Major Urinary Protein-1 Increases Energy Expenditure and Improves Glucose Intolerance through Enhancing Mitochondrial Function in Skeletal Muscle of Diabetic Mice

Resveratrol improves health and survival of mice on a high-calorie diet

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Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

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FGF-21 as a novel metabolic regulator

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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

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Mitochondrial dysfunction and type 2 diabetes

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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

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Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

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Role of Mitochondrial Dysfunction in Insulin Resistance

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Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

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The lipocalin protein family: structural and sequence overview

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Hepatokines and metabolism: Deciphering communication from the liver

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Adipocyte Fatty Acid-binding Protein Modulates Inflammatory Responses in Macrophages through a Positive Feedback Loop Involving c-Jun NH2-terminal Kinases and Activator Protein-1

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Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes

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Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice

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Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research

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The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance

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Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice

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Adropin Is a Brain Membrane-bound Protein Regulating Physical Activity via the NB-3/Notch Signaling Pathway in Mice

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Follistatin Promotes Adipocyte Differentiation, Browning, and Energy Metabolism

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Major Urinary Protein Regulation of Chemical Communication and Nutrient Metabolism

Zhou, Y., & Rui, L. (2010) · Vitamins and hormones · doi:10.1016/s0083-6729(10)83006-7 · Cited by 97

Urine Proteome Analysis Reflects Atherosclerotic Disease in an ApoE−/− Mouse Model and Allows the Discovery of New Candidate Biomarkers in Mouse and Human Atherosclerosis

Mühlen, C. V. Z., Schiffer, E., Sackmann, C., Zürbig, P., Neudorfer, I., Zirlik, A., Htun, N., Iphöfer, A., Jänsch, L., Mischak, H., et al. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.013847 · Cited by 92

Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis

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The PPAR–microbiota–metabolic organ trilogy to fine‐tune physiology

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Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”

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Urinary exosomes and diabetic nephropathy: a proteomic approach

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Comparative Secretome Analyses of Primary Murine White and Brown Adipocytes Reveal Novel Adipokines

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Myeloid FoxO1 depletion attenuates hepatic inflammation and prevents nonalcoholic steatohepatitis

Lee, S., Usman, T. O., Yamauchi, J., Chhetri, G., Wang, X., Coudriet, G. M., Zhu, C., Gao, J., McConnell, R., Krantz, K., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci154333 · Cited by 64

Adiponectin-Mediated Antilipotoxic Effects in Regenerating Pancreatic Islets

Ye, R., Wang, M., Wang, Q. A., & Scherer, P. E. (2015) · Endocrinology · doi:10.1210/en.2015-1066 · Cited by 59

Effect of a high‐protein diet on food intake and liver metabolism during pregnancy, lactation and after weaning in mice

Kuhla, B., Kucia, M., Görs, S., Albrecht, D., Langhammer, M., Kuhla, S., & Metges, C. C. (2010) · PROTEOMICS · doi:10.1002/pmic.200900789 · Cited by 48

VEGF and VEGFB Play Balancing Roles in Adipose Differentiation, Gene Expression, and Function

Jin, H., Li, D., Wang, X., Jia, J., Chen, Y., Yao, Y., Zhao, C., Lü, X., Zhang, S., Togo, J., et al. (2018) · Endocrinology · doi:10.1210/en.2017-03246 · Cited by 47

Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training

Kleinert, M., Parker, B. L., Jensen, T. E., Raun, S. H., Pham, T. C. P., Han, X., James, D. E., Richter, E. A., & Sylow, L. (2018) · Scientific Reports · doi:10.1038/s41598-018-28540-5 · Cited by 46

Lipocalin 13 protein protects against hepatic steatosis by both inhibiting lipogenesis and stimulating fatty acid β-oxidation

Sheng, L., Cho, K. W., Zhou, Y., Shen, H., & Rui, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.256677 · Cited by 45

Bone healing in an aged murine fracture model is characterized by sustained callus inflammation and decreased cell proliferation

Hebb, J. H., Ashley, J. W., McDaniel, L. D., Lopas, L. A., Tobias, J. W., Hankenson, K. D., & Ahn, J. (2017) · Journal of Orthopaedic Research® · doi:10.1002/jor.23652 · Cited by 45

Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders

Pervin, S., Reddy, S. T., & Singh, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.653179 · Cited by 42

Lipocalin-13 regulates glucose metabolism by both insulin-dependent and insulin-independent mechanisms

Cho, K. W., Zhou, Y., Sheng, L., & Rui, L. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.00459-10 · Cited by 42

Major urinary protein 5, a scent communication protein, is regulated by dietary restriction and subsequent re-feeding in mice

