Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

Rubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350 · see citing works

Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase

Huang, J. T., Welch, J. S., Ricote, M., Binder, C. J., Willson, T. M., Kelly, C., Witztum, J. L., Funk, C. D., Conrad, D. J., & Glass, C. K. (1999) · Nature · doi:10.1038/22572 · Cited by 854 · see citing works

Superoxide and peroxynitrite inatherosclerosis.

White, C. R., Brock, T. A., Chang, L. Y., Crapo, J. D., BRISCOE, P. M., Ku, D. D., Bradley, W. A., Gianturco, S. H., Gore, J. Z., & Freeman, B. Α. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.1044 · Cited by 685 · see citing works

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

Münzel, T. F., Sayegh, H. S., Freeman, B. Α., Tarpey, M. M., & Harrison, D. G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117637 · Cited by 654 · see citing works

Formation and Properties of Peroxynitrite as Studied by Laser Flash Photolysis, High-Pressure Stopped-Flow Technique, and Pulse Radiolysis

Kissner, R., Nauser, T., Bugnon, P., Lye, P. G., & Koppenol, W. H. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970160x · Cited by 629 · see citing works

Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro

Podrez, E. A., Schmitt, D. C., Hoff, H. F., & Hazen, S. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5549 · Cited by 492 · see citing works

cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.

Moro, M. Á., Russel, R., Cellek, S., Lizasoaín, I., Su, Y., Darley-Usmar, V. M., Radomski, M. W., & Moncada, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1480 · Cited by 473 · see citing works

Reactive Nitrogen Intermediates Promote Low Density Lipoprotein Oxidation in Human Atherosclerotic Intima

Leeuwenburgh, C., Hardy, M. M., Hazen, S. L., Wagner, P. D., Oh‐ishi, S., Steinbrecher, U. P., & Heinecke, J. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.3.1433 · Cited by 461 · see citing works

Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species

Podrez, E. A., Febbraio, M., Sheibani, N., Schmitt, D. C., Silverstein, R. L., Hajjar, D. P., Cohen, P. A., Frazier, W. A., Hoff, H. F., & Hazen, S. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8574 · Cited by 455 · see citing works

Structure and Function of Cyclic Nucleotide-Dependent Protein Kinases

Francis, S. H., & Corbin, J. D. (1994) · Annual Review of Physiology · doi:10.1146/annurev.ph.56.030194.001321 · Cited by 441 · see citing works

Paradoxical fate and biological action of peroxynitrite on human platelets.

Moro, M. Á., Darley-Usmar, V. M., Goodwin, D. A., Read, N. G., Zamora-Pino, R., Feelisch, M., Radomski, M. W., & Moncada, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6702 · Cited by 363 · see citing works

The vasodilator‐stimulated phosphoprotein (VASP) is involved in cGMP‐ and cAMP‐mediated inhibition of agonist‐induced platelet aggregation, but is dispensable for smooth muscle function

Aszódi, A., Pfeifer, A., Ahmad, M., Glauner, M., Zhou, X., Ny, L., Andersson, K., Kehrel, B. E., Offermanns, S., & Fässler, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.37 · Cited by 347 · see citing works

Analysis and Regulation of Vasodilator-stimulated Phosphoprotein Serine 239 Phosphorylation in Vitro and in Intact Cells Using a Phosphospecific Monoclonal Antibody

Smolenski, A., Bachmann, C., Reinhard, K., Hönig‐Liedl, P., Jarchau, T., Hoschuetzky, H., & Walter, U. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20029 · Cited by 332 · see citing works

Nitration of Unsaturated Fatty Acids by Nitric Oxide-Derived Reactive Nitrogen Species Peroxynitrite, Nitrous Acid, Nitrogen Dioxide, and Nitronium Ion

O'Donnell, V. B., Eiserich, J. P., Chumley, P. H., Jablonsky, M. J., Krishna, N. R., Kirk, M., Barnes, S., Darley-Usmar, V. M., & Freeman, B. A. (1999) · Chemical Research in Toxicology · doi:10.1021/tx980207u · Cited by 289 · see citing works

Peroxynitrite modification of low‐density lipoprotein leads to recognition by the macrophage scavenger receptor

Graham, A., Hogg, N., Kalyanaraman, B., O'leary, V. J., Darley-Usmar, V. M., & Moncada, S. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80269-z · Cited by 278 · see citing works

Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP

Haslam, R. J., Davidson, M. M. L., & Desjardins, J. (1978) · Biochemical Journal · doi:10.1042/bj1760083 · Cited by 242 · see citing works

Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice

Hauser, W., Knobeloch, K., Eigenthaler, M., Gambaryan, S. P., Krenn, V., Geiger, J., Glazova, M. V., Rohde, E., Horak, I. D., Walter, U., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8120 · Cited by 222 · see citing works

Pathophysiology of nitric oxide and related species: free radical reactions and modification of biomolecules

Eiserich, J. P., Patel, R. P., & O’Donnell, V. B. (1998) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(99)00002-3 · Cited by 210 · see citing works

The formation of nitric oxide donors from peroxynitrite

Moro, M. Á., Darley-Usmar, V. M., Lizasoaín, I., Su, Y., Knowles, R. G., Moncada, S., & Radomski, M. W. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb16404.x · Cited by 197 · see citing works

S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme.

Stamler, J. S., Simon, D. I., Jaraki, O., Osborne, J. A., Francis, S., Mullins, M. E., Singel, D. J., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8087 · Cited by 185 · see citing works

Concentration and regulation of cyclic nucleotides, cyclic‐nucleotide‐dependent protein kinases and one of their major substrates in human platelets

Eigenthaler, M., NOLTE, C., Halbrügge, M., & Walter, U. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb16803.x · Cited by 169 · see citing works

Cyclic Nucleotides and Phosphodiesterases in Platelets

Dickinson, N., Jang, E., & Haslam, R. (1999) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615861 · Cited by 164 · see citing works

Nitrosation of Uric Acid by Peroxynitrite

Skinner, K. A., White, C. R., Patel, R. P., Tan, S., Barnes, S., KIRK, M. C., Darley-Usmar, V. M., & Parks, D. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24491 · Cited by 133 · see citing works

Oxidative Modification and Nitration of Human Low-Density Lipoproteins by the Reaction of Hypochlorous Acid with Nitrite

Panasenko, O. M., Briviba, K., Klotz, L., & Sies, H. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0171 · Cited by 93 · see citing works

Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice

Claudio Napoli, A., Cirino, G., Soldato, P. D., Sorrentino, R., Sica, V., Condorelli, M., Pinto, A., & Ignarro, L. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041602898 · Cited by 84 · see citing works

Nitric oxide-dependent and independent effects on human platelets treated with peroxynitrite

Brown, A. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00182-5 · Cited by 81 · see citing works

Vicinal Nitrohydroxyeicosatrienoic Acids: Vasodilator Lipids Formed by Reaction of Nitrogen Dioxide with Arachidonic Acid

Balazy, M., Iesaki, T., Park, J. L., Jiang, H., Kaminski, P. M., & Wolin, M. S. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29269-7 · Cited by 73 · see citing works

Synthesis of conjugated nitroalkenes via nitroselenenylation of alkenes

Hayama, T., Tomoda, S., Takeuchi, Y., & Nomura, Y. (1982) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)85699-3 · Cited by 67 · see citing works

Platelets: A practical approach

(1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)88598-6 · Cited by 65 · see citing works

Trifluoroacetoxy-phenylselenation of nitroolefins regioselective preparation of nitroallylic alcohol derivatives and their use as multiple coupling reagents

Seebàch, D., Calderari, G., & Knochel, P. (1985) · Tetrahedron · doi:10.1016/s0040-4020(01)96725-0 · Cited by 63 · see citing works

The reaction of low levels of nitrogen dioxide with methyl linoleate in the presence and absence of oxygen

Gallon, A. A., & Pryor, W. A. (1994) · Lipids · doi:10.1007/bf02536725 · Cited by 61 · see citing works

The identification of the allylic nitrite and nitro derivatives of methyl linoleate and methyl linolenate by negative chemical ionization mass spectroscopy

Gallon, A. A., & Pryor, W. A. (1993) · Lipids · doi:10.1007/bf02535776 · Cited by 45 · see citing works

Antithrombotic effects of peroxynitrite: Inhibition and reversal of aggregation in human platelets

Yin, K., Lai, P.-S., Rodrı́guez, A. R., Spur, B. W., & Wong, P. Y.-K. (1995) · Prostaglandins · doi:10.1016/0090-6980(95)00119-0 · Cited by 33 · see citing works

Is · NO News Bad News in Acute Respiratory Distress Syndrome?

Baldus, S. E., Castro, L., Eiserich, J. P., & Freeman, B. Α. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.2.ed2000c · Cited by 24 · see citing works

Free radical biology and medicine: it's a gas, man!

