The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition

Stat3 as an Oncogene

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The STATs of cancer — new molecular targets come of age

Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278 · see citing works

Apoptosis

Johnstone, R. W., Ruefli, A. A., & Lowe, S. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00625-6 · Cited by 2,236 · see citing works

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

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Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

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A decade of CDK5

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What does Stat3 do?

Levy, D., & Lee, C.-K. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15650 · Cited by 925 · see citing works

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876 · see citing works

Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300

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Stat proteins and oncogenesis

Bromberg, J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15617 · Cited by 846 · see citing works

What does Stat3 do?

Levy, D. E., & Lee, C.-K. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215650 · Cited by 734 · see citing works

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

Lee, H., Herrmann, A., Deng, J.-H., Kujawski, M., Niu, G., Li, Z., Forman, S., Jove, R., Pardoll, D. M., & Yu, H. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.02.015 · Cited by 683 · see citing works

Stat3 Activation Is Required for Cellular Transformation by v- <i>src</i>

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Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB

Yang, J., Liao, X., Agarwal, M. K., Barnes, L., Auron, P. E., & Stark, G. R. (2007) · Genes &amp; Development · doi:10.1101/gad.1553707 · Cited by 611 · see citing works

Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells

Gritsko, T., Williams, A., Turkson, J., Kaneko, S., Bowman, T., Huang, M., Nam, S., Eweis, I., Diaz, N., Sullivan, D., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1752 · Cited by 563 · see citing works

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

Lo, H., Hsu, S.-C., Ali‐Seyed, M., Gündüz, M., Xia, W., Wei, Y., Bartholomeusz, G. A., Shih, J. Y., & Hung, M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.007 · Cited by 539 · see citing works

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

Bowman, T., Broome, M. A., Sinibaldi, D., Wharton, W., Pledger, W. J., Sedivy, J. M., Irby, R., Yeatman, T., Courtneidge, S. A., & Jove, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131568898 · Cited by 488 · see citing works

Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation

Yang, J., Chatterjee-Kishore, M., Staugaitis, S. M., Nguyen, H., Schlessinger, K., Levy, D. E., & Stark, G. R. (2005) · Cancer Research · doi:10.1158/0008-5472.939.65.3 · Cited by 405 · see citing works

Role of Stat3 in Regulating p53 Expression and Function

Niu, G., Wright, K. L., Ma, Y., Wright, G. M., Huang, M., Irby, R., Briggs, J., Karras, J. G., Cress, W. D., Pardoll, D. M., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7432-7440.2005 · Cited by 398 · see citing works

STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene

Kiuchi, N., Nakajima, K., Ichiba, M., Fukada, T., Narimatsu, M., Mizuno, K., Hibi, M., & Hirano, T. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.1.63 · Cited by 396 · see citing works

How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene

Chatterjee‐Kishore, M., Wright, K. L., Ting, J. P. ‐., & Stark, G. R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.15.4111 · Cited by 347 · see citing works

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

Turner, N. C., Lord, C. J., Iorns, E. J., Brough, R., Swift, S., Elliott, R. J. R., Rayter, S., Tutt, A. N. J., & Ashworth, A. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.61 · Cited by 322 · see citing works

BCR/ABL Regulates Mammalian RecA Homologs, Resulting in Drug Resistance

Słupianek, A., Schmütte, C., Tombline, G., Nieborowska-Skorska, M., Hoser, G., Nowicki, M. O., Pierce, A. J., Fishel, R. A., & Skórski, T. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00357-4 · Cited by 313 · see citing works

Repair of and checkpoint response to topoisomerase I-mediated DNA damage

Pommier, Y. G., Redon, C., Rao, V. A., Seiler, J. A., Sordet, O., Takemura, H., Antony, S., Meng, L., Liao, Z., Kohlhagen, G., et al. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.016 · Cited by 299 · see citing works

Cyclin D1 Is Transcriptionally Regulated by and Required for Transformation by Activated Signal Transducer and Activator of Transcription 3

Leslie, K., Lang, C., Devgan, G., Azare, J., Berishaj, M., Gerald, W., Kim, Y. B., Paz, K., Darnell, J. E., Albanese, C., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2203 · Cited by 285 · see citing works

Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis

Gong, X., Tang, X., Wiedmann, M. W., Xuemin, W., Peng, J., Zheng, D., Blair, L. A. C., Marshall, J. J., & Mao, Z. (2003) · Neuron · doi:10.1016/s0896-6273(03)00191-0 · Cited by 260 · see citing works

Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1

Shen, Y., Devgan, G., Darnell, J. E., & Bromberg, J. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1543 · Cited by 249 · see citing works

Signal Transducers and Activators of Transcription 3 Pathway Activation in Drug-Resistant Ovarian Cancer

Duan, Z., Foster, R., Bell, D. A., Mahoney, J., Wolak, K. E., Vaidya, A. P., Hampel, C., Lee, H., & Seiden, M. V. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0861 · Cited by 247 · see citing works

Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression

Diaz, N., Minton, S. E., Cox, C., Bowman, T. L., Gritsko, T., Garcia, R., Eweis, I., Wloch, M., Livingston, S., Seijo, E., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1749 · Cited by 241 · see citing works

Stat Protein Transactivation Domains Recruit p300/CBP through Widely Divergent Sequences

Paulson, M. S., Pisharody, S., Li, P., Levy, D. E., Guadagno, S. N., & Mui, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25343 · Cited by 234 · see citing works

Fusion Tyrosine Kinases Induce Drug Resistance by Stimulation of Homology-Dependent Recombination Repair, Prolongation of G 2 /M Phase, and Protection from Apoptosis

Słupianek, A., Hoser, G., Majsterek, I., Bronisz, A., Malecki, M. T., Błasiak, J., Fishel, R. A., & Skórski, T. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4189-4201.2002 · Cited by 205 · see citing works

Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death

Tian, B., Yang, Q., & Mao, Z. (2009) · Nature Cell Biology · doi:10.1038/ncb1829 · Cited by 184 · see citing works

Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a

Giraud, S., Bienvenu, F., Avril, S., Gascan, H., Heery, D. M., & Coqueret, O. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111486200 · Cited by 149 · see citing works

Disruption of Murine Mus81 Increases Genomic Instability and DNA Damage Sensitivity but Does Not Promote Tumorigenesis

Dendouga, N., Gao, H. J., Moechars, D., Janicot, M., Vialard, J. E., & McGowan, C. H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7569-7579.2005 · Cited by 146 · see citing works

Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias

Beneklı, M., Baumann, H., & Wetzler, M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.21.3264 · Cited by 140 · see citing works

Activation of Signal Transducer and Activator of Transcription 3 through a Phosphomimetic Serine 727 Promotes Prostate Tumorigenesis Independent of Tyrosine 705 Phosphorylation

Qin, H. R., Kim, H., Kim, J., Hurt, E. M., Klarmann, G. J., Kawasaki, B. T., Serrat, M. A. D., & Farrar, W. L. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1125 · Cited by 139 · see citing works

Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

Fu, A. K. Y., Fu, W., Ng, A. K. Y., Chien, W. W. Y., Ng, Y.-P., Wang, J. H.-C., & Ip, N. Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307606100 · Cited by 135 · see citing works

Exploring the roles of Mus81-Eme1/Mms4 at perturbed replication forks

Osman, F., & Whitby, M. C. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.019 · Cited by 121 · see citing works

The STAT3 oncogene as a predictive marker of drug resistance

Barré, B., Vigneron, A. M., Perkins, N. D., Roninson, I. B., Gamelin, E. C., & Coqueret, O. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.11.001 · Cited by 120 · see citing works

Cdk5 Regulates STAT3 Activation and Cell Proliferation in Medullary Thyroid Carcinoma Cells

Lin, H., Chen, M., Chiu, C.-Y., Song, Y.-M., & Lin, S.-Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607234200 · Cited by 117 · see citing works

Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene

Giraud, S., Hurlstone, A. F. L., Avril, S., & Coqueret, O. (2004) · Oncogene · doi:10.1038/sj.onc.1207972 · Cited by 105 · see citing works

Signal Transducer and Activator of Transcription 3 Is a Key Regulator of Keratinocyte Survival and Proliferation following UV Irradiation

Sano, S., Chan, K. S., Kira, M., Kataoka, K., Takagi, S., Tarutani, M., Itami, S., Kiguchi, K., Yokoi, M., Sugasawa, K., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4359 · Cited by 101 · see citing works

STAT1

Thomas, M., Finnegan, C. E., Rogers, K., Purcell, J. W., Trimble, A., Johnston, P. G., & Boland, M. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1864 · Cited by 99 · see citing works

Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2

Wang, C., Song, J. H., Song, D. K., Yong, V. W., Shuaib, A. M., & Hao, C. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401804 · Cited by 89 · see citing works

The STAT3 Transcription Factor Is a Target for the Myc and Riboblastoma Proteins on the Cdc25A Promoter

Barré, B., Vigneron, A. M., & Coqueret, O. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413203200 · Cited by 86 · see citing works

Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma

Flørenes, V. A., Lü, C., Bhattacharya, N., Rak, J. W., Sheehan, C., Slingerland, J. M., & Kerbel, R. S. (1999) · Oncogene · doi:10.1038/sj.onc.1202382 · Cited by 79 · see citing works

Cisplatin Mimics ARF Tumor Suppressor Regulation of RelA (p65) Nuclear Factor-κB Transactivation

Campbell, K. J., Witty, J., Rocha, S., & Perkins, N. D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2234 · Cited by 77 · see citing works

Increased Ezrin Expression and Activation by CDK5 Coincident with Acquisition of the Senescent Phenotype

Yang, H.-S., & Hinds, P. W. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00135-7 · Cited by 75 · see citing works

The Cell Cycle Inhibitor p21 Binds to the myc and cdc25A Promoters upon DNA Damage and Induces Transcriptional Repression

Vigneron, A. M., Cherier, J., Barré, B., Gamelin, E. C., & Coqueret, O. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602492200 · Cited by 73 · see citing works

Cellular Senescence Requires CDK5 Repression of Rac1 Activity

Alexander, K., Yang, H.-S., & Hinds, P. W. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2808-2819.2004 · Cited by 67 · see citing works

The EGFR-STAT3 Oncogenic Pathway Up-regulates the Eme1 Endonuclease to Reduce DNA Damage after Topoisomerase I Inhibition

Vigneron, A. M., Gamelin, E. C., & Coqueret, O. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5115 · Cited by 64 · see citing works

Src Inhibits Adriamycin-Induced Senescence and G2 Checkpoint Arrest by Blocking the Induction of p21waf1

Vigneron, A. M., Roninson, I. B., Gamelin, E. C., & Coqueret, O. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0461 · Cited by 61 · see citing works

DNA Replication Stalling Attenuates Tyrosine Kinase Signaling to Suppress S Phase Progression

Shields, B. J., Hauser, C., Bukczynska, P. E., Court, N. W., & Tiganis, T. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.06.003 · Cited by 59 · see citing works

Cyclin-dependent Kinase Inhibitors Uncouple Cell Cycle Progression from Mitochondrial Apoptotic Functions in DNA-damaged Cancer Cells

Le, H.-V., Minn, A. J., & Massagué, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504689200 · Cited by 47 · see citing works

Transcriptional Regulation by a DNA-associated Form of Cyclin D1

Bienvenu, F., Barré, B., Giraud, S., Avril, S., & Coqueret, O. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0654 · Cited by 47 · see citing works

Cooperative Roles of c-Abl and Cdk5 in Regulation of p53 in Response to Oxidative Stress

Lee, J., Jeong, M.-W., Kim, W., Choi, Y. H., & Kim, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706201200 · Cited by 42 · see citing works

Cross-Linking of Signal Transducer and Activator of Transcription 3—A Molecular Marker for the Photodynamic Reaction in Cells and Tumors

Henderson, B. W., Daroqui, C., Tracy, E., Vaughan, L. A., Loewen, G., Cooper, M. T., & Baumann, H. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2950 · Cited by 38 · see citing works

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works

Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery

Hu, Y., Dong, Z., & Liu, K. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-02949-5 · Cited by 288 · see citing works

The Emerging Role of Cdk5 in Cancer

Pozo, K., & Bibb, J. A. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.09.001 · Cited by 174 · see citing works

Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy

Thuya, W. L., Cao, Y., Ho, P. C., Wong, A. L., Wang, L., Zhou, J., Nicot, C., & Goh, B. C. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.01.003 · Cited by 139 · see citing works

A Quantitative Proteomic Approach of the Different Stages of Colorectal Cancer Establishes OLFM4 as a New Nonmetastatic Tumor Marker

Besson, D., Pavageau, A.-H., Valo, I., Bourreau, A., Bélanger, A., Eymerit-Morin, C., Moulière, A., Chassevent, A., Boisdron-Celle, M., Morel, A., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.009712 · Cited by 128 · see citing works