Giller, K., Huebbe, P., Doering, F., Pallauf, K., & Rimbach, G. H. (2013) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2013.0101 · Cited by 41

Changes in Gene Expression Associated with FTO Overexpression in Mice

Merkestein, M., McTaggart, J. S., Lee, S., Kramer, H., McMurray, F., Lafond, M., Boutens, L., Cox, R., & Ashcroft, F. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097162 · Cited by 39

Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis‐associated cachexia

Cheung, W. W., Sheng, H., Wang, Z., Ding, W. Q., Zheng, R., Gonzalez, A., Zhan, J., Zhou, P. H., Li, S., Esparza, M. C., et al. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12497 · Cited by 34

Social dominance‐related major urinary proteins and the regulatory mechanism in mice

Guo, H.-F., Fang, Q., Huo, Y., Zhang, Y., & Zhang, J. (2015) · Integrative Zoology · doi:10.1111/1749-4877.12165 · Cited by 32

Secreted MUP1 that reduced under ER stress attenuates ER stress induced insulin resistance through suppressing protein synthesis in hepatocytes

Gao, R., Wang, H., Li, T., Wang, J., Ren, Z., Cai, N., Ai, H., Li, S., Lü, Y., Zhu, Y., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106585 · Cited by 33

Regulation of Sexually Dimorphic Expression of Major Urinary Proteins

Penn, D. J., Zala, S. M., & Luzynski, K. C. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.822073 · Cited by 36

Restriction on an Energy-Dense Diet Improves Markers of Metabolic Health and Cellular Aging in Mice Through Decreasing Hepatic mTOR Activity

Schloesser, A., Campbell, G. M., Glüer, C., Rimbach, G. H., & Huebbe, P. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1630 · Cited by 34

Novel Short-Clustered Maltodextrin as a Dietary Starch Substitute Attenuates Metabolic Dysregulation and Restructures Gut Microbiota in db / db Mice

Kong, H., Yu, L., Gu, Z., Li, C., Ban, X., Cheng, L., Hong, Y., & Li, Z. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c05798 · Cited by 31

High Fat Diet-Induced Changes in Hepatic Protein Abundance in Mice

Luo, M., Mengos, A. E., Stubblefield, T. M., & Mandarino, L. J. (2012) · Journal of Proteomics & Bioinformatics · doi:10.4172/jpb.1000214 · Cited by 31

Metabolomic profiling of urinary changes in mice with monosodium glutamate-induced obesity

Pelantová, H., Bártová, S., Anýž, J., Holubová, M., Železná, B., Maletı́nská, L., Novák, D., Lacinová, Z., Šulc, M., Haluzı́k, M., et al. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-9133-0 · Cited by 30

Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases

Singh, R., Pervin, S., Lee, S., Kuo, A., Grijalva, V. R., David, J., Vergnes, L., & Reddy, S. T. (2018) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s159315 · Cited by 29

Protective Effects of Hydrolyzed Chicken Extract (Probeptigen®/Cmi-168) on Memory Retention and Brain Oxidative Stress in Senescence-Accelerated Mice

Chou, M.-Y., Chen, Y., Lin, L.-H., Nakao, Y., Lim, A. L., Wang, M.-F., & Yong, S. M. (2019) · Nutrients · doi:10.3390/nu11081870 · Cited by 30

Exercise and High-Fat Diet in Obesity: Functional Genomics Perspectives of Two Energy Homeostasis Pillars

Ghanemi, A., Melouane, A., Yoshioka, M., & St‐Amand, J. (2020) · Genes · doi:10.3390/genes11080875 · Cited by 31

Lipocalin 13 regulation of glucose and lipid metabolism in obesity

Zhou, Y., & Rui, L. (2013) · Vitamins & Hormones · doi:10.1016/b978-0-12-407766-9.00015-8 · Cited by 28

Integrated Proteomic Analysis of Major Isoaspartyl-Containing Proteins in the Urine of Wild Type and Protein l -Isoaspartate O-Methyltransferase-Deficient Mice

Dai, S., Ni, W., Patananan, A. N., Clarke, S. G., Karger, B. L., & Zhou, Z. S. (2013) · Analytical Chemistry · doi:10.1021/ac303428h · Cited by 28

Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice

Kainulainen, H., Papaioannou, K., Silvennoinen, M., Autio, R., Saarela, J., Oliveira, B. M. S., Nyqvist, M., Pasternack, A. H., Hoen, P. A. C. ’., Kujala, U. M., et al. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.10.001 · Cited by 27

Macrophage tumor necrosis factor‐alpha deletion does not protect against obesity‐associated metabolic dysfunction