Pryor, W. A., Houk, K. N., Foote, C. S., Fukuto, J. M., Ignarro, L. J., Squadrito, G. L., & Davies, K. J. A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00614.2005 · Cited by 465 · see citing works

Nitrolinoleic acid. An endogenous peroxisome proliferator-activated receptor γ ligand

Schopfer, F. J., Lin, Y., Baker, P. R. S., Cui, T., Garcia-Barrio, M., Zhang, J., Chen, K., Chen, Y. E., & Freeman, B. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408384102 · Cited by 428 · see citing works

Fatty Acid Transduction of Nitric Oxide Signaling

Baker, P. R. S., Lin, Y., Schopfer, F. J., Woodcock, S. R., Groeger, A. L., Batthyany, C., Sweeney, S., Long, M. H., Iles, K. E., Baker, L. M. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504212200 · Cited by 358 · see citing works

Nitrated Fatty Acids: Endogenous Anti-inflammatory Signaling Mediators

Cui, T., Schopfer, F. J., Zhang, J., Chen, K., Ichikawa, T., Baker Paul, R. S., Batthyany, C., Chacko, B. K., Feng, X., Patel, R. P., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603357200 · Cited by 351 · see citing works

Reversible Post-translational Modification of Proteins by Nitrated Fatty Acids in Vivo

Batthyany, C., Schopfer, F. J., Baker, P. R. S., Durán, R., Baker, L. M. S., Huang, Y., Cerveñansky, C., Branchaud, B. P., & Freeman, B. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602814200 · Cited by 285 · see citing works

Nitro-fatty acid formation and signaling

Freeman, B. A., Baker, P. R. S., Schopfer, F. J., Woodcock, S. R., Napolitano, A., & d'Ischia, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800004200 · Cited by 265 · see citing works

The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal

Forman, H. J., Fukuto, J. M., Miller, T., Zhang, H., Rinna, A., & Levy, S. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.06.011 · Cited by 226 · see citing works

Red cell membrane and plasma linoleic acid nitration products: Synthesis, clinical identification, and quantitation

Baker, P. R. S., Schopfer, F. J., Sweeney, S., & Freeman, B. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402587101 · Cited by 201 · see citing works

Fatty Acid Transduction of Nitric Oxide Signaling

Schopfer, F. J., Baker, P. R. S., Giles, G. I., Chumley, P., Batthyány, C., Crawford, J. H., Patel, R. P., Hogg, N., Branchaud, B. P., Lancaster, J. R., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414689200 · Cited by 171 · see citing works

Nitrolinoleate Inhibits Superoxide Generation, Degranulation, and Integrin Expression by Human Neutrophils: Novel Antiinflammatory Properties of Nitric Oxide–Derived Reactive Species in Vascular Cells

Coles, B., Bloodsworth, A., Clark, S. R., Lewis, M. J., Cross, A. R., Freeman, B. A., & O’Donnell, V. B. (2002) · Circulation Research · doi:10.1161/01.res.0000032114.68919.ef · Cited by 168 · see citing works

Nitro-linoleic acid inhibits vascular smooth muscle cell proliferation via the Keap1/Nrf2 signaling pathway

Villacorta, L., Zhang, J., Garcia-Barrio, M. T., Chen, X.-L., Freeman, B. A., Chen, Y. E., & Cui, T. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00261.2007 · Cited by 144 · see citing works

Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation

Lima, É. S., Bonini, M. G., Augusto, O., Barbeiro, H. V., de Souza, H. P., & Abdalla, D. S. P. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.005 · Cited by 132 · see citing works

Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review

Das, U. N. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2018.01.002 · Cited by 129 · see citing works

Convergence of nitric oxide and lipid signaling: Anti-inflammatory nitro-fatty acids

Baker, P. R. S., Schopfer, F. J., O’Donnell, V. B., & Freeman, B. Α. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.021 · Cited by 124 · see citing works

Nitro-oleic acid inhibits angiotensin II-induced hypertension

Zhang, J., Villacorta, L., Chang, L., Fan, Z., Hamblin, M., Zhu, T., Chen, C. S., Cole, M. P., Schopfer, F. J., Deng, C. X., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.218404 · Cited by 121 · see citing works

Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression

Wright, M. M., Schopfer, F. J., Baker, P. R. S., Vidyasagar, V., Powell, P., Chumley, P., Iles, K. E., Freeman, B. Α., & Agarwal, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506541103 · Cited by 119 · see citing works

Olives and olive oil are sources of electrophilic fatty acid nitroalkenes

Fazzari, M., Trostchansky, A., Schopfer, F. J., Salvatore, S. R., Sánchez-Calvo, B., Vitturi, D., Valderrama, R., Barroso, J. B., Radi, R., Freeman, B. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084884 · Cited by 114 · see citing works