Regulation of Multi-drug Resistance in hepatocellular carcinoma cells is TRPC6/Calcium Dependent

Wen, L., Liang, C., Chen, E., Chen, W., Liang, F., Zhi, X., Wei, T., Xue, F., Li, G., Yang, Q., et al. (2016) · Scientific Reports · doi:10.1038/srep23269 · Cited by 115 · see citing works

Chemotherapy-induced senescence, an adaptive mechanism driving resistance and tumor heterogeneity

Guillon, J., Petit, C., Toutain, B., Guette, C., Lelièvre, E., & Coqueret, O. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1652047 · Cited by 102 · see citing works

STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy

Spitzner, M., Ebner, R., Wolff, H. A., Ghadimi, Β. M., Wienands, J., & Grade, M. (2014) · Cancers · doi:10.3390/cancers6041986 · Cited by 91 · see citing works

STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle

Morgan, E. L., Wasson, C. W., Hanson, L., Kealy, D., Pentland, I., McGuire, V. A., Scarpini, C. G., Coleman, N., Arthur, J. S. C., Parish, J. L., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006975 · Cited by 87 · see citing works

Role of Bcl-3 in solid tumors

Maldonado, V., & Meléndez-Zajgla, J. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-152 · Cited by 86 · see citing works

Extraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase Cdk5

Arif, A. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.06.027 · Cited by 83 · see citing works

Targeting cyclin dependent kinase 5 in hepatocellular carcinoma – A novel therapeutic approach

Ehrlich, S. M., Liebl, J., Ardelt, M. A., Lehr, T., Toni, E. N. D., Mayr, D. C., Brandl, L., Kirchner, T., Stefan Zahler, A., Gerbes, A. L., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.01.031 · Cited by 80 · see citing works

TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway

Yu, H.-P., Xie, J., Li, B., Sun, Y., Gao, Q.-G., Ding, Z.-H., Wu, H.-R., & Qin, Z. (2015) · Scientific Reports · doi:10.1038/srep09853 · Cited by 72 · see citing works

A temporal examination of calcium signaling in cancer- from tumorigenesis, to immune evasion, and metastasis

Xu, M., Seas, A., Kiyani, M., Ji, K. S. Y., & Bell, H. N. (2018) · Cell & Bioscience · doi:10.1186/s13578-018-0223-5 · Cited by 65 · see citing works

Critical Role for Lysine 685 in Gene Expression Mediated by Transcription Factor Unphosphorylated STAT3

Dasgupta, M., Unal, H., Willard, B., Yang, J., Karnik, S. S., & Stark, G. R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.603894 · Cited by 64 · see citing works

Cdk5 links with DNA damage response and cancer

Liu, W., Li, J., Song, Y., Li, Y., Jia, Y., & Zhao, H. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0611-1 · Cited by 64 · see citing works

Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser 727 on STAT3 in prostate cancer cells

Hsu, F.-N., Chen, M., Lin, K., Peng, Y.-T., Li, P.-C., Lin, E., Chiang, M.-C., Hsieh, J., & Lin, H. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00615.2012 · Cited by 61 · see citing works

Escape from p21-mediated Oncogene-induced Senescence Leads to Cell Dedifferentiation and Dependence on Anti-apoptotic Bcl-xL and MCL1 Proteins

Trécesson, S. D. C., Guillemin, Y., Bélanger, A., Bernard, A.-C., Preisser, L., Ravon, E., Gamelin, E. C., Juin, P. P., Barré, B., & Coqueret, O. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.186437 · Cited by 58 · see citing works

X-box Binding Protein 1 Regulates Unfolded Protein, Acute-Phase, and DNA Damage Responses During Regeneration of Mouse Liver

Argemí, J., Kress, T. R., Chang, H. C. Y., Ferrero, R., Bértolo, C., Moreno, H., González-Aparicio, M., Uriarte, I., Guembe, L., Segura, V., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.12.040 · Cited by 58 · see citing works

Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1

Jonchère, B., Vétillard, A., Toutain, B., Lam, D., Bernard, A.-C., Henry, C., Trécesson, S. D. C., Gamelin, E. C., Juin, P. P., Guette, C., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2774 · Cited by 54 · see citing works

Phosphoregulation of the RNA-binding Protein Hu Antigen R (HuR) by Cdk5 Affects Centrosome Function

Filippova, N., Yang, X., King, P. H., & Nabors, B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.353912 · Cited by 51 · see citing works

How should we define STAT3 as an oncogene and as a potential target for therapy?