Al-Adhami, A., Unger, C. A., Ennis, S. L., Altomare, D., Ji, H., Hope, M. C., Velázquez, K. T., & Enos, R. T. (2021) · The FASEB Journal · doi:10.1096/fj.202100543rr · Cited by 27

Abundant plasma protein depletion using ammonium sulfate precipitation and Protein A affinity chromatography

Pringels, L., Broeckx, V., Boonen, K., Landuyt, B., & Schoofs, L. (2018) · Journal of Chromatography B · doi:10.1016/j.jchromb.2018.04.045 · Cited by 26

Proteomic quantitative study of dorsal root ganglia and sciatic nerve in type 2 diabetic mice

Leal-Julià, M., Vilches, J., Onieva, A., Verdés, S., Sánchez, Á., Chillón, M., Navarro, X., & Bosch, A. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101408 · Cited by 26

The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research

Greve, S., Kuhn, G. A., Saenz-de-Juano, M. D., Ghosh, A., von Meyenn, F., & Giller, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-17195-y · Cited by 26

Region-Resolved Quantitative Proteome Profiling Reveals Molecular Dynamics Associated With Chronic Pain in the PNS and Spinal Cord

Barry, A. M., Sondermann, J. R., Sondermann, J.-H., Gómez‐Varela, D., & Schmidt, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00259 · Cited by 25

Comparative Proteomic Analysis of Liver Tissues and Serum in db/db Mice

Zhang, Y., Wu, X., Xu, M., Yue, T., Ling, P., Fang, T., Luo, S., Xu, S., & Weng, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179687 · Cited by 24

The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli

Pedrotti, S., Caccia, R., Neguembor, M. V., García-Manteiga, J. M., Ferri, G., Palma, C. D., Canu, T., Giovarelli, M., Marra, P., Fiocchi, A., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav1472 · Cited by 24

Butylated Hydroxytoluene Is a Ligand of Urinary Proteins Derived from Female Mice

Kwak, J., Josue, J., Faranda, A. P., Opiekun, M. C., Preti, G., Osada, K., Yamazaki, K., & Beauchamp, G. K. (2011) · Chemical Senses · doi:10.1093/chemse/bjr015 · Cited by 23

Message in a bottle: major urinary proteins and their multiple roles in mouse intraspecific chemical communication

Mucignat‐Caretta, C., & Caretta, A. (2014) · Animal Behaviour · doi:10.1016/j.anbehav.2014.08.006 · Cited by 23

OmicApproaches in Environmental Issues

Abril, N., Ruiz-Laguna, J., Osuna-Jiménez, I., Vioque-Fernández, A., Fernández-Cisnal, R., Chicano‐Gálvez, E., Alhama, J., López‐Barea, J., & Pueyo, C. (2011) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2011.582259 · Cited by 23

Effects of Edible Insect Tenebrio molitor Larva Fermentation Extract as a Substitute Protein on Hepatosteatogenesis and Proteomic Changes in Obese Mice Induced by High-Fat Diet

Ham, J. R., Choi, R., Lee, Y., & Lee, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073615 · Cited by 25

Regulation of hepatic oxidative stress by voltage‐gated proton channels (Hv1/VSOP) in Kupffer cells and its potential relationship with glucose metabolism

Kawai, T., Kayama, K., Tatsumi, S., Akter, S., Miyawaki, N., Okochi, Y., Abe, M., Sakimura, K., Yamamoto, H., Kihara, S., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202001056rrr · Cited by 20

Proteomic analysis of changes in protein expression in liver mitochondria in apoE knockout mice

Suski, M., Olszanecki, R., Madej, J., Totoń‐Żurańska, J., Niepsuj, A., Jawień, J., Bujak-Giżycka, B., Okoń, K., & Korbut, R. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.03.003 · Cited by 21

Characterization of the serum and liver proteomes in gut-microbiota-lacking mice

Tung, Y., Chen, Y., Chuang, H.-L., Huang, W.-C., Lo, C.-T., Liao, C.-C., & Huang, C. (2017) · International Journal of Medical Sciences · doi:10.7150/ijms.17792 · Cited by 22

Hepatic Tumor Formation in Adult Mice Developmentally Exposed to Organotin

Katz, T. A., Grimm, S. L., Kaushal, A., Dong, J., Treviño, L. S., Jangid, R. K., Gaitán, A. V., Bertocchio, J., Guan, Y., Robertson, M. J., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp5414 · Cited by 21

Strategy for NMR metabolomic analysis of urine in mouse models of obesity— from sample collection to interpretation of acquired data