Redox-Dependent Anti-Inflammatory Signaling Actions of Unsaturated Fatty Acids

Delmastro-Greenwood, M. M., Freeman, B. Α., & Wendell, S. G. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170341 · Cited by 114 · see citing works

Nitrolinoleate, a nitric oxide-derived mediator of cell function: Synthesis, characterization, and vasomotor activity

Lim, D. G., Sweeney, S., Bloodsworth, A., White, C. R., Chumley, P. H., Krishna, N. R., Schopfer, F., O'Donnell, V. B., Eiserich, J. P., & Freeman, B. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232409599 · Cited by 110 · see citing works

Nitro–Fatty Acids Reduce Atherosclerosis in Apolipoprotein E–Deficient Mice

Rudolph, T. K., Rudolph, V., Edreira, M. M., Cole, M. P., Bonacci, G., Schopfer, F. J., Woodcock, S. R., Franek, A., Pekarova, M., Khoo, N. K. H., et al. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.109.201582 · Cited by 109 · see citing works

Characterization of linoleic acid nitration in human blood plasma by mass spectrometry

Lima, É. S., Di Mascio, P., Rubbo, H., & Abdalla, D. S. P. (2002) · Biochemistry · doi:10.1021/bi025504j · Cited by 103 · see citing works

Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase

Charles, R. L., Rudyk, O., Prysyazhna, O., Kamynina, A., Yang, J., Morisseau, C., Hammock, B. D., Freeman, B. A., & Eaton, P. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402965111 · Cited by 100 · see citing works

Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion

Pride, C. K., Mo, L., Quesnelle, K., Dagda, R. K., Murillo, D., Geary, L., Corey, C., Portella, R., Zharikov, S., St Croix, C., et al. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvt224 · Cited by 97 · see citing works

ENA/VASP proteins: multifunctional regulators of actin cytoskeleton dynamics

Antonio, S. S. (2004) · Frontiers in bioscience · doi:10.2741/1324 · Cited by 96 · see citing works

Angiotensin 1-7 and Mas decrease thrombosis in Bdkrb2−/− mice by increasing NO and prostacyclin to reduce platelet spreading and glycoprotein VI activation

Fang, C., Stavrou, E. X., Schmaier, A. A., Grobe, N., Morris, M., Chen, A., Nieman, M. T., Adams, G. N., Larusch, G. A., Zhou, Y., et al. (2013) · Blood · doi:10.1182/blood-2012-09-459156 · Cited by 84 · see citing works

New insights into the role of fatty acids in the pathogenesis and resolution of inflammatory bowel disease

Shores, D. R., Binion, D. G., Freeman, B. Α., & Baker, P. R. S. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21560 · Cited by 84 · see citing works

Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine

Salvatore, S. R., Vitturi, D. A., Baker, P. R. S., Bonacci, G., Koenitzer, J. R., Woodcock, S. R., Freeman, B. A., & Schopfer, F. J. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m037804 · Cited by 82 · see citing works

Nitro-oleic Acid, a Novel and Irreversible Inhibitor of Xanthine Oxidoreductase

Kelley, E. E., Batthyany, C. I., Hundley, N. J., Woodcock, S. R., Bonacci, G., Del Rio, J. M., Schopfer, F. J., Lancaster, J. R., Freeman, B. A., & Tarpey, M. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802402200 · Cited by 81 · see citing works

Activation of vascular endothelial nitric oxide synthase and heme oxygenase-1 expression by electrophilic nitro-fatty acids

Khoo, N. K. H., Rudolph, V., Cole, M. P., Golin-Bisello, F., Schopfer, F. J., Woodcock, S. R., Batthyany, C., & Freeman, B. A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.10.046 · Cited by 79 · see citing works

Macrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleate

Ferreira, A. M., Ferrari, M. I., Trostchansky, A., Batthyany, C., Souza, J. M., Alvarez, M. N., López, G. V., Baker, P. R. S., Schopfer, F. J., O'Donnell, V., et al. (2009) · Biochemical Journal · doi:10.1042/bj20080701 · Cited by 78 · see citing works

The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus

Oates, J. C., & Gilkeson, G. S. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.06.001 · Cited by 77 · see citing works

Role of reactive nitrogen species in blood platelet functions

Olas, B., & Wachowicz, B. (2007) · Platelets · doi:10.1080/09537100701504087 · Cited by 80 · see citing works

Nitrated lipids: A class of cell-signaling molecules

Kalyanaraman, B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404309101 · Cited by 73 · see citing works

Cholesteryl nitrolinoleate, a nitrated lipid present in human blood plasma and lipoproteins