Sellier, H., Rébillard, A., Guette, C., Barré, B., & Coqueret, O. (2013) · JAK-STAT · doi:10.4161/jkst.24716 · Cited by 51 · see citing works

A kinase of many talents: non-neuronal functions of CDK5 in development and disease

Sharma, S., & Siciński, P. (2020) · Open Biology · doi:10.1098/rsob.190287 · Cited by 50 · see citing works

STAT3 Contributes to Radioresistance in Cancer

Wang, X., Zhang, X., Qiu, C., & Yang, N. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01120 · Cited by 50 · see citing works

Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer

Alexander, A., Karakaş, C., Chen, X., Carey, J. P. W., Yi, M., Bondy, M. L., Thompson, P. A., Cheung, K., Ellis, I. O., Gong, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14689 · Cited by 48 · see citing works

STAT3 as a new autophagy regulator

Jonchère, B., Bélanger, A., Guette, C., Barré, B., & Coqueret, O. (2013) · JAK-STAT · doi:10.4161/jkst.24353 · Cited by 47 · see citing works

MicroRNA-26a/cyclin-dependent kinase 5 axis controls proliferation, apoptosis and in vivo tumor growth of diffuse large B-cell lymphoma cell lines

Farina, F. M., Inguscio, A., Kunderfranco, P., Cortesi, A., Elia, L., & Quintavalle, M. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.291 · Cited by 47 · see citing works

SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma

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The Role of CDK5 in Tumours and Tumour Microenvironments

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Uridine-cytidine kinase 2 promotes metastasis of hepatocellular carcinoma cells via the Stat3 pathway

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Repurposing of niclosamide as a STAT3 inhibitor to enhance the anticancer effect of chemotherapeutic drugs in treating colorectal cancer

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Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors

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Dancing rhinos in stilettos

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Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis

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A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

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Tfh Exosomes Derived from Allergic Rhinitis Promote DC Maturation Through miR-142-5p/CDK5/STAT3 Pathway

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Unraveling the role of STAT3 in Cancer Cachexia: pathogenic mechanisms and therapeutic opportunities

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TP5, a Peptide Inhibitor of Aberrant and Hyperactive CDK5/p25: A Novel Therapeutic Approach against Glioblastoma

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Inhibition of Stat3 by peptide aptamer rS3-PA enhances growth suppressive effects of irinotecan on colorectal cancer cells

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Phosphorylation of STAT3 by axonal Cdk5 promotes axonal regeneration by modulating mitochondrial activity

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Research advances in natural sesquiterpene lactones: overcoming cancer drug resistance through modulation of key signaling pathways

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Sodium orthovanadate suppresses palmitate-induced cardiomyocyte apoptosis by regulation of the JAK2/STAT3 signaling pathway

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FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma

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Cdk5 Phosphorylation of STAT3 in Dorsal Root Ganglion Neurons Is Involved in Promoting Axonal Regeneration After Peripheral Nerve Injury

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CDK5: Insights into its roles in diseases

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Cetuximab promotes SN38 sensitivity via suppression of heat shock protein 27 in colorectal cancer cells with wild-type RAS

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Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, China

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TP5: A Novel Therapeutic Approach Targeting Aberrant and Hyperactive CDK5/p25 for the Treatment of Colorectal Carcinoma

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Circulating miRNAs as new activators of the JAK-STAT3 pathway

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The Duality of Cdk5: A Master Regulator in Neurodevelopment and a Hijacked Oncogene in Cancer

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LOXL2 reduces susceptibility to PARP inhibitors by promoting super-enhancer-regulated DNA damage repair in high-grade serous ovarian cancer

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Autophagy-related Protein LC3 in Egyptian Colorectal Cancer: Impact and Possible Relation to STAT3 andmiRNA 101.

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Rôle de la kinase Akt dans la chimiorésistance : Régulation de l’équilibre Apoptose-Sénescence

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BindingDB Entry 50019728: Novel Medicinal Chemistry Strategies Targeting CDK5 for Drug Discovery.

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The EGFR-STAT3 Oncogenic Pathway Up-regulates the Eme1 Endonuclease to Reduce DNA Damage after Topoisomerase I Inhibition

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Identification of novel regulators of STAT3 activity

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CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3

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