UCP3 in Brown Adipose Tissue Does Not Impair Nonshivering Thermogenesis

Liebig, M., von Praun, C., Heldmaier, G., & Klingenspor, M. (2004) · Physiological and Biochemical Zoology · doi:10.1086/381464 · Cited by 19 · see citing works

Influence of genotype on the differential ontogeny of uncoupling protein 2 and 3 in subcutaneous adipose tissue and muscle in neonatal pigs

Mostyn, A., Litten, J. C., Perkins, K. S., Alves‐Guerra, M., Pecqueur, C., Miroux, B., Symonds, M. E., & Clarke, L. (2004) · Journal of Endocrinology · doi:10.1677/joe.1.05448 · Cited by 18 · see citing works

Searching for type 2 diabetes genes: prospects in pharmacotherapy

Sesti, G. (2002) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500078 · Cited by 15 · see citing works

Uncoupling of protein‐3 induces an uncontrolled uncoupling of mitochondria after expression in muscle derived L6 cells

Guerini, D., Prati, E. G. P., Desai, U. J., Nick, H. P., Flammer, R., Grueninger, S., Cumin, F., Kaleko, M., Connelly, S., & Chiesi, M. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02773.x · Cited by 14 · see citing works

UCP1 muscle gene transfer and mitochondrial proton leak mediated thermogenesis

Larrarte, E., Margareto, J., Novo, F. J., Martí, A., & Martínez, J. A. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00201-1 · Cited by 14 · see citing works

Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?

Doliba, N. M., Liu, Q., Li, C., Chen, J., Chen, P., Liu, C., Frederick, D. W., Baur, J. A., Bennett, M. J., Naji, A., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.09.010 · Cited by 13 · see citing works

Protein-mediated energy-dissipating pathways in mitochondria

Starkov, A. A. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.02.009 · Cited by 13 · see citing works

Functional analysis of skunk cabbage SfUCPB, a unique uncoupling protein lacking the fifth transmembrane domain, in yeast cells

Ito, K., Matsukawa, K., & Kato, Y. S. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.08.058 · Cited by 13 · see citing works

Different effects of maternal parity, cold exposure and nutrient restriction in late pregnancy on the abundance of mitochondrial proteins in the kidney, liver and lung of postnatal sheep

Yakubu, D. P., Mostyn, A., Wilson, V. G., Pearce, S., Alves‐Guerra, M., Pecqueur, C., Miroux, B., Budge, H., Stephenson, T. J., & Symonds, M. E. (2007) · Reproduction · doi:10.1530/rep-06-0211 · Cited by 10 · see citing works

Molecular Properties of Purified Human Uncoupling Protein 2 Refolded from Bacterial Inclusion Bodies

Jekabsons, M. B., Echtay, K. S., Aréchaga, I., & Brand, M. D. (2003) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1027335713635 · Cited by 10 · see citing works

Strategies for Successful Over-Expression of Human Membrane Transport Systems Using Bacterial Hosts: Future Perspectives

Galluccio, M., Console, L., Pochini, L., Scalise, M., Giangregorio, N., & Indiveri, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073823 · Cited by 8 · see citing works

The roles of orexins on sleep/wakefulness, energy homeostasis and intestinal secretion

Mäkelä, K. A. (2010) · Cited by 7 · see citing works

Molecular cloning of lamprey uncoupling protein and assessment of its uncoupling activity using a yeast heterologous expression system

Wang, C., Sun, G., Chen, K., Lv, Z., Peng, S., Jiang, X., Xiang, Y., & Zhang, C. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.09.003 · Cited by 6 · see citing works

The Uncoupling Proteins Family: From Thermogenesis to the Regulation of ROS

Alves‐Guerra, M., Pecqueur, C., Couplan, E., González‐Barroso, M. M., González‐Barroso, M. M., Ricquier, D., Bouillaud, F., Miroux, B., & Shaw, A. (2002) · Cell and molecular responses to stress · doi:10.1016/s1568-1254(02)80020-1 · Cited by 5 · see citing works

Molecular cloning of amphioxus uncoupling protein and assessment of its uncoupling activity using a yeast heterologous expression system

Chen, K., Sun, G., Lv, Z., Wang, C., Jiang, X., Li, D., & Zhang, C. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.131 · Cited by 5 · see citing works

Acanthamoeba castellanii Uncoupling Protein: A Complete Sequence, Activity, and Role in Response to Oxidative Stress

Antos-Krzemińska, N., Kicińska, A., Nowak, W., & Jarmuszkiewicz, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512501 · Cited by 4 · see citing works

Cell-free production and characterisation of human uncoupling protein 1–3

Rebuffet, E., Frick, A., Järvå, M. A., & Törnroth‐Horsefield, S. (2017) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2017.04.003 · Cited by 4 · see citing works

Tumor-Specific EphA2 Receptor Tyrosine Kinase Inhibits Anti-Tumor Immunity by Recruiting Suppressive Myeloid Populations in Murine Models of Non-Small Cell Lung Cancer

Shiuan, E. F., Wang, S., & Brantley‐Sieders, D. M. (2025) · Cancers · doi:10.3390/cancers17162693 · Cited by 2 · see citing works

Energy Expenditure in Obesity

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Energy Homeostasis

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Endocrine regulation of adipose tissue thermogenesis in the fetal and neonatal sheep

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The Role of Energy Expenditure in the Regulation of Energy Balance

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Uncoupling Protein-2 Modulation of Reactive Oxygen Species and Cell Viability in the Pancreatic Beta Cell

Lee, S. (2008) · TSpace (University of Toronto) · Cited by 1 · see citing works

Mitochondrial uncoupling protein 3 blocks skin carcinogenesis and drives bulge stem cell differentiation and epidermal turnover

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A High-Throughput Assay for Modulators of NNT Activity in Permeabilized Yeast Cells

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LeakRegulation and Physiology of Mitochondrial Proton

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Métabolisme énergétique mitochondrial dans les neuropathies héréditaires associées aux mutations des gènes OPA1 et MFN2

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The use of a genetic strategy to study the role of modulation of oxidative stress by uncoupling proteins 2 and 3 in the pathogenesis of Type 2 Diabetes.

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A Coupled Understanding of UCP2 Function and Metabolic Reprogramming

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Tumor-specific EphA2 receptor tyrosine kinase inhibits anti-tumor immunity by recruiting suppressive myeloid populations in NSCLCPreprint

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THE EPHA2/EPHRIN-A1 AXIS REGULATES HOST-TUMOR INTERACTIONS

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Quel est le rôle des protéines découplantes mitochondriales chez les mammifères et les oiseaux ?

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Current Awareness

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Impact de la perte du transporteur mitochondrial UCP2 sur la physiologie de l'intestin et l'immunité favorisant la tumorigenèse colorectale

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A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast

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Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria

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Yeast-expression and molecular properties of human mitochondrial Uncoupling Protein 2

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Functional expression of the rat brown adipose tissue uncoupling protein in Saccharomyces cerevisiae

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A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2

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