Lima, É. S., Mascio, P. D., & Abdalla, D. S. P. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200467-jlr200 · Cited by 72 · see citing works

Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review

Das, U. N. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2018.02.004 · Cited by 71 · see citing works

Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation

Zhang, G., Xiang, B., Dong, A., Skoda, R. C., Daugherty, A., Smyth, S. S., Du, X., & Li, Z. (2011) · Blood · doi:10.1182/blood-2011-03-341107 · Cited by 69 · see citing works

Ginsenoside-Rp3 inhibits platelet activation and thrombus formation by regulating MAPK and cyclic nucleotide signaling

Irfan, M., Jeong, D., Kwon, H.-W., Shin, J.-H., Park, S., Kwak, D., Kim, T., Lee, D., Park, H.-J., & Rhee, M. H. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.06.002 · Cited by 62 · see citing works

Nitroalkenes Suppress Lipopolysaccharide-Induced Signal Transducer and Activator of Transcription Signaling in Macrophages: A Critical Role of Mitogen-Activated Protein Kinase Phosphatase 1

Ichikawa, T., Zhang, J., Chen, K., Liu, Y., Schopfer, F. J., Baker, P. R. S., Freeman, B. Α., Chen, Y. E., & Cui, T. (2008) · Endocrinology · doi:10.1210/en.2007-1639 · Cited by 61 · see citing works

Nitroarachidonic acid, a novel peroxidase inhibitor of prostaglandin endoperoxide H synthases 1 and 2

Trostchansky, A., Bonilla, L., Thomas, C. P., O'Donnell, V. B., Marnett, L. J., Radi, R., & Rubbo, H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.154518 · Cited by 58 · see citing works

Modulation of Nitrated Lipid Signaling by Multidrug Resistance Protein 1 (MRP1): Glutathione Conjugation and MRP1-Mediated Efflux Inhibit Nitrolinoleic Acid-Induced, PPARγ-Dependent Transcription Activation

Alexander, R. L., Bates, D. J. P., Wright, M. W., King, S. B., & Morrow, C. S. (2006) · Biochemistry · doi:10.1021/bi0605639 · Cited by 58 · see citing works

Nitro-oleic acid protects against endotoxin-induced endotoxemia and multiorgan injury in mice

Wang, H., Liu, H., Jia, Z., Olsen, C. D., Litwin, S. E., Guan, G., & Yang, T. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00439.2009 · Cited by 55 · see citing works

The mechanism of oleic acid nitration by •NO2

Jain, K., Anjaiah, S., Marathi, A., Roy, U. K., Falck, J. R., & Balazy, M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.015 · Cited by 54 · see citing works

Nitro-fatty acids in cardiovascular regulation and diseases characteristics and molecular mechanisms

Villacorta, L. (2015) · Frontiers in bioscience · doi:10.2741/4425 · Cited by 50 · see citing works

Nitroalkylation — A redox sensitive signaling pathway

Geisler, A. C., & Rudolph, T. K. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.06.014 · Cited by 44 · see citing works

Cardiovascular Consequences When Nitric Oxide and Lipid Signaling Converge

Rudolph, V., & Freeman, B. Α. (2009) · Circulation Research · doi:10.1161/circresaha.109.202077 · Cited by 43 · see citing works

The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling

Freeman, B. Α., O’Donnell, V. B., & Schopfer, F. J. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.05.002 · Cited by 43 · see citing works

Discovery of bioactive nitrated lipids and nitro-lipid-protein adducts using mass spectrometry-based approaches

Melo, T., Montero‐Bullón, J., Domingues, P. M., & Domingues, M. R. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101106 · Cited by 44 · see citing works

Aging, lipid modifications and phospholipases—new concepts

Balazy, M., & Nigam, S. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00065-x · Cited by 39 · see citing works

DETANO and Nitrated Lipids Increase Chloride Secretion across Lung Airway Cells

Chen, L., Bosworth, C. A., Pico, T., Collawn, J. F., Varga, K., Gao, Z., Clancy, J. P., Fortenberry, J. A., Lancaster, J. R., & Matalon, S. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0005oc · Cited by 35 · see citing works

Trans-arachidonic acids: new mediators of nitro-oxidative stress

Balazy, M., & Chemtob, S. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.05.003 · Cited by 33 · see citing works

Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway

Iles, K. E., Wright, M. M., Cole, M. P., Welty, N. E., Ware, L. B., Matthay, M. A., Schopfer, F. J., Baker, P. R. S., Agarwal, A., & Freeman, B. Α. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.001 · Cited by 30 · see citing works

Fatty Acid Transduction of Nitric Oxide Signaling

Cole, M. P., & Freeman, B. Α. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00011-3 · Cited by 29 · see citing works