Pelantová, H., Bugáňová, M., Anýž, J., Železná, B., Maletı́nská, L., Novák, D., Haluzı́k, M., & Kuzma, M. (2015) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2015.06.036 · Cited by 20

Regulation of gene expression during the fasting-feeding cycle of the liver displays mouse strain specificity

Chi, Y., Youn, D. Y., Xiaoli, A. M., Liu, L. P., Pessin, J. B., Yang, F., & Pessin, J. E. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012349 · Cited by 19

Comparative proteomic study of liver lipid droplets and mitochondria in mice housed at different temperatures

Liu, Q., Zhou, Z., Liu, P., & Zhang, S. (2019) · FEBS Letters · doi:10.1002/1873-3468.13509 · Cited by 19

Integration of transcriptomics and metabolomics profiling reveals the metabolic pathways affected in dictamnine-induced hepatotoxicity in mice

Li, Z., Wang, L.-L., Zhou, J., Zheng, X., Jiang, Y., Li, P., & Li, H. (2019) · Journal of Proteomics · doi:10.1016/j.jprot.2019.103603 · Cited by 19

The mdx Mutation in the 129/Sv Background Results in a Milder Phenotype: Transcriptome Comparative Analysis Searching for the Protective Factors

Calyjur, P. C., de Almeida, C., Ayub-Guerrieri, D., Ribeiro, A. F., Fernandes, S., Ishiba, R., dos Santos, A. L. F., Onofre-Oliveira, P. C. G., & Vainzof, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150748 · Cited by 18

The effects of Gentiana dahurica Fisch on alcoholic liver disease revealed by RNA sequencing

Cao, H., Xi, S.-Y., He, W., Ma, X., Liu, L., Xu, J., Zhang, K., Li, Y., & Jin, L. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113422 · Cited by 18

Differential Proteomic Analysis of STAT6 Knockout Mice Reveals New Regulatory Function in Liver Lipid Homeostasis

Iff, J., Wang, W., Sajic, T., Oudry, N., Gueneau, E., Gérard Hopfgartner, D., Varesio, E., & Szántó, I. (2009) · Journal of Proteome Research · doi:10.1021/pr9003272 · Cited by 17

Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model

Chen, C.-C., Lee, T.-Y., Kwok, C., Hsu, Y.-P., Shih, K., Lin, Y., & Ho, L.-T. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.03.155 · Cited by 17

A Leptin Receptor Antagonist Attenuates Adipose Tissue Browning and Muscle Wasting in Infantile Nephropathic Cystinosis-Associated Cachexia

Gonzalez, A., Cheung, W. W., Perens, E. A., OLIVEIRA, E. A., Gertler, A., & MAK, R. H. K. (2021) · Cells · doi:10.3390/cells10081954 · Cited by 16

Transplantation of committed pre-adipocytes from brown adipose tissue improves whole-body glucose homeostasis

Dewal, R. S., Yang, F. T., Baer, L. A., Vidal, P., Hernández‐Saavedra, D., Seculov, N. P., Ghosh, A., Noé, F., Togliatti, O., Hughes, L., et al. (2024) · iScience · doi:10.1016/j.isci.2024.108927 · Cited by 16

Acyl-CoA binding protein for the experimental treatment of anorexia

Chen, H., Moriceau, S., Joseph, A., Mailliet, F., Li, S., Tolle, V., Duriez, P., Dardennes, R. M., Durand, S., Carbonnier, V., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adl0715 · Cited by 16

Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice

Kim, C. J., Singh, C., Lee, C., DiMagno, K., O'Donnell, M., Kaczmarek, M., Ahmed, A., Salvo‐Schaich, J., Perez, A. M., Letsou, W., et al. (2023) · Physiological Reports · doi:10.14814/phy2.15674 · Cited by 12

Neglected markers: Altered serum proteome in murine models of disease

Gianazza, E., Vegeto, E., Eberini, I., Sensi, C., & Miller, I. (2012) · PROTEOMICS · doi:10.1002/pmic.201100320 · Cited by 14

15N metabolic labeling: Evidence for a stable isotope effect on plasma protein levels and peptide chromatographic retention times

Webhofer, C., Zhang, Y., Brusis, J., Reckow, S., Landgraf, R., Maccarrone, G., Turck, C. W., & Filiou, M. D. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.12.013 · Cited by 14

Integration of transcriptomics and metabolomics analysis for unveiling the toxicological profile in the liver of mice exposed to uranium in drinking water

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Adipose MDM2 regulates systemic insulin sensitivity

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Quantitative proteomics reveals decreased expression of major urinary proteins in the liver of apoE/ eNOS ‐ DKO mice

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Identification of MUP1 as a Regulator for Glucose and Lipid Metabolism in Mice

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