Regulation of protein kinase C by nitroarachidonic acid: Impact on human platelet activation

Bonilla, L., O’Donnell, V. B., Clark, S., Rubbo, H., & Trostchansky, A. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.03.001 · Cited by 28 · see citing works

The Role of Olive Oil in Cardiometabolic Risk

Salvo, A., & Tuttolomondo, A. (2025) · Metabolites · doi:10.3390/metabo15030190 · Cited by 28 · see citing works

Nitro-oleic acid desensitizes TRPA1 and TRPV1 agonist responses in adult rat DRG neurons

Zhang, X., Koronowski, K. B., Li, L., Freeman, B. Α., Woodcock, S. R., & de Groat, W. C. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.10.020 · Cited by 26 · see citing works

Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate

Hughan, K. S., Wendell, S. G., Delmastro-Greenwood, M. M., Helbling, N. L., Corey, C. G., Bellavia, L., Potti, G. K., Grimes, G. J., Goodpaster, B. H., Kim‐Shapiro, D. B., et al. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09016 · Cited by 26 · see citing works

Nitroalkenes induce rat aortic smooth muscle cell apoptosis via activation of caspase-dependent pathways

Tang, X., Guo, Y., Nakamura, K., Huang, H., Hamblin, M., Chang, L., Villacorta, L., Yin, K., Ouyang, H., & Zhang, J. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.091 · Cited by 21 · see citing works

Nitrated fatty acids prevent TNFα-stimulated inflammatory and atherogenic responses in endothelial cells

Hwang, J., Lee, K. E., Lim, J.-Y., & Park, S. I. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.030 · Cited by 21 · see citing works

6-Methylnitroarachidonate: A novel esterified nitroalkene that potently inhibits platelet aggregation and exerts cGMP-mediated vascular relaxation

Blanco, F., Ferreira, A. M., López, G. V., Bonilla, L., González, M., Cerecetto, H., Trostchansky, A., & Rubbo, H. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.031 · Cited by 21 · see citing works

New perspectives on bioactivity of olive oil: evidence from animal models, human interventions and the use of urinary proteomic biomarkers

da Silva, S. R. A., Combet, E., Figueira, M. E., Koeck, T., Mullen, W., & Bronze, M. R. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115002323 · Cited by 19 · see citing works

Profiling and relative quantification of multiply nitrated and oxidized fatty acids

Milic, I., Griesser, E., Vemula, V., Ieda, N., Nakagawa, H., Miyata, N., Galano, J., Oger, C., Durand, T., & Fedorova, M. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-8766-3 · Cited by 18 · see citing works

The role of insulin as an antithrombotic humoral factor

Chakraborty, K., & Sinha, A. K. (2003) · BioEssays · doi:10.1002/bies.10375 · Cited by 17 · see citing works

Characterization of phospholipid nitroxidation by LC-MS in biomimetic models and in H9c2 Myoblast using a lipidomic approach

Melo, T., Domingues, P. M., Ribeiro‐Rodrigues, T., Girão, H., Segundo, M. A., & Domingues, M. R. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.033 · Cited by 16 · see citing works

Pharmacological actions of dieckol on modulation of platelet functions and thrombus formation via integrin αIIbβ3 and cAMP signaling

Irfan, M., Kwon, T.-H., Kwon, H.-W., & Rhee, M. H. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106088 · Cited by 14 · see citing works

Mechanisms Underlying Nitroglycerin-Induced Superoxide Production in Platelets

Münzel, T. F., Mülsch, A., & Kleschyov, A. L. (2002) · Circulation · doi:10.1161/01.cir.0000021663.39699.30 · Cited by 14 · see citing works

Nitroalkenes: Synthesis, Characterization, and Effects on Macrophage Activation

Ferreira, A. M., Trostchansky, A., Ferrari, M., Souza, J. M., & Rubbo, H. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)01203-2 · Cited by 13 · see citing works

Reduction of Death Rate Due to Acute Myocardial Infarction in Subjects with Cancers through Systemic Restoration of Impaired Nitric Oxide

Ghosh, R., Ray, U., Jana, P., Bhattacharya, R., Banerjee, D., & Sinha, A. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088639 · Cited by 12 · see citing works

Nitrosation and nitration of bioactive molecules: toward the basis of disease and its prevention

d’Ischia, M. (2005) · Comptes Rendus Chimie · doi:10.1016/j.crci.2005.02.008 · Cited by 12 · see citing works

Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles

Tao, S., Zhang, Y., Wang, Q., Qiao, C., Deng, W., Liang, S., Wei, J., Wei, W., Yu, H., Li, X., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.969575 · Cited by 11 · see citing works

Understanding the nitrolipidome: From chemistry to mass spectrometry and biological significance of modified complex lipids

Neves, B., Pérez‐Sala, D., Ferreira, H. B., Guerra, I. M. S., Moreira, A. S. P., Domingues, P. M., Domingues, M. R., & Melo, T. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101176 · Cited by 11 · see citing works

Biomimetic nitration of the linoleic acid metabolite 13-hydroxyoctadecadienoic acid: isolation and spectral characterization of novel chain-rearranged epoxy nitro derivatives

Manini, P., Camera, E., Picardo, M., Napolitano, A., & d’Ischia, M. (2007) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2007.09.007 · Cited by 10 · see citing works

Redox Regulation of Soluble Epoxide Hydrolase—Implications for Cardiovascular Health and Disease

Charles, R. L., & Eaton, P. (2022) · Cells · doi:10.3390/cells11121932 · Cited by 10 · see citing works

The critical roles of cyclic AMP/cyclic AMP-dependent protein kinase in platelet physiology

Yan, R., Li, S., & Dai, K. (2008) · Frontiers in Biology · doi:10.1007/s11515-008-0098-7 · Cited by 10 · see citing works

p-Terphenyl curtisian E inhibits in vitro platelet aggregation via cAMP elevation and VASP phosphorylation

Kamruzzaman, S. M., Yayeh, T., Ji, H. D., Park, J. Y., Kwon, Y.-S., Lee, I., Kim, S., Oh, S. H., Kim, S., Roh, S., et al. (2013) · Vascular Pharmacology · doi:10.1016/j.vph.2013.07.002 · Cited by 10 · see citing works

Atypical PKCζ transduces electrophilic fatty acid signaling in pulmonary epithelial cells

Guo, C., Schopfer, F. J., Gonzales, L. W., Wang, P., Freeman, B. Α., & Gow, A. J. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.07.003 · Cited by 9 · see citing works

Blood Platelet as a Peripheral Cell in Oxidative Stress in Psychiatric Disorders

Wachowicz, B. (2015) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_16 · Cited by 10 · see citing works

Isomerization and Nitro-Oxidation of Arachidonic Acid by NO2

Balazy, M., & López-Fernández, J. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9194-2_36 · Cited by 8 · see citing works

The effect of the electrophilic fatty acid nitro-oleic acid on TRP channel function in sensory neurons

Beckel, J. M., & de Groat, W. C. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.03.015 · Cited by 8 · see citing works

Activation of TRPC channels contributes to OA‐NO2‐induced responses in guinea‐pig dorsal root ganglion neurons

Zhang, X., Beckel, J. M., Daugherty, S. L., Wang, T., Woodcock, S. R., Freeman, B. Α., & de Groat, W. C. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.271783 · Cited by 8 · see citing works

Tomato pomace-derived nitrated fatty acids: Synthesis and antiplatelet activity

Rodríguez, L., Lagos, F., Mastrogiovanni, M., Flores, A., Plaza, A., Tellería, F., Palomo, I. F., Eduardo Fuentes, Q., & Trostchansky, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117154 · Cited by 7 · see citing works

Electrophilic Nitro-Fatty Acids: Nitric Oxide and Nitrite-Derived Metabolic and Inflammatory Signaling Mediators

Freeman, B. Α., Pekarová, M., Rubbo, H., & Trostchansky, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00016-8 · Cited by 7 · see citing works

Diminishing Inflammation by Reducing Oxidant Generation: Nitrated Fatty Acid-Mediated Inactivation of Xanthine Oxidoreductase

Kelley, E. E. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-11488-6_4 · Cited by 7 · see citing works

Long-chain polyunsaturated fatty acids

Das, U. N. (2002) · Springer eBooks · doi:10.1007/978-1-4419-8564-4_9 · Cited by 6 · see citing works

Isolation and study of insulin activated nitric oxide synthase inhibitory protein in acute myocardial infarction subjects

Ray, U., Khan, G. A., Chakraborty, K., Basuroy, S., Patra, S. C., Girish, G. V., Bhattacharya, G., & Sinha, A. K. (2012) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-011-0672-8 · Cited by 5 · see citing works

Nitrated Lipids

Freedman, J. E. (2002) · Circulation Research · doi:10.1161/01.res.0000033471.67751.85 · Cited by 5 · see citing works

Bioactive Lipids and the Gut-Brain Axis: Diet as a Modulator of Bioactivity and Diversity of Lipids in the Brain

Ledo, A., Rocha, B. S., & Laranjinha, J. A. N. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-11488-6_10 · Cited by 4 · see citing works

Lipid Peroxidation and Nitration

Davies, S. S., & Guo, L. (2013) · Wiley eBooks · doi:10.1002/9781118355886.ch2 · Cited by 4 · see citing works

Lipid Oxidation

Fauzi, N. M., & Spickett, C. M. (2015) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-19096-9_4 · Cited by 3 · see citing works

Neurochemical Aspects of Oxidative and Nitrosative Stress

Farooqui, A. A. (2014) · Springer eBooks · doi:10.1007/978-3-319-04111-7_6 · Cited by 3 · see citing works

Enzymatic nitration of the oleic acid derivatives: Synthesis, isolation and characterization

Li, J., Tian, J., Fei, X., Wang, X., Xu, L., & Wang, Y. (2013) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/j.molcatb.2013.10.001 · Cited by 2 · see citing works

Nitric Oxide Biochemistry: Pathophysiology of Nitric Oxide-Mediated Protein Modifications

Rossi‐George, A., & Gow, A. J. (2009) · Contemporary clinical neuroscience · doi:10.1007/978-1-60327-342-8_2 · Cited by 2 · see citing works

Inhibitory Effects of Scopoletin in Collagen-induced Human Platelet Aggregation

Kwon, H.-W., Shin, J.-H., Park, C.-E., & Lee, D. (2019) · Korean Journal of Clinical Laboratory Science · doi:10.15324/kjcls.2019.51.1.34 · Cited by 1 · see citing works

Modulação da ativação dos receptores ativados por proliferadores de peroxissoma (PPAR) e dos receptores x hepáticos (LXR) por LNO2

Ferderbar, S. (2016) · doi:10.11606/t.9.2016.tde-05122016-180239

Detecção e caracterização de lipídios nitrados no plasma e nas lipoproteínas humanas

Lima, É. S. (2003) · doi:10.11606/t.9.2003.tde-25082022-091710

Protective Effects on the Cardiovascular System

Chang, Z., Gu, J., & Li, X. (2025) · Springer eBooks · doi:10.1007/978-981-95-2824-0_7

Nitrated fatty acids: Dietary origins, metabolic pathways, and therapeutic potential in cardiometabolic health

Rodríguez, L., Fernandez-Rojas, M., Morales-Malvarez, L., Eduardo Fuentes, Q., & Trostchansky, A. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.108175

Enhanced Antiplatelet Activity of Nitrated Fatty Acid Extracts from Phaseolus vulgaris L.

Rodríguez, L., Montecino-Garrido, H. L., Lagos, F., Carrasco, B., Palomo, I. F., Ormazabal, P., Trostchansky, A., & Eduardo Fuentes, Q. (2026) · Molecules · doi:10.3390/molecules31030488

Etude des mécanismes de détection, d'adaptation et de protection d'une souche de Pseudomonas fluorescens isolée de l'air en réponse au NO2 gazeux, marqueur de pollution automobile

Depayras, S. (2019) · doi:10.70675/cb0776cazb400z448az8ac6z4893e793d792

Novel Antiinflammatory Properties of Nitric Oxide–Derived Reactive Species in Vascular Cells

Neutrophils, H., Coles, B., Bloodsworth, A., Clark, S. R., Lewis, M. J., Cross, A. R., Freeman, B. A., & O’donnell, V. B. (2016)

Nitrolinoleate Inhibits Superoxide Generation, Degranulation, and Integrin Expression by Human Neutrophils: Novel Antiinflammatory Properties of Nitric Oxide–Derived Reactive Species in Vascular Cells

Coles, B., Bloodsworth, A., Clark, S. R., Lewis, M. J., Cross, A. R., Freeman, B. A., & O’Donnell, V. B. (2002) · Circulation Research · doi:10.1161/01.res.0000032114.68919.ef · Cited by 168 · see citing works

Direct inhibition of platelet function by organic nitrates via nitric oxide formation

Weber, A., Strobach, H., & Schrör, K. (1993) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(93)90134-u · Cited by 59 · see citing works

Nitric Oxide Inhibits Thrombin Receptor-activating Peptide-induced Phosphoinositide 3-Kinase Activity in Human Platelets

Pigazzi, A., Heydrick, S. J., Folli, F. B., Benoit, S., Michelson, A. D., & Loscalzo, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.14368 · Cited by 101 · see citing works

Nitrovasodilators and cGMP inhibit human platelet activation.

Doni, M. G., Alexandre, A., Padoin, E., Bertoncello, S., & Deana, R. (1991) · PubMed · Cited by 11 · see citing works